The network for 'negative regulation of biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of biosynthetic process

Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
RPD3 Rpd3p 0.999
HHT1 Hht1p 0.997
SIR4 Sir4p 0.992
RAP1 Rap1p 0.991
SIN3 Sin3p 0.989
CYC8 Cyc8p 0.985
HHF1 Hhf1p 0.983
SIR2 Sir2p 0.977
RXT2 Rxt2p 0.961
HDA1 Hda1p 0.957
SNF1 Snf1p 0.951
SUM1 Sum1p 0.950
RLF2 Rlf2p 0.949
PHO23 Pho23p 0.927
DCP2 Dcp2p 0.909
SIN4 Sin4p 0.902
ORC2 Orc2p 0.894
ASF1 Asf1p 0.889
HOG1 Hog1p 0.888
PGD1 Pgd1p 0.879
RGR1 Rgr1p 0.871
GLC7 Glc7p 0.857
RIM101 Rim101p 0.834
PAP2 Pap2p 0.829
SAS2 Sas2p 0.824
SET1 Set1p 0.819
GCN5 Gcn5p 0.811
RPN4 Rpn4p 0.809
RLM1 Rlm1p 0.802
RCO1 Rco1p 0.800
SPT16 Spt16p 0.793
CTI6 Cti6p 0.787
RIF1 Rif1p 0.784
ORC5 Orc5p 0.782
SLX5 Slx5p 0.779
ADR1 Adr1p 0.779
SDS3 Sds3p 0.763
MRC1 Mrc1p 0.762
UME1 Ume1p 0.746
YTA7 Yta7p 0.745
RTF1 Rtf1p 0.741
ORC3 Orc3p 0.740
CSE2 Cse2p 0.736
UBP10 Ubp10p 0.735
HAT1 Hat1p 0.734
SSN8 Ssn8p 0.733
HMO1 Hmo1p 0.724
MED2 Med2p 0.722
SGV1 Sgv1p 0.720
MOT1 Mot1p 0.719
ROX3 Rox3p 0.718
RSC2 Rsc2p 0.708
SSN3 Ssn3p 0.703
AFT1 Aft1p 0.702
HTB1 Htb1p 0.681
SNT1 Snt1p 0.674
HIR1 Hir1p 0.662
MED7 Med7p 0.658
NRG1 Nrg1p 0.654
CDC6 Cdc6p 0.641
DHH1 Dhh1p 0.637
GIS1 Gis1p 0.636
ITC1 Itc1p 0.627
RTT106 Rtt106p 0.625
HTZ1 Htz1p 0.619
SSD1 Ssd1p 0.619
HST1 Hst1p 0.618
UBP8 Ubp8p 0.608
GAL11 Gal11p 0.605
ISW1 Isw1p 0.603
FKH2 Fkh2p 0.602
NUT1 Nut1p 0.601
DOA1 Doa1p 0.600
CDC28 Cdc28p 0.595
PAT1 Pat1p 0.595
HHF2 Hhf2p 0.589
SCH9 Sch9p 0.589
MED1 Med1p 0.589
RSC8 Rsc8p 0.587
TIF4632 Tif4632p 0.579
SWI4 Swi4p 0.576
HHO1 Hho1p 0.568
SIR3 Sir3p 0.566
VPS36 Vps36p 0.562
HDA2 Hda2p 0.558
RPA135 Rpa135p 0.554
UME6 Ume6p 0.545
CTK1 Ctk1p 0.541
RAD9 Rad9p 0.532
CDC45 Cdc45p 0.532
SCP160 Scp160p 0.523
SRP1 Srp1p 0.521
HCM1 Hcm1p 0.520
HHT2 Hht2p 0.519
SWD1 Swd1p 0.513
CMK2 Cmk2p 0.513
CTF18 Ctf18p 0.512
ISW2 Isw2p 0.512
MCM7 Mcm7p 0.510
NHP6A Nhp6ap 0.499
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
egl-18 Protein EGL-18 0.986
elt-6 Protein ELT-6 0.705
his-1 Protein HIS-1 0.639
pha-4 Protein PHA-4 0.610
his-16 Protein HIS-16 0.606
his-5 Protein HIS-5 0.439
hcp-3 Protein HCP-3 0.412
nhr-67 Protein NHR-67 0.401
eya-1 Protein EYA-1 0.388
mes-4 Protein MES-4 0.382
ten-1 Protein TEN-1 0.374
zip-7 Protein ZIP-7 0.361
hbl-1 Protein HBL-1 0.338
lin-53 Protein LIN-53 0.326
mab-5 Protein MAB-5 0.318
his-45 Protein HIS-45 0.316
unc-62 Protein UNC-62 0.314
egl-46 Protein EGL-46 0.312
his-46 Protein HIS-46 0.309
eor-1 Protein EOR-1 0.308
his-31 Protein HIS-31 0.281
lin-35 Protein LIN-35 0.278
egl-13 Protein EGL-13 0.277
nhr-2 Protein NHR-2 0.265
vab-3 Protein VAB-3 0.256
his-64 Protein HIS-64 0.250
flt-1 Protein FLT-1 0.239
gpb-2 Protein GPB-2 0.235
his-61 Protein HIS-61 0.231
let-502 Protein LET-502 0.220
glp-1 Protein GLP-1 0.215
his-4 Protein HIS-4 0.209
wrm-1 Protein WRM-1 0.201
his-42 Protein HIS-42 0.200
mom-2 Protein MOM-2 0.191
lsy-22 Protein LSY-22 0.186
rsp-1 Protein RSP-1 0.183
pry-1 Protein PRY-1 0.170
his-52 Protein HIS-52 0.164
tbx-8 Protein TBX-8 0.158
cdt-2 Protein CDT-2 0.156
unc-73 Protein UNC-73 0.154
his-24 Protein HIS-24 0.149
atn-1 Protein ATN-1 0.147
CELE_F17C11.10 Protein F17C11.10 0.147
nhr-6 Protein NHR-6 0.146
CELE_C24H12.5 Protein C24H12.5 0.145
ztf-2 Protein ZTF-2 0.134
plk-3 Protein PLK-3 0.132
hlh-2 Protein HLH-2 0.132
plc-1 Protein PLC-1 0.130
saeg-1 Protein SAEG-1 0.130
nhr-25 Protein NHR-25 0.129
peb-1 Protein PEB-1 0.128
ceh-32 Protein CEH-32 0.127
pdr-1 Protein PDR-1 0.121
his-48 Protein HIS-48 0.121
npp-4 Protein NPP-4 0.119
mnp-1 Protein MNP-1 0.119
his-29 Protein HIS-29 0.118
CELE_T26A8.4 Protein T26A8.4 0.115
puf-3 Protein PUF-3 0.114
rgs-7 Protein RGS-7 0.114
num-1 Protein NUM-1 0.114
crm-1 Protein CRM-1 0.112
rnr-1 Protein RNR-1 0.108
fbf-2 Protein FBF-2 0.108
egl-27 Protein EGL-27 0.108
deb-1 Protein DEB-1 0.107
F39B2.1 Protein F39B2.1 0.106
ran-1 Protein RAN-1 0.106
his-62 Protein HIS-62 0.104
klp-16 Protein KLP-16 0.103
mcm-4 Protein MCM-4 0.103
mat-3 Protein MAT-3 0.103
eftu-2 Protein EFTU-2 0.102
daf-1 Protein DAF-1 0.102
daf-14 Protein DAF-14 0.101
unc-52 Protein UNC-52 0.100
mig-38 Protein MIG-38 0.100
kle-2 Protein KLE-2 0.100
snr-2 Protein SNR-2 0.099
mix-1 Protein MIX-1 0.098
drap-1 Protein DRAP-1 0.096
cec-5 Protein CEC-5 0.096
mls-2 Protein MLS-2 0.096
tam-1 Protein TAM-1 0.095
vps-33.2 Protein VPS-33.2 0.095
ceh-20 Protein CEH-20 0.095
mcm-7 Protein MCM-7 0.095
ulp-2 Protein ULP-2 0.095
egl-5 Protein EGL-5 0.094
ceh-27 Protein CEH-27 0.092
his-14 Protein HIS-14 0.092
bed-3 Protein BED-3 0.092
hlh-1 Protein HLH-1 0.091
ceh-36 Protein CEH-36 0.089
lin-13 Protein LIN-13 0.089
mcm-5 Protein MCM-5 0.085
attf-2 Protein ATTF-2 0.085
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Danio rerio
Name Description Probability Func Analog Organism
notch1a notch homolog 1a 0.894
jag2 jagged 2 0.866
fgf3 fibroblast growth factor 3 0.841
sox9b SRY-box containing gene 9b 0.831
dlx2a distal-less homeobox gene 2a 0.765
pcna proliferating cell nuclear antigen 0.718
ndr2 nodal-related 2 0.689
mecom MDS1 and EVI1 complex locus 0.670
egr1 early growth response 1 0.667
mab21l2 mab-21-like 2 0.640
prox1 prospero-related homeobox gene 1 0.612
tfap2a transcription factor AP-2 alpha 0.588
zic2a zic family member 2 (odd-paired homolog, Drosophila), a 0.573
foxi1 forkhead box I1 0.571
otpb orthopedia homolog b 0.565
emx3 empty spiracles homeobox 3 0.539
hnf1ba HNF1 homeobox Ba 0.538
pbx1a pre-B-cell leukemia transcription factor 1a 0.531
atp1a1a.2 ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide 0.484
tbx1 T-box 1 0.482
prdm1a PR domain containing 1a, with ZNF domain 0.481
tbx2a T-box gene 2a 0.469
dlx3b distal-less homeobox gene 3b 0.462
dlx5a distal-less homeobox gene 5a 0.459
nova2 neuro-oncological ventral antigen 2 0.453
ccnd1 cyclin D1 0.441
fsta follistatin a 0.439
gro1 groucho 1 0.401
bmp2b bone morphogenetic protein 2b 0.389
snai1b snail homolog 1b (Drosophila) 0.380
tp53 tumor protein p53 0.370
zic2b zic family member 2 (odd-paired homolog, Drosophila) b 0.368
tal1 T-cell acute lymphocytic leukemia 1 0.361
fli1a friend leukemia integration 1a 0.354
lhx1a LIM homeobox 1a 0.349
pax8 paired box gene 8 0.335
boc brother of CDO 0.326
gata6 GATA-binding protein 6 0.325
chd chordin 0.321
foxa3 forkhead box A3 0.314
whsc1 Wolf-Hirschhorn syndrome candidate 1 0.308
gdf11 growth differentiation factor 11 0.304
gata5 GATA-binding protein 5 0.290
dlc deltaC 0.277
arx aristaless related homeobox 0.266
rx2 retinal homeobox gene 2 0.264
tac1 tachykinin 1 0.261
sox3 SRY-box containing gene 3 0.257
znf503 zinc finger protein 503 0.255
hand2 heart and neural crest derivatives expressed transcript 2 0.244
cry1a cryptochrome 1a 0.239
evx1 even-skipped homeobox 1 0.239
spry4 sprouty (Drosophila) homolog 4 0.237
tyr tyrosinase 0.235
dnmt7 DNA (cytosine-5-)-methyltransferase 7 0.230
msxe muscle segment homeobox E 0.229
gli1 GLI-Kruppel family member 1 0.227
spaw southpaw 0.226
ikzf1 IKAROS family zinc finger 1 (Ikaros) 0.225
dusp6 dual specificity phosphatase 6 0.223
ins preproinsulin 0.223
sox19a SRY-box containing gene 19a 0.222
pitx2 paired-like homeodomain transcription factor 2 0.218
pou3f2 POU class 3 homeobox 2 0.218
pcdh18b protocadherin 18b 0.215
gcm2 glial cells missing homolog 2 (Drosophila) 0.215
cdx4 caudal type homeo box transcription factor 4 0.214
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.207
nkx2.5 NK2 transcription factor related 5 0.206
sox11b SRY-box containing gene 11b 0.204
ascl1a achaete-scute complex-like 1a (Drosophila) 0.203
klf4 Kruppel-like factor 4 0.198
esr1 estrogen receptor 1 0.195
tll1 tolloid-like 1 0.194
six2a sine oculis-related homeobox 2a 0.189
sesn1 sestrin 1 0.185
hnrnpab heterogeneous nuclear ribonucleoprotein A/B 0.183
esr2a estrogen receptor 2a 0.182
jag1b jagged 1b 0.176
plekhg4 pleckstrin homology domain containing, family G (with RhoGef domain) member 4 0.172
emx1 empty spiracles homeobox 1 0.172
ezh2 enhancer of zeste homolog 2 (Drosophila) 0.164
otx1b orthodenticle homolog 1b 0.163
her7 hairy and enhancer of split related-7 0.162
insm1b insulinoma-associated 1b 0.161
sox1a SRY-box containing gene 1a 0.156
hoxd4a homeo box D4a 0.156
osr2 odd-skipped related 2 (Drosophila) 0.156
nr2f5 nuclear receptor subfamily 2, group F, member 5 0.154
hnrnpk heterogeneous nuclear ribonucleoprotein K 0.152
ncl nucleolin 0.150
pax3a paired box gene 3a 0.149
tfeb transcription factor EB 0.147
vsx2 visual system homeobox 2 0.147
vcana versican a 0.146
has2 hyaluronan synthase 2 0.144
foxi3a forkhead box I3a 0.143
traf4a tnf receptor-associated factor 4a 0.143
alcama activated leukocyte cell adhesion molecule a 0.142
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.141
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Drosophila melanogaster
Name Description Probability Func Analog Organism
CTCF CG8591 gene product from transcript CG8591-RA 0.999
Mad Mothers against dpp 0.995
Trl Trithorax-like 0.994
Sir2 CG5216 gene product from transcript CG5216-RA 0.991
dsx doublesex 0.989
brat brain tumor 0.983
N Notch 0.982
Snr1 Snf5-related 1 0.978
CtBP C-terminal Binding Protein 0.976
Scm Sex comb on midleg 0.976
mam mastermind 0.975
Fmr1 CG6203 gene product from transcript CG6203-RC 0.975
ci cubitus interruptus 0.974
hep hemipterous 0.966
ato atonal 0.966
E2f2 E2F transcription factor 2 0.964
os outstretched 0.961
ash1 absent, small, or homeotic discs 1 0.961
esc extra sexcombs 0.959
pr-set7 CG3307 gene product from transcript CG3307-RC 0.958
gpp grappa 0.958
foxo forkhead box, sub-group O 0.954
Top2 Topoisomerase 2 0.952
E(spl) Enhancer of split 0.947
Iswi Imitation SWI 0.946
eyg eyegone 0.945
Ubx Ultrabithorax 0.940
shn schnurri 0.938
gro groucho 0.933
HLHm7 E(spl) region transcript m7 0.932
ss spineless 0.931
smt3 CG4494 gene product from transcript CG4494-RA 0.926
ara araucan 0.923
spen split ends 0.918
Sce Sex combs extra 0.917
piwi CG6122 gene product from transcript CG6122-RA 0.914
dpn deadpan 0.906
Nf-YC Nuclear factor Y-box C 0.903
Pten CG5671 gene product from transcript CG5671-RB 0.900
Rpd3 CG7471 gene product from transcript CG7471-RA 0.897
Pcl Polycomblike 0.896
Su(var)205 Suppressor of variegation 205 0.893
nub nubbin 0.892
tll tailless 0.887
Thor CG8846 gene product from transcript CG8846-RA 0.886
phyl phyllopod 0.881
salm spalt major 0.864
gsb gooseberry 0.862
heph hephaestus 0.861
tan tantalus 0.853
D1 D1 chromosomal protein 0.852
Su(var)2-10 Suppressor of variegation 2-10 0.850
ed echinoid 0.840
lwr lesswright 0.839
Pka-C1 cAMP-dependent protein kinase 1 0.838
Pp1-87B Protein phosphatase 1 at 87B 0.831
pb proboscipedia 0.830
crol crooked legs 0.830
fu fused 0.830
CycB Cyclin B 0.822
BEAF-32 Boundary element-associated factor of 32kD 0.821
abd-A abdominal A 0.819
Pc Polycomb 0.819
mrn marionette 0.817
Kr-h1 Kruppel homolog 1 0.811
yki yorkie 0.805
SRPK CG8174 gene product from transcript CG8174-RA 0.797
Taf1 TBP-associated factor 1 0.792
MED26 Mediator complex subunit 26 0.792
slp1 sloppy paired 1 0.787
Su(var)3-7 Suppressor of variegation 3-7 0.781
ems empty spiracles 0.780
Rbf Retinoblastoma-family protein 0.772
mirr mirror 0.769
E(var)3-9 Enhancer of variegation 3-9 0.769
HGTX CG13475 gene product from transcript CG13475-RB 0.767
Doc2 Dorsocross2 0.757
Sep2 Septin-2 0.753
Trf2 TATA box binding protein-related factor 2 0.752
Socs36E Suppressor of cytokine signaling at 36E 0.748
toy twin of eyeless 0.746
Ets97D Ets at 97D 0.739
CG9986 CG9986 gene product from transcript CG9986-RA 0.737
gt giant 0.737
barr barren 0.736
crm cramped 0.733
Optix CG18455 gene product from transcript CG18455-RA 0.732
nmo nemo 0.732
Pli Pellino 0.731
inv invected 0.730
bab2 CG9102 gene product from transcript CG9102-RA 0.730
dco discs overgrown 0.722
wg wingless 0.722
sca scabrous 0.721
al aristaless 0.716
e(y)3 enhancer of yellow 3 0.713
how held out wings 0.710
Cdk9 Cyclin-dependent kinase 9 0.706
sax saxophone 0.704
sim single-minded 0.702
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Jun Jun oncogene 0.911
Junb jun B proto-oncogene 0.731
Tcfe2a transcription factor E2a 0.589
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.574
Fos FBJ osteosarcoma oncogene 0.458
Pcna proliferating cell nuclear antigen 0.447
Dbp D site of albumin promoter (albumin D-box) binding protein 0.427
Smad7 SMAD family member 7 0.421
Klf4 Kruppel-like factor 4 (gut) 0.415
Lhx5 LIM homeobox 5 0.402
Dusp1 dual specificity phosphatase 1 0.391
Nfix nuclear factor I/X (CCAAT-binding transcription factor) 0.373
Ppp1r15a protein phosphatase 1, regulatory (inhibitor) subunit 15A 0.371
Nfib nuclear factor I/B 0.360
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.357
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.351
Cdk5r1 cyclin-dependent kinase 5, regulatory subunit 1 0.350
Nfya nuclear transcription factor-Y alpha 0.346
Tgfbr2 transforming growth factor, beta receptor II 0.334
Cntn4 contactin 4 0.331
Phf12 PHD finger protein 12 0.330
Id1 inhibitor of DNA binding 1 0.330
Slc5a1 solute carrier family 5 (sodium/glucose cotransporter), member 1 0.327
Met met proto-oncogene 0.322
Rorb RAR-related orphan receptor B 0.322
Lbr lamin B receptor 0.320
Rest RE1-silencing transcription factor 0.318
Ier2 immediate early response 2 0.315
Ldha lactate dehydrogenase A 0.315
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.306
Gfi1 growth factor independent 1 transcription repressor 0.300
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.299
Myc myelocytomatosis oncogene 0.287
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.277
Cxxc5 CXXC finger 5 0.274
Cdkn2b cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.270
S100a8 S100 calcium binding protein A8 0.263
Cd40lg CD40 ligand 0.258
Nrg1 neuregulin 1 0.255
Shox2 short stature homeobox 2 0.251
Pde4b phosphodiesterase 4B, cAMP specific 0.251
Tp53 tumor protein p53 0.251
Pgam1 phosphoglycerate mutase 1 (brain) 0.250
Eif4h eukaryotic translation initiation factor 4H 0.250
Fgfr2 fibroblast growth factor receptor 2 0.246
Trim28 tripartite motif-containing 28 0.243
Barhl2 BarH-like homeobox 2 0.241
Hes1 hairy and enhancer of split 1 (Drosophila) 0.237
Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.235
Rara retinoic acid receptor, alpha 0.231
Ptpn1 protein tyrosine phosphatase, non-receptor type 1 0.231
Rxra retinoid X receptor alpha 0.229
Ppp2cb protein phosphatase 2, catalytic subunit, beta isoform 0.227
Ccnd1 cyclin D1 0.226
Kcnt1 potassium channel, subfamily T, member 1 0.226
Nfia nuclear factor I/A 0.226
Bcl2 B-cell CLL/lymphoma 2 0.224
Cxcl2 chemokine (C-X-C motif) ligand 2 0.222
Mgp matrix Gla protein 0.222
Dlg1 discs, large homolog 1 (Drosophila) 0.215
Ccl4 chemokine (C-C motif) ligand 4 0.215
Pou3f2 POU class 3 homeobox 2 0.214
Errfi1 ERBB receptor feedback inhibitor 1 0.213
Lzts2 leucine zipper, putative tumor suppressor 2 0.212
Alx1 ALX homeobox 1 0.212
Hoxc4 homeo box C4 0.212
Casp2 caspase 2 0.209
Fgfr1 Fibroblast growth factor receptor 1 0.208
Socs3 suppressor of cytokine signaling 3 0.208
Iapp islet amyloid polypeptide 0.208
Nr1d2 nuclear receptor subfamily 1, group D, member 2 0.207
Dusp6 dual specificity phosphatase 6 0.207
Prss3 protease, serine, 3 0.207
Klf6 Kruppel-like factor 6 0.206
Rhob ras homolog gene family, member B 0.205
Map3k3 mitogen activated protein kinase kinase kinase 3 0.203
Ptma prothymosin alpha 0.201
Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 0.200
S100a9 S100 calcium binding protein A9 0.197
Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.196
Klf2 Kruppel-like factor 2 (lung) 0.195
Grin2d glutamate receptor, ionotropic, N-methyl D-aspartate 2D 0.192
Kdm6b lysine (K)-specific demethylase 6B 0.191
RGD1565591 similar to Ski protein 0.191
Usf2 upstream transcription factor 2, c-fos interacting 0.190
Grk1 G protein-coupled receptor kinase 1 0.190
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.189
Sp1 Sp1 transcription factor 0.184
Cask calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.183
Gjb3 gap junction protein, beta 3 0.181
Nr4a1 nuclear receptor subfamily 4, group A, member 1 0.180
Vax2 ventral anterior homeobox 2 0.177
Mip major intrinsic protein of lens fiber 0.176
Neurog1 neurogenin 1 0.176
Kctd13 potassium channel tetramerisation domain containing 13 0.176
Ctdsp1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 0.175
Il1r1 interleukin 1 receptor, type I 0.175
Dag1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.173
Egr4 early growth response 4 0.172
Runx1 runt-related transcription factor 1 0.172