The network for 'acetyl coa metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

acetyl coa metabolic process

The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.

Name Description Probability Func Analog Organism
PDB1 Pdb1p 0.167
CYM1 Cym1p 0.153
LPD1 Lpd1p 0.128
LAT1 Lat1p 0.087
FAA1 Faa1p 0.027
PDA1 Pda1p 0.024
ACC1 Acc1p 0.022
SAM2 Sam2p 0.018
YAT1 Yat1p 0.018
APE3 Ape3p 0.014
LSC1 Lsc1p 0.013
SUC2 Suc2p 0.013
CAM1 Cam1p 0.013
SRD1 Srd1p 0.013
ADY2 Ady2p 0.012
ALD6 Ald6p 0.012
YJR085C hypothetical protein 0.012
YOL038C-A hypothetical protein 0.011
ARP10 Arp10p 0.011
LEU2 Leu2p 0.011
YLR162W hypothetical protein 0.011
FAS1 Fas1p 0.011
YLR264C-A hypothetical protein 0.011
MER1 Mer1p 0.010
SPL2 Spl2p 0.010
YLR042C hypothetical protein 0.010
CIT2 Cit2p 0.010
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
cyc1 cytochrome c-1 0.370
dlat dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) 0.351
sdhb succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 0.156
ndufv1 NADH dehydrogenase (ubiquinone) flavoprotein 1 0.104
sucla2 succinate-CoA ligase, ADP-forming, beta subunit 0.079
ppm1aa protein phosphatase, Mg2+/Mn2+ dependent, 1Aa 0.076
etfa electron-transfer-flavoprotein, alpha polypeptide 0.054
dlst dihydrolipoamide S-succinyltransferase 0.044
ndufa10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10 0.030
sdha succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.026
slc25a11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 0.023
dldh dihydrolipoamide dehydrogenase 0.020
nnt nicotinamide nucleotide transhydrogenase 0.019
uqcrc1 ubiquinol-cytochrome c reductase core protein I 0.017
zgc:112329 zgc:112329 0.017
got2b glutamic-oxaloacetic transaminase 2b, mitochondrial (aspartate aminotransferase 2) 0.014
aco2 aconitase 2, mitochondrial 0.014
capzb capping protein (actin filament) muscle Z-line, beta 0.013
prdx3 peroxiredoxin 3 0.013
pmpca peptidase (mitochondrial processing) alpha 0.012
pdha1a pyruvate dehydrogenase (lipoamide) alpha 1a 0.011
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
PDHX pyruvate dehydrogenase complex, component X 1.000
DLAT dihydrolipoamide S-acetyltransferase 0.994
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) 0.994
ACAT1 acetyl-CoA acetyltransferase 1 0.803
DLD dihydrolipoamide dehydrogenase 0.576
SGK3 serum/glucocorticoid regulated kinase family, member 3 0.220
PDHB pyruvate dehydrogenase (lipoamide) beta 0.085
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 0.067
EEF2K eukaryotic elongation factor-2 kinase 0.061
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) 0.056
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha 0.046
ACAD8 acyl-CoA dehydrogenase family, member 8 0.043
GTF2I general transcription factor IIi 0.032
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 0.031
FHL2 four and a half LIM domains 2 0.027
BRAP BRCA1 associated protein 0.021
TP53BP1 tumor protein p53 binding protein 1 0.018
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial 0.016
DNM1L dynamin 1-like 0.016
CPT2 carnitine palmitoyltransferase 2 0.015
BCL2 B-cell CLL/lymphoma 2 0.014
AACS acetoacetyl-CoA synthetase 0.013
ETFDH electron-transferring-flavoprotein dehydrogenase 0.013
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit 0.012
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 0.011
CYCS cytochrome c, somatic 0.011
ACSF2 acyl-CoA synthetase family member 2 0.011
ZNF350 zinc finger protein 350 0.011
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.010
ZER1 zer-1 homolog (C. elegans) 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Hadh hydroxyacyl-Coenzyme A dehydrogenase 0.258
Eci2 enoyl-Coenzyme A delta isomerase 2 0.184
D10Jhu81e DNA segment, Chr 10, Johns Hopkins University 81 expressed 0.135
Ndufs1 NADH dehydrogenase (ubiquinone) Fe-S protein 1 0.096
Atp5a1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1 0.075
Fasn fatty acid synthase 0.053
Acadvl acyl-Coenzyme A dehydrogenase, very long chain 0.052
Fam158a family with sequence similarity 158, member A 0.026
Vdac2 voltage-dependent anion channel 2 0.026
Decr1 2,4-dienoyl CoA reductase 1, mitochondrial 0.026
Acadm acyl-Coenzyme A dehydrogenase, medium chain 0.025
Retsat retinol saturase (all trans retinol 13,14 reductase) 0.025
Clybl citrate lyase beta like 0.024
Rpgrip1l Rpgrip1-like 0.024
Macrod1 MACRO domain containing 1 0.023
Elmod3 ELMO/CED-12 domain containing 3 0.022
Hadhb hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit 0.021
Chpt1 choline phosphotransferase 1 0.020
Idh3a isocitrate dehydrogenase 3 (NAD+) alpha 0.020
Acad11 acyl-Coenzyme A dehydrogenase family, member 11 0.019
Adck3 aarF domain containing kinase 3 0.018
Entpd5 ectonucleoside triphosphate diphosphohydrolase 5 0.016
1810049H13Rik RIKEN cDNA 1810049H13 gene 0.016
Mvd mevalonate (diphospho) decarboxylase 0.015
Fh1 fumarate hydratase 1 0.015
Etfdh electron transferring flavoprotein, dehydrogenase 0.015
Gstz1 glutathione transferase zeta 1 (maleylacetoacetate isomerase) 0.014
Acaa1b acetyl-Coenzyme A acyltransferase 1B 0.013
Acat1 acetyl-Coenzyme A acetyltransferase 1 0.013
Gpd1 glycerol-3-phosphate dehydrogenase 1 (soluble) 0.013
Uqcrc2 ubiquinol cytochrome c reductase core protein 2 0.012
Ephx2 epoxide hydrolase 2, cytoplasmic 0.012
Acsl1 acyl-CoA synthetase long-chain family member 1 0.012
Cpt2 carnitine palmitoyltransferase 2 0.011
Plin5 perilipin 5 0.011
Crat carnitine acetyltransferase 0.011
Ech1 enoyl coenzyme A hydratase 1, peroxisomal 0.011
Dgat2 diacylglycerol O-acyltransferase 2 0.011
Eci1 enoyl-Coenzyme A delta isomerase 1 0.011
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Rattus norvegicus
Name Description Probability Func Analog Organism
Acat3 acetyl-Coenzyme A acetyltransferase 3 0.776
Fasn fatty acid synthase 0.615
Sdha succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.539
Lss lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 0.526
Acly ATP citrate lyase 0.256
Dlat dihydrolipoamide S-acetyltransferase 0.251
Me1 malic enzyme 1, NADP(+)-dependent, cytosolic 0.243
Pcyt2 phosphate cytidylyltransferase 2, ethanolamine 0.220
Slc25a1 solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1 0.220
Dhcr7 7-dehydrocholesterol reductase 0.202
Hadhb hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit 0.201
Cpt2 carnitine palmitoyltransferase 2 0.195
Atp5f1 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1 0.193
Pex19 peroxisomal biogenesis factor 19 0.185
Scd1 stearoyl-Coenzyme A desaturase 1 0.170
Pgk1 phosphoglycerate kinase 1 0.165
Ube2b ubiquitin-conjugating enzyme E2B (RAD6 homolog, S. cerevisiae) 0.164
Etfdh electron-transferring-flavoprotein dehydrogenase 0.155
Acadl acyl-Coenzyme A dehydrogenase, long-chain 0.141
Hadha hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit 0.117
Tkt transketolase 0.113
Pdhx pyruvate dehydrogenase complex, component X 0.109
Acadm acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain 0.106
Acaca acetyl-coenzyme A carboxylase alpha 0.103
Etfa electron-transfer-flavoprotein, alpha polypeptide 0.086
Pfkm phosphofructokinase, muscle 0.082
Acadvl acyl-Coenzyme A dehydrogenase, very long chain 0.079
Ndufs1 NADH dehydrogenase (ubiquinone) Fe-S protein 1 0.076
Fdft1 farnesyl diphosphate farnesyl transferase 1 0.073
Srebf1 sterol regulatory element binding transcription factor 1 0.070
Ech1 enoyl coenzyme A hydratase 1, peroxisomal 0.066
Vdac1 voltage-dependent anion channel 1 0.065
Slc22a1 solute carrier family 22 (organic cation transporter), member 1 0.065
Bckdha branched chain ketoacid dehydrogenase E1, alpha polypeptide 0.063
Eci1 enoyl-Coenzyme A delta isomerase 1 0.063
RGD1565095 similar to hypothetical protein MGC52110 0.053
Decr1 2,4-dienoyl CoA reductase 1, mitochondrial 0.053
Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 0.047
Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 0.044
Gfm1 G elongation factor, mitochondrial 1 0.044
Acox1 acyl-Coenzyme A oxidase 1, palmitoyl 0.042
Atp1a4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.040
Tst thiosulfate sulfurtransferase 0.038
Gpd1 glycerol-3-phosphate dehydrogenase 1 (soluble) 0.038
Dgat1 diacylglycerol O-acyltransferase homolog 1 (mouse) 0.038
Acss2 acyl-CoA synthetase short-chain family member 2 0.037
Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 0.036
Hibadh 3-hydroxyisobutyrate dehydrogenase 0.035
Dlst dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) 0.035
Slc25a20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 0.033
Vegfb vascular endothelial growth factor B 0.032
Acsl1 acyl-CoA synthetase long-chain family member 1 0.032
Senp2 Sumo1/sentrin/SMT3 specific peptidase 2 0.032
Ppm1a protein phosphatase 1A, magnesium dependent, alpha isoform 0.031
Akap1 A kinase (PRKA) anchor protein 1 0.029
Acat1 acetyl-coenzyme A acetyltransferase 1 0.028
Pink1 PTEN induced putative kinase 1 0.028
Slc23a1 solute carrier family 23 (nucleobase transporters), member 1 0.028
Slc25a10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 0.028
Cops7a COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis) 0.027
Gpam glycerol-3-phosphate acyltransferase, mitochondrial 0.027
Acacb acetyl-Coenzyme A carboxylase beta 0.027
Fdps farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) 0.027
Pmpca peptidase (mitochondrial processing) alpha 0.027
Acox2 acyl-Coenzyme A oxidase 2, branched chain 0.026
Fbp1 fructose-1,6-bisphosphatase 1 0.026
Gbe1 glucan (1,4-alpha-), branching enzyme 1 0.026
Slc13a1 solute carrier family 13 (sodium/sulfate symporters), member 1 0.026
Ndrg2 N-myc downstream regulated gene 2 0.025
Capza2 capping protein (actin filament) muscle Z-line, alpha 2 0.025
LOC306766 hypothetical LOC306766 0.024
March5 membrane-associated ring finger (C3HC4) 5 0.024
Ppp1r2 protein phosphatase 1, regulatory (inhibitor) subunit 2 0.024
Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 0.023
Mug1 murinoglobulin 1 0.023
Dpys dihydropyrimidinase 0.023
Ehhadh enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase 0.023
Slc10a1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 0.023
Syngr2 synaptogyrin 2 0.022
Hspa9 heat shock protein 9 0.021
Acot2 acyl-CoA thioesterase 2 0.021
Slco1a1 solute carrier organic anion transporter family, member 1a1 0.021
Dmgdh dimethylglycine dehydrogenase 0.020
Alas1 aminolevulinate, delta-, synthase 1 0.020
Opa1 optic atrophy 1 homolog (human) 0.020
Tom1 target of myb1 homolog (chicken) 0.020
Acads acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain 0.020
Mlxipl MLX interacting protein-like 0.019
Bpnt1 3'(2'), 5'-bisphosphate nucleotidase 1 0.019
Acox3 acyl-Coenzyme A oxidase 3, pristanoyl 0.019
Fabp1 fatty acid binding protein 1, liver 0.019
Pc pyruvate carboxylase 0.019
Chp calcium binding protein p22 0.019
Pdha1 pyruvate dehydrogenase (lipoamide) alpha 1 0.018
Ppp1r3c protein phosphatase 1, regulatory (inhibitor) subunit 3C 0.018
Abcb11 ATP-binding cassette, subfamily B (MDR/TAP), member 11 0.018
Nmt1 N-myristoyltransferase 1 0.018
Cyp51 cytochrome P450, family 51 0.018
Ivd isovaleryl coenzyme A dehydrogenase 0.018
Gcgr glucagon receptor 0.017