The network for 'response to salt stress' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to salt stress

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
CAB3 Cab3p 0.690
PSR2 Psr2p 0.565
MYO5 Myo5p 0.472
AQY2 Aqy2p 0.388
DOT6 Dot6p 0.299
MIG2 Mig2p 0.250
YKR015C hypothetical protein 0.172
VHS1 Vhs1p 0.152
GLN3 Gln3p 0.141
PSR1 Psr1p 0.133
VHS2 Vhs2p 0.122
MYO3 Myo3p 0.116
UBP9 Ubp9p 0.097
GAT2 Gat2p 0.097
NRG1 Nrg1p 0.095
GLE1 Gle1p 0.080
SIN3 Sin3p 0.074
HOT1 Hot1p 0.073
ENA5 Ena5p 0.073
MOB1 Mob1p 0.070
ZAP1 Zap1p 0.064
MIG3 Mig3p 0.061
SIS2 Sis2p 0.059
HXT7 Hxt7p 0.058
YPL150W hypothetical protein 0.058
CHD1 Chd1p 0.057
TBS1 Tbs1p 0.057
HXT3 Hxt3p 0.056
CKB1 Ckb1p 0.056
GAL11 Gal11p 0.056
DAL81 Dal81p 0.054
ROX1 Rox1p 0.054
ENA1 Ena1p 0.053
RPI1 Rpi1p 0.053
YPL014W hypothetical protein 0.052
PSK2 Psk2p 0.051
DSE3 Dse3p 0.051
MKS1 Mks1p 0.049
SPT20 Spt20p 0.049
SSP1 Ssp1p 0.049
NDE2 Nde2p 0.046
YKL187C hypothetical protein 0.046
HAL5 Hal5p 0.046
CNB1 Cnb1p 0.044
ARP8 Arp8p 0.043
BSD2 Bsd2p 0.043
UBR2 Ubr2p 0.042
SMP1 Smp1p 0.042
RSC9 Rsc9p 0.042
ATG29 Atg29p 0.041
ARO1 Aro1p 0.041
SGF73 Sgf73p 0.041
YKR075C hypothetical protein 0.041
WSC4 Wsc4p 0.041
ASM4 Asm4p 0.041
VID24 Vid24p 0.041
KAP95 Kap95p 0.040
FMP48 Fmp48p 0.040
MBR1 Mbr1p 0.040
YNL295W hypothetical protein 0.040
PHO80 Pho80p 0.039
GCN2 Gcn2p 0.039
VMA13 Vma13p 0.038
YNL194C hypothetical protein 0.038
CSR2 Csr2p 0.038
GAL7 Gal7p 0.037
ICY1 Icy1p 0.037
CAT8 Cat8p 0.037
PTC2 Ptc2p 0.036
RMA1 Rma1p 0.036
VHS3 Vhs3p 0.036
ENA2 Ena2p 0.035
FRT1 Frt1p 0.035
YLR297W hypothetical protein 0.035
YNL234W hypothetical protein 0.035
ARR3 Arr3p 0.034
PPZ1 Ppz1p 0.034
MET4 Met4p 0.034
PCL9 Pcl9p 0.033
STP3 Stp3p 0.033
PHO12 Pho12p 0.033
REG2 Reg2p 0.033
TAO3 Tao3p 0.033
VAC7 Vac7p 0.033
LYS5 Lys5p 0.033
VPS8 Vps8p 0.032
SDP1 Sdp1p 0.032
YMR102C hypothetical protein 0.032
TPO2 Tpo2p 0.032
YJR115W hypothetical protein 0.032
VPS27 Vps27p 0.032
KRE29 Kre29p 0.031
PNS1 Pns1p 0.031
YPL216W hypothetical protein 0.031
MSN1 Msn1p 0.031
RIM13 Rim13p 0.031
TOR2 Tor2p 0.031
YGR067C hypothetical protein 0.031
IME1 Ime1p 0.031
ADY2 Ady2p 0.031
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
nkb-3 Protein NKB-3 0.016
cat-1 Protein CAT-1 0.015
snx-17 Protein SNX-17 0.014
sma-3 Protein SMA-3 0.013
flt-1 Protein FLT-1 0.013
CELE_T01B11.2 Protein T01B11.2 0.012
F55H12.4 Protein F55H12.4 0.012
cnd-1 Protein CND-1 0.012
sta-1 Protein STA-1 0.011
soc-2 Protein SOC-2 0.011
dct-1 Protein DCT-1 0.011
ten-1 Protein TEN-1 0.011
rskn-2 Protein RSKN-2 0.010
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
slc26a3 solute carrier family 26, member 3 0.937
slc9a3.2 solute carrier family 9 (sodium/hydrogen exchanger), member 3.2 0.931
trpv6 transient receptor potential cation channel, subfamily V, member 6 0.924
slc26a4 solute carrier family 26, member 4 0.719
ca2 carbonic anhydrase II 0.711
ca15a carbonic anhydrase XV a 0.580
ef1a elongation factor 1-alpha 0.421
slc4a1b solute carrier family 4, anion exchanger, member 1b 0.419
rhcgb Rhesus blood group, C glycoprotein b 0.378
rhag Rhesus blood group-associated glycoprotein 0.359
atp6v1al ATPase, H+ transporting, lysosomal V1 subunit A, like 0.318
rhcgl1 Rhesus blood group, C glycoprotein, like 1 0.310
avpl arginine vasopressin-like 0.286
slc12a10.2 solute carrier family 12 (sodium/potassium/chloride transporters), member 10.2 0.249
mgp matrix Gla protein 0.236
unc45b unc-45 homolog B (C. elegans) 0.157
epas1b endothelial PAS domain protein 1b 0.143
si:ch211-284e13.2 si:ch211-284e13.2 0.133
ccng1 cyclin G1 0.132
slc3a2 solute carrier family 3, member 2 0.116
slc4a1a solute carrier family 4, anion exchanger, member 1a 0.108
LOC790901 glucose-dependent insulinotropic polypeptide 0.099
tm9sf2 transmembrane 9 superfamily member 2 0.098
slc17a8 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8 0.094
atp6v1a ATPase, H+ transporting, lysosomal V1 subunit A 0.085
pdzk1 PDZ domain containing 1 0.080
ahsg alpha-2-HS-glycoprotein 0.080
mstnb myostatin b 0.076
slc17a7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 0.074
pcdh15a protocadherin 15a 0.074
LOC100005108 novel protein similar to solute carrier family 26, member 5 (slc26a5) 0.072
lmo2 LIM domain only 2 (rhombotin-like 1) 0.067
zar1 zygote arrest 1 0.066
wnt10a wingless-type MMTV integration site family, member 10a 0.061
acsl4a acyl-CoA synthetase long-chain family member 4a 0.059
myog myogenin 0.059
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.050
gapdh glyceraldehyde-3-phosphate dehydrogenase 0.049
atp2b1a ATPase, Ca++ transporting, plasma membrane 1a 0.047
chuk conserved helix-loop-helix ubiquitous kinase 0.046
tmprss4a transmembrane protease, serine 4a 0.044
slc4a4b solute carrier family 4, sodium bicarbonate cotransporter, member 4b 0.042
camsap1l1 calmodulin regulated spectrin-associated protein 1-like 1 0.040
chrm2a cholinergic receptor, muscarinic 2a 0.039
fabp11a fatty acid binding protein 11a 0.039
zgc:56010 zgc:56010 0.036
pnrc2 proline-rich nuclear receptor coactivator 2 0.036
hspb1 heat shock protein, alpha-crystallin-related, 1 0.035
adra2b adrenergic, alpha-2B-, receptor 0.032
gnaia guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a 0.031
ccl-c11b chemokine CCL-C11b 0.030
slc2a1a solute carrier family 2 (facilitated glucose transporter), member 1a 0.030
pho phoenix 0.029
ednra endothelin receptor type A 0.029
LOC567131 calcitonin gene-related peptide type 1 receptor-like 0.028
nfe2l2 nuclear factor (erythroid-derived 2)-like 2 0.028
stac3 SH3 and cysteine rich domain 3 0.026
ptpn1 protein tyrosine phosphatase, non-receptor type 1 0.026
ptbp1a polypyrimidine tract binding protein 1a 0.025
clock clock 0.025
zfyve26 zinc finger, FYVE domain containing 26 0.024
eif3s10 eukaryotic translation initiation factor 3, subunit 10 (theta) 0.024
casrl calcium-sensing receptor, like 0.024
timp2a tissue inhibitor of metalloproteinase 2a 0.023
mbnl3 muscleblind-like 3 (Drosophila) 0.023
olig3 oligodendrocyte transcription factor 3 0.023
cyp1a cytochrome P450, family 1, subfamily A 0.023
slc16a3 solute carrier family 16 (monocarboxylic acid transporters), member 3 0.022
cldn12 claudin 12 0.022
cyp24a1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.022
zgc:92715 zgc:92715 0.022
nsfb N-ethylmaleimide-sensitive factor b 0.022
cldnh claudin h 0.022
bactin2 bactin2 0.021
ghrl ghrelin/obestatin preprohormone 0.021
cryaa crystallin, alpha A 0.021
nme2a non-metastatic cells 2a, protein (NM23B) expressed in 0.021
ntn2 netrin 2 0.021
plekha3 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3 0.020
dnajb1b DnaJ (Hsp40) homolog, subfamily B, member 1b 0.020
slc2a12 solute carrier family 2 (facilitated glucose transporter), member 12 0.020
tlr21 toll-like receptor 21 0.019
tfe3b transcription factor binding to IGHM enhancer 3b 0.019
calca calcitonin/calcitonin-related polypeptide, alpha 0.019
bbc3 BCL2 binding component 3 0.018
hdlbp high density lipoprotein-binding protein (vigilin) 0.018
rrm2b ribonucleotide reductase M2 b 0.017
exorh extra-ocular rhodopsin 0.017
ush1c Usher syndrome 1C (autosomal recessive, severe) 0.017
zgc:112334 zgc:112334 0.017
nras neuroblastoma RAS viral (v-ras) oncogene homolog 0.016
zorba Orb/CPEB-related RNA-binding protein 0.016
hsp70l heat shock cognate 70-kd protein, like 0.016
chn1 chimerin (chimaerin) 1 0.016
pdk2 pyruvate dehydrogenase kinase, isoenzyme 2 0.016
cyp51 cytochrome P450, family 51 0.016
cdh17 cadherin 17, LI cadherin (liver-intestine) 0.016
LOC100005504 Gig2-like protein DreL 0.016
smyhc1 slow myosin heavy chain 1 0.016
si:dkey-71l1.7 si:dkey-71l1.7 0.015
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Mekk1 CG7717 gene product from transcript CG7717-RB 0.406
Nmdar2 NMDA receptor 2 0.241
Ca-beta Ca2+-channel-protein-beta-subunit 0.226
ppk11 pickpocket 11 0.118
CG12370 CG12370 gene product from transcript CG12370-RB 0.094
Mpk2 CG5475 gene product from transcript CG5475-RB 0.084
plx pollux 0.076
Rel Relish 0.059
CG32635 CG32635 gene product from transcript CG32635-RA 0.057
cwo clockwork orange 0.052
Atf-2 Activating transcription factor-2 0.048
spo spook 0.038
Irk3 Inwardly rectifying potassium channel 3 0.036
CG11398 CG11398 gene product from transcript CG11398-RA 0.036
Gr32a Gustatory receptor 32a 0.035
CG6776 CG6776 gene product from transcript CG6776-RA 0.034
CG33289 CG33289 gene product from transcript CG33289-RA 0.033
CG14864 CG14864 gene product from transcript CG14864-RB 0.032
Gyc76C Guanylyl cyclase at 76C 0.031
p38b CG7393 gene product from transcript CG7393-RA 0.028
mp multiplexin 0.027
Tbh Tyramine beta hydroxylase 0.027
CG32792 CG32792 gene product from transcript CG32792-RF 0.026
CG11071 CG11071 gene product from transcript CG11071-RA 0.026
CG4328 CG4328 gene product from transcript CG4328-RB 0.026
5-HT7 Serotonin receptor 7 0.026
Nach CG8178 gene product from transcript CG8178-RA 0.026
tweek CG42555 gene product from transcript CG42555-RD 0.025
Rab7 Rab-protein 7 0.025
Gr33a Gustatory receptor 33a 0.024
mth methuselah 0.022
CG9339 CG9339 gene product from transcript CG9339-RG 0.021
CG5001 CG5001 gene product from transcript CG5001-RA 0.020
Ric Ras which interacts with Calmodulin 0.020
dib disembodied 0.019
CG13792 CG13792 gene product from transcript CG13792-RA 0.019
CG13117 CG13117 gene product from transcript CG13117-RA 0.019
Gr59c Gustatory receptor 59c 0.019
CG13568 CG13568 gene product from transcript CG13568-RG 0.019
kat-60L1 katanin p60-like 1 0.018
Gr64c Gustatory receptor 64c 0.017
Tpi Triose phosphate isomerase 0.017
cert ceramide transfer protein 0.017
CG11317 CG11317 gene product from transcript CG11317-RA 0.016
Hnf4 Hepatocyte nuclear factor 4 0.016
ppk25 pickpocket 25 0.016
CG10431 CG10431 gene product from transcript CG10431-RA 0.016
Pkg21D cGMP-dependent protein kinase 21D 0.015
sima similar 0.015
Spn77Ba Serpin 77Ba 0.014
CG34388 CG34388 gene product from transcript CG34388-RC 0.014
Or46a Odorant receptor 46a 0.014
CG14401 CG14401 gene product from transcript CG14401-RA 0.013
stnB stoned B 0.013
nompC no mechanoreceptor potential C 0.013
Gr64a Gustatory receptor 64a 0.012
CG14234 CG14234 gene product from transcript CG14234-RA 0.012
NAAT1 Nutrient Amino Acid Transporter 1 0.012
AR-2 Allatostatin Receptor 2 0.012
Gr43a Gustatory receptor 43a 0.012
Rapgap1 CG34374 gene product from transcript CG34374-RD 0.012
CG13506 CG13506 gene product from transcript CG13506-RA 0.012
CG12522 CG12522 gene product from transcript CG12522-RA 0.012
Rim CG33547 gene product from transcript CG33547-RB 0.012
gcm2 CG3858 gene product from transcript CG3858-RA 0.011
CG14369 CG14369 gene product from transcript CG14369-RA 0.011
Tsp29Fb Tetraspanin 29Fb 0.011
CG8765 CG8765 gene product from transcript CG8765-RA 0.011
ppk pickpocket 0.011
CG2678 CG2678 gene product from transcript CG2678-RA 0.011
Gr39a Gustatory receptor 39a 0.011
whd withered 0.011
Mvl Malvolio 0.010
ClC-b Chloride channel-b 0.010
pain painless 0.010
syd sunday driver 0.010
Gr64f Gustatory receptor 64f 0.010
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
MAPK14 mitogen-activated protein kinase 14 1.000
SCNN1B sodium channel, nonvoltage-gated 1, beta 0.978
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.956
SNTA1 syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component) 0.812
SMN1 survival of motor neuron 1, telomeric 0.794
MAPK1 mitogen-activated protein kinase 1 0.772
DNM2 dynamin 2 0.752
ZFP36L1 zinc finger protein 36, C3H type-like 1 0.736
CCR5 chemokine (C-C motif) receptor 5 0.732
PAX8 paired box 8 0.731
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 0.726
SP1 Sp1 transcription factor 0.725
LRRK2 leucine-rich repeat kinase 2 0.672
MAP2K6 mitogen-activated protein kinase kinase 6 0.603
FASLG Fas ligand (TNF superfamily, member 6) 0.598
MKNK1 MAP kinase interacting serine/threonine kinase 1 0.570
MAPK3 mitogen-activated protein kinase 3 0.568
DUSP1 dual specificity phosphatase 1 0.562
ANXA7 annexin A7 0.548
NCOA3 nuclear receptor coactivator 3 0.526
MAPK11 mitogen-activated protein kinase 11 0.517
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 0.507
MED31 mediator complex subunit 31 0.492
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 0.487
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.486
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like 0.481
HSF1 heat shock transcription factor 1 0.449
BAK1 BCL2-antagonist/killer 1 0.441
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.401
CRH corticotropin releasing hormone 0.382
ATF2 activating transcription factor 2 0.372
TTN titin 0.346
MAP2K3 mitogen-activated protein kinase kinase 3 0.322
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.299
DUSP9 dual specificity phosphatase 9 0.282
ATXN3 ataxin 3 0.258
RNF144B ring finger protein 144B 0.241
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.237
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.233
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor 0.216
SCNN1A sodium channel, nonvoltage-gated 1 alpha 0.208
DUSP7 dual specificity phosphatase 7 0.205
ADAMTSL4 ADAMTS-like 4 0.197
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 0.193
SUMO3 SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae) 0.189
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.160
CPNE6 copine VI (neuronal) 0.158
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 0.147
WNK1 WNK lysine deficient protein kinase 1 0.146
SOCS3 suppressor of cytokine signaling 3 0.144
DUSP16 dual specificity phosphatase 16 0.127
RB1 retinoblastoma 1 0.124
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.121
KCTD17 potassium channel tetramerisation domain containing 17 0.118
FAM107A family with sequence similarity 107, member A 0.117
ARHGAP9 Rho GTPase activating protein 9 0.111
FNBP1 formin binding protein 1 0.096
FGFR1 fibroblast growth factor receptor 1 0.094
ZNF431 zinc finger protein 431 0.092
RNR2 l-rRNA 0.092
PKM2 pyruvate kinase, muscle 0.092
FAM48A family with sequence similarity 48, member A 0.091
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.090
TYK2 tyrosine kinase 2 0.089
SCNN1G sodium channel, nonvoltage-gated 1, gamma 0.088
OBSL1 obscurin-like 1 0.086
PHC2 polyhomeotic homolog 2 (Drosophila) 0.084
SNX9 sorting nexin 9 0.080
UBE2D1 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) 0.079
DNM1 dynamin 1 0.078
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.078
VDAC1 voltage-dependent anion channel 1 0.075
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 0.071
HSPB1 heat shock 27kDa protein 1 0.070
EGLN3 egl nine homolog 3 (C. elegans) 0.070
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 0.069
EPN1 epsin 1 0.068
PACSIN1 protein kinase C and casein kinase substrate in neurons 1 0.063
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.062
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.059
FLNB filamin B, beta 0.057
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.057
CEP110 centrosomal protein 110kDa 0.055
KAT2B K(lysine) acetyltransferase 2B 0.055
C2orf18 chromosome 2 open reading frame 18 0.055
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.054
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D 0.054
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 0.054
DPP4 dipeptidyl-peptidase 4 0.054
IQGAP1 IQ motif containing GTPase activating protein 1 0.054
EGLN1 egl nine homolog 1 (C. elegans) 0.054
BAD BCL2-associated agonist of cell death 0.053
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 0.052
HOXA1 homeobox A1 0.050
PKN1 protein kinase N1 0.050
NDFIP2 Nedd4 family interacting protein 2 0.047
KIAA1033 KIAA1033 0.046
MAPK15 mitogen-activated protein kinase 15 0.045
NEB nebulin 0.045
GNLY granulysin 0.041
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Hspa8 heat shock protein 8 0.236
Hsph1 heat shock 105/110 protein 1 0.096
Scnn1g sodium channel, nonvoltage-gated 1, gamma 0.035
Slc4a1 solute carrier family 4 (anion exchanger), member 1 0.034
Ubb ubiquitin B 0.031
Prol1 proline rich, lacrimal 1 0.030
Hrh2 histamine receptor H 2 0.027
Slc22a25 solute carrier family 22, member 25 0.023
Grk1 G protein-coupled receptor kinase 1 0.021
Calcr calcitonin receptor 0.021
Reg3b regenerating islet-derived 3 beta 0.018
Ugt8 UDP glycosyltransferase 8 0.016
Fosl1 fos-like antigen 1 0.014
Ccl2 chemokine (C-C motif) ligand 2 0.014
Gstm2 glutathione S-transferase mu 2 0.014
Stip1 stress-induced phosphoprotein 1 0.013
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.013
Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 0.012
Cckar cholecystokinin A receptor 0.012
Pip prolactin induced protein 0.012
Ptger1 prostaglandin E receptor 1 (subtype EP1) 0.012
Gzmk granzyme K 0.012
Lalba lactalbumin, alpha 0.011
Ccl3 chemokine (C-C motif) ligand 3 0.011
Olr226 olfactory receptor 226 0.011
Gabrp gamma-aminobutyric acid (GABA-A) receptor, pi 0.011
Dlx5 distal-less homeobox 5 0.011
Stra6 stimulated by retinoic acid gene 6 0.011
Prl prolactin 0.010
Folh1 folate hydrolase 1 0.010
Accn2 amiloride-sensitive cation channel 2, neuronal 0.010