The network for 'telomere maintenance via telomerase' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

telomere maintenance via telomerase

The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase.

Name Description Probability Func Analog Organism
RFA2 Rfa2p 0.966
EST2 Est2p 0.924
RFA1 Rfa1p 0.854
MEC1 Mec1p 0.632
SGS1 Sgs1p 0.401
DNA2 Dna2p 0.383
CDC13 Cdc13p 0.354
RAD53 Rad53p 0.319
TEL1 Tel1p 0.310
POL12 Pol12p 0.256
STN1 Stn1p 0.245
TEN1 Ten1p 0.230
STI1 Sti1p 0.227
MSH6 Msh6p 0.186
NOP10 Nop10p 0.163
RIF1 Rif1p 0.161
POL1 Pol1p 0.160
RMI1 Rmi1p 0.150
SMC6 Smc6p 0.137
PIF1 Pif1p 0.120
RFA3 Rfa3p 0.099
RAD5 Rad5p 0.096
YDL156W hypothetical protein 0.079
DUN1 Dun1p 0.073
EST1 Est1p 0.065
VAC17 Vac17p 0.056
YKU80 Yku80p 0.052
TTI2 Tti2p 0.052
SWM2 Swm2p 0.051
CSM2 Csm2p 0.047
PRI1 Pri1p 0.047
YLR162W hypothetical protein 0.045
EBS1 Ebs1p 0.041
IRC5 Irc5p 0.040
POL2 Pol2p 0.038
HHO1 Hho1p 0.038
RNH201 Rnh201p 0.036
RIO1 Rio1p 0.034
PRS2 Prs2p 0.033
YLR363W-A hypothetical protein 0.033
SRD1 Srd1p 0.031
URA3 Ura3p 0.031
YLR264C-A hypothetical protein 0.030
RTT105 Rtt105p 0.029
SPT15 Spt15p 0.028
THG1 Thg1p 0.028
MER1 Mer1p 0.027
ARP10 Arp10p 0.027
LEU2 Leu2p 0.027
YOL038C-A hypothetical protein 0.026
DED1 Ded1p 0.026
YMR147W hypothetical protein 0.026
YOR390W hypothetical protein 0.026
SEN54 Sen54p 0.025
MMS1 Mms1p 0.025
CDC9 Cdc9p 0.025
YGR071C hypothetical protein 0.025
RAP1 Rap1p 0.024
RTT107 Rtt107p 0.024
FHL1 Fhl1p 0.024
RAD51 Rad51p 0.023
FYV7 Fyv7p 0.023
ARG8 Arg8p 0.023
FAF1 Faf1p 0.023
MGS1 Mgs1p 0.022
ADH2 Adh2p 0.022
SIR4 Sir4p 0.022
FCP1 Fcp1p 0.022
SAE2 Sae2p 0.022
EXO1 Exo1p 0.022
YAR068W hypothetical protein 0.021
SGT2 Sgt2p 0.021
MSH3 Msh3p 0.021
POL32 Pol32p 0.021
SIR3 Sir3p 0.021
HO Hop 0.021
PDS1 Pds1p 0.021
SFT1 Sft1p 0.021
YIL151C hypothetical protein 0.020
YLR042C hypothetical protein 0.020
YPR157W hypothetical protein 0.020
HCH1 Hch1p 0.020
ATP6 Atp6p 0.020
CUP1-1 Cup1-1p 0.020
YER186C hypothetical protein 0.020
OGG1 Ogg1p 0.020
YNR071C hypothetical protein 0.019
YBR013C hypothetical protein 0.019
HHT2 Hht2p 0.019
MET8 Met8p 0.019
BSC1 Bsc1p 0.019
MF(ALPHA)2 Mf(alpha)2p 0.019
HPF1 Hpf1p 0.019
SSP1 Ssp1p 0.019
CHA1 Cha1p 0.019
HXT3 Hxt3p 0.019
FMT1 Fmt1p 0.019
RAD9 Rad9p 0.019
YOR342C hypothetical protein 0.019
CAB4 Cab4p 0.018
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
RPA1 replication protein A1, 70kDa 0.999
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1 0.951
TERF2IP telomeric repeat binding factor 2, interacting protein 0.782
RPA2 replication protein A2, 32kDa 0.759
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 0.649
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.565
RPA3 replication protein A3, 14kDa 0.465
NBN nibrin 0.413
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor 0.412
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 0.343
WRN Werner syndrome, RecQ helicase-like 0.311
TOP3A topoisomerase (DNA) III alpha 0.289
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.262
POT1 protection of telomeres 1 homolog (S. pombe) 0.243
MSH2 mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) 0.200
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.152
RFC1 replication factor C (activator 1) 1, 145kDa 0.127
BLM Bloom syndrome, RecQ helicase-like 0.095
SLX4 SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) 0.089
MSH3 mutS homolog 3 (E. coli) 0.076
DAXX death-domain associated protein 0.059
FNBP1 formin binding protein 1 0.059
HUS1 HUS1 checkpoint homolog (S. pombe) 0.055
ATM ataxia telangiectasia mutated 0.044
MSH6 mutS homolog 6 (E. coli) 0.038
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.037
ORC2 origin recognition complex, subunit 2 0.034
BANP BTG3 associated nuclear protein 0.032
ACD adrenocortical dysplasia homolog (mouse) 0.029
TGIF1 TGFB-induced factor homeobox 1 0.025
AXIN1 axin 1 0.024
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast) 0.024
MAPK7 mitogen-activated protein kinase 7 0.023
RAD17 RAD17 homolog (S. pombe) 0.021
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.019
MDM4 Mdm4 p53 binding protein homolog (mouse) 0.016
TERF2 telomeric repeat binding factor 2 0.016
MDC1 mediator of DNA-damage checkpoint 1 0.015
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.014
RUNX1 runt-related transcription factor 1 0.014
STAG1 stromal antigen 1 0.011
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Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 0.936
Chordc1 cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1 0.828
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.235
Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha 0.204
Msh2 mutS homolog 2 (E. coli) 0.198
Igh immunoglobulin heavy chain complex 0.182
Hspa8 heat shock protein 8 0.166
Tipin timeless interacting protein 0.147
Wrn Werner syndrome homolog (human) 0.115
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.108
Skil SKI-like 0.104
Iqcb1 IQ calmodulin-binding motif containing 1 0.098
Terf1 telomeric repeat binding factor 1 0.098
Stip1 stress-induced phosphoprotein 1 0.093
Hsph1 heat shock 105kDa/110kDa protein 1 0.087
Rfc1 replication factor C (activator 1) 1 0.081
Smn1 survival motor neuron 1 0.071
Rpgrip1l Rpgrip1-like 0.069
Daxx Fas death domain-associated protein 0.064
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.064
Rrm1 ribonucleotide reductase M1 0.064
Dnajc9 DnaJ (Hsp40) homolog, subfamily C, member 9 0.055
Mcm7 minichromosome maintenance deficient 7 (S. cerevisiae) 0.052
Ahi1 Abelson helper integration site 1 0.050
Prkdc protein kinase, DNA activated, catalytic polypeptide 0.047
Nphp4 nephronophthisis 4 (juvenile) homolog (human) 0.046
Dkc1 dyskeratosis congenita 1, dyskerin homolog (human) 0.044
Mcm4 minichromosome maintenance deficient 4 homolog (S. cerevisiae) 0.039
Pot1a protection of telomeres 1A 0.039
Mcm2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae) 0.037
Nphp1 nephronophthisis 1 (juvenile) homolog (human) 0.037
Tubgcp2 tubulin, gamma complex associated protein 2 0.035
Prim1 DNA primase, p49 subunit 0.032
Mdm4 transformed mouse 3T3 cell double minute 4 0.030
Mre11a meiotic recombination 11 homolog A (S. cerevisiae) 0.029
Sae1 SUMO1 activating enzyme subunit 1 0.029
Acd adrenocortical dysplasia 0.028
Rnaseh2a ribonuclease H2, large subunit 0.028
Tdp1 tyrosyl-DNA phosphodiesterase 1 0.028
Parp1 poly (ADP-ribose) polymerase family, member 1 0.025
Mdm2 transformed mouse 3T3 cell double minute 2 0.022
H2afx H2A histone family, member X 0.021
Timeless timeless homolog (Drosophila) 0.021
Mcm3 minichromosome maintenance deficient 3 (S. cerevisiae) 0.020
Tuba1b tubulin, alpha 1B 0.019
Exosc7 exosome component 7 0.019
Fgf2 fibroblast growth factor 2 0.019
Vcp valosin containing protein 0.019
Fkbp4 FK506 binding protein 4 0.019
Nde1 nuclear distribution gene E homolog 1 (A nidulans) 0.018
Gins4 GINS complex subunit 4 (Sld5 homolog) 0.017
Cdk4 cyclin-dependent kinase 4 0.016
Mcm5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) 0.016
Pold3 polymerase (DNA-directed), delta 3, accessory subunit 0.016
Dmd dystrophin, muscular dystrophy 0.016
Mad2l1 MAD2 mitotic arrest deficient-like 1 (yeast) 0.016
Rfc2 replication factor C (activator 1) 2 0.015
Ttn titin 0.015
Invs inversin 0.015
Pold1 polymerase (DNA directed), delta 1, catalytic subunit 0.015
Itgb1bp2 integrin beta 1 binding protein 2 0.015
Prpsap2 phosphoribosyl pyrophosphate synthetase-associated protein 2 0.015
Prim2 DNA primase, p58 subunit 0.015
Rfc3 replication factor C (activator 1) 3 0.015
Stat1 signal transducer and activator of transcription 1 0.014
Sf3a3 splicing factor 3a, subunit 3 0.014
Dtymk deoxythymidylate kinase 0.014
Mlh1 mutL homolog 1 (E. coli) 0.014
Lmna lamin A 0.014
Siva1 SIVA1, apoptosis-inducing factor 0.014
Nup93 nucleoporin 93 0.014
Gja1 gap junction protein, alpha 1 0.013
Pms2 postmeiotic segregation increased 2 (S. cerevisiae) 0.013
Mcm8 minichromosome maintenance deficient 8 (S. cerevisiae) 0.013
Huwe1 HECT, UBA and WWE domain containing 1 0.013
Tubb5 tubulin, beta 5 0.013
Tcf3 transcription factor 3 0.012
Eftud2 elongation factor Tu GTP binding domain containing 2 0.012
Rttn rotatin 0.012
Lsm2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.012
Cdkn2aipnl CDKN2A interacting protein N-terminal like 0.011
Cdc23 CDC23 (cell division cycle 23, yeast, homolog) 0.011
Gpn3 GPN-loop GTPase 3 0.011
Nup85 nucleoporin 85 0.011
Fam83h family with sequence similarity 83, member H 0.011
Cct7 chaperonin containing Tcp1, subunit 7 (eta) 0.011
Ints9 integrator complex subunit 9 0.010
Nup107 nucleoporin 107 0.010
Rbl1 retinoblastoma-like 1 (p107) 0.010
Hspd1 heat shock protein 1 (chaperonin) 0.010
Lin9 lin-9 homolog (C. elegans) 0.010
Dna2 DNA replication helicase 2 homolog (yeast) 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism