The network for 'phosphatidylinositol metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

phosphatidylinositol metabolic process

The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
GAA1 Gaa1p 0.914
GAB1 Gab1p 0.852
GPI17 Gpi17p 0.783
GPI8 Gpi8p 0.725
GLO3 Glo3p 0.681
LAS21 Las21p 0.670
GPI16 Gpi16p 0.513
RGD1 Rgd1p 0.460
FIG4 Fig4p 0.442
GUP1 Gup1p 0.334
PIK1 Pik1p 0.303
GCS1 Gcs1p 0.295
PER1 Per1p 0.277
SPF1 Spf1p 0.269
GOT1 Got1p 0.269
INP52 Inp52p 0.268
RSN1 Rsn1p 0.258
SLC1 Slc1p 0.257
ALG8 Alg8p 0.247
VPS15 Vps15p 0.230
HOC1 Hoc1p 0.229
TGL1 Tgl1p 0.219
SAC7 Sac7p 0.215
KCS1 Kcs1p 0.205
KRE5 Kre5p 0.197
ARV1 Arv1p 0.196
GDS1 Gds1p 0.194
YNL035C hypothetical protein 0.186
PSD2 Psd2p 0.175
PMR1 Pmr1p 0.173
OSH7 Osh7p 0.171
INP53 Inp53p 0.166
MON2 Mon2p 0.164
YOR316C-A hypothetical protein 0.158
PIS1 Pis1p 0.157
BST1 Bst1p 0.154
SEY1 Sey1p 0.153
RFT1 Rft1p 0.150
ALG6 Alg6p 0.146
NMT1 Nmt1p 0.144
VPS38 Vps38p 0.138
GWT1 Gwt1p 0.138
SEC59 Sec59p 0.137
LSB5 Lsb5p 0.136
KKQ8 Kkq8p 0.131
STT4 Stt4p 0.131
PTC7 Ptc7p 0.126
ERD2 Erd2p 0.124
CNE1 Cne1p 0.124
GGA1 Gga1p 0.121
MDL1 Mdl1p 0.119
YOL087C hypothetical protein 0.118
PST2 Pst2p 0.117
YGR205W hypothetical protein 0.114
GPI13 Gpi13p 0.113
FAR11 Far11p 0.109
YHR177W hypothetical protein 0.109
PHS1 Phs1p 0.109
SAM2 Sam2p 0.109
ARF3 Arf3p 0.108
WSC3 Wsc3p 0.107
TRS130 Trs130p 0.107
YFR016C hypothetical protein 0.106
TCB3 Tcb3p 0.105
SEC61 Sec61p 0.104
IRS4 Irs4p 0.103
VPS13 Vps13p 0.098
YJR015W hypothetical protein 0.094
GPI1 Gpi1p 0.094
SFB3 Sfb3p 0.091
AGE1 Age1p 0.090
ROT2 Rot2p 0.088
MNN2 Mnn2p 0.087
STV1 Stv1p 0.086
CBK1 Cbk1p 0.086
TSC11 Tsc11p 0.085
PFY1 Pfy1p 0.084
VPH2 Vph2p 0.082
KAP120 Kap120p 0.082
EDE1 Ede1p 0.081
SEC63 Sec63p 0.081
PDR17 Pdr17p 0.081
FRA1 Fra1p 0.079
GMH1 Gmh1p 0.078
YNL108C hypothetical protein 0.078
CWH43 Cwh43p 0.078
LAG1 Lag1p 0.076
YJR012C hypothetical protein 0.076
KES1 Kes1p 0.076
CSR1 Csr1p 0.075
RCE1 Rce1p 0.074
RTT105 Rtt105p 0.073
TPT1 Tpt1p 0.073
YPL066W hypothetical protein 0.072
PFA4 Pfa4p 0.071
HSV2 Hsv2p 0.069
FPR3 Fpr3p 0.069
SCJ1 Scj1p 0.067
ARL1 Arl1p 0.067
MNN5 Mnn5p 0.067
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
gdf6a growth differentiation factor 6a 0.062
disp1 dispatched homolog 1 (Drosophila) 0.026
cyfip2 cytoplasmic FMR1 interacting protein 2 0.018
ptch1 patched 1 0.015
drd2b dopamine receptor D2b 0.012
syt11a synaptotagmin XIa 0.011
pmela premelanosome protein a 0.011
acvr2a activin receptor IIa 0.011
prox2 prospero homeobox 2 0.011
pde6c phosphodiesterase 6C, cGMP-specific, cone, alpha prime 0.011
slc26a5 solute carrier family 26, member 5 0.011
zgc:112359 zgc:112359 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Rala Ras-related protein 0.015
CG3004 CG3004 gene product from transcript CG3004-RA 0.013
brp bruchpilot 0.012
oa2 octopamine receptor 2 0.010
Tbh Tyramine beta hydroxylase 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.999
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.994
FGFR2 fibroblast growth factor receptor 2 0.987
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.973
FGFR1 fibroblast growth factor receptor 1 0.966
NRP1 neuropilin 1 0.925
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.891
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.884
EGFR epidermal growth factor receptor 0.852
PLCG1 phospholipase C, gamma 1 0.849
LAT linker for activation of T cells 0.744
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.737
IRS1 insulin receptor substrate 1 0.633
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.548
FGF1 fibroblast growth factor 1 (acidic) 0.538
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.531
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.503
MTMR12 myotubularin related protein 12 0.500
MTM1 myotubularin 1 0.481
MPDZ multiple PDZ domain protein 0.462
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.431
VEGFA vascular endothelial growth factor A 0.423
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 0.389
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.362
SOS1 son of sevenless homolog 1 (Drosophila) 0.344
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.306
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.230
ADORA2A adenosine A2a receptor 0.229
PDGFA platelet-derived growth factor alpha polypeptide 0.213
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast) 0.196
SNAP25 synaptosomal-associated protein, 25kDa 0.185
GRB7 growth factor receptor-bound protein 7 0.179
MTMR6 myotubularin related protein 6 0.177
BECN1 beclin 1, autophagy related 0.144
VAC14 Vac14 homolog (S. cerevisiae) 0.143
NOS1 nitric oxide synthase 1 (neuronal) 0.142
RAB5A RAB5A, member RAS oncogene family 0.139
CD81 CD81 molecule 0.139
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.135
GAB1 GRB2-associated binding protein 1 0.132
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.132
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.126
SH3GL2 SH3-domain GRB2-like 2 0.122
PIK3CB phosphoinositide-3-kinase, catalytic, beta polypeptide 0.120
PPP1R9B protein phosphatase 1, regulatory (inhibitor) subunit 9B 0.119
PIKFYVE phosphoinositide kinase, FYVE finger containing 0.118
MTMR9 myotubularin related protein 9 0.113
INSR insulin receptor 0.113
CD9 CD9 molecule 0.101
SMAD9 SMAD family member 9 0.100
SYK spleen tyrosine kinase 0.097
PTPRB protein tyrosine phosphatase, receptor type, B 0.096
AMPH amphiphysin 0.094
C17orf28 chromosome 17 open reading frame 28 0.091
SOS2 son of sevenless homolog 2 (Drosophila) 0.087
GRB10 growth factor receptor-bound protein 10 0.086
PGF placental growth factor 0.085
ATG14 ATG14 autophagy related 14 homolog (S. cerevisiae) 0.083
FGF10 fibroblast growth factor 10 0.082
SLC6A3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.080
FGF2 fibroblast growth factor 2 (basic) 0.078
ITSN1 intersectin 1 (SH3 domain protein) 0.075
SPAG9 sperm associated antigen 9 0.074
GRB2 growth factor receptor-bound protein 2 0.069
FGF7 fibroblast growth factor 7 0.066
RNF6 ring finger protein (C3H2C3 type) 6 0.062
TMEM173 transmembrane protein 173 0.061
PDGFC platelet derived growth factor C 0.060
SPOP speckle-type POZ protein 0.060
BLNK B-cell linker 0.059
GMFB glia maturation factor, beta 0.058
DNM1 dynamin 1 0.057
CD63 CD63 molecule 0.056
VAV3 vav 3 guanine nucleotide exchange factor 0.056
ARRDC3 arrestin domain containing 3 0.055
ACBD3 acyl-CoA binding domain containing 3 0.055
UVRAG UV radiation resistance associated gene 0.054
GAB2 GRB2-associated binding protein 2 0.053
FRS2 fibroblast growth factor receptor substrate 2 0.053
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.050
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.047
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.044
SFN stratifin 0.043
DCTN1 dynactin 1 0.043
PTPRJ protein tyrosine phosphatase, receptor type, J 0.043
SLA Src-like-adaptor 0.042
PIGS phosphatidylinositol glycan anchor biosynthesis, class S 0.041
BAI1 brain-specific angiogenesis inhibitor 1 0.041
TP53BP1 tumor protein p53 binding protein 1 0.041
OSBPL9 oxysterol binding protein-like 9 0.040
PRKACB protein kinase, cAMP-dependent, catalytic, beta 0.039
RAB6A RAB6A, member RAS oncogene family 0.039
BTBD1 BTB (POZ) domain containing 1 0.039
C19orf61 chromosome 19 open reading frame 61 0.038
TSPAN4 tetraspanin 4 0.037
PIGT phosphatidylinositol glycan anchor biosynthesis, class T 0.036
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast) 0.036
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 0.036
SH3BP2 SH3-domain binding protein 2 0.036
HIPK3 homeodomain interacting protein kinase 3 0.035
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Mus musculus
Name Description Probability Func Analog Organism
Kdr kinase insert domain protein receptor 0.810
Nos3 nitric oxide synthase 3, endothelial cell 0.789
Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) 0.684
Trp53 transformation related protein 53 0.649
Shc1 src homology 2 domain-containing transforming protein C1 0.643
Cbl Casitas B-lineage lymphoma 0.603
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.548
Inpp5d inositol polyphosphate-5-phosphatase D 0.514
Plcg1 phospholipase C, gamma 1 0.433
Crk v-crk sarcoma virus CT10 oncogene homolog (avian) 0.402
Ednrb endothelin receptor type B 0.352
Flt4 FMS-like tyrosine kinase 4 0.336
Flt1 FMS-like tyrosine kinase 1 0.306
Lig4 ligase IV, DNA, ATP-dependent 0.285
Pik3cb phosphatidylinositol 3-kinase, catalytic, beta polypeptide 0.285
Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.275
Vegfa vascular endothelial growth factor A 0.261
Lama5 laminin, alpha 5 0.224
Col1a1 collagen, type I, alpha 1 0.210
Lepr leptin receptor 0.183
Igh immunoglobulin heavy chain complex 0.180
Fyn Fyn proto-oncogene 0.178
Slc9a3r2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 0.174
Csf1 colony stimulating factor 1 (macrophage) 0.161
Myo6 myosin VI 0.151
Prkdc protein kinase, DNA activated, catalytic polypeptide 0.147
Itsn1 intersectin 1 (SH3 domain protein 1A) 0.137
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.135
Bcl6 B-cell leukemia/lymphoma 6 0.133
Blnk B-cell linker 0.124
Rb1 retinoblastoma 1 0.119
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.115
Ctnnb1 catenin (cadherin associated protein), beta 1 0.110
Tgfbr1 transforming growth factor, beta receptor I 0.108
Gab1 growth factor receptor bound protein 2-associated protein 1 0.108
Becn1 beclin 1, autophagy related 0.107
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.105
Pdgfb platelet derived growth factor, B polypeptide 0.102
Plxnd1 plexin D1 0.101
Mapk9 mitogen-activated protein kinase 9 0.099
Cd22 CD22 antigen 0.095
Cdh5 cadherin 5 0.094
Ptch1 patched homolog 1 0.094
Apc adenomatosis polyposis coli 0.088
Ap2b1 adaptor-related protein complex 2, beta 1 subunit 0.086
Eng endoglin 0.084
Agrp agouti related protein 0.083
Sirpa signal-regulatory protein alpha 0.080
Efr3a EFR3 homolog A (S. cerevisiae) 0.079
Ptprb protein tyrosine phosphatase, receptor type, B 0.079
Pik3cg phosphoinositide-3-kinase, catalytic, gamma polypeptide 0.075
Src Rous sarcoma oncogene 0.073
Sorbs3 sorbin and SH3 domain containing 3 0.069
Lyst lysosomal trafficking regulator 0.066
Notch2 Notch gene homolog 2 (Drosophila) 0.066
Tmem204 transmembrane protein 204 0.065
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.065
Tek endothelial-specific receptor tyrosine kinase 0.062
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.060
Homer1 homer homolog 1 (Drosophila) 0.058
Prkcb protein kinase C, beta 0.056
Jag2 jagged 2 0.056
Kcnab3 potassium voltage-gated channel, shaker-related subfamily, beta member 3 0.055
Crkl v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.054
Pik3r6 phosphoinositide-3-kinase, regulatory subunit 6 0.054
Met met proto-oncogene 0.053
Sst somatostatin 0.053
Tgfbr2 transforming growth factor, beta receptor II 0.052
Cacnb2 calcium channel, voltage-dependent, beta 2 subunit 0.051
Eps15 epidermal growth factor receptor pathway substrate 15 0.051
Pten phosphatase and tensin homolog 0.050
Esr1 estrogen receptor 1 (alpha) 0.050
Plcb3 phospholipase C, beta 3 0.050
Nbn nibrin 0.049
Slc27a1 solute carrier family 27 (fatty acid transporter), member 1 0.049
Stat5b signal transducer and activator of transcription 5B 0.048
Ids iduronate 2-sulfatase 0.048
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.048
Epb4.1l2 erythrocyte protein band 4.1-like 2 0.048
Parvg parvin, gamma 0.047
Rasgrp1 RAS guanyl releasing protein 1 0.047
Cxcl14 chemokine (C-X-C motif) ligand 14 0.047
Bcar1 breast cancer anti-estrogen resistance 1 0.046
Gnptab N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits 0.046
Atp6v1d ATPase, H+ transporting, lysosomal V1 subunit D 0.045
Kifc3 kinesin family member C3 0.045
Snx13 sorting nexin 13 0.044
Scn1b sodium channel, voltage-gated, type I, beta 0.044
Sh3gl2 SH3-domain GRB2-like 2 0.044
Sema6d sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 0.044
Ate1 arginyltransferase 1 0.043
Braf Braf transforming gene 0.043
Spry2 sprouty homolog 2 (Drosophila) 0.042
Prkch protein kinase C, eta 0.042
Dok3 docking protein 3 0.042
Acvrl1 activin A receptor, type II-like 1 0.042
Elavl2 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B) 0.041
Ap2a1 adaptor protein complex AP-2, alpha 1 subunit 0.041
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.041
Nrp1 neuropilin 1 0.041
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Rattus norvegicus
Name Description Probability Func Analog Organism
Slc16a8 solute carrier family 16, member 8 (monocarboxylic acid transporter 3) 0.013
Amph amphiphysin 0.013
Kcna3 potassium voltage-gated channel, shaker-related subfamily, member 3 0.012
Grm1 glutamate receptor, metabotropic 1 0.012
Olr1500 olfactory receptor 1500 0.011
Gad1 glutamate decarboxylase 1 0.011
Ip6k1 inositol hexakisphosphate kinase 1 0.011
Dlg4 discs, large homolog 4 (Drosophila) 0.011
Grik1 glutamate receptor, ionotropic, kainate 1 0.010
Slc8a2 solute carrier family 8 (sodium/calcium exchanger), member 2 0.010