The network for 'proteasomal protein catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

proteasomal protein catabolic process

The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
CDC48 Cdc48p 1.000
SKP1 Skp1p 0.994
KAR2 Kar2p 0.987
PRE2 Pre2p 0.979
PRE1 Pre1p 0.978
UFD1 Ufd1p 0.977
UBP6 Ubp6p 0.975
NPL4 Npl4p 0.973
CDC23 Cdc23p 0.968
PRE6 Pre6p 0.961
MND2 Mnd2p 0.960
HRD1 Hrd1p 0.951
ECM29 Ecm29p 0.946
RPT6 Rpt6p 0.937
RPT2 Rpt2p 0.934
RPN10 Rpn10p 0.932
PRE10 Pre10p 0.930
RAD23 Rad23p 0.926
RPT1 Rpt1p 0.924
PPH22 Pph22p 0.923
CDC27 Cdc27p 0.919
UFD2 Ufd2p 0.908
DOC1 Doc1p 0.906
PPH21 Pph21p 0.903
SWM1 Swm1p 0.888
FYV10 Fyv10p 0.882
CDC16 Cdc16p 0.876
APC2 Apc2p 0.863
PUP1 Pup1p 0.858
APC5 Apc5p 0.852
PRE7 Pre7p 0.847
VID30 Vid30p 0.839
PRE5 Pre5p 0.830
UBX2 Ubx2p 0.813
SCL1 Scl1p 0.811
GID7 Gid7p 0.810
UBC7 Ubc7p 0.800
RPN11 Rpn11p 0.800
MAD2 Mad2p 0.796
CDC53 Cdc53p 0.777
KSP1 Ksp1p 0.777
RMD5 Rmd5p 0.775
OTU1 Otu1p 0.774
PRE8 Pre8p 0.769
UBR1 Ubr1p 0.767
CDC26 Cdc26p 0.763
PUP3 Pup3p 0.740
PRE4 Pre4p 0.721
UMP1 Ump1p 0.713
PUP2 Pup2p 0.700
CDC34 Cdc34p 0.698
YOS9 Yos9p 0.683
PRE9 Pre9p 0.681
CDC55 Cdc55p 0.668
RPT3 Rpt3p 0.658
APC1 Apc1p 0.655
RPN13 Rpn13p 0.655
RPT4 Rpt4p 0.634
CUR1 Cur1p 0.627
RPN12 Rpn12p 0.623
YBP2 Ybp2p 0.622
MUB1 Mub1p 0.590
APC4 Apc4p 0.587
YPI1 Ypi1p 0.557
DSK2 Dsk2p 0.554
CTF13 Ctf13p 0.545
RAD6 Rad6p 0.543
RPN9 Rpn9p 0.537
MET30 Met30p 0.535
CDC4 Cdc4p 0.531
CDC20 Cdc20p 0.526
MOH1 Moh1p 0.523
YPT1 Ypt1p 0.523
RPN4 Rpn4p 0.512
RPN7 Rpn7p 0.511
HRT1 Hrt1p 0.505
HRD3 Hrd3p 0.497
DER1 Der1p 0.482
SCJ1 Scj1p 0.474
APC11 Apc11p 0.440
GRR1 Grr1p 0.439
VPS27 Vps27p 0.438
DFM1 Dfm1p 0.436
REG1 Reg1p 0.433
MAD3 Mad3p 0.399
BUB3 Bub3p 0.398
SLK19 Slk19p 0.397
SSM4 Ssm4p 0.396
RPN2 Rpn2p 0.391
YLR352W hypothetical protein 0.390
APP1 App1p 0.377
YNL155W hypothetical protein 0.372
UBA1 Uba1p 0.367
RKR1 Rkr1p 0.353
CUE1 Cue1p 0.350
SSE2 Sse2p 0.341
IRC15 Irc15p 0.340
UBX7 Ubx7p 0.314
BCK1 Bck1p 0.310
RPN3 Rpn3p 0.307
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
rpn-7 Protein RPN-7 0.492
rpn-12 Protein RPN-12 0.414
pas-4 Protein PAS-4 0.407
pas-2 Protein PAS-2 0.350
pbs-3 Protein PBS-3 0.333
rpt-5 Protein RPT-5 0.319
rpn-3 Protein RPN-3 0.300
npl-4.2 Protein NPL-4.2 0.293
rpt-2 Protein RPT-2 0.288
rpt-3 Protein RPT-3 0.287
pbs-5 Protein PBS-5 0.270
pbs-2 Protein PBS-2 0.188
cul-1 Protein CUL-1 0.185
rpn-2 Protein RPN-2 0.138
rpn-6.1 Protein RPN-6.1 0.131
imb-2 Protein IMB-2 0.124
pbs-1 Protein PBS-1 0.112
pas-1 Protein PAS-1 0.102
daf-21 Protein DAF-21 0.101
mig-5 Protein MIG-5 0.093
F25B3.6 Protein F25B3.6 0.091
CELE_K08F4.1 Protein K08F4.1 0.090
bub-1 Protein BUB-1 0.090
app-1 Protein APP-1 0.088
rpt-4 Protein RPT-4 0.084
syx-17 Protein SYX-17 0.080
npl-4.1 Protein NPL-4.1 0.075
rpn-5 Protein RPN-5 0.072
pbs-7 Protein PBS-7 0.070
rod-1 Protein ROD-1 0.070
egl-18 Protein EGL-18 0.069
pbs-6 Protein PBS-6 0.066
F37A4.1 Protein F37A4.1 0.063
R11A8.7 Protein R11A8.7 0.062
pbs-4 Protein PBS-4 0.062
tba-2 Protein TBA-2 0.061
zyg-9 Protein ZYG-9 0.060
taf-5 Protein TAF-5 0.059
gpr-2 Protein GPR-2 0.059
atx-3 Protein ATX-3 0.058
pcn-1 Protein PCN-1 0.056
ebp-2 Protein EBP-2 0.054
rpn-1 Protein RPN-1 0.053
ima-2 Protein IMA-2 0.052
hgrs-1 Protein HGRS-1 0.052
dnj-12 Protein DNJ-12 0.051
his-42 Protein HIS-42 0.049
rad-26 Protein RAD-26 0.045
stam-1 Protein STAM-1 0.045
csn-3 Protein CSN-3 0.044
C49H3.9 Protein C49H3.9 0.044
zen-4 Protein ZEN-4 0.043
ima-3 Protein IMA-3 0.040
mdf-2 Protein MDF-2 0.038
K08E3.5 Protein K08E3.5 0.036
rpn-9 Protein RPN-9 0.035
CELE_F52C6.12 Protein F52C6.12 0.034
pas-6 Protein PAS-6 0.034
dsh-2 Protein DSH-2 0.033
K02B2.1 Protein K02B2.1 0.031
dpy-30 Protein DPY-30 0.031
ztf-7 Protein ZTF-7 0.030
Y71H2AM.20 Protein Y71H2AM.20 0.029
B0041.5 Protein B0041.5 0.028
D1081.8 Protein D1081.8 0.028
klp-16 Protein KLP-16 0.027
ubq-1 Protein UBQ-1 0.027
cdc-48.2 Protein CDC-48.2 0.026
ran-1 Protein RAN-1 0.026
pas-3 Protein PAS-3 0.026
pas-7 Protein PAS-7 0.026
pap-1 Protein PAP-1 0.026
C35A5.8 Protein C35A5.8 0.025
prp-21 Protein PRP-21 0.025
W09D10.1 Protein W09D10.1 0.025
xbp-1 Protein XBP-1 0.025
sel-12 Protein SEL-12 0.025
F08B4.7 Protein F08B4.7 0.024
asb-1 Protein ASB-1 0.024
mom-2 Protein MOM-2 0.024
pup-2 Protein PUP-2 0.024
emo-1 Protein EMO-1 0.024
his-6 Protein HIS-6 0.024
rsp-7 Protein RSP-7 0.023
lsy-22 Protein LSY-22 0.023
ZC434.8 Protein ZC434.8 0.023
par-5 Protein PAR-5 0.023
F46F11.6 Protein F46F11.6 0.022
dlc-1 Protein DLC-1 0.022
rpt-1 Protein RPT-1 0.022
CELE_B0334.5 Protein B0334.5 0.022
csnk-1 Protein CSNK-1 0.022
tbb-2 Protein TBB-2 0.022
hsp-1 Protein HSP-1 0.022
T22C1.1 Protein T22C1.1 0.021
Y47D3A.29 Protein Y47D3A.29 0.021
pri-2 Protein PRI-2 0.021
C23H3.3 Protein C23H3.3 0.021
CELE_F20D1.3 Protein F20D1.3 0.021
swsn-6 Protein SWSN-6 0.021
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
psmd6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.827
psma6a proteasome (prosome, macropain) subunit, alpha type, 6a 0.772
psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.760
zgc:92775 zgc:92775 0.719
psma4 proteasome (prosome, macropain) subunit, alpha type, 4 0.660
psmb1 proteasome (prosome, macropain) subunit, beta type, 1 0.654
psma8 proteasome (prosome, macropain) subunit, alpha type, 8 0.635
psmd12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.634
psmb4 proteasome (prosome, macropain) subunit, beta type, 4 0.629
psmb7 proteasome (prosome, macropain) subunit, beta type, 7 0.596
psmb3 proteasome (prosome, macropain) subunit, beta type, 3 0.586
hspa4b heat shock protein 4b 0.554
hspa5 heat shock protein 5 0.526
psma1 proteasome (prosome, macropain) subunit, alpha type, 1 0.518
psmc4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.515
tacc3 transforming, acidic coiled-coil containing protein 3 0.512
psmb5 proteasome (prosome, macropain) subunit, beta type, 5 0.476
adrm1b adhesion regulating molecule 1b 0.458
psmb2 proteasome (prosome, macropain) subunit, beta type, 2 0.456
psmc6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.455
psmd1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.454
si:rp71-45k5.4 si:rp71-45k5.4 0.443
psmc1b proteasome (prosome, macropain) 26S subunit, ATPase, 1b 0.428
psmd13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 0.420
psma2 proteasome (prosome, macropain) subunit, alpha type, 2 0.370
ywhabb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b 0.368
kif23 kinesin family member 23 0.350
bnip3lb BCL2/adenovirus E1B interacting protein 3-like b 0.337
psmc3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 0.328
ck2b casein kinase 2 beta 0.326
dnajc3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.322
usp5 ubiquitin specific protease 5 0.321
ccnb1 cyclin B1 0.314
max myc-associated factor X 0.309
zgc:86903 zgc:86903 0.308
smad9 MAD homolog 9 (Drosophila) 0.295
zgc:123326 zgc:123326 0.288
chuk conserved helix-loop-helix ubiquitous kinase 0.286
psmc1a proteasome (prosome, macropain) 26S subunit, ATPase, 1a 0.264
syvn1 synovial apoptosis inhibitor 1, synoviolin 0.264
nup93 nucleoporin 93 0.264
kpna4 karyopherin alpha 4 (importin alpha 3) 0.253
psmc5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.240
hyou1 hypoxia up-regulated 1 0.226
zgc:110116 zgc:110116 0.224
bsdc1 BSD domain containing 1 0.215
eif1b eukaryotic translation initiation factor 1B 0.213
blmh bleomycin hydrolase 0.213
ccna2 cyclin A2 0.206
ythdf1 YTH domain family, member 1 0.205
cdc20 cell division cycle 20 homolog 0.204
vcp valosin containing protein 0.204
rqcd1 RCD1 required for cell differentiation1 homolog (S. pombe) 0.196
psmb11 proteasome (prosome, macropain) subunit, beta type, 11 0.183
flii flightless I homolog (Drosophila) 0.180
hist2h2l histone 2, H2, like 0.179
arpp19a cAMP-regulated phosphoprotein 19a 0.176
psmd3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 0.171
btg2 B-cell translocation gene 2 0.171
ciapin1 cytokine induced apoptosis inhibitor 1 0.169
aurkb aurora kinase B 0.166
cdca8 cell division cycle associated 8 0.165
mobkl3 MOB1, Mps One Binder kinase activator-like 3 (yeast) 0.165
mxa myxovirus (influenza) resistance A 0.163
hnrpkl heterogeneous nuclear ribonucleoprotein K, like 0.163
ywhaba tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a 0.163
gmnn geminin, DNA replication inhibitor 0.160
ik IK cytokine 0.159
fxr2 fragile X mental retardation, autosomal homolog 2 0.158
ypel3 yippee-like 3 0.158
psmd4b proteasome (prosome, macropain) 26S subunit, non-ATPase, 4b 0.154
psma6b proteasome (prosome, macropain) subunit, alpha type, 6b 0.154
skp2 S-phase kinase-associated protein 2 (p45) 0.153
psmb6 proteasome (prosome, macropain) subunit, beta type, 6 0.153
sirt1 sirtuin (silent mating type information regulation 2 homolog) 1 0.149
tfap2a transcription factor AP-2 alpha 0.149
ddx42 DEAD (Asp-Glu-Ala-Asp) box polypeptide 42 0.147
ube2g2 ubiquitin-conjugating enzyme E2G 2 0.147
polr2b polymerase (RNA) II (DNA directed) polypeptide B 0.144
cand1 cullin-associated and neddylation-dissociated 1 0.142
prkrir protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) 0.141
psmb8 proteasome (prosome, macropain) subunit, beta type, 8 0.140
tp53 tumor protein p53 0.139
si:ch211-69g19.2 si:ch211-69g19.2 0.137
gspt1l G1 to S phase transition 1, like 0.135
tfpi2 tissue factor pathway inhibitor 2 0.135
dusp1 dual specificity phosphatase 1 0.133
hug HuG 0.132
dvl3 dishevelled, dsh homolog 3 (Drosophila) 0.131
kpna2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 0.130
cdh1 cadherin 1, epithelial 0.128
klhdc10 kelch domain containing 10 0.128
tram1 translocating chain-associating membrane protein 1 0.127
baxa bcl2-associated X protein, a 0.127
gdi2 GDP dissociation inhibitor 2 0.127
rtkn2 rhotekin 2 0.126
bc2 putative breast adenocarcinoma marker 0.123
cdt1 chromatin licensing and DNA replication factor 1 0.122
psmb10 proteasome (prosome, macropain) subunit, beta type, 10 0.122
psmd11a proteasome (prosome, macropain) 216S subunit, non-ATPase, 11a 0.121
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
tefu telomere fusion 0.918
Ras85D Ras oncogene at 85D 0.841
Prosbeta2 Proteasome beta2 subunit 0.829
Mov34 CG3416 gene product from transcript CG3416-RA 0.684
Pros26.4 Proteasome 26S subunit subunit 4 ATPase 0.670
Rpt3 CG16916 gene product from transcript CG16916-RA 0.642
brm brahma 0.625
Rpn9 CG10230 gene product from transcript CG10230-RB 0.606
Rpt4 CG3455 gene product from transcript CG3455-RA 0.564
Rpt1 CG1341 gene product from transcript CG1341-RA 0.502
Prosbeta1 Proteasome beta1 subunit 0.478
Pros29 Proteasome 29kD subunit 0.466
nej nejire 0.453
CycB3 Cyclin B3 0.428
CG13349 CG13349 gene product from transcript CG13349-RA 0.415
UbcD2 Ubiquitin conjugating enzyme 2 0.405
Pros54 Proteasome 54kD subunit 0.384
Rpn2 CG11888 gene product from transcript CG11888-RA 0.378
flfl falafel 0.360
Incenp Inner centromere protein 0.336
Rpn11 CG18174 gene product from transcript CG18174-RA 0.330
Prosalpha7 Proteasome alpha7 subunit 0.327
Tbp-1 Tat-binding protein-1 0.320
Rpn1 CG7762 gene product from transcript CG7762-RA 0.311
Stat92E Signal-transducer and activator of transcription protein at 92E 0.300
Pros45 CG1489 gene product from transcript CG1489-RA 0.298
Pros28.1 Proteasome 28kD subunit 1 0.287
dos daughter of sevenless 0.280
ago archipelago 0.277
Rab11 Rab-protein 11 0.270
lin19 lin-19-like 0.265
slmb supernumerary limbs 0.254
Prosbeta3 Proteasome beta3 subunit 0.243
Prosalpha5 Proteasome alpha5 subunit 0.239
Rpn6 Proteasome p44.5 subunit 0.238
dsh dishevelled 0.235
swm second mitotic wave missing 0.226
ncd non-claret disjunctional 0.225
Rpn7 CG5378 gene product from transcript CG5378-RA 0.219
14-3-3epsilon CG31196 gene product from transcript CG31196-RA 0.218
CycB Cyclin B 0.210
Prosbeta5 Proteasome beta5 subunit 0.202
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.196
Top1 Topoisomerase 1 0.192
CG12321 CG12321 gene product from transcript CG12321-RA 0.187
geminin CG3183 gene product from transcript CG3183-RA 0.178
CycD Cyclin D 0.176
Stim Stromal interaction molecule 0.169
Sara Smad anchor for receptor activation 0.165
CSN4 COP9 complex homolog subunit 4 0.165
Tab2 TAK1-associated binding protein 2 0.162
CG6961 CG6961 gene product from transcript CG6961-RA 0.160
Iswi Imitation SWI 0.160
disp dispatched 0.157
Prosbeta7 Proteasome beta7 subunit 0.157
skd skuld 0.155
hpo hippo 0.155
dco discs overgrown 0.149
CG5555 CG5555 gene product from transcript CG5555-RA 0.146
nct nicastrin 0.145
Pros35 Proteasome 35kD subunit 0.144
Tip60 CG6121 gene product from transcript CG6121-RA 0.140
krz kurtz 0.140
Rpd3 CG7471 gene product from transcript CG7471-RA 0.136
fzy fizzy 0.133
brat brain tumor 0.133
Rpn5 CG1100 gene product from transcript CG1100-RA 0.132
cav caravaggio 0.128
Cam Calmodulin 0.126
pr-set7 CG3307 gene product from transcript CG3307-RC 0.125
smo smoothened 0.123
Cdc37 CG12019 gene product from transcript CG12019-RA 0.123
wdb widerborst 0.122
Mcm10 Sensitized chromosome inheritance modifier 19 0.120
Cul-5 Cullin-5 0.119
ras raspberry 0.118
p53 CG33336 gene product from transcript CG33336-RB 0.118
dup double parked 0.118
pim pimples 0.113
pie pineapple eye 0.111
CG4673 CG4673 gene product from transcript CG4673-RB 0.111
p47 CG11139 gene product from transcript CG11139-RA 0.110
RYBP Ring and YY1 Binding Protein 0.104
Cap-G CG34438 gene product from transcript CG34438-RF 0.101
CanB2 Calcineurin B2 0.100
CG32581 CG32581 gene product from transcript CG32581-RB 0.100
CG17331 CG17331 gene product from transcript CG17331-RA 0.100
RASSF8 CG5053 gene product from transcript CG5053-RA 0.098
SAK Sak kinase 0.096
CG9772 CG9772 gene product from transcript CG9772-RB 0.096
CG8290 CG8290 gene product from transcript CG8290-RA 0.093
Rpn3 Regulatory particle non-ATPase 3 0.093
Nipped-A CG33554 gene product from transcript CG33554-RE 0.093
Akt1 CG4006 gene product from transcript CG4006-RA 0.092
Herp Homocysteine-induced endoplasmic reticulum protein 0.092
Fcp1 CG12252 gene product from transcript CG12252-RA 0.091
jar jaguar 0.089
CG8974 CG8974 gene product from transcript CG8974-RD 0.087
CycE Cyclin E 0.087
Sep2 Septin-2 0.086
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 1.000
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 1.000
CUL1 cullin 1 1.000
UBC ubiquitin C 1.000
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 1.000
TP53 tumor protein p53 1.000
SKP1 S-phase kinase-associated protein 1 0.999
VCP valosin containing protein 0.999
CUL3 cullin 3 0.999
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.998
RNF11 ring finger protein 11 0.997
UBE2D2 ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) 0.995
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 0.994
UBE2D3 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) 0.993
CDC20 cell division cycle 20 homolog (S. cerevisiae) 0.989
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.989
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 0.988
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.988
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.987
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.987
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.985
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 0.984
UBQLN1 ubiquilin 1 0.981
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.980
RBX1 ring-box 1, E3 ubiquitin protein ligase 0.980
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 0.977
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.976
BTRC beta-transducin repeat containing 0.975
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 0.974
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.973
SKP2 S-phase kinase-associated protein 2 (p45) 0.972
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.967
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 0.963
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.957
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 0.954
COPS5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) 0.954
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 0.952
CDK2 cyclin-dependent kinase 2 0.950
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.948
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 0.938
BUB1B budding uninhibited by benzimidazoles 1 homolog beta (yeast) 0.933
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 0.932
PLK1 polo-like kinase 1 0.931
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 0.927
GSK3B glycogen synthase kinase 3 beta 0.923
XIAP X-linked inhibitor of apoptosis 0.923
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.920
SMAD2 SMAD family member 2 0.920
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) 0.918
YY1 YY1 transcription factor 0.908
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 0.900
OTUB1 OTU domain, ubiquitin aldehyde binding 1 0.899
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 0.896
CDC27 cell division cycle 27 homolog (S. cerevisiae) 0.895
CCNB1 cyclin B1 0.894
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 0.893
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.890
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.886
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) 0.882
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2 0.881
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.878
MDM4 Mdm4 p53 binding protein homolog (mouse) 0.852
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 0.842
SMAD4 SMAD family member 4 0.837
ATXN3 ataxin 3 0.837
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.833
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.830
POMP proteasome maturation protein 0.825
SQSTM1 sequestosome 1 0.809
ANAPC7 anaphase promoting complex subunit 7 0.807
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 0.797
HUWE1 HECT, UBA and WWE domain containing 1 0.796
RB1 retinoblastoma 1 0.791
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.785
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.785
CCNA2 cyclin A2 0.775
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.770
RFWD2 ring finger and WD repeat domain 2 0.763
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.748
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.743
UFD1L ubiquitin fusion degradation 1 like (yeast) 0.739
CKS1B CDC28 protein kinase regulatory subunit 1B 0.730
UBA1 ubiquitin-like modifier activating enzyme 1 0.721
FBXW11 F-box and WD repeat domain containing 11 0.719
RAD23B RAD23 homolog B (S. cerevisiae) 0.706
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.705
CREBBP CREB binding protein 0.702
SYVN1 synovial apoptosis inhibitor 1, synoviolin 0.702
ADRM1 adhesion regulating molecule 1 0.699
HDAC1 histone deacetylase 1 0.698
FBXW2 F-box and WD repeat domain containing 2 0.682
BIRC2 baculoviral IAP repeat containing 2 0.671
UBE2D1 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) 0.656
FBXO5 F-box protein 5 0.646
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 0.639
BRCA1 breast cancer 1, early onset 0.637
SMAD1 SMAD family member 1 0.632
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.628
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.627
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.623
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 0.999
Ctnnb1 catenin (cadherin associated protein), beta 1 0.997
Psmd4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.983
Psma2 proteasome (prosome, macropain) subunit, alpha type 2 0.975
Mdm2 transformed mouse 3T3 cell double minute 2 0.963
Psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.954
Pten phosphatase and tensin homolog 0.936
Psma5 proteasome (prosome, macropain) subunit, alpha type 5 0.935
Psmb7 proteasome (prosome, macropain) subunit, beta type 7 0.920
Psmb6 proteasome (prosome, macropain) subunit, beta type 6 0.917
Psma7 proteasome (prosome, macropain) subunit, alpha type 7 0.913
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.904
Psma6 proteasome (prosome, macropain) subunit, alpha type 6 0.904
Psmc3 proteasome (prosome, macropain) 26S subunit, ATPase 3 0.868
Vhl von Hippel-Lindau tumor suppressor 0.868
Psma1 proteasome (prosome, macropain) subunit, alpha type 1 0.844
Per1 period homolog 1 (Drosophila) 0.844
Axin1 axin 1 0.822
Vcp valosin containing protein 0.799
Clock circadian locomotor output cycles kaput 0.797
Cdk1 cyclin-dependent kinase 1 0.786
Stat3 signal transducer and activator of transcription 3 0.772
Usp9x ubiquitin specific peptidase 9, X chromosome 0.768
Per2 period homolog 2 (Drosophila) 0.756
Ccnb1 cyclin B1 0.751
Smurf2 SMAD specific E3 ubiquitin protein ligase 2 0.748
Mbd3 methyl-CpG binding domain protein 3 0.737
Psmb4 proteasome (prosome, macropain) subunit, beta type 4 0.726
Arhgef7 Rho guanine nucleotide exchange factor (GEF7) 0.722
Cops2 COP9 (constitutive photomorphogenic) homolog, subunit 2 (Arabidopsis thaliana) 0.715
Gsk3b glycogen synthase kinase 3 beta 0.702
Adrm1 adhesion regulating molecule 1 0.701
Skp1a S-phase kinase-associated protein 1A 0.696
Thra thyroid hormone receptor alpha 0.690
Notch2 Notch gene homolog 2 (Drosophila) 0.689
Ncstn nicastrin 0.660
Spcs2 signal peptidase complex subunit 2 homolog (S. cerevisiae) 0.628
Cul3 cullin 3 0.627
Ccne1 cyclin E1 0.614
Psmd12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.607
Arrb2 arrestin, beta 2 0.605
Psmc6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.605
Brca1 breast cancer 1 0.603
Skil SKI-like 0.601
Ngly1 N-glycanase 1 0.576
Psma3 proteasome (prosome, macropain) subunit, alpha type 3 0.555
Fzr1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.548
Bcl2 B-cell leukemia/lymphoma 2 0.542
Cops5 COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana) 0.530
Kpna1 karyopherin (importin) alpha 1 0.530
Ube2d3 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) 0.527
Pax8 paired box gene 8 0.521
Mdm4 transformed mouse 3T3 cell double minute 4 0.507
Psmd14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.504
Dyrk1a dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a 0.503
Rnf2 ring finger protein 2 0.490
Nploc4 nuclear protein localization 4 homolog (S. cerevisiae) 0.487
Atf4 activating transcription factor 4 0.486
Birc5 baculoviral IAP repeat-containing 5 0.483
Csnk1g2 casein kinase 1, gamma 2 0.476
Pias2 protein inhibitor of activated STAT 2 0.475
Psmb3 proteasome (prosome, macropain) subunit, beta type 3 0.469
Smad7 MAD homolog 7 (Drosophila) 0.466
Ccnb2 cyclin B2 0.461
Pomp proteasome maturation protein 0.451
Smarcd1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 0.447
Sox9 SRY-box containing gene 9 0.445
Psmc5 protease (prosome, macropain) 26S subunit, ATPase 5 0.445
Mlf2 myeloid leukemia factor 2 0.441
Kpna3 karyopherin (importin) alpha 3 0.440
Rnf111 ring finger 111 0.433
Ube2g1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans) 0.432
Hif1a hypoxia inducible factor 1, alpha subunit 0.429
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.427
Psmd3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 0.424
Hsf1 heat shock factor 1 0.408
Cdca8 cell division cycle associated 8 0.405
Ppp2ca protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform 0.403
Fgfr1 fibroblast growth factor receptor 1 0.401
Agap3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 0.385
Aamp angio-associated migratory protein 0.384
Gnb2 guanine nucleotide binding protein (G protein), beta 2 0.377
Cry1 cryptochrome 1 (photolyase-like) 0.368
Ccna2 cyclin A2 0.356
Ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform 0.354
Rarb retinoic acid receptor, beta 0.354
Psmb5 proteasome (prosome, macropain) subunit, beta type 5 0.353
Rpgrip1l Rpgrip1-like 0.351
Notch1 Notch gene homolog 1 (Drosophila) 0.351
Bmi1 Bmi1 polycomb ring finger oncogene 0.343
Mllt1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 0.330
Yap1 yes-associated protein 1 0.311
Dnaja2 DnaJ (Hsp40) homolog, subfamily A, member 2 0.305
Gclm glutamate-cysteine ligase, modifier subunit 0.305
Ring1 ring finger protein 1 0.305
Tax1bp1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.303
Igf1r insulin-like growth factor I receptor 0.295
Prc1 protein regulator of cytokinesis 1 0.294
Aurka aurora kinase A 0.287
Cdk2 cyclin-dependent kinase 2 0.287
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Psma5 proteasome (prosome, macropain) subunit, alpha type 5 0.964
Psma3 proteasome (prosome, macropain) subunit, alpha type 3 0.804
Psmb3 proteasome (prosome, macropain) subunit, beta type 3 0.655
Psma2 proteasome (prosome, macropain) subunit, alpha type 2 0.571
Psma4 proteasome (prosome, macropain) subunit, alpha type 4 0.536
Psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.528
Psmb2 proteasome (prosome, macropain) subunit, beta type 2 0.475
Psmb6 proteasome (prosome, macropain) subunit, beta type 6 0.450
Psma7 proteasome (prosome, macropain) subunit, alpha type 7 0.447
Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.252
Psmc1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.167
Psmc4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.154
Psmb4 proteasome (prosome, macropain) subunit, beta type 4 0.143
Hsp90b1 heat shock protein 90, beta, member 1 0.127
Psmb1 proteasome (prosome, macropain) subunit, beta type 1 0.106
Ubxn1 UBX domain protein 1 0.098
Hprt1 hypoxanthine phosphoribosyltransferase 1 0.086
Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) 0.086
Sec61a1 Sec61 alpha 1 subunit (S. cerevisiae) 0.081
Psmd6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.081
Calr calreticulin 0.058
Eef2 eukaryotic translation elongation factor 2 0.055
Pomp proteasome maturation protein 0.053
Manf mesencephalic astrocyte-derived neurotrophic factor 0.052
Psmd8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 0.051
Pdia4 protein disulfide isomerase family A, member 4 0.050
Psmb7 proteasome (prosome, macropain) subunit, beta type 7 0.049
Phax phosphorylated adaptor for RNA export 0.046
Psmb5 proteasome (prosome, macropain) subunit, beta type 5 0.045
Cnbp CCHC-type zinc finger, nucleic acid binding protein 0.044
Psmc5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.041
Creld2 cysteine-rich with EGF-like domains 2 0.037
Serp1 stress-associated endoplasmic reticulum protein 1 0.035
Traf4af1 TRAF4 associated factor 1 0.033
Psme2 proteasome (prosome, macropain) activator subunit 2 0.031
Rbbp7 retinoblastoma binding protein 7 0.031
Cand1 cullin-associated and neddylation-dissociated 1 0.030
Dnajc3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.030
Prdx1 peroxiredoxin 1 0.029
Sumo1 SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) 0.028
Dnajb11 DnaJ (Hsp40) homolog, subfamily B, member 11 0.027
Spag5 sperm associated antigen 5 0.027
Mapre1 microtubule-associated protein, RP/EB family, member 1 0.027
Asf1b ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.025
Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) 0.024
Rpn2 ribophorin II 0.024
Canx calnexin 0.024
Ufd1l ubiquitin fusion degradation 1 like (yeast) 0.023
Psmb10 proteasome (prosome, macropain) subunit, beta type 10 0.022
Ccnb1 cyclin B1 0.022
Cenpi centromere protein I 0.022
Dnaja1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.022
Eif5a eukaryotic translation initiation factor 5A 0.021
Psma1 proteasome (prosome, macropain) subunit, alpha type 1 0.021
Psmd13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 0.021
Ube2i ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.021
Txnl1 thioredoxin-like 1 0.020
Pdia6 protein disulfide isomerase family A, member 6 0.020
Rpn1 ribophorin I 0.019
Syngr2 synaptogyrin 2 0.019
Myo1c myosin IC 0.018
Higd1a HIG1 hypoxia inducible domain family, member 1A 0.017
Ptges3 prostaglandin E synthase 3 (cytosolic) 0.017
Slc35b1 solute carrier family 35, member B1 0.017
Foxm1 forkhead box M1 0.016
Dnaja2 DnaJ (Hsp40) homolog, subfamily A, member 2 0.016
Top2a topoisomerase (DNA) II alpha 0.016
Cmtm6 CKLF-like MARVEL transmembrane domain containing 6 0.016
Mgat2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase 0.016
Ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform 0.015
Lbr lamin B receptor 0.014
Hyou1 hypoxia up-regulated 1 0.014
Arf1 ADP-ribosylation factor 1 0.014
Cdc37 cell division cycle 37 homolog (S. cerevisiae) 0.014
Gmfb glia maturation factor, beta 0.013
Zfand5 zinc finger, AN1-type domain 5 0.013
Dnpep aspartyl aminopeptidase 0.013
Psmd7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 0.012
Lamp2 lysosomal-associated membrane protein 2 0.012
Timm23 translocase of inner mitochondrial membrane 23 homolog (yeast) 0.012
Psmd4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.012
LOC100310874 antisense RNA overlapping MCH 0.012
Psmc3 proteasome (prosome, macropain) 26S subunit, ATPase 3 0.012
Rab11a RAB11a, member RAS oncogene family 0.011
Hspa5 heat shock protein 5 0.011
Psmd3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 0.011
Usp14 ubiquitin specific peptidase 14 0.011
Nsfl1c NSFL1 (p97) cofactor (p47) 0.011
Sfpq splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) 0.011
Rgs19 regulator of G-protein signaling 19 0.011
Axin1 axin 1 0.010
Ppp2ca protein phosphatase 2, catalytic subunit, alpha isoform 0.010
Lrrc59 leucine rich repeat containing 59 0.010
Dnajc5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.010
Akt1s1 AKT1 substrate 1 (proline-rich) 0.010
Myo1b myosin Ib 0.010