The network for 'response to heat' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to heat

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
STI1 Sti1p 0.844
YDJ1 Ydj1p 0.771
SSE1 Sse1p 0.660
HSP42 Hsp42p 0.601
NUP100 Nup100p 0.535
PBS2 Pbs2p 0.518
AHA1 Aha1p 0.501
MOB1 Mob1p 0.490
SSA4 Ssa4p 0.385
NUP116 Nup116p 0.334
SSK1 Ssk1p 0.310
HSP82 Hsp82p 0.253
PTC1 Ptc1p 0.228
SSK2 Ssk2p 0.208
HSP78 Hsp78p 0.203
GIP2 Gip2p 0.202
PPZ1 Ppz1p 0.200
SIS1 Sis1p 0.190
HSP104 Hsp104p 0.186
CTI6 Cti6p 0.183
NBP2 Nbp2p 0.181
MSN2 Msn2p 0.179
STE5 Ste5p 0.176
MYO4 Myo4p 0.174
RXT3 Rxt3p 0.167
SNF1 Snf1p 0.163
RPI1 Rpi1p 0.150
SSA2 Ssa2p 0.141
BUR6 Bur6p 0.138
RPN4 Rpn4p 0.134
MIG2 Mig2p 0.129
CPR6 Cpr6p 0.128
SAP30 Sap30p 0.122
FES1 Fes1p 0.113
MSG5 Msg5p 0.111
NTO1 Nto1p 0.108
ZEO1 Zeo1p 0.107
SIN3 Sin3p 0.107
SSE2 Sse2p 0.105
TSL1 Tsl1p 0.105
CUP9 Cup9p 0.104
POM34 Pom34p 0.103
HSP31 Hsp31p 0.101
KAP95 Kap95p 0.101
CLA4 Cla4p 0.100
NUP157 Nup157p 0.099
RPD3 Rpd3p 0.097
BTN2 Btn2p 0.097
CTK1 Ctk1p 0.096
RPS10B Rps10bp 0.094
MMS22 Mms22p 0.093
CBK1 Cbk1p 0.092
BOI2 Boi2p 0.091
SYP1 Syp1p 0.089
DOT6 Dot6p 0.089
OPY2 Opy2p 0.088
SNF4 Snf4p 0.087
TPK1 Tpk1p 0.086
MSN5 Msn5p 0.086
SGT2 Sgt2p 0.086
CPR7 Cpr7p 0.085
PKH2 Pkh2p 0.085
SAC3 Sac3p 0.085
RGD1 Rgd1p 0.085
RPL10 Rpl10p 0.084
WSC3 Wsc3p 0.081
RPB3 Rpb3p 0.081
ASH1 Ash1p 0.080
RIM101 Rim101p 0.080
DED1 Ded1p 0.080
HDA2 Hda2p 0.077
SCH9 Sch9p 0.077
MBR1 Mbr1p 0.077
BOI1 Boi1p 0.076
NUP170 Nup170p 0.076
FLO8 Flo8p 0.074
HSF1 Hsf1p 0.073
SSA3 Ssa3p 0.072
MIG3 Mig3p 0.072
CTK3 Ctk3p 0.072
CYC8 Cyc8p 0.072
RIM15 Rim15p 0.072
VHS1 Vhs1p 0.072
BCK1 Bck1p 0.071
HAL5 Hal5p 0.069
YKR075C hypothetical protein 0.069
TPK2 Tpk2p 0.068
ALD4 Ald4p 0.068
VAC7 Vac7p 0.066
RPB11 Rpb11p 0.066
NUP49 Nup49p 0.066
TOS8 Tos8p 0.066
CRZ1 Crz1p 0.065
RGS2 Rgs2p 0.064
SSA1 Ssa1p 0.064
YOL036W hypothetical protein 0.064
BEM3 Bem3p 0.064
BMH2 Bmh2p 0.063
HSC82 Hsc82p 0.063
STE11 Ste11p 0.063
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
hsp-16.2 Protein HSP-16.2 0.912
hsp-16.41 Protein HSP-16.41 0.846
hsp-70 Protein HSP-70 0.804
F44E5.4 Protein F44E5.4 0.550
hsp-16.1 Protein HSP-16.1 0.472
hsp-16.48 Protein HSP-16.48 0.326
daf-21 Protein DAF-21 0.249
mpk-1 Protein MPK-1 0.163
par-5 Protein PAR-5 0.151
nhr-17 Protein NHR-17 0.128
goa-1 Protein GOA-1 0.118
mat-3 Protein MAT-3 0.111
hsp-4 Protein HSP-4 0.107
paqr-1 Protein PAQR-1 0.096
mrp-1 Protein MRP-1 0.092
ifg-1 Protein IFG-1 0.091
pqn-59 Protein PQN-59 0.086
mig-15 Protein MIG-15 0.085
rsks-1 Protein RSKS-1 0.084
sax-7 Protein SAX-7 0.077
dnj-19 Protein DNJ-19 0.076
lea-1 Protein LEA-1 0.070
M57.2 Protein M57.2 0.069
CELE_F14E5.2 Protein F14E5.2 0.067
vab-8 Protein VAB-8 0.067
pdfr-1 Protein PDFR-1 0.065
hsp-16.11 Protein HSP-16.11 0.064
plc-1 Protein PLC-1 0.061
F44E2.8 Protein F44E2.8 0.059
rpl-16 Protein RPL-16 0.058
ceh-18 Protein CEH-18 0.057
C09G1.4 Protein C09G1.4 0.056
pmk-1 Protein PMK-1 0.055
unc-32 Protein UNC-32 0.055
egl-8 Protein EGL-8 0.055
ergo-1 Protein ERGO-1 0.054
ZC395.10 Protein ZC395.10 0.053
rskn-1 Protein RSKN-1 0.052
hsp-1 Protein HSP-1 0.052
prp-8 Protein PRP-8 0.051
arf-1.2 Protein ARF-1.2 0.048
gsr-1 Protein GSR-1 0.048
math-33 Protein MATH-33 0.047
unc-104 Protein UNC-104 0.046
rpl-15 Protein RPL-15 0.046
ccch-1 Protein CCCH-1 0.046
pup-2 Protein PUP-2 0.046
lag-1 Protein LAG-1 0.045
spe-9 Protein SPE-9 0.045
par-3 Protein PAR-3 0.045
sqd-1 Protein SQD-1 0.044
rps-2 Protein RPS-2 0.043
snt-1 Protein SNT-1 0.043
soc-2 Protein SOC-2 0.043
F08H9.3 Protein F08H9.3 0.043
F31D4.2 Protein F31D4.2 0.043
Y54G9A.5 Protein Y54G9A.5 0.042
sec-8 Protein SEC-8 0.042
rpl-12 Protein RPL-12 0.042
F58B3.6 Protein F58B3.6 0.041
inx-1 Protein INX-1 0.041
ttx-1 Protein TTX-1 0.041
CELE_F55C5.8 Protein F55C5.8 0.040
sng-1 Protein SNG-1 0.040
F35H10.3 Protein F35H10.3 0.040
F10E9.1 Protein F10E9.1 0.040
C30F12.3 Protein C30F12.3 0.040
fasn-1 Protein FASN-1 0.040
dnj-12 Protein DNJ-12 0.039
asd-1 Protein ASD-1 0.039
Y65B4BR.5 Protein Y65B4BR.5 0.039
ZC443.4 Protein ZC443.4 0.039
ccpp-1 Protein CCPP-1 0.039
rpn-1 Protein RPN-1 0.038
pal-1 Protein PAL-1 0.038
aph-2 Protein APH-2 0.038
mdt-28 Protein MDT-28 0.038
pkc-1 Protein PKC-1 0.037
Y94H6A.7 Protein Y94H6A.7 0.037
eat-4 Protein EAT-4 0.037
rpb-2 Protein RPB-2 0.037
osm-6 Protein OSM-6 0.037
rfp-1 Protein RFP-1 0.036
T23F2.4 Protein T23F2.4 0.036
unc-11 Protein UNC-11 0.036
ztf-7 Protein ZTF-7 0.035
dmd-7 Protein DMD-7 0.035
che-13 Protein CHE-13 0.034
alg-1 Protein ALG-1 0.034
pme-2 Protein PME-2 0.034
frm-3 Protein FRM-3 0.034
sipa-1 Protein SIPA-1 0.034
lmn-1 Protein LMN-1 0.034
ztf-22 Protein ZTF-22 0.033
epc-1 Protein EPC-1 0.033
ncam-1 Protein NCAM-1 0.033
elpc-3 Protein ELPC-3 0.033
F08H9.4 Protein F08H9.4 0.032
CELE_Y106G6D.7 Protein Y106G6D.7 0.032
cdc-48.2 Protein CDC-48.2 0.032
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
hspa5 heat shock protein 5 0.714
hsp90a.2 heat shock protein 90-alpha 2 0.383
atf3 activating transcription factor 3 0.288
nf1a neurofibromin 1a 0.196
wnt10a wingless-type MMTV integration site family, member 10a 0.146
cfl2l cofilin 2, like 0.107
hsp90b1 heat shock protein 90, beta (grp94), member 1 0.098
ncl nucleolin 0.083
igf1rb insulin-like growth factor 1b receptor 0.082
smyhc1 slow myosin heavy chain 1 0.077
hyou1 hypoxia up-regulated 1 0.059
pdia4 protein disulfide isomerase associated 4 0.056
entpd3 ectonucleoside triphosphate diphosphohydrolase 3 0.055
cyp1a cytochrome P450, family 1, subfamily A 0.051
myog myogenin 0.048
hspb9 heat shock protein, alpha-crystallin-related, 9 0.047
calr calreticulin and calreticulin 0.043
pdia3 protein disulfide isomerase family A, member 3 0.042
dnajc3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.042
ef1a elongation factor 1-alpha 0.038
tnni1al troponin I, skeletal, slow like 0.038
p2rx2 purinergic receptor P2X, ligand-gated ion channel, 2 0.037
mmp9 matrix metalloproteinase 9 0.036
manf mesencephalic astrocyte-derived neurotrophic factor 0.033
hspd1 heat shock 60kD protein 1 (chaperonin) 0.032
gpia glucose phosphate isomerase a 0.031
bmper BMP binding endothelial regulator 0.027
copeb core promoter element binding protein 0.027
desma desmin a 0.027
calrl calreticulin like 0.026
calrl2 calreticulin, like 2 0.026
sae1 SUMO1 activating enzyme subunit 1 0.025
igf1 insulin-like growth factor 1 0.024
hsp70l heat shock cognate 70-kd protein, like 0.024
epo erythropoietin 0.023
dnaja1l DnaJ (Hsp40) homolog, subfamily A, member 1, like 0.023
nudc nuclear distribution gene C homolog 0.022
cx43 connexin 43 0.022
ntrk2b neurotrophic tyrosine kinase, receptor, type 2b 0.022
dnajb1b DnaJ (Hsp40) homolog, subfamily B, member 1b 0.021
nrxn2a neurexin 2a 0.021
prp19 PRP19/PSO4 homolog (S. cerevisiae) 0.021
irf9 interferon regulatory factor 9 0.021
phox2b paired-like homeobox 2b 0.021
blm Bloom syndrome 0.020
epb41 erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) 0.020
nipblb novel protein similar to vertebrate Nipped-B homolog and nipped-b homolog b (Drosophila) 0.019
zgc:63721 zgc:63721 0.019
cry3 cryptochrome 3 0.019
hnrnpa0l heterogeneous nuclear ribonucleoprotein A0, like 0.018
LOC100003514 protein kinase C alpha type-like 0.018
p2rx3b purinergic receptor P2X, ligand-gated ion channel, 3b 0.018
myhz2 myosin, heavy polypeptide 2, fast muscle specific 0.018
pcna proliferating cell nuclear antigen 0.017
pdip5 protein disulfide isomerase-related protein (provisional) 0.017
pak2a p21 (CDKN1A)-activated kinase 2a 0.016
rps8a ribosomal protein S8a 0.016
eny2 enhancer of yellow 2 homolog (Drosophila) 0.016
runx1 runt-related transcription factor 1 0.016
stac3 SH3 and cysteine rich domain 3 0.016
glra1 glycine receptor, alpha 1 0.015
qk quaking 0.015
ssrp1a structure specific recognition protein 1a 0.015
cse1l chromosome segregation 1-like (S. cerevisiae) 0.015
zgc:55259 zgc:55259 0.015
nap1l1 nucleosome assembly protein 1, like 1 0.015
slc6a9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 0.015
taf1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor 0.015
tnni2a.4 troponin I, skeletal, fast 2a.4 0.015
gtf2b general transcription factor IIB 0.014
trpv6 transient receptor potential cation channel, subfamily V, member 6 0.014
nf1b neurofibromin 1b 0.014
tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.014
fgf13b fibroblast growth factor 13b 0.014
bactin1 bactin1 0.013
psmc6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.013
usp10 ubiquitin specific peptidase 10 0.013
prkcbb protein kinase C, beta b 0.013
ret1 receptor tyrosine kinase 0.013
slc6a5 solute carrier family 6 (neurotransmitter transporter, glycine), member 5 0.012
nr1d2b nuclear receptor subfamily 1, group D, member 2b 0.012
elavl1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.012
ptpra protein tyrosine phosphatase, receptor type, A 0.012
odc1 ornithine decarboxylase 1 0.012
ube2na ubiquitin-conjugating enzyme E2Na 0.012
scn8ab sodium channel, voltage-gated, type VIII, alpha b 0.012
nadl1.2 neural adhesion molecule L1.2 0.012
nutf2 nuclear transport factor 2 0.012
cbr1l carbonyl reductase 1-like 0.012
stmn2b stathmin-like 2b 0.012
hnrnph1l heterogeneous nuclear ribonucleoprotein H1, like 0.012
recql5 RecQ protein-like 5 0.011
trpv1 transient receptor potential cation channel subfamily V member 1 0.011
gadd45aa growth arrest and DNA-damage-inducible, alpha, a 0.011
eif3s10 eukaryotic translation initiation factor 3, subunit 10 (theta) 0.011
clock clock 0.011
vmhc ventricular myosin heavy chain 0.011
rpl3 ribosomal protein L3 0.011
snrnp40 small nuclear ribonucleoprotein 40 (U5) 0.011
lass2 LAG1 homolog, ceramide synthase 2 (S. cerevisiae) 0.011
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
GstE6 Glutathione S transferase E6 0.971
GstD1 Glutathione S transferase D1 0.958
Hsp70Ab Heat-shock-protein-70Ab 0.883
GstE7 Glutathione S transferase E7 0.811
GstD4 Glutathione S transferase D4 0.810
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.780
Hsp27 Heat shock protein 27 0.666
Hsp70Aa Heat-shock-protein-70Aa 0.557
Hsp26 Heat shock protein 26 0.494
GstD5 Glutathione S transferase D5 0.444
Hsp68 Heat shock protein 68 0.439
stv starvin 0.389
Vrp1 Verprolin 1 0.378
Hsp23 Heat shock protein 23 0.370
GstD10 Glutathione S transferase D10 0.310
bsk basket 0.308
Nlp Nucleoplasmin 0.282
Sep2 Septin-2 0.271
stnA stoned A 0.260
Dlic Dynein light intermediate chain 0.259
Rac1 CG2248 gene product from transcript CG2248-RA 0.253
iav inactive 0.253
Mekk1 CG7717 gene product from transcript CG7717-RB 0.249
Trap1 CG3152 gene product from transcript CG3152-RA 0.245
Hsp70Ba Heat-shock-protein-70Ba 0.228
shi shibire 0.226
para paralytic 0.224
Tpi Triose phosphate isomerase 0.191
Trx-2 thioredoxin-2 0.182
Mpk2 CG5475 gene product from transcript CG5475-RB 0.179
endoA endophilin A 0.176
Ace Acetylcholine esterase 0.164
chico CG5686 gene product from transcript CG5686-RB 0.156
scb scab 0.155
Ras85D Ras oncogene at 85D 0.142
boca CG30498 gene product from transcript CG30498-RA 0.140
bves CG32513 gene product from transcript CG32513-RA 0.139
hts hu li tai shao 0.136
Iswi Imitation SWI 0.128
Chc Clathrin heavy chain 0.128
ImpL3 Ecdysone-inducible gene L3 0.128
Syt1 Synaptotagmin 1 0.128
GstE3 Glutathione S transferase E3 0.126
GstD9 Glutathione S transferase D9 0.121
RpL30 Ribosomal protein L30 0.119
GstD6 Glutathione S transferase D6 0.118
RpII215 RNA polymerase II 215kD subunit 0.117
Lis-1 Lissencephaly-1 0.109
Mdr65 Multiple drug resistance 65 0.108
p120ctn Adherens junction protein p120 0.101
tko technical knockout 0.094
Hsp22 Heat shock protein 22 0.090
CrebB-17A Cyclic-AMP response element binding protein B at 17A 0.088
Gef26 CG9491 gene product from transcript CG9491-RB 0.088
CG32685 CG32685 gene product from transcript CG32685-RC 0.088
CG9796 CG9796 gene product from transcript CG9796-RA 0.088
stnB stoned B 0.086
Parp Poly-(ADP-ribose) polymerase 0.084
CG43073 CG43073 gene product from transcript CG43073-RF 0.082
foxo forkhead box, sub-group O 0.081
pain painless 0.081
MED19 Mediator complex subunit 19 0.081
Itp-r83A Inositol 1,4,5,-tris-phosphate receptor 0.081
Akt1 CG4006 gene product from transcript CG4006-RA 0.080
RpS23 Ribosomal protein S23 0.078
Spf45 CG17540 gene product from transcript CG17540-RB 0.076
ST6Gal Sialyltransferase 0.075
Nup153 Nucleoporin 153 0.072
HisCl1 Histamine-gated chloride channel subunit 1 0.071
CG15199 CG15199 gene product from transcript CG15199-RA 0.070
Parg Poly(ADP-ribose) glycohydrolase 0.070
PPP4R2r Protein phosphatase 4 regulatory subunit 2-related protein 0.070
Vmat Vesicular monoamine transporter 0.069
5-HT1A Serotonin receptor 1A 0.068
dnc dunce 0.068
rl rolled 0.068
axo axotactin 0.068
asf1 anti-silencing factor 1 0.067
cert ceramide transfer protein 0.066
CG6776 CG6776 gene product from transcript CG6776-RA 0.066
krz kurtz 0.065
e ebony 0.065
CG2118 CG2118 gene product from transcript CG2118-RB 0.065
betaTub60D beta-Tubulin at 60D 0.065
NLaz Neural Lazarillo 0.065
Cpr73D Cuticular protein 73D 0.064
hep hemipterous 0.063
GstD3 Glutathione S transferase D3 0.063
ran CG1404 gene product from transcript CG1404-RB 0.063
noi noisette 0.062
Nf1 Neurofibromin 1 0.061
MED27 Mediator complex subunit 27 0.060
CG5645 CG5645 gene product from transcript CG5645-RA 0.060
lwr lesswright 0.059
debcl death executioner Bcl-2 homologue 0.059
bchs blue cheese 0.058
CG12203 CG12203 gene product from transcript CG12203-RA 0.058
comt comatose 0.057
Nf-YB Nuclear factor Y-box B 0.057
nan nanchung 0.056
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.990
HSPB8 heat shock 22kDa protein 8 0.982
BAG3 BCL2-associated athanogene 3 0.822
HSPB1 heat shock 27kDa protein 1 0.794
MAPK14 mitogen-activated protein kinase 14 0.778
CRYAB crystallin, alpha B 0.579
HSPA8 heat shock 70kDa protein 8 0.575
FGFR2 fibroblast growth factor receptor 2 0.426
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.415
HDAC1 histone deacetylase 1 0.401
CDK9 cyclin-dependent kinase 9 0.335
RPLP1 ribosomal protein, large, P1 0.297
HSPH1 heat shock 105kDa/110kDa protein 1 0.280
HSPA1B heat shock 70kDa protein 1B 0.278
FKBP4 FK506 binding protein 4, 59kDa 0.268
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.266
DHX30 DEAH (Asp-Glu-Ala-His) box polypeptide 30 0.244
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 0.179
HSPA1A heat shock 70kDa protein 1A 0.178
IL8 interleukin 8 0.157
MAP2K4 mitogen-activated protein kinase kinase 4 0.127
MAP3K1 mitogen-activated protein kinase kinase kinase 1 0.126
CDC37 cell division cycle 37 homolog (S. cerevisiae) 0.123
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.117
THOC5 THO complex 5 0.114
IRAK2 interleukin-1 receptor-associated kinase 2 0.107
RPS3A ribosomal protein S3A 0.101
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.096
NXF1 nuclear RNA export factor 1 0.092
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.089
LRRK2 leucine-rich repeat kinase 2 0.087
SNTA1 syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component) 0.083
MAPK1 mitogen-activated protein kinase 1 0.083
RBBP7 retinoblastoma binding protein 7 0.080
NOSTRIN nitric oxide synthase trafficker 0.069
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.069
DNM2 dynamin 2 0.066
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.065
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) 0.064
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.063
HDAC2 histone deacetylase 2 0.060
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.057
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.056
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.056
VCP valosin containing protein 0.055
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.054
DHX9 DEAH (Asp-Glu-Ala-His) box polypeptide 9 0.052
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.051
RBBP4 retinoblastoma binding protein 4 0.050
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.050
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.048
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.048
IL1RN interleukin 1 receptor antagonist 0.047
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.043
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.041
HSPB2 heat shock 27kDa protein 2 0.040
CACYBP calcyclin binding protein 0.039
FGF1 fibroblast growth factor 1 (acidic) 0.037
IL1B interleukin 1, beta 0.036
AR androgen receptor 0.036
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.033
SQSTM1 sequestosome 1 0.032
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.032
PPID peptidylprolyl isomerase D 0.031
PDIA3 protein disulfide isomerase family A, member 3 0.031
CAV1 caveolin 1, caveolae protein, 22kDa 0.030
FGF10 fibroblast growth factor 10 0.030
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.029
FGFR1 fibroblast growth factor receptor 1 0.028
RPA1 replication protein A1, 70kDa 0.028
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa 0.028
MYD88 myeloid differentiation primary response gene (88) 0.028
PARP1 poly (ADP-ribose) polymerase 1 0.028
RB1 retinoblastoma 1 0.028
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.028
IL1RAP interleukin 1 receptor accessory protein 0.028
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.027
SUMO1 SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) 0.027
PRKCSH protein kinase C substrate 80K-H 0.027
HNRPDL heterogeneous nuclear ribonucleoprotein D-like 0.027
EP300 E1A binding protein p300 0.027
RPA2 replication protein A2, 32kDa 0.027
PTN pleiotrophin 0.026
EED embryonic ectoderm development 0.025
PDCD6IP programmed cell death 6 interacting protein 0.025
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.025
IQGAP1 IQ motif containing GTPase activating protein 1 0.024
HSPE1 heat shock 10kDa protein 1 (chaperonin 10) 0.024
BAG2 BCL2-associated athanogene 2 0.024
COASY CoA synthase 0.023
IRAK3 interleukin-1 receptor-associated kinase 3 0.023
DDX5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 0.022
MAP3K4 mitogen-activated protein kinase kinase kinase 4 0.022
STIP1 stress-induced-phosphoprotein 1 0.022
ARRB1 arrestin, beta 1 0.022
PPP5C protein phosphatase 5, catalytic subunit 0.022
TARDBP TAR DNA binding protein 0.021
MAPK3 mitogen-activated protein kinase 3 0.021
BAD BCL2-associated agonist of cell death 0.021
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.021
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Hspa1b heat shock protein 1B 0.888
Mapk14 mitogen-activated protein kinase 14 0.873
Trp53 transformation related protein 53 0.862
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.760
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.759
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.714
Hsph1 heat shock 105kDa/110kDa protein 1 0.687
Pten phosphatase and tensin homolog 0.657
Stat3 signal transducer and activator of transcription 3 0.475
Hspa8 heat shock protein 8 0.377
Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 0.301
Hnrpdl heterogeneous nuclear ribonucleoprotein D-like 0.287
Nos1 nitric oxide synthase 1, neuronal 0.285
Egln1 EGL nine homolog 1 (C. elegans) 0.281
Actn2 actinin alpha 2 0.231
Ptges3 prostaglandin E synthase 3 (cytosolic) 0.223
Nos3 nitric oxide synthase 3, endothelial cell 0.220
Hdac2 histone deacetylase 2 0.218
E2f1 E2F transcription factor 1 0.206
Tlr4 toll-like receptor 4 0.198
Hsp90b1 heat shock protein 90, beta (Grp94), member 1 0.197
Hspa5 heat shock protein 5 0.181
Srsf3 serine/arginine-rich splicing factor 3 0.172
Suds3 suppressor of defective silencing 3 homolog (S. cerevisiae) 0.172
Dnaja1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.153
Chordc1 cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1 0.149
Hspa1a heat shock protein 1A 0.147
Atf2 activating transcription factor 2 0.146
Prkcc protein kinase C, gamma 0.145
Gdnf glial cell line derived neurotrophic factor 0.143
Gpi1 glucose phosphate isomerase 1 0.140
Anp32e acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.127
Tardbp TAR DNA binding protein 0.125
Rac1 RAS-related C3 botulinum substrate 1 0.120
Lyst lysosomal trafficking regulator 0.116
Gapdh glyceraldehyde-3-phosphate dehydrogenase 0.111
Sfpq splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) 0.111
Prkce protein kinase C, epsilon 0.107
Gclm glutamate-cysteine ligase, modifier subunit 0.105
Hnrnpm heterogeneous nuclear ribonucleoprotein M 0.103
Myd88 myeloid differentiation primary response gene 88 0.102
Grb10 growth factor receptor bound protein 10 0.100
Ncl nucleolin 0.099
Ccl2 chemokine (C-C motif) ligand 2 0.097
Pfkl phosphofructokinase, liver, B-type 0.097
Cacybp calcyclin binding protein 0.090
Hspd1 heat shock protein 1 (chaperonin) 0.087
Pkm2 pyruvate kinase, muscle 0.087
Bag3 BCL2-associated athanogene 3 0.082
Psen1 presenilin 1 0.081
Il6 interleukin 6 0.079
Notch2 Notch gene homolog 2 (Drosophila) 0.077
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.076
Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 0.076
Hdac1 histone deacetylase 1 0.075
Il6st interleukin 6 signal transducer 0.074
Hnrnpa3 heterogeneous nuclear ribonucleoprotein A3 0.074
Serbp1 serpine1 mRNA binding protein 1 0.072
Fst follistatin 0.071
Ldb3 LIM domain binding 3 0.070
Fkbp4 FK506 binding protein 4 0.070
Mdm2 transformed mouse 3T3 cell double minute 2 0.069
Hnrnpd heterogeneous nuclear ribonucleoprotein D 0.068
Wfikkn2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.066
Fas Fas (TNF receptor superfamily member 6) 0.065
Insr insulin receptor 0.065
Mapk11 mitogen-activated protein kinase 11 0.063
Pgk1 phosphoglycerate kinase 1 0.063
Ep300 E1A binding protein p300 0.062
H3f3a H3 histone, family 3A 0.062
Bsn bassoon 0.061
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.061
Stat6 signal transducer and activator of transcription 6 0.061
Il10 interleukin 10 0.060
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.060
Klc2 kinesin light chain 2 0.058
Mapk1 mitogen-activated protein kinase 1 0.057
Kit kit oncogene 0.057
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.056
Sox10 SRY-box containing gene 10 0.055
Vhl von Hippel-Lindau tumor suppressor 0.052
Xpo1 exportin 1, CRM1 homolog (yeast) 0.051
Ppp5c protein phosphatase 5, catalytic subunit 0.048
Cd28 CD28 antigen 0.048
Dlgap1 discs, large (Drosophila) homolog-associated protein 1 0.048
Tpi1 triosephosphate isomerase 1 0.047
Nsf N-ethylmaleimide sensitive fusion protein 0.046
Ezh2 enhancer of zeste homolog 2 (Drosophila) 0.046
Inhba inhibin beta-A 0.044
Parp1 poly (ADP-ribose) polymerase family, member 1 0.044
Camk2a calcium/calmodulin-dependent protein kinase II alpha 0.044
Msh2 mutS homolog 2 (E. coli) 0.044
Atm ataxia telangiectasia mutated homolog (human) 0.044
Homer1 homer homolog 1 (Drosophila) 0.043
Dnajb1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.043
Lep leptin 0.043
Hmgb1 high mobility group box 1 0.042
Nes nestin 0.042
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.042
Ahsa1 AHA1, activator of heat shock protein ATPase homolog 1 (yeast) 0.042
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.987
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.920
Hsph1 heat shock 105/110 protein 1 0.883
Hspa1a heat shock 70kD protein 1A 0.863
Socs3 suppressor of cytokine signaling 3 0.858
Stip1 stress-induced phosphoprotein 1 0.849
Hspa8 heat shock protein 8 0.817
Aldoa aldolase A, fructose-bisphosphate 0.795
Il1b interleukin 1 beta 0.773
Dnaja1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.730
Mif macrophage migration inhibitory factor 0.706
Hspb1 heat shock protein 1 0.690
Mstn myostatin 0.594
Fkbp4 FK506 binding protein 4 0.525
Dnaja4 DnaJ (Hsp40) homolog, subfamily A, member 4 0.520
Casp1 caspase 1 0.489
Cav3 caveolin 3 0.449
Ubb ubiquitin B 0.443
Gapdh glyceraldehyde-3-phosphate dehydrogenase 0.425
Ccl2 chemokine (C-C motif) ligand 2 0.413
Hmgb2 high mobility group box 2 0.404
Cxcl2 chemokine (C-X-C motif) ligand 2 0.398
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.392
Foxd3 forkhead box D3 0.376
Ptgs2 prostaglandin-endoperoxide synthase 2 0.343
Cxcl10 chemokine (C-X-C motif) ligand 10 0.340
Ssb Sjogren syndrome antigen B 0.317
Myh1 myosin, heavy polypeptide 1, skeletal muscle, adult 0.301
Lilrb4 leukocyte immunoglobulin-like receptor, subfamily B, member 4 0.293
Eif2b5 eukaryotic translation initiation factor 2B, subunit 5 epsilon 0.286
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.278
Bcl2l1 Bcl2-like 1 0.270
Csf1 colony stimulating factor 1 (macrophage) 0.265
Hspd1 heat shock protein 1 (chaperonin) 0.265
Canx calnexin 0.264
Tacr1 tachykinin receptor 1 0.264
Pebp1 phosphatidylethanolamine binding protein 1 0.260
Tpm1 tropomyosin 1, alpha 0.252
Des desmin 0.250
LOC681996 similar to AHA1, activator of heat shock 90kDa protein ATPase homolog 1 0.248
Cox8a cytochrome c oxidase subunit VIIIa 0.243
RGD1562618 similar to RIKEN cDNA 6030419C18 gene 0.242
Dnajb1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.241
Bsg basigin 0.239
Cish cytokine inducible SH2-containing protein 0.226
Stat5b signal transducer and activator of transcription 5B 0.223
St13 suppression of tumorigenicity 13 0.215
S1pr2 sphingosine-1-phosphate receptor 2 0.213
Uqcrc1 ubiquinol-cytochrome c reductase core protein I 0.207
Socs2 suppressor of cytokine signaling 2 0.206
Parp14 poly (ADP-ribose) polymerase family, member 14 0.200
Actc1 actin, alpha, cardiac muscle 1 0.197
Myh3 myosin, heavy chain 3, skeletal muscle, embryonic 0.195
Pkm2 pyruvate kinase, muscle 0.193
Foxa3 forkhead box A3 0.193
Nras neuroblastoma ras oncogene 0.191
Icam1 intercellular adhesion molecule 1 0.182
Hnrnpu heterogeneous nuclear ribonucleoprotein U 0.178
Il10 interleukin 10 0.174
Cdc37 cell division cycle 37 homolog (S. cerevisiae) 0.173
B4galt1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.164
Plscr3 phospholipid scramblase 3 0.160
Myh7 myosin, heavy chain 7, cardiac muscle, beta 0.159
Il1a interleukin 1 alpha 0.159
Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.147
P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 0.147
Casq2 calsequestrin 2 (cardiac muscle) 0.146
Usf2 upstream transcription factor 2, c-fos interacting 0.144
Phkg1 phosphorylase kinase, gamma 1 0.143
Galr1 galanin receptor 1 0.142
Mmp13 matrix metallopeptidase 13 0.141
Ankrd1 ankyrin repeat domain 1 (cardiac muscle) 0.138
Cxcl9 chemokine (C-X-C motif) ligand 9 0.135
Cyp2c7 cytochrome P450, family 2, subfamily c, polypeptide 7 0.134
Ap2a1 adaptor-related protein complex 2, alpha 1 subunit 0.133
Hck hemopoietic cell kinase 0.132
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.126
Vom1r101 vomeronasal 1 receptor 101 0.125
Git1 G protein-coupled receptor kinase interacting ArfGAP 1 0.121
Ccr5 chemokine (C-C motif) receptor 5 0.120
Efna5 ephrin A5 0.120
Il1rl2 interleukin 1 receptor-like 2 0.119
Fmnl1 formin-like 1 0.114
F2rl2 coagulation factor II (thrombin) receptor-like 2 0.113
Tgfbr2 transforming growth factor, beta receptor II 0.112
Htr3a 5-hydroxytryptamine (serotonin) receptor 3a 0.112
Cyct cytochrome c, testis 0.111
Ripk3 receptor-interacting serine-threonine kinase 3 0.111
Rrad Ras-related associated with diabetes 0.109
Reg3g regenerating islet-derived 3 gamma 0.108
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.106
Abp1 amiloride binding protein 1 (amine oxidase, copper-containing) 0.106
Fosl1 fos-like antigen 1 0.106
Cd14 CD14 molecule 0.105
Mmp12 matrix metallopeptidase 12 0.105
Irf1 interferon regulatory factor 1 0.104
Gbp2 guanylate binding protein 2 0.104
Tacr3 tachykinin receptor 3 0.103
Prkacb protein kinase, cAMP dependent, catalytic, beta 0.102
Fgfr2 fibroblast growth factor receptor 2 0.100