The network for 'negative regulation of cellular biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of cellular biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
RPD3 Rpd3p 0.997
RLF2 Rlf2p 0.988
RAP1 Rap1p 0.986
HHT1 Hht1p 0.986
SIN3 Sin3p 0.982
SUM1 Sum1p 0.979
HDA1 Hda1p 0.973
SIR4 Sir4p 0.955
HOG1 Hog1p 0.944
CYC8 Cyc8p 0.936
SNF1 Snf1p 0.930
RXT2 Rxt2p 0.908
HHF1 Hhf1p 0.907
CTI6 Cti6p 0.902
ORC5 Orc5p 0.890
GLC7 Glc7p 0.890
RIM101 Rim101p 0.888
UME1 Ume1p 0.880
RTT106 Rtt106p 0.875
SIN4 Sin4p 0.869
DHH1 Dhh1p 0.868
HMO1 Hmo1p 0.864
PAP2 Pap2p 0.862
SIR2 Sir2p 0.857
RTF1 Rtf1p 0.844
YTA7 Yta7p 0.838
YAK1 Yak1p 0.817
RPN4 Rpn4p 0.812
SET1 Set1p 0.802
SWI4 Swi4p 0.794
MRC1 Mrc1p 0.782
ASF1 Asf1p 0.780
ADR1 Adr1p 0.779
SAS2 Sas2p 0.755
BDF1 Bdf1p 0.753
NRG1 Nrg1p 0.744
CTK1 Ctk1p 0.742
ORC3 Orc3p 0.738
FHL1 Fhl1p 0.735
ITC1 Itc1p 0.735
SAP30 Sap30p 0.734
SDS3 Sds3p 0.733
PSY2 Psy2p 0.731
ISW2 Isw2p 0.728
RCO1 Rco1p 0.722
HAT1 Hat1p 0.719
ORC2 Orc2p 0.704
GAL11 Gal11p 0.695
PAT1 Pat1p 0.693
SPT16 Spt16p 0.679
REG1 Reg1p 0.678
RIF1 Rif1p 0.670
DED1 Ded1p 0.659
CTF18 Ctf18p 0.654
SLX5 Slx5p 0.649
RSC2 Rsc2p 0.647
SNF5 Snf5p 0.646
MED2 Med2p 0.634
GLN3 Gln3p 0.628
SCH9 Sch9p 0.627
HHO1 Hho1p 0.618
GCR2 Gcr2p 0.615
SET2 Set2p 0.611
PHO23 Pho23p 0.607
MCM2 Mcm2p 0.595
IFH1 Ifh1p 0.591
UBP8 Ubp8p 0.585
CDC14 Cdc14p 0.566
SNT1 Snt1p 0.563
VID30 Vid30p 0.562
TUP1 Tup1p 0.557
RSP5 Rsp5p 0.549
ORC1 Orc1p 0.546
EAF3 Eaf3p 0.544
HCM1 Hcm1p 0.542
RGR1 Rgr1p 0.537
CSE2 Cse2p 0.536
CDC6 Cdc6p 0.529
HAT2 Hat2p 0.528
SLX8 Slx8p 0.525
HFI1 Hfi1p 0.521
HDA2 Hda2p 0.520
NUP157 Nup157p 0.515
MMS22 Mms22p 0.515
CCR4 Ccr4p 0.515
TIF4632 Tif4632p 0.514
VID24 Vid24p 0.512
SUI3 Sui3p 0.509
FOB1 Fob1p 0.508
HIR1 Hir1p 0.506
RIA1 Ria1p 0.504
EAF1 Eaf1p 0.501
HHF2 Hhf2p 0.499
RAD9 Rad9p 0.496
SPT21 Spt21p 0.494
STH1 Sth1p 0.493
SRM1 Srm1p 0.492
NTO1 Nto1p 0.491
MED7 Med7p 0.487
NUT1 Nut1p 0.485
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
egl-18 Protein EGL-18 0.985
pha-4 Protein PHA-4 0.675
elt-6 Protein ELT-6 0.477
mix-1 Protein MIX-1 0.394
lin-53 Protein LIN-53 0.383
his-64 Protein HIS-64 0.357
nhr-2 Protein NHR-2 0.352
plk-3 Protein PLK-3 0.349
his-16 Protein HIS-16 0.343
wrm-1 Protein WRM-1 0.338
mab-5 Protein MAB-5 0.317
his-1 Protein HIS-1 0.311
mcm-7 Protein MCM-7 0.274
daf-4 Protein DAF-4 0.253
hbl-1 Protein HBL-1 0.247
his-61 Protein HIS-61 0.237
mcm-2 Protein MCM-2 0.232
tbx-8 Protein TBX-8 0.229
hda-1 Protein HDA-1 0.219
unc-62 Protein UNC-62 0.216
eor-1 Protein EOR-1 0.201
mes-4 Protein MES-4 0.198
tam-1 Protein TAM-1 0.194
let-502 Protein LET-502 0.190
CELE_C12D8.1 Protein C12D8.1 0.188
flt-1 Protein FLT-1 0.186
nhr-67 Protein NHR-67 0.181
unc-37 Protein UNC-37 0.181
pry-1 Protein PRY-1 0.176
rsp-1 Protein RSP-1 0.167
CELE_Y41E3.11 Protein Y41E3.11 0.164
his-31 Protein HIS-31 0.161
egl-13 Protein EGL-13 0.159
hlh-2 Protein HLH-2 0.155
egl-46 Protein EGL-46 0.146
cnd-1 Protein CND-1 0.143
lin-35 Protein LIN-35 0.143
nhr-25 Protein NHR-25 0.141
top-2 Protein TOP-2 0.139
cpb-3 Protein CPB-3 0.139
pop-1 Protein POP-1 0.137
mex-5 Protein MEX-5 0.134
CELE_F19F10.9 Protein F19F10.9 0.132
his-3 Protein HIS-3 0.131
eya-1 Protein EYA-1 0.129
lsy-22 Protein LSY-22 0.125
his-4 Protein HIS-4 0.125
egl-27 Protein EGL-27 0.123
daf-1 Protein DAF-1 0.123
rskn-2 Protein RSKN-2 0.120
CELE_F54D5.5 Protein F54D5.5 0.120
egg-6 Protein EGG-6 0.120
zip-7 Protein ZIP-7 0.118
puf-3 Protein PUF-3 0.118
atg-2 Protein ATG-2 0.118
his-5 Protein HIS-5 0.115
fkh-2 Protein FKH-2 0.112
ceh-27 Protein CEH-27 0.111
rad-26 Protein RAD-26 0.111
daf-12 Protein DAF-12 0.110
hil-2 Protein HIL-2 0.110
his-24 Protein HIS-24 0.105
eftu-2 Protein EFTU-2 0.104
pdr-1 Protein PDR-1 0.103
dcn-1 Protein DCN-1 0.103
lin-17 Protein LIN-17 0.102
T28C6.7 Protein T28C6.7 0.102
xpo-1 Protein XPO-1 0.098
lin-66 Protein LIN-66 0.098
his-38 Protein HIS-38 0.096
pos-1 Protein POS-1 0.096
attf-2 Protein ATTF-2 0.095
CELE_C17E4.6 Protein C17E4.6 0.095
T28F4.1 Protein T28F4.1 0.094
Y7A9D.1 Protein Y7A9D.1 0.094
spd-5 Protein SPD-5 0.094
CELE_C23G10.8 Protein C23G10.8 0.093
mom-2 Protein MOM-2 0.093
F26B1.2 Protein F26B1.2 0.093
hlh-1 Protein HLH-1 0.093
cdc-25.1 Protein CDC-25.1 0.091
tag-319 Protein TAG-319 0.091
bed-3 Protein BED-3 0.091
Y82E9BR.13 Protein Y82E9BR.13 0.090
skp-1 Protein SKP-1 0.089
ptr-6 Protein PTR-6 0.088
mls-2 Protein MLS-2 0.088
C27F2.8 Protein C27F2.8 0.088
hmg-1.1 Protein HMG-1.1 0.088
his-46 Protein HIS-46 0.086
atn-1 Protein ATN-1 0.084
patr-1 Protein PATR-1 0.081
D1081.8 Protein D1081.8 0.081
his-51 Protein HIS-51 0.081
his-48 Protein HIS-48 0.080
CELE_C24H12.5 Protein C24H12.5 0.079
lin-29 Protein LIN-29 0.079
his-42 Protein HIS-42 0.079
aak-2 Protein AAK-2 0.079
cdt-2 Protein CDT-2 0.079
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Danio rerio
Name Description Probability Func Analog Organism
foxi1 forkhead box I1 0.956
ndr2 nodal-related 2 0.929
pcna proliferating cell nuclear antigen 0.898
fgf3 fibroblast growth factor 3 0.850
jag2 jagged 2 0.796
pax6a paired box gene 6a 0.743
snai1b snail homolog 1b (Drosophila) 0.709
whsc1 Wolf-Hirschhorn syndrome candidate 1 0.633
nkx2.3 NK2 transcription factor related 3 0.631
her15.1 hairy and enhancer of split-related 15.1 0.616
fezf2 FEZ family zinc finger 2 0.613
notch1a notch homolog 1a 0.600
lft2 lefty2 0.587
gli1 GLI-Kruppel family member 1 0.584
sox9b SRY-box containing gene 9b 0.583
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.564
zic2b zic family member 2 (odd-paired homolog, Drosophila) b 0.513
mll myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.495
gata6 GATA-binding protein 6 0.489
gro1 groucho 1 0.477
nkx2.5 NK2 transcription factor related 5 0.475
fgf8a fibroblast growth factor 8 a 0.473
tbx2a T-box gene 2a 0.473
prdm1a PR domain containing 1a, with ZNF domain 0.469
hnf1ba HNF1 homeobox Ba 0.455
tfap2a transcription factor AP-2 alpha 0.454
twist3 twist3 0.440
disp1 dispatched homolog 1 (Drosophila) 0.438
mab21l2 mab-21-like 2 0.433
jam3b junctional adhesion molecule 3b 0.416
prmt1 protein arginine methyltransferase 1 0.412
sox2 SRY-box containing gene 2 0.401
her8a hairy-related 8a 0.396
lhx1a LIM homeobox 1a 0.393
sox1a SRY-box containing gene 1a 0.390
sox19a SRY-box containing gene 19a 0.384
bmp2b bone morphogenetic protein 2b 0.367
eng2a engrailed 2a 0.356
lft1 lefty1 0.347
hmx1 H6 homeo box 1 0.346
dlx5a distal-less homeobox gene 5a 0.346
tac1 tachykinin 1 0.335
otx1b orthodenticle homolog 1b 0.325
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.320
ascl1b achaete-scute complex-like 1b (Drosophila) 0.315
chd chordin 0.312
dlx2a distal-less homeobox gene 2a 0.310
etv5b ets variant 5b 0.294
traf4a tnf receptor-associated factor 4a 0.292
tardbp TAR DNA binding protein 0.285
pcdh18b protocadherin 18b 0.282
dlc deltaC 0.280
her12 hairy-related 12 0.276
myca myelocytomatosis oncogene a 0.275
otx2 orthodenticle homolog 2 0.271
rxrga retinoid x receptor, gamma a 0.266
six3a sine oculis homeobox homolog 3a 0.264
bmp4 bone morphogenetic protein 4 0.261
pax8 paired box gene 8 0.259
klf4 Kruppel-like factor 4 0.257
dlx1a distal-less homeobox gene 1a 0.257
ripply1 ripply1 0.256
emx1 empty spiracles homeobox 1 0.255
fgf19 fibroblast growth factor 19 0.250
tagln2 transgelin 2 0.248
vsx1 visual system homeobox 1 homolog, chx10-like 0.248
dlx3b distal-less homeobox gene 3b 0.245
six3b sine oculis homeobox homolog 3b 0.244
tbx6 T-box gene 6 0.239
etv2 ets variant gene 2 0.239
emx3 empty spiracles homeobox 3 0.237
eomesa eomesodermin homolog a 0.236
boc brother of CDO 0.233
ube2i ubiquitin-conjugating enzyme E2I 0.229
her11 hairy-related 11 0.228
irx4b iroquois homeobox protein 4b 0.228
foxa3 forkhead box A3 0.228
cyp1b1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.227
hhex hematopoietically expressed homeobox 0.224
msxc muscle segment homeobox C 0.221
six2a sine oculis-related homeobox 2a 0.221
pitx2 paired-like homeodomain transcription factor 2 0.219
vsx2 visual system homeobox 2 0.217
plekhg4 pleckstrin homology domain containing, family G (with RhoGef domain) member 4 0.216
rx2 retinal homeobox gene 2 0.216
hmga1a high mobility group AT-hook 1a 0.214
hoxa3a homeo box A3a 0.213
hoxb8a homeo box B8a 0.210
tal1 T-cell acute lymphocytic leukemia 1 0.210
mcm5 MCM5 minichromosome maintenance deficient 5 (S. cerevisiae) 0.207
six4b sine oculis homeobox homolog 4b 0.207
dla deltaA 0.205
hoxd4a homeo box D4a 0.204
tgif1 TGFB-induced factor homeobox 1 0.199
dct dopachrome tautomerase 0.199
ptf1a pancreas specific transcription factor, 1a 0.198
rarga retinoic acid receptor gamma a 0.193
foxc1a forkhead box C1a 0.192
her1 hairy-related 1 0.192
atoh1a atonal homolog 1a 0.190
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Drosophila melanogaster
Name Description Probability Func Analog Organism
kay kayak 1.000
CTCF CG8591 gene product from transcript CG8591-RA 0.999
fu fused 0.998
E(spl) Enhancer of split 0.998
Iswi Imitation SWI 0.998
Mad Mothers against dpp 0.998
Snr1 Snf5-related 1 0.997
smt3 CG4494 gene product from transcript CG4494-RA 0.997
ato atonal 0.997
Pcl Polycomblike 0.997
slmb supernumerary limbs 0.997
shn schnurri 0.997
Sir2 CG5216 gene product from transcript CG5216-RA 0.996
Sce Sex combs extra 0.993
brk brinker 0.993
sd scalloped 0.990
Pc Polycomb 0.989
Trl Trithorax-like 0.989
InR Insulin-like receptor 0.988
ash1 absent, small, or homeotic discs 1 0.988
lwr lesswright 0.987
ci cubitus interruptus 0.986
dco discs overgrown 0.986
p53 CG33336 gene product from transcript CG33336-RB 0.977
dpp decapentaplegic 0.970
eyg eyegone 0.968
Pka-C1 cAMP-dependent protein kinase 1 0.967
pr-set7 CG3307 gene product from transcript CG3307-RC 0.965
Scm Sex comb on midleg 0.962
Nf-YC Nuclear factor Y-box C 0.960
Pp1-87B Protein phosphatase 1 at 87B 0.959
CtBP C-terminal Binding Protein 0.957
nmo nemo 0.954
yki yorkie 0.951
esc extra sexcombs 0.950
ems empty spiracles 0.950
His2Av Histone H2A variant 0.949
ct cut 0.947
D1 D1 chromosomal protein 0.947
phyl phyllopod 0.947
hep hemipterous 0.943
dsx doublesex 0.942
lid little imaginal discs 0.939
mam mastermind 0.939
E(var)3-9 Enhancer of variegation 3-9 0.938
Su(var)205 Suppressor of variegation 205 0.936
Gdi GDP dissociation inhibitor 0.933
E(z) Enhancer of zeste 0.932
Pcaf CG4107 gene product from transcript CG4107-RA 0.931
crol crooked legs 0.928
BEAF-32 Boundary element-associated factor of 32kD 0.922
ara araucan 0.917
wg wingless 0.916
mor moira 0.914
SuUR Suppressor of Under-Replication 0.907
ey eyeless 0.904
kn knot 0.902
Tip60 CG6121 gene product from transcript CG6121-RA 0.895
barr barren 0.894
Fmr1 CG6203 gene product from transcript CG6203-RC 0.891
mus209 mutagen-sensitive 209 0.889
tin tinman 0.887
tsh teashirt 0.882
sty sprouty 0.881
egg eggless 0.880
Ubx Ultrabithorax 0.874
e(y)3 enhancer of yellow 3 0.874
Rpd3 CG7471 gene product from transcript CG7471-RA 0.870
brat brain tumor 0.866
Rga Regena 0.857
Trf2 TATA box binding protein-related factor 2 0.856
Cap-G CG34438 gene product from transcript CG34438-RF 0.854
Ser Serrate 0.854
mrn marionette 0.854
dally division abnormally delayed 0.853
sli slit 0.851
how held out wings 0.844
nab CG33545 gene product from transcript CG33545-RC 0.843
zpg zero population growth 0.837
ph-p polyhomeotic proximal 0.836
gro groucho 0.828
pan pangolin 0.822
sna snail 0.813
rin rasputin 0.813
hipk homeodomain interacting protein kinase 0.811
SoxN SoxNeuro 0.810
slp1 sloppy paired 1 0.805
HLHm7 E(spl) region transcript m7 0.804
E2f2 E2F transcription factor 2 0.800
polo CG12306 gene product from transcript CG12306-RA 0.799
eya eyes absent 0.798
os outstretched 0.797
RpII215 RNA polymerase II 215kD subunit 0.795
abd-A abdominal A 0.788
gsb gooseberry 0.788
esg escargot 0.787
hb hunchback 0.782
cnc cap-n-collar 0.779
Smr Smrter 0.777
en engrailed 0.775
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Junb jun B proto-oncogene 0.824
Tgfbr2 transforming growth factor, beta receptor II 0.727
Jun Jun oncogene 0.726
Dusp1 dual specificity phosphatase 1 0.659
Tcfe2a transcription factor E2a 0.641
Nr4a1 nuclear receptor subfamily 4, group A, member 1 0.534
Nfib nuclear factor I/B 0.531
Ier2 immediate early response 2 0.517
Ppp1r15a protein phosphatase 1, regulatory (inhibitor) subunit 15A 0.505
Fos FBJ osteosarcoma oncogene 0.474
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.447
Hes1 hairy and enhancer of split 1 (Drosophila) 0.443
Cdc42 cell division cycle 42 (GTP binding protein) 0.432
Fgfr1 Fibroblast growth factor receptor 1 0.427
Egr1 early growth response 1 0.420
Dbp D site of albumin promoter (albumin D-box) binding protein 0.405
Lzts2 leucine zipper, putative tumor suppressor 2 0.377
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.372
Klf4 Kruppel-like factor 4 (gut) 0.369
Btg2 BTG family, member 2 0.359
Shox2 short stature homeobox 2 0.349
Arf6 ADP-ribosylation factor 6 0.320
Stat5b signal transducer and activator of transcription 5B 0.312
S100a6 S100 calcium binding protein A6 0.308
Pspn persephin 0.304
Zfp36 zinc finger protein 36 0.304
Dchs1 dachsous 1 (Drosophila) 0.302
Ppp2cb protein phosphatase 2, catalytic subunit, beta isoform 0.297
Klf2 Kruppel-like factor 2 (lung) 0.292
Fgfr2 fibroblast growth factor receptor 2 0.290
Nfia nuclear factor I/A 0.286
Errfi1 ERBB receptor feedback inhibitor 1 0.271
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.271
Rhob ras homolog gene family, member B 0.271
Gcm1 glial cells missing homolog 1 (Drosophila) 0.262
Kcnt1 potassium channel, subfamily T, member 1 0.257
Sfpq splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) 0.251
Hoxc4 homeo box C4 0.248
Hmgb2 high mobility group box 2 0.246
RGD1565591 similar to Ski protein 0.244
Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 0.242
Egr2 early growth response 2 0.238
Mybl2 myeloblastosis oncogene-like 2 0.236
Pcna proliferating cell nuclear antigen 0.229
Rorb RAR-related orphan receptor B 0.225
Cd40lg CD40 ligand 0.224
LOC100362814 hypothetical protein LOC100362814 0.223
Foxd1 forkhead box D1 0.223
Smad6 SMAD family member 6 0.222
Grk1 G protein-coupled receptor kinase 1 0.222
Casp2 caspase 2 0.219
Il12b interleukin 12B 0.219
Sp1 Sp1 transcription factor 0.216
Rap1b RAP1B, member of RAS oncogene family 0.215
Gja1 gap junction protein, alpha 1 0.213
Sox18 SRY (sex determining region Y)-box 18 0.211
Lphn1 latrophilin 1 0.210
Barhl2 BarH-like homeobox 2 0.209
Fyn FYN oncogene related to SRC, FGR, YES 0.208
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.207
Ahr aryl hydrocarbon receptor 0.207
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.205
Erbb4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.203
Gata4 GATA binding protein 4 0.202
Dusp6 dual specificity phosphatase 6 0.201
Smad7 SMAD family member 7 0.199
S100a8 S100 calcium binding protein A8 0.196
Pds5b PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) 0.196
Ncan neurocan 0.195
Rest RE1-silencing transcription factor 0.193
S100a9 S100 calcium binding protein A9 0.193
Met met proto-oncogene 0.190
Lhx5 LIM homeobox 5 0.190
Nfya nuclear transcription factor-Y alpha 0.188
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.182
Hmgb1 high mobility group box 1 0.181
Siah1a seven in absentia 1A 0.179
Gfi1 growth factor independent 1 transcription repressor 0.178
Hmgn2 high mobility group nucleosomal binding domain 2 0.178
Flt1 FMS-related tyrosine kinase 1 0.178
Cga glycoprotein hormones, alpha polypeptide 0.177
Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.175
Dag1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.174
S100a4 S100 calcium-binding protein A4 0.172
Ptgfr prostaglandin F receptor 0.171
St8sia2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.170
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.170
Klf6 Kruppel-like factor 6 0.168
Grm8 glutamate receptor, metabotropic 8 0.168
Nr4a3 nuclear receptor subfamily 4, group A, member 3 0.166
Pax9 paired box 9 0.166
Capn5 calpain 5 0.163
Ppp1cb protein phosphatase 1, catalytic subunit, beta isoform 0.163
Kdm6b lysine (K)-specific demethylase 6B 0.160
Vax2 ventral anterior homeobox 2 0.158
Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.157
Nono non-POU domain containing, octamer-binding 0.156
Socs3 suppressor of cytokine signaling 3 0.155
Tcf4 transcription factor 4 0.154
Anxa2 annexin A2 0.152