The network for 'negative regulation of nucleobase containing compound metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of nucleobase containing compound metabolic process

Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
RPD3 Rpd3p 0.999
SIN3 Sin3p 0.992
PHO23 Pho23p 0.988
SIR2 Sir2p 0.987
RAP1 Rap1p 0.980
HHF1 Hhf1p 0.978
HDA1 Hda1p 0.976
ORC2 Orc2p 0.964
RLF2 Rlf2p 0.955
HHT1 Hht1p 0.952
SIN4 Sin4p 0.945
RXT2 Rxt2p 0.924
SET1 Set1p 0.923
ORC5 Orc5p 0.916
CTI6 Cti6p 0.893
ITC1 Itc1p 0.892
YCS4 Ycs4p 0.890
HOG1 Hog1p 0.889
SIR4 Sir4p 0.879
RPN4 Rpn4p 0.877
DIA2 Dia2p 0.875
YTA7 Yta7p 0.863
GLN3 Gln3p 0.848
GAL11 Gal11p 0.846
GLC7 Glc7p 0.836
UME6 Ume6p 0.831
SNT1 Snt1p 0.825
RCO1 Rco1p 0.815
ORC1 Orc1p 0.810
SUM1 Sum1p 0.793
SSN3 Ssn3p 0.787
SDS3 Sds3p 0.787
CYC8 Cyc8p 0.777
HMO1 Hmo1p 0.772
VID22 Vid22p 0.770
MRC1 Mrc1p 0.764
RAD9 Rad9p 0.763
PGD1 Pgd1p 0.762
GBP2 Gbp2p 0.758
SLX5 Slx5p 0.750
ASF1 Asf1p 0.749
ADR1 Adr1p 0.748
RTT106 Rtt106p 0.740
MED2 Med2p 0.739
HTZ1 Htz1p 0.736
CKA2 Cka2p 0.700
SPT16 Spt16p 0.699
CDC6 Cdc6p 0.693
SET3 Set3p 0.687
DOT6 Dot6p 0.681
RTF1 Rtf1p 0.680
SAP30 Sap30p 0.672
UBP10 Ubp10p 0.668
NAT1 Nat1p 0.665
CDC45 Cdc45p 0.649
ISW2 Isw2p 0.647
SAS2 Sas2p 0.641
NRG1 Nrg1p 0.637
FKH1 Fkh1p 0.633
CTF18 Ctf18p 0.621
CCR4 Ccr4p 0.620
PHO4 Pho4p 0.615
SIR3 Sir3p 0.606
RAD6 Rad6p 0.605
NET1 Net1p 0.593
HTB1 Htb1p 0.585
SET2 Set2p 0.577
MET4 Met4p 0.576
ARP4 Arp4p 0.571
SWI4 Swi4p 0.567
MED6 Med6p 0.562
RSC2 Rsc2p 0.562
SPT8 Spt8p 0.557
SCH9 Sch9p 0.549
CUP9 Cup9p 0.546
RAD53 Rad53p 0.546
NUP1 Nup1p 0.543
FKH2 Fkh2p 0.541
HTA2 Hta2p 0.540
MCM7 Mcm7p 0.537
IZH4 Izh4p 0.536
SRM1 Srm1p 0.535
GCR2 Gcr2p 0.534
RIF1 Rif1p 0.532
HAT1 Hat1p 0.531
NST1 Nst1p 0.525
SPT10 Spt10p 0.523
HTA1 Hta1p 0.515
MOT1 Mot1p 0.514
SMC4 Smc4p 0.511
ESC2 Esc2p 0.507
SIC1 Sic1p 0.506
HST1 Hst1p 0.505
STP22 Stp22p 0.503
CHL1 Chl1p 0.498
BRE2 Bre2p 0.496
CMK2 Cmk2p 0.495
PAP2 Pap2p 0.494
RGR1 Rgr1p 0.493
RLM1 Rlm1p 0.483
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
egl-18 Protein EGL-18 0.965
pha-4 Protein PHA-4 0.764
elt-6 Protein ELT-6 0.511
eya-1 Protein EYA-1 0.455
lin-53 Protein LIN-53 0.433
his-64 Protein HIS-64 0.391
attf-2 Protein ATTF-2 0.344
zip-7 Protein ZIP-7 0.327
his-1 Protein HIS-1 0.317
his-16 Protein HIS-16 0.311
cdt-2 Protein CDT-2 0.289
let-502 Protein LET-502 0.265
mes-4 Protein MES-4 0.255
his-31 Protein HIS-31 0.248
his-68 Protein HIS-68 0.246
egl-27 Protein EGL-27 0.230
his-5 Protein HIS-5 0.221
his-48 Protein HIS-48 0.209
hlh-2 Protein HLH-2 0.205
rad-26 Protein RAD-26 0.198
T20F7.1 Protein T20F7.1 0.191
C34F6.9 Protein C34F6.9 0.182
wrm-1 Protein WRM-1 0.182
lin-13 Protein LIN-13 0.174
daf-4 Protein DAF-4 0.170
his-46 Protein HIS-46 0.157
dbl-1 Protein DBL-1 0.157
hlh-1 Protein HLH-1 0.155
fkh-2 Protein FKH-2 0.155
hcp-3 Protein HCP-3 0.151
his-52 Protein HIS-52 0.150
nhr-2 Protein NHR-2 0.146
nfya-1 Protein NFYA-1 0.146
pop-1 Protein POP-1 0.145
lin-40 Protein LIN-40 0.145
hlh-11 Protein HLH-11 0.142
nhr-67 Protein NHR-67 0.142
atg-2 Protein ATG-2 0.142
daf-21 Protein DAF-21 0.140
mab-5 Protein MAB-5 0.139
his-47 Protein HIS-47 0.138
qua-1 Protein QUA-1 0.138
C55B6.1 Protein C55B6.1 0.135
zyg-1 Protein ZYG-1 0.133
lin-11 Protein LIN-11 0.133
pdr-1 Protein PDR-1 0.129
his-3 Protein HIS-3 0.129
egl-46 Protein EGL-46 0.127
mat-3 Protein MAT-3 0.125
pabp-2 Protein PABP-2 0.124
cnd-1 Protein CND-1 0.121
rfp-1 Protein RFP-1 0.120
prp-8 Protein PRP-8 0.120
CELE_F19F10.9 Protein F19F10.9 0.115
his-61 Protein HIS-61 0.114
his-30 Protein HIS-30 0.113
bar-1 Protein BAR-1 0.111
cfim-2 Protein CFIM-2 0.111
his-29 Protein HIS-29 0.108
T27A8.2 Protein T27A8.2 0.106
Y87G2A.1 Protein Y87G2A.1 0.105
rha-1 Protein RHA-1 0.104
irx-1 Protein IRX-1 0.102
rsp-1 Protein RSP-1 0.101
let-418 Protein LET-418 0.098
mix-1 Protein MIX-1 0.097
R11D1.1 Protein R11D1.1 0.097
exc-7 Protein EXC-7 0.096
fkb-6 Protein FKB-6 0.096
tag-260 Protein TAG-260 0.096
eor-1 Protein EOR-1 0.095
his-62 Protein HIS-62 0.094
hda-1 Protein HDA-1 0.094
tbx-8 Protein TBX-8 0.093
ceh-27 Protein CEH-27 0.091
T18D3.1 Protein T18D3.1 0.091
flt-1 Protein FLT-1 0.091
his-38 Protein HIS-38 0.090
klp-19 Protein KLP-19 0.090
plc-1 Protein PLC-1 0.087
patr-1 Protein PATR-1 0.087
npp-7 Protein NPP-7 0.086
egl-13 Protein EGL-13 0.086
nhr-25 Protein NHR-25 0.084
F39B2.1 Protein F39B2.1 0.084
his-50 Protein HIS-50 0.083
unc-62 Protein UNC-62 0.083
his-4 Protein HIS-4 0.082
CELE_C23G10.8 Protein C23G10.8 0.081
cpna-3 Protein CPNA-3 0.080
glp-1 Protein GLP-1 0.080
mls-2 Protein MLS-2 0.079
his-39 Protein HIS-39 0.079
dcr-1 Protein DCR-1 0.079
csn-4 Protein CSN-4 0.078
his-15 Protein HIS-15 0.078
daf-14 Protein DAF-14 0.077
unc-53 Protein UNC-53 0.076
hmg-1.1 Protein HMG-1.1 0.076
capg-1 Protein CAPG-1 0.075
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Danio rerio
Name Description Probability Func Analog Organism
ndr2 nodal-related 2 0.973
lhx5 LIM homeobox 5 0.906
wt1a wilms tumor 1a 0.897
fgf3 fibroblast growth factor 3 0.894
lhx1a LIM homeobox 1a 0.888
tbx6 T-box gene 6 0.815
bmp2b bone morphogenetic protein 2b 0.775
gro1 groucho 1 0.773
dlx2a distal-less homeobox gene 2a 0.723
mll myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.721
snai1b snail homolog 1b (Drosophila) 0.714
jag2 jagged 2 0.705
pou3f3a POU class 3 homeobox 3a 0.702
zic2a zic family member 2 (odd-paired homolog, Drosophila), a 0.674
gata6 GATA-binding protein 6 0.645
sox19a SRY-box containing gene 19a 0.618
khdrbs1a KH domain containing, RNA binding, signal transduction associated 1a 0.590
twist3 twist3 0.580
pcna proliferating cell nuclear antigen 0.579
per2 period homolog 2 (Drosophila) 0.575
dusp6 dual specificity phosphatase 6 0.564
tfap2a transcription factor AP-2 alpha 0.545
chd chordin 0.531
pax2a paired box gene 2a 0.517
ins preproinsulin 0.513
sox9b SRY-box containing gene 9b 0.497
eng2a engrailed 2a 0.483
evx1 even-skipped homeobox 1 0.482
smad7 MAD, mothers against decapentaplegic homolog 7 (Drosophila) 0.478
mab21l2 mab-21-like 2 0.467
traf4a tnf receptor-associated factor 4a 0.465
pbx1a pre-B-cell leukemia transcription factor 1a 0.454
dlx1a distal-less homeobox gene 1a 0.451
foxa2 forkhead box A2 0.448
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.432
cry1a cryptochrome 1a 0.429
lft2 lefty2 0.424
esr2a estrogen receptor 2a 0.423
otx2 orthodenticle homolog 2 0.418
znf703 zinc finger protein 703 0.405
flh floating head 0.405
foxi1 forkhead box I1 0.397
egr1 early growth response 1 0.395
pitx2 paired-like homeodomain transcription factor 2 0.390
whsc1 Wolf-Hirschhorn syndrome candidate 1 0.385
sox1a SRY-box containing gene 1a 0.383
tbx1 T-box 1 0.371
notch1b notch homolog 1b 0.359
hp1bp3 heterochromatin protein 1, binding protein 3 0.358
pou3f2 POU class 3 homeobox 2 0.358
zfp36l1a zinc finger protein 36, C3H type-like 1a 0.349
sox2 SRY-box containing gene 2 0.349
emx1 empty spiracles homeobox 1 0.341
gata4 GATA-binding protein 4 0.332
hand2 heart and neural crest derivatives expressed transcript 2 0.329
hoxb1b homeo box B1b 0.317
lef1 lymphocyte enhancer binding factor 1 0.316
klf4 Kruppel-like factor 4 0.312
alcamb activated leukocyte cell adhesion molecule b 0.308
irx4b iroquois homeobox protein 4b 0.305
pcdh18a protocadherin 18a 0.298
hnrnpk heterogeneous nuclear ribonucleoprotein K 0.297
foxa3 forkhead box A3 0.294
junb jun B proto-oncogene 0.292
ppp1r12a protein phosphatase 1, regulatory (inhibitor) subunit 12A 0.289
adipoql adiponectin, C1Q and collagen domain containing, like 0.286
zic2b zic family member 2 (odd-paired homolog, Drosophila) b 0.286
osr1 odd-skipped related 1 (Drosophila) 0.276
dnmt7 DNA (cytosine-5-)-methyltransferase 7 0.265
gbx2 gastrulation brain homeo box 2 0.264
vsx1 visual system homeobox 1 homolog, chx10-like 0.263
tll1 tolloid-like 1 0.255
suv39h1b suppressor of variegation 3-9 homolog 1b 0.254
hmgb2b high-mobility group box 2b 0.252
gata5 GATA-binding protein 5 0.251
dlx5a distal-less homeobox gene 5a 0.250
tp53 tumor protein p53 0.249
mecom MDS1 and EVI1 complex locus 0.244
rargb retinoic acid receptor, gamma b 0.244
meis3 myeloid ecotropic viral integration site 3 0.241
odz4 odd Oz/ten-m homolog 4 0.240
sox19b SRY-box containing gene 19b 0.236
fsta follistatin a 0.236
ptf1a pancreas specific transcription factor, 1a 0.233
gata3 GATA-binding protein 3 0.233
ntn1b netrin 1b 0.231
fgf8a fibroblast growth factor 8 a 0.229
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.229
hnf1ba HNF1 homeobox Ba 0.229
insra insulin receptor a 0.227
pou5f1 POU domain, class 5, transcription factor 1 0.224
vcana versican a 0.224
nkx2.1b NK2 homeobox 1b 0.217
vsx2 visual system homeobox 2 0.216
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.214
nkx2.5 NK2 transcription factor related 5 0.213
runx2a runt-related transcription factor 2a 0.212
smo smoothened homolog (Drosophila) 0.212
hmx1 H6 homeo box 1 0.210
her1 hairy-related 1 0.208
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Pcl Polycomblike 0.999
E(z) Enhancer of zeste 0.999
CTCF CG8591 gene product from transcript CG8591-RA 0.998
Pc Polycomb 0.998
gpp grappa 0.998
Snr1 Snf5-related 1 0.998
Mad Mothers against dpp 0.998
hep hemipterous 0.998
gro groucho 0.997
shn schnurri 0.996
trx trithorax 0.995
BEAF-32 Boundary element-associated factor of 32kD 0.994
ash1 absent, small, or homeotic discs 1 0.993
E(spl) Enhancer of split 0.989
esc extra sexcombs 0.988
Iswi Imitation SWI 0.985
kay kayak 0.985
pan pangolin 0.980
wg wingless 0.978
slmb supernumerary limbs 0.978
Scm Sex comb on midleg 0.977
pr-set7 CG3307 gene product from transcript CG3307-RC 0.976
klu klumpfuss 0.974
crm cramped 0.974
Ubx Ultrabithorax 0.972
E(var)3-9 Enhancer of variegation 3-9 0.968
p53 CG33336 gene product from transcript CG33336-RB 0.967
brat brain tumor 0.966
Trl Trithorax-like 0.964
ara araucan 0.964
tws twins 0.963
slp1 sloppy paired 1 0.960
InR Insulin-like receptor 0.953
CtBP C-terminal Binding Protein 0.952
dco discs overgrown 0.948
gsb gooseberry 0.946
Fmr1 CG6203 gene product from transcript CG6203-RC 0.945
en engrailed 0.944
CycB Cyclin B 0.944
Optix CG18455 gene product from transcript CG18455-RA 0.943
ci cubitus interruptus 0.943
ss spineless 0.942
D1 D1 chromosomal protein 0.942
mam mastermind 0.941
pb proboscipedia 0.936
yki yorkie 0.934
wapl wings apart-like 0.933
eve even skipped 0.932
smt3 CG4494 gene product from transcript CG4494-RA 0.930
ato atonal 0.927
hrg hiiragi 0.923
HLHmdelta E(spl) region transcript mdelta 0.916
osa CG7467 gene product from transcript CG7467-RD 0.905
dally division abnormally delayed 0.904
sna snail 0.904
ftz fushi tarazu 0.902
eyg eyegone 0.901
sd scalloped 0.899
cnc cap-n-collar 0.899
ush u-shaped 0.898
Su(var)3-7 Suppressor of variegation 3-7 0.895
Su(var)205 Suppressor of variegation 205 0.894
sti sticky 0.894
nub nubbin 0.893
E2f2 E2F transcription factor 2 0.891
hth homothorax 0.890
brm brahma 0.888
N Notch 0.888
tsh teashirt 0.887
ash2 absent, small, or homeotic discs 2 0.883
pdm2 POU domain protein 2 0.871
Ser Serrate 0.869
XNP CG4548 gene product from transcript CG4548-RA 0.858
His2Av Histone H2A variant 0.857
Dp DP transcription factor 0.845
Acf1 ATP-dependent chromatin assembly factor large subunit 0.842
lok loki 0.837
Pp1-87B Protein phosphatase 1 at 87B 0.831
Slbp Stem-loop binding protein 0.831
Rpd3 CG7471 gene product from transcript CG7471-RA 0.830
Sam-S S-adenosylmethionine Synthetase 0.829
Doc2 Dorsocross2 0.819
phyl phyllopod 0.816
mor moira 0.816
Eip63E Ecdysone-induced protein 63E 0.815
Chd1 Chromodomain-helicase-DNA-binding protein 1 0.814
rept reptin 0.806
al aristaless 0.803
nab CG33545 gene product from transcript CG33545-RC 0.802
nkd naked cuticle 0.802
Cka Connector of kinase to AP-1 0.798
Max CG9648 gene product from transcript CG9648-RA 0.797
HGTX CG13475 gene product from transcript CG13475-RB 0.794
bcd bicoid 0.794
mod modulo 0.790
crol crooked legs 0.785
piwi CG6122 gene product from transcript CG6122-RA 0.785
kn knot 0.781
HLHm7 E(spl) region transcript m7 0.774
sog short gastrulation 0.765
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Jun Jun oncogene 0.789
Tgfbr2 transforming growth factor, beta receptor II 0.584
Junb jun B proto-oncogene 0.577
Ppp2cb protein phosphatase 2, catalytic subunit, beta isoform 0.548
Nfia nuclear factor I/A 0.524
Fos FBJ osteosarcoma oncogene 0.509
Ahr aryl hydrocarbon receptor 0.497
Ier2 immediate early response 2 0.439
Met met proto-oncogene 0.437
Hes1 hairy and enhancer of split 1 (Drosophila) 0.423
Creb1 cAMP responsive element binding protein 1 0.409
Pgam1 phosphoglycerate mutase 1 (brain) 0.409
Sfrs1 splicing factor, arginine/serine-rich 1 0.391
Dbp D site of albumin promoter (albumin D-box) binding protein 0.390
Nfib nuclear factor I/B 0.388
Uncx UNC homeobox 0.355
Sdc3 syndecan 3 0.342
Dusp1 dual specificity phosphatase 1 0.333
Vim vimentin 0.332
Nfya nuclear transcription factor-Y alpha 0.332
Tcfe2a transcription factor E2a 0.326
Ptma prothymosin alpha 0.322
Ncan neurocan 0.320
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.307
Trim28 tripartite motif-containing 28 0.304
Id1 inhibitor of DNA binding 1 0.302
Anxa2 annexin A2 0.301
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.299
Stip1 stress-induced phosphoprotein 1 0.289
Ralgds ral guanine nucleotide dissociation stimulator 0.285
Nr1d2 nuclear receptor subfamily 1, group D, member 2 0.282
Ptprk protein tyrosine phosphatase, receptor type, K, extracellular region 0.273
Arf6 ADP-ribosylation factor 6 0.273
Adra2b adrenergic, alpha-2B-, receptor 0.263
Anxa5 annexin A5 0.263
Klf4 Kruppel-like factor 4 (gut) 0.260
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.260
Tmpo thymopoietin 0.255
Ankrd1 ankyrin repeat domain 1 (cardiac muscle) 0.253
Id3 inhibitor of DNA binding 3 0.251
Eif4h eukaryotic translation initiation factor 4H 0.250
Socs3 suppressor of cytokine signaling 3 0.249
Fgfr1 Fibroblast growth factor receptor 1 0.244
Dynll1 dynein light chain LC8-type 1 0.244
Cask calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.239
Smad7 SMAD family member 7 0.232
Shox2 short stature homeobox 2 0.231
Wbp11 WW domain binding protein 11 0.230
Mgp matrix Gla protein 0.227
Dcc deleted in colorectal carcinoma 0.220
Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.219
Smad6 SMAD family member 6 0.219
Cyss cystatin S 0.217
Bcl2 B-cell CLL/lymphoma 2 0.213
Pcna proliferating cell nuclear antigen 0.212
Gna12 guanine nucleotide binding protein (G protein) alpha 12 0.201
Grk1 G protein-coupled receptor kinase 1 0.201
Flt1 FMS-related tyrosine kinase 1 0.201
Gata4 GATA binding protein 4 0.200
Btg2 BTG family, member 2 0.200
Rorb RAR-related orphan receptor B 0.200
S100a10 S100 calcium binding protein A10 0.199
Ppm1g protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform 0.196
Hand2 heart and neural crest derivatives expressed 2 0.196
Cnga3 cyclic nucleotide gated channel alpha 3 0.195
Lrfn2 leucine rich repeat and fibronectin type III domain containing 2 0.195
Hnrnpr heterogeneous nuclear ribonucleoprotein R 0.195
Synpo synaptopodin 0.193
Dusp6 dual specificity phosphatase 6 0.192
Khdrbs1 KH domain containing, RNA binding, signal transduction associated 1 0.191
Ppp1r15a protein phosphatase 1, regulatory (inhibitor) subunit 15A 0.190
Sf1 splicing factor 1 0.189
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.189
Myc myelocytomatosis oncogene 0.182
Faslg Fas ligand (TNF superfamily, member 6) 0.182
S100a8 S100 calcium binding protein A8 0.179
Crygb crystallin, gamma B 0.179
Ubtf upstream binding transcription factor, RNA polymerase I 0.177
Il12b interleukin 12B 0.176
Fgfr2 fibroblast growth factor receptor 2 0.175
Chrna4 cholinergic receptor, nicotinic, alpha 4 0.173
Lgals1 lectin, galactoside-binding, soluble, 1 0.173
Neurog1 neurogenin 1 0.171
Lzts2 leucine zipper, putative tumor suppressor 2 0.171
Flna filamin A, alpha 0.171
Erbb4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.170
Sh3bp1 SH3-domain binding protein 1 0.169
Siah1a seven in absentia 1A 0.168
Calm2 calmodulin 2 0.168
Chrnb3 cholinergic receptor, nicotinic, beta 3 0.167
Zfp382 zinc finger protein 382 0.166
Prl8a9 prolactin family 8, subfamily a, member 9 0.162
Pip5k1c phosphatidylinositol-4-phosphate 5-kinase, type I, gamma 0.161
Pou3f2 POU class 3 homeobox 2 0.161
Crybb3 crystallin, beta B3 0.159
Klf2 Kruppel-like factor 2 (lung) 0.156
Eif4enif1 eukaryotic translation initiation factor 4E nuclear import factor 1 0.156
Cd40lg CD40 ligand 0.155
Hdac2 histone deacetylase 2 0.152
Arpc1b actin related protein 2/3 complex, subunit 1B 0.150