The network for 'positive regulation of nucleobase containing compound metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of nucleobase containing compound metabolic process

Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
SIN3 Sin3p 0.992
GAL11 Gal11p 0.974
GLN3 Gln3p 0.959
SWI6 Swi6p 0.948
MSN2 Msn2p 0.925
HHT1 Hht1p 0.920
SNF2 Snf2p 0.912
YAK1 Yak1p 0.906
SLT2 Slt2p 0.905
SNF6 Snf6p 0.900
HSP82 Hsp82p 0.899
URE2 Ure2p 0.895
SPT15 Spt15p 0.890
TOR1 Tor1p 0.889
SSN3 Ssn3p 0.878
GCN5 Gcn5p 0.873
YAP1 Yap1p 0.870
RTG3 Rtg3p 0.869
SSN2 Ssn2p 0.865
SIN4 Sin4p 0.861
ADA2 Ada2p 0.854
SWI1 Swi1p 0.851
MET4 Met4p 0.846
ROX3 Rox3p 0.832
RXT2 Rxt2p 0.830
SPT8 Spt8p 0.826
CHD1 Chd1p 0.822
RGR1 Rgr1p 0.808
RIM101 Rim101p 0.800
CCR4 Ccr4p 0.795
CDC28 Cdc28p 0.786
CDC6 Cdc6p 0.786
SRB4 Srb4p 0.782
MKS1 Mks1p 0.780
SNF5 Snf5p 0.763
CYC8 Cyc8p 0.748
MED1 Med1p 0.743
RPT6 Rpt6p 0.736
FKH1 Fkh1p 0.735
CTI6 Cti6p 0.724
MIG1 Mig1p 0.722
RIM15 Rim15p 0.722
SNF1 Snf1p 0.717
MCM1 Mcm1p 0.716
DCP2 Dcp2p 0.712
KIN28 Kin28p 0.693
INO4 Ino4p 0.681
MKK2 Mkk2p 0.680
RAS2 Ras2p 0.678
PPH21 Pph21p 0.676
DOT6 Dot6p 0.672
MOT2 Mot2p 0.668
MPT5 Mpt5p 0.658
NUP157 Nup157p 0.655
ARG81 Arg81p 0.643
HAP4 Hap4p 0.628
YTA7 Yta7p 0.627
HMO1 Hmo1p 0.626
SFL1 Sfl1p 0.623
PGD1 Pgd1p 0.623
PTC1 Ptc1p 0.615
CLB1 Clb1p 0.611
GAL80 Gal80p 0.603
RPD3 Rpd3p 0.602
SKN7 Skn7p 0.599
MOT1 Mot1p 0.598
STD1 Std1p 0.597
SNT1 Snt1p 0.589
MDS3 Mds3p 0.581
MSN4 Msn4p 0.573
KSS1 Kss1p 0.569
AFT1 Aft1p 0.565
STE20 Ste20p 0.558
HOG1 Hog1p 0.557
MUS81 Mus81p 0.555
NUT2 Nut2p 0.551
MED2 Med2p 0.550
RTF1 Rtf1p 0.542
UTP22 Utp22p 0.538
NUP84 Nup84p 0.532
CDC39 Cdc39p 0.529
RSC4 Rsc4p 0.527
SRB5 Srb5p 0.524
MSS11 Mss11p 0.524
SSN8 Ssn8p 0.516
CGI121 Cgi121p 0.512
ESA1 Esa1p 0.511
RHO1 Rho1p 0.508
GYL1 Gyl1p 0.500
SPT7 Spt7p 0.500
HTB1 Htb1p 0.498
CPR6 Cpr6p 0.498
PCC1 Pcc1p 0.496
MED6 Med6p 0.493
FYV8 Fyv8p 0.488
KSP1 Ksp1p 0.485
RPN10 Rpn10p 0.474
CAT8 Cat8p 0.471
MRS6 Mrs6p 0.471
PHO80 Pho80p 0.469
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
pha-4 Protein PHA-4 1.000
egl-18 Protein EGL-18 0.999
elt-6 Protein ELT-6 0.993
nhr-67 Protein NHR-67 0.984
vab-3 Protein VAB-3 0.950
nhr-49 Protein NHR-49 0.926
unc-62 Protein UNC-62 0.883
zip-7 Protein ZIP-7 0.869
pbrm-1 Protein PBRM-1 0.867
egl-44 Protein EGL-44 0.862
pop-1 Protein POP-1 0.842
egl-46 Protein EGL-46 0.822
lin-17 Protein LIN-17 0.781
fkh-2 Protein FKH-2 0.757
hnd-1 Protein HND-1 0.751
lntl-1 Protein LNTL-1 0.731
daf-1 Protein DAF-1 0.721
apr-1 Protein APR-1 0.711
mat-3 Protein MAT-3 0.701
zfp-3 Protein ZFP-3 0.698
egl-13 Protein EGL-13 0.698
daf-3 Protein DAF-3 0.651
rad-26 Protein RAD-26 0.644
pkg-1 Protein PKG-1 0.633
D1081.8 Protein D1081.8 0.629
his-31 Protein HIS-31 0.627
mep-1 Protein MEP-1 0.624
ten-1 Protein TEN-1 0.608
abl-1 Protein ABL-1 0.598
hif-1 Protein HIF-1 0.589
lin-36 Protein LIN-36 0.589
eya-1 Protein EYA-1 0.586
cam-1 Protein CAM-1 0.584
let-60 Protein LET-60 0.580
smp-1 Protein SMP-1 0.571
hlh-1 Protein HLH-1 0.559
hbl-1 Protein HBL-1 0.556
lin-12 Protein LIN-12 0.556
unc-42 Protein UNC-42 0.549
nhr-45 Protein NHR-45 0.546
bar-1 Protein BAR-1 0.533
abi-1 Protein ABI-1 0.515
egl-8 Protein EGL-8 0.512
hlh-2 Protein HLH-2 0.511
unc-73 Protein UNC-73 0.509
K10D6.4 Protein K10D6.4 0.501
ajm-1 Protein AJM-1 0.495
sea-2 Protein SEA-2 0.495
his-64 Protein HIS-64 0.490
lin-35 Protein LIN-35 0.489
mab-31 Protein MAB-31 0.487
his-1 Protein HIS-1 0.485
sel-10 Protein SEL-10 0.474
nhr-34 Protein NHR-34 0.473
ldb-1 Protein LDB-1 0.466
CELE_Y41E3.11 Protein Y41E3.11 0.465
npp-1 Protein NPP-1 0.454
rsp-1 Protein RSP-1 0.452
soc-2 Protein SOC-2 0.452
bet-1 Protein BET-1 0.451
T28F4.1 Protein T28F4.1 0.442
CELE_F47G4.4 Protein F47G4.4 0.438
attf-2 Protein ATTF-2 0.431
flh-2 Protein FLH-2 0.427
Y47D3A.29 Protein Y47D3A.29 0.422
F26B1.2 Protein F26B1.2 0.422
rps-2 Protein RPS-2 0.418
mig-5 Protein MIG-5 0.415
eor-2 Protein EOR-2 0.415
his-5 Protein HIS-5 0.412
ceh-34 Protein CEH-34 0.411
dpy-22 Protein DPY-22 0.411
glp-1 Protein GLP-1 0.410
svh-2 Protein SVH-2 0.410
ceh-16 Protein CEH-16 0.405
daf-14 Protein DAF-14 0.400
hmg-4 Protein HMG-4 0.392
lin-48 Protein LIN-48 0.392
mel-28 Protein MEL-28 0.381
wrm-1 Protein WRM-1 0.381
mab-5 Protein MAB-5 0.378
eef-1A.1 Protein EEF-1A.1 0.375
fntb-1 Protein FNTB-1 0.375
tmc-2 Protein TMC-2 0.374
lsy-22 Protein LSY-22 0.372
F28B3.1 Protein F28B3.1 0.371
lsy-2 Protein LSY-2 0.368
ceh-27 Protein CEH-27 0.367
unc-86 Protein UNC-86 0.355
ceh-36 Protein CEH-36 0.352
ceh-20 Protein CEH-20 0.351
unc-26 Protein UNC-26 0.348
let-19 Protein LET-19 0.346
skp-1 Protein SKP-1 0.344
pmk-1 Protein PMK-1 0.344
pes-1 Protein PES-1 0.343
pry-1 Protein PRY-1 0.341
his-46 Protein HIS-46 0.336
T04C9.1 Protein T04C9.1 0.334
nfyb-1 Protein NFYB-1 0.331
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Danio rerio
Name Description Probability Func Analog Organism
flh floating head 0.988
ndr2 nodal-related 2 0.946
chd chordin 0.942
hand2 heart and neural crest derivatives expressed transcript 2 0.935
dlc deltaC 0.888
pitx3 paired-like homeodomain transcription factor 3 0.885
tbx1 T-box 1 0.881
hnf1ba HNF1 homeobox Ba 0.877
dlx2a distal-less homeobox gene 2a 0.869
tp53 tumor protein p53 0.830
gli1 GLI-Kruppel family member 1 0.813
notch1a notch homolog 1a 0.803
shha sonic hedgehog a 0.792
myf5 myogenic factor 5 0.790
nkx2.2a NK2 transcription factor related 2a 0.784
runx2b runt-related transcription factor 2b 0.779
dlx5a distal-less homeobox gene 5a 0.689
lhx5 LIM homeobox 5 0.661
sox1a SRY-box containing gene 1a 0.660
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.659
foxi1 forkhead box I1 0.654
gata3 GATA-binding protein 3 0.646
hoxc4a homeo box C4a 0.638
runx2a runt-related transcription factor 2a 0.630
otx2 orthodenticle homolog 2 0.625
nanos3 nanos homolog 3 0.617
tbx20 T-box 20 0.600
pax8 paired box gene 8 0.598
foxa3 forkhead box A3 0.594
osr1 odd-skipped related 1 (Drosophila) 0.580
barx1 BarH-like homeobox 1 0.574
sox19a SRY-box containing gene 19a 0.565
tal1 T-cell acute lymphocytic leukemia 1 0.562
gata5 GATA-binding protein 5 0.555
dusp6 dual specificity phosphatase 6 0.546
rhoab ras homolog gene family, member Ab 0.536
spry4 sprouty (Drosophila) homolog 4 0.533
eomesa eomesodermin homolog a 0.523
spaw southpaw 0.521
bmp4 bone morphogenetic protein 4 0.518
oep one-eyed pinhead 0.511
eng2a engrailed 2a 0.493
bmp2b bone morphogenetic protein 2b 0.491
six1b sine oculis homeobox homolog 1b 0.487
nr2e3 nuclear receptor subfamily 2, group E, member 3 0.484
ptf1a pancreas specific transcription factor, 1a 0.476
irx1b iroquois homeobox protein 1, b 0.470
wnt5b wingless-type MMTV integration site family, member 5b 0.458
atoh1a atonal homolog 1a 0.449
lhx1a LIM homeobox 1a 0.438
myod1 myogenic differentiation 1 0.437
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.429
gata6 GATA-binding protein 6 0.427
tbx16 T-box gene 16 0.422
fezf2 FEZ family zinc finger 2 0.420
wnt11 wingless-type MMTV integration site family, member 11 0.420
raraa retinoic acid receptor, alpha a 0.412
rx3 retinal homeobox gene 3 0.412
six3b sine oculis homeobox homolog 3b 0.408
fn1 fibronectin 1 0.391
socs3a suppressor of cytokine signaling 3a 0.389
wnt3a wingless-type MMTV integration site family, member 3A 0.382
junb jun B proto-oncogene 0.376
mab21l2 mab-21-like 2 0.373
nrg2a neuregulin 2a 0.372
foxa2 forkhead box A2 0.362
hif1ab hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b 0.362
fgfr4 fibroblast growth factor receptor 4 0.360
pcna proliferating cell nuclear antigen 0.358
irx4b iroquois homeobox protein 4b 0.356
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.353
lft1 lefty1 0.352
crabp2a cellular retinoic acid binding protein 2, a 0.338
prl prolactin 0.332
fibin fin bud initiation factor 0.331
ntla no tail a 0.329
hoxc6a homeo box C6a 0.318
pax6a paired box gene 6a 0.318
fgf4 fibroblast growth factor 4 0.317
igf3 insulin-like growth factor 3 0.315
trim71 tripartite motif-containing 71 0.313
hhex hematopoietically expressed homeobox 0.311
neurod neurogenic differentiation 0.306
tgfb3 transforming growth factor, beta 3 0.301
isl1 islet1 0.300
nkx2.2b NK2 transcription factor related 2b 0.294
gdnf glial cell derived neurotrophic factor 0.293
rx2 retinal homeobox gene 2 0.292
pax6b paired box gene 6b 0.287
wnt10b wingless-type MMTV integration site family, member 10b 0.285
sox32 SRY-box containing gene 32 0.281
oprd1b opioid receptor, delta 1b 0.281
jun jun proto-oncogene 0.278
bhlhe22 basic helix-loop-helix family, member e22 0.275
mef2d myocyte enhancer factor 2d 0.275
pdlim3b PDZ and LIM domain 3b 0.271
nfkbiab nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b 0.268
otpb orthopedia homolog b 0.267
oprm1 opioid receptor, mu 1 0.265
wnt2ba wingless-type MMTV integration site family, member 2Ba 0.265
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Akt1 CG4006 gene product from transcript CG4006-RA 1.000
Ubx Ultrabithorax 0.998
Snr1 Snf5-related 1 0.988
mys myospheroid 0.986
EcR Ecdysone receptor 0.986
N Notch 0.983
hth homothorax 0.971
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.970
InR Insulin-like receptor 0.968
da daughterless 0.967
trx trithorax 0.959
pan pangolin 0.956
mor moira 0.947
Dad Daughters against dpp 0.938
e(y)3 enhancer of yellow 3 0.934
dac dachshund 0.933
wg wingless 0.928
Mad Mothers against dpp 0.921
osa CG7467 gene product from transcript CG7467-RD 0.920
dco discs overgrown 0.916
Rac2 CG8556 gene product from transcript CG8556-RA 0.915
Pten CG5671 gene product from transcript CG5671-RB 0.913
bcd bicoid 0.908
Dll Distal-less 0.908
nmo nemo 0.903
TER94 CG2331 gene product from transcript CG2331-RA 0.899
Med Medea 0.894
CtBP C-terminal Binding Protein 0.881
eyg eyegone 0.879
ecd ecdysoneless 0.871
klu klumpfuss 0.870
mam mastermind 0.864
phl pole hole 0.861
Su(H) Suppressor of Hairless 0.854
HLHm7 E(spl) region transcript m7 0.848
Dref DNA replication-related element factor 0.847
ed echinoid 0.847
bs blistered 0.847
Egfr Epidermal growth factor receptor 0.844
dm diminutive 0.823
Rac1 CG2248 gene product from transcript CG2248-RA 0.814
tgo tango 0.801
ci cubitus interruptus 0.799
Tollo CG6890 gene product from transcript CG6890-RA 0.798
Tor Target of rapamycin 0.791
hep hemipterous 0.787
l(2)37Cb lethal (2) 37Cb 0.787
CG4699 CG4699 gene product from transcript CG4699-RJ 0.783
Rheb CG1081 gene product from transcript CG1081-RA 0.779
opa odd paired 0.778
ush u-shaped 0.768
slmb supernumerary limbs 0.761
noi noisette 0.760
ac achaete 0.759
Sir2 CG5216 gene product from transcript CG5216-RA 0.754
Hrb27C Heterogeneous nuclear ribonucleoprotein at 27C 0.746
Sos Son of sevenless 0.740
Ser Serrate 0.739
Mi-2 CG8103 gene product from transcript CG8103-RA 0.733
CkIIalpha Casein kinase II alpha subunit 0.730
car carnation 0.721
lz lozenge 0.719
Nrg Neuroglian 0.716
gro groucho 0.708
ato atonal 0.707
dome domeless 0.704
CycA Cyclin A 0.704
C15 CG7937 gene product from transcript CG7937-RA 0.697
ftz-f1 ftz transcription factor 1 0.697
Antp Antennapedia 0.691
sens senseless 0.688
Bre1 CG10542 gene product from transcript CG10542-RA 0.682
ey eyeless 0.678
ss spineless 0.677
mib1 mind bomb 1 0.675
al aristaless 0.671
babo baboon 0.671
Ulp1 CG12359 gene product from transcript CG12359-RA 0.670
disco disconnected 0.670
ap apterous 0.669
jing CG9397 gene product from transcript CG9397-RI 0.665
sns sticks and stones 0.665
siz schizo 0.664
spi spitz 0.662
en engrailed 0.658
pnt pointed 0.657
tai taiman 0.655
exd extradenticle 0.654
SoxN SoxNeuro 0.649
ems empty spiracles 0.648
HLH54F CG5005 gene product from transcript CG5005-RA 0.644
MED15 Mediator complex subunit 15 0.629
ro rough 0.620
CG11347 CG11347 gene product from transcript CG11347-RE 0.618
pb proboscipedia 0.618
lola longitudinals lacking 0.614
CG10263 CG10263 gene product from transcript CG10263-RC 0.613
Mekk1 CG7717 gene product from transcript CG7717-RB 0.613
dnc dunce 0.612
jeb jelly belly 0.612
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Fgfr1 Fibroblast growth factor receptor 1 0.794
Rara retinoic acid receptor, alpha 0.782
Jak2 Janus kinase 2 0.686
Nr4a3 nuclear receptor subfamily 4, group A, member 3 0.667
Junb jun B proto-oncogene 0.628
Tgfbr2 transforming growth factor, beta receptor II 0.607
Ncr1 natural cytotoxicity triggering receptor 1 0.570
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.549
Prdm2 PR domain containing 2, with ZNF domain 0.539
Ptafr platelet-activating factor receptor 0.528
Ppp1r15a protein phosphatase 1, regulatory (inhibitor) subunit 15A 0.524
Jak1 Janus kinase 1 0.499
Notch3 Notch homolog 3 (Drosophila) 0.487
Itgam integrin, alpha M 0.480
Acvr1 activin A receptor, type I 0.478
Cd4 Cd4 molecule 0.473
Ddr1 discoidin domain receptor tyrosine kinase 1 0.468
Egr1 early growth response 1 0.447
Slc8a2 solute carrier family 8 (sodium/calcium exchanger), member 2 0.439
Klf6 Kruppel-like factor 6 0.434
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.434
Psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.425
Jun Jun oncogene 0.425
Fos FBJ osteosarcoma oncogene 0.421
Psmc1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.418
Dusp1 dual specificity phosphatase 1 0.414
Smad7 SMAD family member 7 0.411
Rasa1 RAS p21 protein activator (GTPase activating protein) 1 0.387
Met met proto-oncogene 0.377
Fgfr2 fibroblast growth factor receptor 2 0.377
Ciita class II, major histocompatibility complex, transactivator 0.376
S100a10 S100 calcium binding protein A10 0.374
Uts2r urotensin 2 receptor 0.374
Sox17 SRY (sex determining region Y)-box 17 0.373
Zfp36 zinc finger protein 36 0.372
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.371
Sirpa signal-regulatory protein alpha 0.367
Htr1f 5-hydroxytryptamine (serotonin) receptor 1F 0.357
Cmklr1 chemokine-like receptor 1 0.355
Igfbp5 insulin-like growth factor binding protein 5 0.346
Mef2d myocyte enhancer factor 2D 0.343
Phf12 PHD finger protein 12 0.338
Nr4a1 nuclear receptor subfamily 4, group A, member 1 0.337
Prph2 peripherin 2 0.336
Cpd carboxypeptidase D 0.335
Irs1 insulin receptor substrate 1 0.329
Slc6a6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 0.327
Figf c-fos induced growth factor 0.324
Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 0.322
Pdyn prodynorphin 0.319
Slc18a3 solute carrier family 18 (vesicular acetylcholine), member 3 0.318
Tcfe2a transcription factor E2a 0.315
Btg2 BTG family, member 2 0.314
Mc4r melanocortin 4 receptor 0.311
Ucn urocortin 0.310
Kcnj1 potassium inwardly-rectifying channel, subfamily J, member 1 0.310
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.308
Pja2 praja 2, RING-H2 motif containing 0.302
Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 0.301
Tcf4 transcription factor 4 0.299
Eif3e eukaryotic translation initiation factor 3, subunit E 0.297
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.295
Shox2 short stature homeobox 2 0.294
Thop1 thimet oligopeptidase 1 0.294
Synpo synaptopodin 0.293
Nrp1 neuropilin 1 0.292
Cd86 CD86 molecule 0.287
Ngfr nerve growth factor receptor (TNFR superfamily, member 16) 0.282
Rps6ka1 ribosomal protein S6 kinase polypeptide 1 0.280
Smad3 SMAD family member 3 0.277
Tek TEK tyrosine kinase, endothelial 0.276
Cxcl6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.276
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.275
Errfi1 ERBB receptor feedback inhibitor 1 0.275
Ednrb endothelin receptor type B 0.273
Nck1 NCK adaptor protein 1 0.272
Nfib nuclear factor I/B 0.271
Bat3 HLA-B-associated transcript 3 0.270
Tcof1 Treacher Collins-Franceschetti syndrome 1 homolog (human) 0.270
Nr1d2 nuclear receptor subfamily 1, group D, member 2 0.264
Map3k3 mitogen activated protein kinase kinase kinase 3 0.261
Notch2 Notch homolog 2 (Drosophila) 0.260
Scn4a sodium channel, voltage-gated, type IV, alpha subunit 0.260
Pdgfb platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.259
Il8ra interleukin 8 receptor, alpha 0.258
Kit v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.258
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.257
Adcy4 adenylate cyclase 4 0.255
Ar androgen receptor 0.255
Adrb1 adrenergic, beta-1-, receptor 0.255
Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 0.254
Ptpn1 protein tyrosine phosphatase, non-receptor type 1 0.254
Phkg1 phosphorylase kinase, gamma 1 0.252
Stat5b signal transducer and activator of transcription 5B 0.250
Klf13 Kruppel-like factor 13 0.250
Zfp91 zinc finger protein 91 0.249
Lphn2 latrophilin 2 0.246
Fyn FYN oncogene related to SRC, FGR, YES 0.246
Umod uromodulin 0.244
Crebbp CREB binding protein 0.243