The network for 'dna dependent dna replication' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

dna dependent dna replication

A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
MCM2 Mcm2p 0.999
ORC2 Orc2p 0.997
POL1 Pol1p 0.997
MRC1 Mrc1p 0.997
CDC45 Cdc45p 0.996
SLD5 Sld5p 0.994
MCM4 Mcm4p 0.994
POL2 Pol2p 0.986
PSF1 Psf1p 0.979
DPB2 Dpb2p 0.978
POL12 Pol12p 0.973
ORC1 Orc1p 0.973
MCM5 Mcm5p 0.967
POL32 Pol32p 0.962
MCM7 Mcm7p 0.953
CTF4 Ctf4p 0.941
TOF1 Tof1p 0.935
CTF18 Ctf18p 0.912
RFC5 Rfc5p 0.897
MCM10 Mcm10p 0.882
MCM3 Mcm3p 0.872
DIA2 Dia2p 0.870
ORC3 Orc3p 0.849
RFA1 Rfa1p 0.842
DBF4 Dbf4p 0.822
PRI2 Pri2p 0.807
CLB5 Clb5p 0.804
MCM6 Mcm6p 0.795
ORC6 Orc6p 0.793
SMC6 Smc6p 0.764
RAD53 Rad53p 0.687
SDS3 Sds3p 0.668
RFC4 Rfc4p 0.661
RFC1 Rfc1p 0.656
DPB11 Dpb11p 0.650
DPB4 Dpb4p 0.636
POL30 Pol30p 0.605
RAD24 Rad24p 0.588
CDC14 Cdc14p 0.542
RLF2 Rlf2p 0.542
RFC2 Rfc2p 0.541
RFA2 Rfa2p 0.514
PDS1 Pds1p 0.509
CHL1 Chl1p 0.508
RAD27 Rad27p 0.482
MEC1 Mec1p 0.481
SRS2 Srs2p 0.473
RRM3 Rrm3p 0.446
IES3 Ies3p 0.430
MDN1 Mdn1p 0.413
RAD59 Rad59p 0.392
PAP2 Pap2p 0.392
POL3 Pol3p 0.389
POB3 Pob3p 0.365
SLD2 Sld2p 0.352
FKH1 Fkh1p 0.352
POL31 Pol31p 0.351
SNT1 Snt1p 0.345
PHO23 Pho23p 0.334
HST1 Hst1p 0.323
CHD1 Chd1p 0.316
PRI1 Pri1p 0.306
SIP1 Sip1p 0.296
RAD5 Rad5p 0.285
ARP4 Arp4p 0.282
MOT1 Mot1p 0.280
TAH11 Tah11p 0.277
RSC58 Rsc58p 0.273
HAT1 Hat1p 0.264
RAD1 Rad1p 0.258
ORC4 Orc4p 0.255
HST3 Hst3p 0.254
CDC6 Cdc6p 0.251
CDC8 Cdc8p 0.250
RIX1 Rix1p 0.249
RAD52 Rad52p 0.244
RAD9 Rad9p 0.244
BIR1 Bir1p 0.242
NPA3 Npa3p 0.238
HSL1 Hsl1p 0.235
RSC2 Rsc2p 0.234
RSC9 Rsc9p 0.232
TOR2 Tor2p 0.229
SMC4 Smc4p 0.227
MGM101 Mgm101p 0.211
CSM3 Csm3p 0.206
DNA2 Dna2p 0.205
SGV1 Sgv1p 0.203
YLR257W hypothetical protein 0.202
SET3 Set3p 0.198
SWI1 Swi1p 0.197
ESS1 Ess1p 0.196
MMS1 Mms1p 0.193
GRR1 Grr1p 0.193
MSH6 Msh6p 0.191
SPT16 Spt16p 0.191
ORC5 Orc5p 0.191
RAD30 Rad30p 0.186
HOS4 Hos4p 0.185
CDC9 Cdc9p 0.184
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
mcm-2 Protein MCM-2 0.010
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Mcm2 Minichromosome maintenance 2 0.972
RfC4 Replication factor C subunit 4 0.909
Orc2 Origin recognition complex subunit 2 0.793
Mcm6 Minichromosome maintenance 6 0.569
CDC45L CG3658 gene product from transcript CG3658-RA 0.568
mus209 mutagen-sensitive 209 0.383
hd humpty dumpty 0.379
RPA2 Replication protein A2 0.211
dpa disc proliferation abnormal 0.208
mus101 mutagen-sensitive 101 0.201
Ndc80 CG9938 gene product from transcript CG9938-RA 0.177
RfC38 Replication factor C 38kD subunit 0.156
mus304 mutagen-sensitive 304 0.144
BubR1 Bub1-related kinase 0.140
Mcm5 Minichromosome maintenance 5 0.138
Psf1 CG9187 gene product from transcript CG9187-RA 0.128
rad50 CG6339 gene product from transcript CG6339-RD 0.121
tos tosca 0.120
CG9576 CG9576 gene product from transcript CG9576-RA 0.116
Slbp Stem-loop binding protein 0.110
CG8142 CG8142 gene product from transcript CG8142-RA 0.108
DNApol-alpha73 DNA polymerase alpha 73kD 0.108
CG13350 CG13350 gene product from transcript CG13350-RA 0.102
RfC3 Replication factor C subunit 3 0.101
tld tolloid 0.096
Klp61F Kinesin-like protein at 61F 0.090
mus301 mutagen-sensitive 301 0.090
hay haywire 0.086
DNApol-alpha50 DNA polymerase alpha 50kD 0.085
DNApol-alpha60 DNA polymerase alpha 60kD 0.079
ci cubitus interruptus 0.071
CG5524 CG5524 gene product from transcript CG5524-RA 0.070
cav caravaggio 0.063
Orc1 Origin recognition complex subunit 1 0.060
ash1 absent, small, or homeotic discs 1 0.053
CG3430 CG3430 gene product from transcript CG3430-RA 0.053
Mcm10 Sensitized chromosome inheritance modifier 19 0.051
Mcm3 Minichromosome maintenance 3 0.050
Pcaf CG4107 gene product from transcript CG4107-RA 0.049
WRNexo WRN exonuclease 0.047
CG4933 CG4933 gene product from transcript CG4933-RA 0.047
mei-38 meiotic 38 0.046
Pole2 CG10489 gene product from transcript CG10489-RA 0.046
cdc2c CG10498 gene product from transcript CG10498-RC 0.045
Orc5 Origin recognition complex subunit 5 0.045
mus205 mutagen-sensitive 205 0.045
RnrS Ribonucleoside diphosphate reductase small subunit 0.045
asf1 anti-silencing factor 1 0.044
aur aurora 0.042
CG8247 CG8247 gene product from transcript CG8247-RB 0.042
RnrL Ribonucleoside diphosphate reductase large subunit 0.041
bsk basket 0.040
Cdk4 Cyclin-dependent kinase 4 0.039
mre11 meiotic recombination 11 0.038
RecQ5 homolog of RecQ 0.038
Pp1-87B Protein phosphatase 1 at 87B 0.038
CG2199 CG2199 gene product from transcript CG2199-RB 0.038
esg escargot 0.038
Fen1 Flap endonuclease 1 0.038
Psf2 CG18013 gene product from transcript CG18013-RA 0.037
Sse Separase 0.036
CTCF CG8591 gene product from transcript CG8591-RA 0.035
CG3358 CG3358 gene product from transcript CG3358-RA 0.035
Sce Sex combs extra 0.033
fru fruitless 0.033
lat latheo 0.032
CG33332 CG33332 gene product from transcript CG33332-RA 0.032
mei-9 meiotic 9 0.031
cid centromere identifier 0.030
Det Deterin 0.029
piwi CG6122 gene product from transcript CG6122-RA 0.028
CG7544 CG7544 gene product from transcript CG7544-RA 0.028
Gga CG3002 gene product from transcript CG3002-RB 0.028
rod rough deal 0.028
Atac1 ATAC component 1 0.027
Ets97D Ets at 97D 0.026
RecQ4 CG7487 gene product from transcript CG7487-RA 0.026
esc extra sexcombs 0.026
CG4980 CG4980 gene product from transcript CG4980-RA 0.026
CycC Cyclin C 0.025
DMAP1 CG11132 gene product from transcript CG11132-RA 0.025
tefu telomere fusion 0.025
MCPH1 Microcephalin 0.024
dap dacapo 0.024
CG3407 CG3407 gene product from transcript CG3407-RA 0.024
CG9945 CG9945 gene product from transcript CG9945-RB 0.024
His2Av Histone H2A variant 0.024
HipHop HP1-HOAP-interacting protein 0.023
Mcm7 Minichromosome maintenance 7 0.023
ph-d polyhomeotic distal 0.023
Rab23 CG2108 gene product from transcript CG2108-RA 0.022
MRG15 CG6363 gene product from transcript CG6363-RA 0.022
CG10267 CG10267 gene product from transcript CG10267-RB 0.022
DNApol-delta DNA-polymerase-delta 0.022
Irbp Inverted repeat-binding protein 0.022
spn-A spindle A 0.022
Fcp1 CG12252 gene product from transcript CG12252-RA 0.022
NiPp1 Nuclear inhibitor of Protein phosphatase 1 0.022
CG10336 CG10336 gene product from transcript CG10336-RC 0.021
polo CG12306 gene product from transcript CG12306-RA 0.021
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Homo sapiens
Name Description Probability Func Analog Organism
MCM2 minichromosome maintenance complex component 2 1.000
RPA1 replication protein A1, 70kDa 1.000
MCM7 minichromosome maintenance complex component 7 1.000
MCM3 minichromosome maintenance complex component 3 1.000
MCM6 minichromosome maintenance complex component 6 1.000
MCM4 minichromosome maintenance complex component 4 1.000
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.999
CDK2 cyclin-dependent kinase 2 0.998
BRCA1 breast cancer 1, early onset 0.998
ORC1 origin recognition complex, subunit 1 0.997
MCM5 minichromosome maintenance complex component 5 0.997
GINS2 GINS complex subunit 2 (Psf2 homolog) 0.994
SSRP1 structure specific recognition protein 1 0.991
RFC2 replication factor C (activator 1) 2, 40kDa 0.990
CDC45 cell division cycle 45 homolog (S. cerevisiae) 0.987
BLM Bloom syndrome, RecQ helicase-like 0.986
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.983
POLE2 polymerase (DNA directed), epsilon 2 (p59 subunit) 0.981
SMC1A structural maintenance of chromosomes 1A 0.979
RPA2 replication protein A2, 32kDa 0.978
MMS22L MMS22-like, DNA repair protein 0.976
MCM10 minichromosome maintenance complex component 10 0.967
CCNE1 cyclin E1 0.965
RPA3 replication protein A3, 14kDa 0.959
ORC2 origin recognition complex, subunit 2 0.959
CDC6 cell division cycle 6 homolog (S. cerevisiae) 0.952
POLE3 polymerase (DNA directed), epsilon 3 (p17 subunit) 0.950
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.934
RFC4 replication factor C (activator 1) 4, 37kDa 0.920
RFC3 replication factor C (activator 1) 3, 38kDa 0.901
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.900
PARP1 poly (ADP-ribose) polymerase 1 0.891
FEN1 flap structure-specific endonuclease 1 0.874
RFC5 replication factor C (activator 1) 5, 36.5kDa 0.871
CDC7 cell division cycle 7 homolog (S. cerevisiae) 0.868
E2F7 E2F transcription factor 7 0.854
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.841
ASF1B ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.827
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.818
ORC3 origin recognition complex, subunit 3 0.789
CHAF1A chromatin assembly factor 1, subunit A (p150) 0.777
E2F1 E2F transcription factor 1 0.756
E2F8 E2F transcription factor 8 0.749
RAD51 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) 0.747
CSNK2A1 casein kinase 2, alpha 1 polypeptide 0.728
APITD1 apoptosis-inducing, TAF9-like domain 1 0.720
BMPR1A bone morphogenetic protein receptor, type IA 0.694
RMI1 RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) 0.692
CHEK1 CHK1 checkpoint homolog (S. pombe) 0.683
RFC1 replication factor C (activator 1) 1, 145kDa 0.676
PCNA proliferating cell nuclear antigen 0.669
POLA2 polymerase (DNA directed), alpha 2 (70kD subunit) 0.662
FANCA Fanconi anemia, complementation group A 0.656
ORC5 origin recognition complex, subunit 5 0.638
MSH2 mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) 0.628
ORC6 origin recognition complex, subunit 6 0.624
WAPAL wings apart-like homolog (Drosophila) 0.617
CHEK2 CHK2 checkpoint homolog (S. pombe) 0.581
CDC5L CDC5 cell division cycle 5-like (S. pombe) 0.565
FANCM Fanconi anemia, complementation group M 0.554
YY1 YY1 transcription factor 0.526
POLE polymerase (DNA directed), epsilon 0.520
TOP2A topoisomerase (DNA) II alpha 170kDa 0.513
PRIM1 primase, DNA, polypeptide 1 (49kDa) 0.504
CHAF1B chromatin assembly factor 1, subunit B (p60) 0.485
MSH6 mutS homolog 6 (E. coli) 0.484
GINS4 GINS complex subunit 4 (Sld5 homolog) 0.479
SMC3 structural maintenance of chromosomes 3 0.448
MAPK14 mitogen-activated protein kinase 14 0.431
TOPBP1 topoisomerase (DNA) II binding protein 1 0.430
FANCG Fanconi anemia, complementation group G 0.426
RAD21 RAD21 homolog (S. pombe) 0.421
MDC1 mediator of DNA-damage checkpoint 1 0.418
GINS3 GINS complex subunit 3 (Psf3 homolog) 0.405
ATF2 activating transcription factor 2 0.395
CCNE2 cyclin E2 0.390
UNG uracil-DNA glycosylase 0.386
BRCA2 breast cancer 2, early onset 0.377
GINS1 GINS complex subunit 1 (Psf1 homolog) 0.348
CCNB2 cyclin B2 0.328
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.293
SKP2 S-phase kinase-associated protein 2 (p45) 0.292
SNTA1 syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component) 0.292
H2AFX H2A histone family, member X 0.285
CDK4 cyclin-dependent kinase 4 0.283
NBN nibrin 0.282
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.280
CNOT10 CCR4-NOT transcription complex, subunit 10 0.271
RB1 retinoblastoma 1 0.268
CDT1 chromatin licensing and DNA replication factor 1 0.259
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.256
SMC2 structural maintenance of chromosomes 2 0.256
PRIM2 primase, DNA, polypeptide 2 (58kDa) 0.240
RAD50 RAD50 homolog (S. cerevisiae) 0.237
TMPO thymopoietin 0.235
ARRB1 arrestin, beta 1 0.222
RBBP4 retinoblastoma binding protein 4 0.220
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.210
PDS5B PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) 0.210
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 125kDa 0.208
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Mus musculus
Name Description Probability Func Analog Organism
Cdt1 chromatin licensing and DNA replication factor 1 0.999
Mcm2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae) 0.999
Mcm3 minichromosome maintenance deficient 3 (S. cerevisiae) 0.999
Mcm5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) 0.996
Mcm7 minichromosome maintenance deficient 7 (S. cerevisiae) 0.996
Prim1 DNA primase, p49 subunit 0.975
Mcm4 minichromosome maintenance deficient 4 homolog (S. cerevisiae) 0.974
Cdc6 cell division cycle 6 homolog (S. cerevisiae) 0.907
Brca2 breast cancer 2 0.901
Timeless timeless homolog (Drosophila) 0.873
Tipin timeless interacting protein 0.862
Mapk14 mitogen-activated protein kinase 14 0.772
Smc1a structural maintenance of chromosomes 1A 0.689
Lig1 ligase I, DNA, ATP-dependent 0.641
Brca1 breast cancer 1 0.618
Mecp2 methyl CpG binding protein 2 0.561
Rfc2 replication factor C (activator 1) 2 0.556
Pola1 polymerase (DNA directed), alpha 1 0.546
Rfc5 replication factor C (activator 1) 5 0.495
Cdk4 cyclin-dependent kinase 4 0.477
Rpa1 replication protein A1 0.448
Nup85 nucleoporin 85 0.435
Pole2 polymerase (DNA directed), epsilon 2 (p59 subunit) 0.426
Rad51ap1 RAD51 associated protein 1 0.411
Gmnn geminin 0.376
Asf1b ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.330
Rfc4 replication factor C (activator 1) 4 0.327
Rrm2 ribonucleotide reductase M2 0.319
Pole polymerase (DNA directed), epsilon 0.309
Cdca5 cell division cycle associated 5 0.298
Prim2 DNA primase, p58 subunit 0.293
Pold1 polymerase (DNA directed), delta 1, catalytic subunit 0.292
Rfc1 replication factor C (activator 1) 1 0.291
Rpa2 replication protein A2 0.287
Wdhd1 WD repeat and HMG-box DNA binding protein 1 0.275
Ezh2 enhancer of zeste homolog 2 (Drosophila) 0.257
Ncaph non-SMC condensin I complex, subunit H 0.236
Tcf19 transcription factor 19 0.229
Cdc45 cell division cycle 45 homolog (S. cerevisiae) 0.228
Atm ataxia telangiectasia mutated homolog (human) 0.218
Hells helicase, lymphoid specific 0.216
Smc3 structural maintenace of chromosomes 3 0.204
Uhrf1 ubiquitin-like, containing PHD and RING finger domains, 1 0.201
Pcna proliferating cell nuclear antigen 0.182
Rad51 RAD51 homolog (S. cerevisiae) 0.174
Orc2 origin recognition complex, subunit 2 0.174
Rad21 RAD21 homolog (S. pombe) 0.167
Orc6 origin recognition complex, subunit 6 0.152
Chek1 checkpoint kinase 1 homolog (S. pombe) 0.152
Atf2 activating transcription factor 2 0.145
Gins4 GINS complex subunit 4 (Sld5 homolog) 0.144
Hdac1 histone deacetylase 1 0.141
E2f1 E2F transcription factor 1 0.140
Fen1 flap structure specific endonuclease 1 0.135
Aurkb aurora kinase B 0.130
Cdk2 cyclin-dependent kinase 2 0.129
Nup107 nucleoporin 107 0.122
Ccne1 cyclin E1 0.121
Rrm1 ribonucleotide reductase M1 0.113
Pds5a PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae) 0.108
Cks1b CDC28 protein kinase 1b 0.107
Rad50 RAD50 homolog (S. cerevisiae) 0.104
Nbn nibrin 0.101
Cdk1 cyclin-dependent kinase 1 0.099
Mlh1 mutL homolog 1 (E. coli) 0.094
Dhfr dihydrofolate reductase 0.093
Rabep1 rabaptin, RAB GTPase binding effector protein 1 0.090
Parp1 poly (ADP-ribose) polymerase family, member 1 0.088
Suds3 suppressor of defective silencing 3 homolog (S. cerevisiae) 0.088
Dnmt1 DNA methyltransferase (cytosine-5) 1 0.087
Atrx alpha thalassemia/mental retardation syndrome X-linked homolog (human) 0.087
Dnajc9 DnaJ (Hsp40) homolog, subfamily C, member 9 0.086
Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 0.085
Msh2 mutS homolog 2 (E. coli) 0.084
Ccnf cyclin F 0.082
Exo1 exonuclease 1 0.081
Vrk1 vaccinia related kinase 1 0.080
Dtymk deoxythymidylate kinase 0.080
Incenp inner centromere protein 0.080
Orc1 origin recognition complex, subunit 1 0.079
Mybl2 myeloblastosis oncogene-like 2 0.077
Recql RecQ protein-like 0.077
Gins1 GINS complex subunit 1 (Psf1 homolog) 0.076
Pms2 postmeiotic segregation increased 2 (S. cerevisiae) 0.076
Rpgrip1l Rpgrip1-like 0.075
Cdca7l cell division cycle associated 7 like 0.075
Smarcc1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.075
Sass6 spindle assembly 6 homolog (C. elegans) 0.073
Crk v-crk sarcoma virus CT10 oncogene homolog (avian) 0.072
Pola2 polymerase (DNA directed), alpha 2 0.071
Tk1 thymidine kinase 1 0.070
Nudt1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 0.069
Cdca7 cell division cycle associated 7 0.067
Haus6 HAUS augmin-like complex, subunit 6 0.064
Ung uracil DNA glycosylase 0.062
Pds5b PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) 0.059
Mapk11 mitogen-activated protein kinase 11 0.058
Nvl nuclear VCP-like 0.057
Orc5 origin recognition complex, subunit 5 0.057
Hmbs hydroxymethylbilane synthase 0.056
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Rattus norvegicus
Name Description Probability Func Analog Organism
Mcm6 minichromosome maintenance complex component 6 0.134
Tubg1 tubulin, gamma 1 0.037
Top2a topoisomerase (DNA) II alpha 0.030
Asf1b ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.016
Mcm2 minichromosome maintenance complex component 2 0.014
LOC100364212 heterogeneous nuclear ribonucleoprotein K-like 0.011
Mcm5 minichromosome maintenance complex component 5 0.010