The network for 'negative regulation of cellular protein catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of cellular protein catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of cellular protein catabolic process.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
MAD2 Mad2p 0.641
PPH22 Pph22p 0.603
CDC55 Cdc55p 0.514
PPH21 Pph21p 0.466
HHF2 Hhf2p 0.404
CTF13 Ctf13p 0.397
RTS1 Rts1p 0.383
SLK19 Slk19p 0.353
YPI1 Ypi1p 0.305
CDC20 Cdc20p 0.285
SLI15 Sli15p 0.171
KIP1 Kip1p 0.162
IML3 Iml3p 0.155
MAD3 Mad3p 0.143
CHL4 Chl4p 0.142
PIG2 Pig2p 0.129
NBL1 Nbl1p 0.122
FMP48 Fmp48p 0.121
TIP41 Tip41p 0.116
NSL1 Nsl1p 0.112
SDS22 Sds22p 0.081
DSN1 Dsn1p 0.080
CTF3 Ctf3p 0.079
MAD1 Mad1p 0.075
BUB1 Bub1p 0.074
GIP2 Gip2p 0.067
PCL10 Pcl10p 0.064
BRN1 Brn1p 0.063
GLG1 Glg1p 0.056
MTW1 Mtw1p 0.056
ASE1 Ase1p 0.055
MLC1 Mlc1p 0.045
HTA1 Hta1p 0.043
SMC4 Smc4p 0.042
CSL4 Csl4p 0.042
TID3 Tid3p 0.041
CIN8 Cin8p 0.041
CBF1 Cbf1p 0.040
RAD23 Rad23p 0.038
PRS2 Prs2p 0.038
NTO1 Nto1p 0.037
PSP1 Psp1p 0.036
VIK1 Vik1p 0.035
MPH1 Mph1p 0.033
RAD24 Rad24p 0.033
TAF7 Taf7p 0.032
IRC15 Irc15p 0.031
SFI1 Sfi1p 0.031
CSE4 Cse4p 0.031
RPT6 Rpt6p 0.031
PPQ1 Ppq1p 0.031
CDC28 Cdc28p 0.031
HHT1 Hht1p 0.030
BIR1 Bir1p 0.030
YOL038C-A hypothetical protein 0.030
YML053C hypothetical protein 0.030
RAD61 Rad61p 0.030
STB2 Stb2p 0.030
LEU2 Leu2p 0.029
MER1 Mer1p 0.029
SRD1 Srd1p 0.029
YLR162W hypothetical protein 0.029
YBP2 Ybp2p 0.029
YLR264C-A hypothetical protein 0.028
YIL151C hypothetical protein 0.028
CIN1 Cin1p 0.027
CRP1 Crp1p 0.027
PRP28 Prp28p 0.027
GAC1 Gac1p 0.027
HAL5 Hal5p 0.026
SWD3 Swd3p 0.026
ZDS2 Zds2p 0.026
HHT2 Hht2p 0.025
YAR068W hypothetical protein 0.025
BDF2 Bdf2p 0.025
YNL144C hypothetical protein 0.025
TAF11 Taf11p 0.025
ZDS1 Zds1p 0.024
PSK1 Psk1p 0.024
SET4 Set4p 0.024
CUP1-1 Cup1-1p 0.024
CDC48 Cdc48p 0.024
PRE10 Pre10p 0.024
NUP49 Nup49p 0.023
URA3 Ura3p 0.023
ARG8 Arg8p 0.023
HYM1 Hym1p 0.023
SPO12 Spo12p 0.023
SPL2 Spl2p 0.023
YGK3 Ygk3p 0.023
SYN8 Syn8p 0.023
OKP1 Okp1p 0.022
YLR042C hypothetical protein 0.022
ZPS1 Zps1p 0.022
FRA2 Fra2p 0.022
PCT1 Pct1p 0.022
YDL012C hypothetical protein 0.022
TAH11 Tah11p 0.022
BUB3 Bub3p 0.022
JLP2 Jlp2p 0.022
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
gpr-2 Protein GPR-2 0.048
spdl-1 Protein SPDL-1 0.031
his-45 Protein HIS-45 0.030
imb-2 Protein IMB-2 0.027
gpr-1 Protein GPR-1 0.027
ZK1127.5 Protein ZK1127.5 0.025
npp-11 Protein NPP-11 0.023
F15D4.2 Protein F15D4.2 0.022
his-6 Protein HIS-6 0.022
bmk-1 Protein BMK-1 0.022
goa-1 Protein GOA-1 0.021
let-502 Protein LET-502 0.021
hcp-1 Protein HCP-1 0.021
spk-1 Protein SPK-1 0.020
lmn-1 Protein LMN-1 0.019
his-42 Protein HIS-42 0.019
ZK507.6 Protein ZK507.6 0.018
C49H3.9 Protein C49H3.9 0.018
bli-1 Protein BLI-1 0.018
W09D10.1 Protein W09D10.1 0.017
ani-1 Protein ANI-1 0.017
rnr-1 Protein RNR-1 0.017
gex-3 Protein GEX-3 0.017
R11A8.7 Protein R11A8.7 0.017
air-1 Protein AIR-1 0.016
math-33 Protein MATH-33 0.016
abl-1 Protein ABL-1 0.016
ntl-4 Protein NTL-4 0.016
tba-2 Protein TBA-2 0.016
sac-1 Protein SAC-1 0.016
lin-13 Protein LIN-13 0.015
cls-2 Protein CLS-2 0.015
lin-23 Protein LIN-23 0.015
mus-101 Protein MUS-101 0.015
him-10 Protein HIM-10 0.014
htz-1 Protein HTZ-1 0.014
cyp-31A2 Protein CYP-31A2 0.014
F25B3.6 Protein F25B3.6 0.014
tsp-14 Protein TSP-14 0.014
mrck-1 Protein MRCK-1 0.014
uaf-1 Protein UAF-1 0.014
asd-1 Protein ASD-1 0.014
csn-5 Protein CSN-5 0.014
CELE_E01G4.6 Protein E01G4.6 0.014
cul-2 Protein CUL-2 0.013
rpb-2 Protein RPB-2 0.013
pptr-2 Protein PPTR-2 0.013
CELE_F02E9.10 Protein F02E9.10 0.013
hgrs-1 Protein HGRS-1 0.013
syx-17 Protein SYX-17 0.013
snr-2 Protein SNR-2 0.013
gmn-1 Protein GMN-1 0.013
CELE_C36A4.4 Protein C36A4.4 0.013
pac-1 Protein PAC-1 0.013
mel-11 Protein MEL-11 0.012
CELE_C24H12.5 Protein C24H12.5 0.012
csn-1 Protein CSN-1 0.012
his-32 Protein HIS-32 0.012
CELE_K08F4.1 Protein K08F4.1 0.012
unc-116 Protein UNC-116 0.012
col-111 Protein COL-111 0.012
lin-5 Protein LIN-5 0.012
wht-7 Protein WHT-7 0.012
prp-21 Protein PRP-21 0.012
CELE_ZK1025.3 Protein ZK1025.3 0.012
gck-1 Protein GCK-1 0.012
apc-10 Protein APC-10 0.012
mig-15 Protein MIG-15 0.012
B0336.3 Protein B0336.3 0.012
grd-2 Protein GRD-2 0.012
oac-30 Protein OAC-30 0.012
D1081.8 Protein D1081.8 0.012
cyk-4 Protein CYK-4 0.012
T12B3.4 Protein T12B3.4 0.012
hat-1 Protein HAT-1 0.011
cyn-4 Protein CYN-4 0.011
ubq-1 Protein UBQ-1 0.011
bah-1 Protein BAH-1 0.011
col-172 Protein COL-172 0.011
smc-3 Protein SMC-3 0.011
sop-3 Protein SOP-3 0.011
hda-3 Protein HDA-3 0.011
T22C1.1 Protein T22C1.1 0.011
zyg-9 Protein ZYG-9 0.011
F44E2.8 Protein F44E2.8 0.011
rpt-5 Protein RPT-5 0.011
mlt-10 Protein MLT-10 0.011
Y55F3BR.8 Protein Y55F3BR.8 0.011
rpb-7 Protein RPB-7 0.011
exos-1 Protein EXOS-1 0.011
C02B10.5 Protein C02B10.5 0.011
rsd-6 Protein RSD-6 0.011
hmp-1 Protein HMP-1 0.011
noca-1 Protein NOCA-1 0.011
grd-1 Protein GRD-1 0.011
CELE_C25A1.4 Protein C25A1.4 0.011
B0491.1 Protein B0491.1 0.011
sec-31 Protein SEC-31 0.011
his-47 Protein HIS-47 0.011
gld-1 Protein GLD-1 0.011
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Iswi Imitation SWI 0.020
Incenp Inner centromere protein 0.014
fzy fizzy 0.012
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
BUB1B budding uninhibited by benzimidazoles 1 homolog beta (yeast) 0.924
CDC27 cell division cycle 27 homolog (S. cerevisiae) 0.819
ANAPC5 anaphase promoting complex subunit 5 0.532
CDC20 cell division cycle 20 homolog (S. cerevisiae) 0.456
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.455
ANAPC1 anaphase promoting complex subunit 1 0.447
BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) 0.353
SKP1 S-phase kinase-associated protein 1 0.320
BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast) 0.224
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.195
FAS Fas (TNF receptor superfamily, member 6) 0.187
TP53BP1 tumor protein p53 binding protein 1 0.133
CCNA2 cyclin A2 0.132
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.119
TP53 tumor protein p53 0.115
MED15 mediator complex subunit 15 0.114
RAD21 RAD21 homolog (S. pombe) 0.111
CCT8 chaperonin containing TCP1, subunit 8 (theta) 0.111
SP100 SP100 nuclear antigen 0.104
TPBG trophoblast glycoprotein 0.100
CDK2 cyclin-dependent kinase 2 0.098
H2AFX H2A histone family, member X 0.096
ANAPC4 anaphase promoting complex subunit 4 0.092
BRCA2 breast cancer 2, early onset 0.089
ASF1A ASF1 anti-silencing function 1 homolog A (S. cerevisiae) 0.088
ZNF263 zinc finger protein 263 0.086
CCND1 cyclin D1 0.084
CASC5 cancer susceptibility candidate 5 0.080
MDC1 mediator of DNA-damage checkpoint 1 0.078
FANCD2 Fanconi anemia, complementation group D2 0.077
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.075
NBN nibrin 0.073
PSEN1 presenilin 1 0.072
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 0.070
SOD1 superoxide dismutase 1, soluble 0.068
CCNB1 cyclin B1 0.067
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.065
ZNF207 zinc finger protein 207 0.063
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 0.063
SKP2 S-phase kinase-associated protein 2 (p45) 0.063
NBR1 neighbor of BRCA1 gene 1 0.062
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.060
FXR2 fragile X mental retardation, autosomal homolog 2 0.058
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.057
CDC5L CDC5 cell division cycle 5-like (S. pombe) 0.055
GABARAPL1 GABA(A) receptor-associated protein like 1 0.054
ANKRD52 ankyrin repeat domain 52 0.054
SMAD2 SMAD family member 2 0.051
BRCA1 breast cancer 1, early onset 0.051
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 0.050
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.050
COPS8 COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis) 0.050
ANAPC11 anaphase promoting complex subunit 11 0.049
BAG2 BCL2-associated athanogene 2 0.048
DAXX death-domain associated protein 0.048
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.048
CD2BP2 CD2 (cytoplasmic tail) binding protein 2 0.047
PSEN2 presenilin 2 (Alzheimer disease 4) 0.047
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative) 0.046
KPNA3 karyopherin alpha 3 (importin alpha 4) 0.046
TRIM39 tripartite motif containing 39 0.045
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.044
STX5 syntaxin 5 0.043
TOR1A torsin family 1, member A (torsin A) 0.043
ORC2 origin recognition complex, subunit 2 0.042
C19orf39 chromosome 19 open reading frame 39 0.042
CENPE centromere protein E, 312kDa 0.042
DOT1L DOT1-like, histone H3 methyltransferase (S. cerevisiae) 0.041
PRPF6 PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae) 0.040
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.040
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 0.039
SMC3 structural maintenance of chromosomes 3 0.039
RFWD2 ring finger and WD repeat domain 2 0.038
SYVN1 synovial apoptosis inhibitor 1, synoviolin 0.038
MED1 mediator complex subunit 1 0.038
HUWE1 HECT, UBA and WWE domain containing 1 0.037
FBXO5 F-box protein 5 0.037
GFI1B growth factor independent 1B transcription repressor 0.037
EP300 E1A binding protein p300 0.037
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.036
CREBBP CREB binding protein 0.036
TRIM26 tripartite motif containing 26 0.035
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.035
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 0.035
GFER growth factor, augmenter of liver regeneration 0.035
RAD51 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) 0.034
PRNP prion protein 0.033
NCSTN nicastrin 0.033
HERC2 hect domain and RLD 2 0.033
NDC80 NDC80 homolog, kinetochore complex component (S. cerevisiae) 0.033
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 0.033
ANAPC7 anaphase promoting complex subunit 7 0.033
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 0.033
CHD4 chromodomain helicase DNA binding protein 4 0.033
CDKN3 cyclin-dependent kinase inhibitor 3 0.032
TRIM21 tripartite motif containing 21 0.031
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.031
TRIM5 tripartite motif containing 5 0.031
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.031
LMNA lamin A/C 0.030
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 0.997
Ctnnb1 catenin (cadherin associated protein), beta 1 0.913
Cdk1 cyclin-dependent kinase 1 0.726
Pax2 paired box gene 2 0.699
Psen1 presenilin 1 0.672
Ccnb1 cyclin B1 0.660
Notch1 Notch gene homolog 1 (Drosophila) 0.587
Ccna2 cyclin A2 0.520
Pten phosphatase and tensin homolog 0.449
Trp73 transformation related protein 73 0.423
Amhr2 anti-Mullerian hormone type 2 receptor 0.324
Fgfr2 fibroblast growth factor receptor 2 0.315
Prc1 protein regulator of cytokinesis 1 0.313
Brca2 breast cancer 2 0.311
Ccnb2 cyclin B2 0.298
Gli3 GLI-Kruppel family member GLI3 0.296
Birc5 baculoviral IAP repeat-containing 5 0.271
Bub1b budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) 0.255
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.235
Rb1 retinoblastoma 1 0.231
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.225
Notch2 Notch gene homolog 2 (Drosophila) 0.218
Ncstn nicastrin 0.193
Mdm2 transformed mouse 3T3 cell double minute 2 0.191
Shh sonic hedgehog 0.189
Kif22 kinesin family member 22 0.187
Kif20a kinesin family member 20A 0.186
Pax8 paired box gene 8 0.180
Cdk2 cyclin-dependent kinase 2 0.176
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.170
Ptch1 patched homolog 1 0.166
Wnt3a wingless-related MMTV integration site 3A 0.157
Skil SKI-like 0.153
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.144
Cdca8 cell division cycle associated 8 0.139
Lhx1 LIM homeobox protein 1 0.136
Wnt4 wingless-related MMTV integration site 4 0.124
Asf1b ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.123
Hmmr hyaluronan mediated motility receptor (RHAMM) 0.123
Sap18 Sin3-associated polypeptide 18 0.121
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.119
Arid1b AT rich interactive domain 1B (SWI-like) 0.116
Sgol2 shugoshin-like 2 (S. pombe) 0.112
C330027C09Rik RIKEN cDNA C330027C09 gene 0.105
Aurkb aurora kinase B 0.104
Ooep oocyte expressed protein homolog (dog) 0.101
Cdkn2c cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.100
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.092
Aimp1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 0.091
Cops6 COP9 (constitutive photomorphogenic) homolog, subunit 6 (Arabidopsis thaliana) 0.090
Emx2 empty spiracles homolog 2 (Drosophila) 0.082
Axin1 axin 1 0.082
Lepr leptin receptor 0.080
Ar androgen receptor 0.075
Vdac3 voltage-dependent anion channel 3 0.070
Gsk3b glycogen synthase kinase 3 beta 0.069
Kif11 kinesin family member 11 0.069
Foxc1 forkhead box C1 0.069
Spag5 sperm associated antigen 5 0.066
T brachyury 0.065
Kntc1 kinetochore associated 1 0.061
Aph1a anterior pharynx defective 1a homolog (C. elegans) 0.060
Ckap2 cytoskeleton associated protein 2 0.057
Ube2c ubiquitin-conjugating enzyme E2C 0.056
Braf Braf transforming gene 0.056
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.055
Cks2 CDC28 protein kinase regulatory subunit 2 0.052
Mki67 antigen identified by monoclonal antibody Ki 67 0.051
Bub1 budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) 0.051
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.050
Socs1 suppressor of cytokine signaling 1 0.050
Kl klotho 0.049
Nek2 NIMA (never in mitosis gene a)-related expressed kinase 2 0.049
Cbx1 chromobox homolog 1 (Drosophila HP1 beta) 0.049
Bmp7 bone morphogenetic protein 7 0.049
Dll1 delta-like 1 (Drosophila) 0.049
Acd adrenocortical dysplasia 0.047
Wnt1 wingless-related MMTV integration site 1 0.047
Wnt10b wingless related MMTV integration site 10b 0.046
Sox9 SRY-box containing gene 9 0.045
Smarcb1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 0.045
Rrm2 ribonucleotide reductase M2 0.045
Psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.045
Hoxd11 homeobox D11 0.044
4632434I11Rik RIKEN cDNA 4632434I11 gene 0.043
Fzd10 frizzled homolog 10 (Drosophila) 0.043
Nf1 neurofibromatosis 1 0.043
Ube2t ubiquitin-conjugating enzyme E2T (putative) 0.042
Hoxa13 homeobox A13 0.042
Drap1 Dr1 associated protein 1 (negative cofactor 2 alpha) 0.042
Hist1h2bm histone cluster 1, H2bm 0.042
Arid1a AT rich interactive domain 1A (SWI-like) 0.042
Kif4 kinesin family member 4 0.041
Rara retinoic acid receptor, alpha 0.041
Ccnf cyclin F 0.041
Dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.041
Fgf18 fibroblast growth factor 18 0.040
Daxx Fas death domain-associated protein 0.040
Col2a1 collagen, type II, alpha 1 0.039
Wnt9a wingless-type MMTV integration site 9A 0.039
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism