The network for 'nuclear transcribed mrna catabolic process deadenylation dependent decay' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

nuclear transcribed mrna catabolic process deadenylation dependent decay

A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
POP2 Pop2p 0.992
CAF40 Caf40p 0.986
DHH1 Dhh1p 0.944
DEF1 Def1p 0.930
SKI7 Ski7p 0.721
MTR3 Mtr3p 0.721
DCP2 Dcp2p 0.657
CDC39 Cdc39p 0.536
PAT1 Pat1p 0.526
RRP46 Rrp46p 0.510
SKI3 Ski3p 0.436
DCP1 Dcp1p 0.403
LSM2 Lsm2p 0.393
PBY1 Pby1p 0.381
EDC3 Edc3p 0.362
NOT3 Not3p 0.353
SKI2 Ski2p 0.325
CSL4 Csl4p 0.323
PAN3 Pan3p 0.274
SKI8 Ski8p 0.268
PUB1 Pub1p 0.252
TIF4632 Tif4632p 0.225
MOT2 Mot2p 0.198
RPB7 Rpb7p 0.194
NAM7 Nam7p 0.181
NMD2 Nmd2p 0.173
LSM4 Lsm4p 0.164
KEM1 Kem1p 0.161
GBP2 Gbp2p 0.158
PBP1 Pbp1p 0.144
SKI6 Ski6p 0.136
CDC36 Cdc36p 0.120
DNM1 Dnm1p 0.101
MLH2 Mlh2p 0.100
RPO21 Rpo21p 0.098
UBP1 Ubp1p 0.098
MEX67 Mex67p 0.092
RRP45 Rrp45p 0.092
UPF3 Upf3p 0.090
MPT5 Mpt5p 0.088
RRP40 Rrp40p 0.086
YTA6 Yta6p 0.084
HOS2 Hos2p 0.083
MSH3 Msh3p 0.081
LSM1 Lsm1p 0.081
RRP43 Rrp43p 0.076
CCR4 Ccr4p 0.073
YMR086W hypothetical protein 0.073
CTR86 Ctr86p 0.069
DIS3 Dis3p 0.069
RPO26 Rpo26p 0.067
SCD6 Scd6p 0.066
RRP6 Rrp6p 0.061
NGR1 Ngr1p 0.060
RFU1 Rfu1p 0.060
YGL101W hypothetical protein 0.059
AIM3 Aim3p 0.059
RPS10B Rps10bp 0.057
PZF1 Pzf1p 0.056
TFG2 Tfg2p 0.055
ZRG8 Zrg8p 0.054
CAF130 Caf130p 0.049
TIM44 Tim44p 0.049
THP2 Thp2p 0.049
SOK1 Sok1p 0.048
DAL81 Dal81p 0.047
HEM3 Hem3p 0.046
HBT1 Hbt1p 0.046
URA3 Ura3p 0.046
KEI1 Kei1p 0.045
YBL029W hypothetical protein 0.044
SMY2 Smy2p 0.044
CCH1 Cch1p 0.044
YJL107C hypothetical protein 0.044
YLR162W hypothetical protein 0.044
PAM1 Pam1p 0.043
GPH1 Gph1p 0.043
DCS2 Dcs2p 0.043
YLR297W hypothetical protein 0.042
PMP2 Pmp2p 0.042
HER1 Her1p 0.042
CBP1 Cbp1p 0.041
PRS2 Prs2p 0.041
YLR363W-A hypothetical protein 0.041
YLR264C-A hypothetical protein 0.040
GPD2 Gpd2p 0.039
YBR016W hypothetical protein 0.039
CTF13 Ctf13p 0.039
EBS1 Ebs1p 0.039
SRD1 Srd1p 0.038
NST1 Nst1p 0.038
YBL081W hypothetical protein 0.037
RRP42 Rrp42p 0.037
CLU1 Clu1p 0.036
URB2 Urb2p 0.036
SUP35 Sup35p 0.036
ARG8 Arg8p 0.036
YGR169C-A hypothetical protein 0.036
MSH4 Msh4p 0.036
PAM18 Pam18p 0.036
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Dlic Dynein light intermediate chain 0.511
tral trailer hitch 0.486
cact cactus 0.420
rin rasputin 0.379
CG4699 CG4699 gene product from transcript CG4699-RJ 0.331
aub aubergine 0.222
cup CG11181 gene product from transcript CG11181-RB 0.176
RpL22 Ribosomal protein L22 0.096
Tsp96F Tetraspanin 96F 0.089
blot bloated tubules 0.082
Mtr3 CG8025 gene product from transcript CG8025-RA 0.082
l(1)G0289 lethal (1) G0289 0.074
Rab8 Rab-protein 8 0.074
Cul-4 Cullin-4 0.071
wisp wispy 0.063
Liprin-alpha CG11199 gene product from transcript CG11199-RB 0.061
piwi CG6122 gene product from transcript CG6122-RA 0.059
CG10289 CG10289 gene product from transcript CG10289-RA 0.052
Pkn Protein kinase related to protein kinase N 0.047
Crag Calmodulin-binding protein related to a Rab3 GDP/GTP exchange protein 0.046
Hrb27C Heterogeneous nuclear ribonucleoprotein at 27C 0.044
mus309 mutagen-sensitive 309 0.040
aret arrest 0.039
Map205 Microtubule-associated protein 205 0.037
Atx2 Ataxin-2 0.036
Pk61C Protein kinase 61C 0.035
Dcp2 Decapping protein 2 0.035
CG17266 CG17266 gene product from transcript CG17266-RA 0.034
rhi rhino 0.034
twin CG31137 gene product from transcript CG31137-RB 0.034
CG7339 CG7339 gene product from transcript CG7339-RA 0.033
Trn Transportin 0.032
stwl stonewall 0.030
mav maverick 0.030
defl deflated 0.030
bam bag of marbles 0.029
spn-E spindle E 0.029
UBL3 CG9038 gene product from transcript CG9038-RC 0.029
bel belle 0.028
DNApol-alpha50 DNA polymerase alpha 50kD 0.028
RhoGAP92B CG4755 gene product from transcript CG4755-RA 0.027
RpS26 Ribosomal protein S26 0.027
sxc super sex combs 0.026
CG2100 CG2100 gene product from transcript CG2100-RB 0.026
Pen Pendulin 0.026
CG14544 CG14544 gene product from transcript CG14544-RA 0.026
Nipped-B CG17704 gene product from transcript CG17704-RI 0.024
CG8443 CG8443 gene product from transcript CG8443-RA 0.024
dgt4 dim gamma-tubulin 4 0.024
RpL35 Ribosomal protein L35 0.021
sw short wing 0.018
CG10722 CG10722 gene product from transcript CG10722-RA 0.018
del deadlock 0.018
mael maelstrom 0.017
pgant3 polypeptide GalNAc transferase 3 0.017
Adf1 Adh transcription factor 1 0.016
eIF4G eukaryotic translation initiation factor 4G 0.016
CG3434 CG3434 gene product from transcript CG3434-RA 0.016
zpg zero population growth 0.016
eg eagle 0.015
slou slouch 0.015
dap dacapo 0.015
Rpn11 CG18174 gene product from transcript CG18174-RA 0.015
koi klaroid 0.014
RPA2 Replication protein A2 0.014
Ard1 Arrest defective 1 0.014
cuff cutoff 0.014
CG13624 CG13624 gene product from transcript CG13624-RD 0.014
Smg6 CG6369 gene product from transcript CG6369-RA 0.014
armi armitage 0.013
CG9304 CG9304 gene product from transcript CG9304-RA 0.013
Gbeta13F G protein beta-subunit 13F 0.013
eIF-5A CG3186 gene product from transcript CG3186-RA 0.013
fs(1)Yb female sterile (1) Yb 0.013
CycG Cyclin G 0.013
Src64B Src oncogene at 64B 0.012
Dbp73D Dead box protein 73D 0.012
CG12016 CG12016 gene product from transcript CG12016-RA 0.012
cta concertina 0.012
tos tosca 0.012
MED26 Mediator complex subunit 26 0.012
spn-D spindle D 0.011
CG33095 CG33095 gene product from transcript CG33095-RB 0.011
vas vasa 0.011
CG8414 CG8414 gene product from transcript CG8414-RA 0.011
Mtl Mig-2-like 0.011
mus301 mutagen-sensitive 301 0.010
CCKLR-17D1 CCK-like receptor at 17D1 0.010
GATAd CG5034 gene product from transcript CG5034-RA 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
PABPC1 poly(A) binding protein, cytoplasmic 1 1.000
TOB1 transducer of ERBB2, 1 1.000
TNRC6A trinucleotide repeat containing 6A 0.999
PAN3 PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae) 0.992
CNOT1 CCR4-NOT transcription complex, subunit 1 0.987
TNRC6C trinucleotide repeat containing 6C 0.978
DCP1A DCP1 decapping enzyme homolog A (S. cerevisiae) 0.974
TNRC6B trinucleotide repeat containing 6B 0.873
CNOT7 CCR4-NOT transcription complex, subunit 7 0.765
EXOSC7 exosome component 7 0.743
EIF2C1 eukaryotic translation initiation factor 2C, 1 0.734
CNOT8 CCR4-NOT transcription complex, subunit 8 0.705
CNOT2 CCR4-NOT transcription complex, subunit 2 0.686
BTG1 B-cell translocation gene 1, anti-proliferative 0.681
PAIP2 poly(A) binding protein interacting protein 2 0.575
PCBP2 poly(rC) binding protein 2 0.573
EXOSC10 exosome component 10 0.412
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.358
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.347
EIF2C2 eukaryotic translation initiation factor 2C, 2 0.316
CNOT6 CCR4-NOT transcription complex, subunit 6 0.290
GSPT1 G1 to S phase transition 1 0.272
YBX1 Y box binding protein 1 0.211
EXOSC3 exosome component 3 0.172
NOXA1 NADPH oxidase activator 1 0.169
EIF2C4 eukaryotic translation initiation factor 2C, 4 0.165
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.161
PCBP1 poly(rC) binding protein 1 0.150
BTG2 BTG family, member 2 0.119
PARD6B par-6 partitioning defective 6 homolog beta (C. elegans) 0.091
DICER1 dicer 1, ribonuclease type III 0.091
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.085
EXOSC2 exosome component 2 0.082
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 0.077
EXOSC1 exosome component 1 0.074
SMG1 SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans) 0.055
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.054
PRKCZ protein kinase C, zeta 0.050
PABPC3 poly(A) binding protein, cytoplasmic 3 0.049
PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans) 0.044
EXOSC4 exosome component 4 0.044
EIF2C3 eukaryotic translation initiation factor 2C, 3 0.039
CARD11 caspase recruitment domain family, member 11 0.038
KLF4 Kruppel-like factor 4 (gut) 0.036
ATXN2 ataxin 2 0.033
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa 0.032
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.029
PARD3 par-3 partitioning defective 3 homolog (C. elegans) 0.027
DIS3L DIS3 mitotic control homolog (S. cerevisiae)-like 0.026
PAIP1 poly(A) binding protein interacting protein 1 0.025
IER2 immediate early response 2 0.023
CNOT10 CCR4-NOT transcription complex, subunit 10 0.020
PRKCB protein kinase C, beta 0.019
STAU1 staufen, RNA binding protein, homolog 1 (Drosophila) 0.018
GSPT2 G1 to S phase transition 2 0.018
TSC22D1 TSC22 domain family, member 1 0.017
PICK1 protein interacting with PRKCA 1 0.017
CPEB3 cytoplasmic polyadenylation element binding protein 3 0.017
SBF1 SET binding factor 1 0.016
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.016
DUSP1 dual specificity phosphatase 1 0.015
CDCP1 CUB domain containing protein 1 0.014
SH3RF1 SH3 domain containing ring finger 1 0.014
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 0.014
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.014
TOB2 transducer of ERBB2, 2 0.013
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) 0.012
EXOSC5 exosome component 5 0.012
PNRC1 proline-rich nuclear receptor coactivator 1 0.012
CNOT3 CCR4-NOT transcription complex, subunit 3 0.012
EIF4B eukaryotic translation initiation factor 4B 0.011
BARD1 BRCA1 associated RING domain 1 0.011
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Eif2c2 eukaryotic translation initiation factor 2C, 2 1.000
Ddx6 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 0.984
Tnrc6b trinucleotide repeat containing 6b 0.744
Mll3 myeloid/lymphoid or mixed-lineage leukemia 3 0.667
Junb Jun-B oncogene 0.634
Fos FBJ osteosarcoma oncogene 0.598
Bptf bromodomain PHD finger transcription factor 0.524
Dusp1 dual specificity phosphatase 1 0.520
Neurl1a neuralized homolog 1A (Drosophila) 0.343
Egr1 early growth response 1 0.279
Zfp36 zinc finger protein 36 0.219
Gsk3b glycogen synthase kinase 3 beta 0.214
Trim32 tripartite motif-containing 32 0.204
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.181
Brd4 bromodomain containing 4 0.173
Btg2 B-cell translocation gene 2, anti-proliferative 0.172
Btg1 B-cell translocation gene 1, anti-proliferative 0.170
Cnot6 CCR4-NOT transcription complex, subunit 6 0.145
Sp1 trans-acting transcription factor 1 0.123
Nr4a1 nuclear receptor subfamily 4, group A, member 1 0.109
Actn2 actinin alpha 2 0.108
Pard3 par-3 (partitioning defective 3) homolog (C. elegans) 0.104
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.096
Wnk1 WNK lysine deficient protein kinase 1 0.086
Caprin1 cell cycle associated protein 1 0.083
Ier2 immediate early response 2 0.083
Akap9 A kinase (PRKA) anchor protein (yotiao) 9 0.082
Igf1r insulin-like growth factor I receptor 0.081
Nudcd2 NudC domain containing 2 0.079
Irs2 insulin receptor substrate 2 0.077
Mll5 myeloid/lymphoid or mixed-lineage leukemia 5 0.072
Klf6 Kruppel-like factor 6 0.071
Rcor1 REST corepressor 1 0.068
Jun Jun oncogene 0.067
Ldb3 LIM domain binding 3 0.065
Trrap transformation/transcription domain-associated protein 0.060
Mll1 myeloid/lymphoid or mixed-lineage leukemia 1 0.059
Ankhd1 ankyrin repeat and KH domain containing 1 0.056
Pum1 pumilio 1 (Drosophila) 0.054
Tnrc6c trinucleotide repeat containing 6C 0.052
Pabpc1 poly(A) binding protein, cytoplasmic 1 0.047
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.047
Brd2 bromodomain containing 2 0.045
Rc3h1 RING CCCH (C3H) domains 1 0.044
Elavl1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.043
Vegfa vascular endothelial growth factor A 0.042
Akt2 thymoma viral proto-oncogene 2 0.042
Nupl1 nucleoporin like 1 0.038
Celf1 CUGBP, Elav-like family member 1 0.038
Cd28 CD28 antigen 0.038
Csnk2a1 casein kinase 2, alpha 1 polypeptide 0.037
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.037
Nfatc3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 0.037
Arid1a AT rich interactive domain 1A (SWI-like) 0.036
Gm2223 predicted pseudogene 2223 0.035
Rasal1 RAS protein activator like 1 (GAP1 like) 0.034
Ppp1r15a protein phosphatase 1, regulatory (inhibitor) subunit 15A 0.034
Kpnb1 karyopherin (importin) beta 1 0.034
Cnot7 CCR4-NOT transcription complex, subunit 7 0.034
Rfx7 regulatory factor X, 7 0.033
Ncoa1 nuclear receptor coactivator 1 0.033
Smad1 MAD homolog 1 (Drosophila) 0.033
Mafk v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian) 0.033
Map3k1 mitogen-activated protein kinase kinase kinase 1 0.032
Bmpr2 bone morphogenic protein receptor, type II (serine/threonine kinase) 0.031
Klf7 Kruppel-like factor 7 (ubiquitous) 0.030
Vhl von Hippel-Lindau tumor suppressor 0.028
Irf2bp2 interferon regulatory factor 2 binding protein 2 0.028
Atf3 activating transcription factor 3 0.027
Purb purine rich element binding protein B 0.027
Ep300 E1A binding protein p300 0.027
Arid2 AT rich interactive domain 2 (ARID, RFX-like) 0.027
Akt1 thymoma viral proto-oncogene 1 0.027
Tnrc6a trinucleotide repeat containing 6a 0.026
Atp2b1 ATPase, Ca++ transporting, plasma membrane 1 0.026
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.025
Rhog ras homolog gene family, member G 0.025
Chd4 chromodomain helicase DNA binding protein 4 0.025
Xpot exportin, tRNA (nuclear export receptor for tRNAs) 0.024
D19Wsu162e DNA segment, Chr 19, Wayne State University 162, expressed 0.024
Dyrk1a dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a 0.022
Smad4 MAD homolog 4 (Drosophila) 0.022
Mael maelstrom homolog (Drosophila) 0.022
Pafah1b2 platelet-activating factor acetylhydrolase, isoform 1b, subunit 2 0.022
Pknox1 Pbx/knotted 1 homeobox 0.022
Nanos2 nanos homolog 2 (Drosophila) 0.021
Man1a2 mannosidase, alpha, class 1A, member 2 0.021
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.021
Ehmt2 euchromatic histone lysine N-methyltransferase 2 0.020
Taok1 TAO kinase 1 0.020
Bcl2 B-cell leukemia/lymphoma 2 0.020
Klf3 Kruppel-like factor 3 (basic) 0.020
Zmym5 zinc finger, MYM-type 5 0.020
Wdr36 WD repeat domain 36 0.019
Wdr77 WD repeat domain 77 0.019
Kctd20 potassium channel tetramerisation domain containing 20 0.019
Tnfrsf13b tumor necrosis factor receptor superfamily, member 13b 0.019
Map3k5 mitogen-activated protein kinase kinase kinase 5 0.019
Gspt1 G1 to S phase transition 1 0.019
Chd1l chromodomain helicase DNA binding protein 1-like 0.018
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Rattus norvegicus
Name Description Probability Func Analog Organism