The network for 'telomere maintenance via telomere lengthening' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

telomere maintenance via telomere lengthening

Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA.

Name Description Probability Func Analog Organism
EST2 Est2p 0.915
CDC13 Cdc13p 0.879
RFA2 Rfa2p 0.722
MEC1 Mec1p 0.688
RFA1 Rfa1p 0.674
SGS1 Sgs1p 0.469
STN1 Stn1p 0.407
TEL1 Tel1p 0.404
DNA2 Dna2p 0.388
NOP10 Nop10p 0.333
PIF1 Pif1p 0.310
RAD53 Rad53p 0.278
EST1 Est1p 0.242
TEN1 Ten1p 0.206
RIF1 Rif1p 0.155
DUN1 Dun1p 0.101
TTI2 Tti2p 0.080
RAD5 Rad5p 0.079
CSM2 Csm2p 0.072
MSH6 Msh6p 0.068
VAC17 Vac17p 0.067
YKU80 Yku80p 0.066
POL12 Pol12p 0.062
SWM2 Swm2p 0.061
SMC6 Smc6p 0.061
RFA3 Rfa3p 0.059
RIO1 Rio1p 0.056
PRI1 Pri1p 0.052
HHO1 Hho1p 0.051
RMI1 Rmi1p 0.050
POL1 Pol1p 0.047
YLR162W hypothetical protein 0.043
STI1 Sti1p 0.040
YDL156W hypothetical protein 0.038
YLR363W-A hypothetical protein 0.038
TOP3 Top3p 0.037
YOR390W hypothetical protein 0.037
RAD27 Rad27p 0.037
TBF1 Tbf1p 0.035
YBL081W hypothetical protein 0.035
PRS2 Prs2p 0.033
RRP36 Rrp36p 0.033
HHT2 Hht2p 0.033
POL32 Pol32p 0.032
RAP1 Rap1p 0.032
SRD1 Srd1p 0.032
YLR264C-A hypothetical protein 0.031
RIF2 Rif2p 0.031
URA3 Ura3p 0.031
MER1 Mer1p 0.030
SWC7 Swc7p 0.029
ARP10 Arp10p 0.029
LEU2 Leu2p 0.028
YOL038C-A hypothetical protein 0.028
YNR066C hypothetical protein 0.028
HCH1 Hch1p 0.027
GFD2 Gfd2p 0.025
THG1 Thg1p 0.025
HXT3 Hxt3p 0.025
MF(ALPHA)2 Mf(alpha)2p 0.025
FUR4 Fur4p 0.025
YLR126C hypothetical protein 0.025
YJR129C hypothetical protein 0.024
FKH1 Fkh1p 0.023
ARG8 Arg8p 0.023
RAD51 Rad51p 0.023
RAD55 Rad55p 0.023
SAE2 Sae2p 0.023
YLR042C hypothetical protein 0.022
TMA23 Tma23p 0.022
RAD9 Rad9p 0.022
SIR4 Sir4p 0.022
HO Hop 0.022
YAR068W hypothetical protein 0.022
ADH2 Adh2p 0.022
YPR157W hypothetical protein 0.022
MF(ALPHA)1 Mf(alpha)1p 0.021
RTT105 Rtt105p 0.021
STB1 Stb1p 0.021
YKR045C hypothetical protein 0.021
OGG1 Ogg1p 0.021
YHR127W hypothetical protein 0.021
SEN54 Sen54p 0.021
ATP6 Atp6p 0.021
MET8 Met8p 0.021
YNR071C hypothetical protein 0.021
CPR6 Cpr6p 0.020
YBR013C hypothetical protein 0.020
YIR035C hypothetical protein 0.020
BSC1 Bsc1p 0.020
YOL013W-A hypothetical protein 0.020
SFT1 Sft1p 0.020
ZPS1 Zps1p 0.020
DIF1 Dif1p 0.019
RTT107 Rtt107p 0.019
HPF1 Hpf1p 0.019
MIG2 Mig2p 0.019
AUA1 Aua1p 0.019
CUP1-1 Cup1-1p 0.019
REE1 Ree1p 0.019
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 1.000
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 0.999
TERF2 telomeric repeat binding factor 2 0.998
NBN nibrin 0.994
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.989
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1 0.954
TERF2IP telomeric repeat binding factor 2, interacting protein 0.938
ATM ataxia telangiectasia mutated 0.852
ACD adrenocortical dysplasia homolog (mouse) 0.778
FANCD2 Fanconi anemia, complementation group D2 0.706
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.525
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor 0.492
WRN Werner syndrome, RecQ helicase-like 0.418
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.370
TOP3A topoisomerase (DNA) III alpha 0.357
ORC2 origin recognition complex, subunit 2 0.344
STAG1 stromal antigen 1 0.221
MDC1 mediator of DNA-damage checkpoint 1 0.160
HUS1 HUS1 checkpoint homolog (S. pombe) 0.145
POT1 protection of telomeres 1 homolog (S. pombe) 0.138
BLM Bloom syndrome, RecQ helicase-like 0.124
FNBP1 formin binding protein 1 0.104
H2AFX H2A histone family, member X 0.089
MAPRE1 microtubule-associated protein, RP/EB family, member 1 0.074
SLX4 SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) 0.065
BANP BTG3 associated nuclear protein 0.050
MSH3 mutS homolog 3 (E. coli) 0.048
MAPK7 mitogen-activated protein kinase 7 0.047
RAD52 RAD52 homolog (S. cerevisiae) 0.041
FBXO4 F-box protein 4 0.038
TP53BP1 tumor protein p53 binding protein 1 0.032
TGIF1 TGFB-induced factor homeobox 1 0.024
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 0.024
RAD17 RAD17 homolog (S. pombe) 0.024
DCLRE1B DNA cross-link repair 1B 0.023
RPA2 replication protein A2, 32kDa 0.020
DAXX death-domain associated protein 0.018
SMG6 Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans) 0.012
AXIN1 axin 1 0.012
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Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 0.701
Chordc1 cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1 0.244
Hspa8 heat shock protein 8 0.047
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.045
Nphp4 nephronophthisis 4 (juvenile) homolog (human) 0.038
Rpgrip1l Rpgrip1-like 0.035
Skil SKI-like 0.027
Igh immunoglobulin heavy chain complex 0.023
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.023
Mdm4 transformed mouse 3T3 cell double minute 4 0.022
Msh2 mutS homolog 2 (E. coli) 0.021
Nphp1 nephronophthisis 1 (juvenile) homolog (human) 0.021
Wrn Werner syndrome homolog (human) 0.021
Rfc1 replication factor C (activator 1) 1 0.019
Ahi1 Abelson helper integration site 1 0.017
Smn1 survival motor neuron 1 0.017
Mcm7 minichromosome maintenance deficient 7 (S. cerevisiae) 0.016
Prkdc protein kinase, DNA activated, catalytic polypeptide 0.016
Pold1 polymerase (DNA directed), delta 1, catalytic subunit 0.015
Gja1 gap junction protein, alpha 1 0.013
Nup85 nucleoporin 85 0.013
Daxx Fas death domain-associated protein 0.012
Rrm1 ribonucleotide reductase M1 0.012
Ttn titin 0.011
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Rattus norvegicus
Name Description Probability Func Analog Organism