The network for 'regulation of metaphase anaphase transition of cell cycle' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of metaphase anaphase transition of cell cycle

Any process that modulates the frequency, rate or extent of metaphase/anaphase transition of cell cycle.

Name Description Probability Func Analog Organism
PPH21 Pph21p 0.992
MTW1 Mtw1p 0.941
MAD2 Mad2p 0.934
SLK19 Slk19p 0.922
BUB1 Bub1p 0.905
CHL4 Chl4p 0.900
CDC20 Cdc20p 0.892
NSL1 Nsl1p 0.868
CSE4 Cse4p 0.867
DSN1 Dsn1p 0.772
PPH22 Pph22p 0.763
TID3 Tid3p 0.726
SLI15 Sli15p 0.712
SPC105 Spc105p 0.702
BUB3 Bub3p 0.673
SMC4 Smc4p 0.669
IML3 Iml3p 0.601
PPZ1 Ppz1p 0.559
MCM21 Mcm21p 0.559
CDC55 Cdc55p 0.544
MIF2 Mif2p 0.514
ZDS2 Zds2p 0.511
CDC26 Cdc26p 0.465
CDC27 Cdc27p 0.465
HHT1 Hht1p 0.462
DOC1 Doc1p 0.455
CDC16 Cdc16p 0.451
KIP1 Kip1p 0.448
YPI1 Ypi1p 0.446
ASE1 Ase1p 0.403
SPC24 Spc24p 0.395
MAD1 Mad1p 0.387
ZDS1 Zds1p 0.382
CDC23 Cdc23p 0.340
MAD3 Mad3p 0.313
CTF3 Ctf3p 0.309
PDS1 Pds1p 0.286
RTS1 Rts1p 0.284
NUF2 Nuf2p 0.268
IPL1 Ipl1p 0.220
CIN8 Cin8p 0.220
SMC2 Smc2p 0.210
OKP1 Okp1p 0.205
APC4 Apc4p 0.197
SWM1 Swm1p 0.189
MND2 Mnd2p 0.177
CBF2 Cbf2p 0.171
AME1 Ame1p 0.162
MPS1 Mps1p 0.160
CTF19 Ctf19p 0.145
GIP2 Gip2p 0.142
NNF1 Nnf1p 0.132
KIC1 Kic1p 0.125
MCM22 Mcm22p 0.121
DCC1 Dcc1p 0.118
TIP41 Tip41p 0.114
HHF2 Hhf2p 0.093
SPC25 Spc25p 0.092
FMP48 Fmp48p 0.090
ECO1 Eco1p 0.085
APC2 Apc2p 0.082
MMS21 Mms21p 0.081
YBP2 Ybp2p 0.079
PIG2 Pig2p 0.073
DAM1 Dam1p 0.069
SCM3 Scm3p 0.069
PSH1 Psh1p 0.067
SMC6 Smc6p 0.066
BRN1 Brn1p 0.058
CBF1 Cbf1p 0.051
CTF13 Ctf13p 0.049
SOL1 Sol1p 0.049
SDS22 Sds22p 0.048
RAD53 Rad53p 0.047
GAC1 Gac1p 0.047
CSM1 Csm1p 0.046
PCL10 Pcl10p 0.045
FIN1 Fin1p 0.043
CDH1 Cdh1p 0.042
BFA1 Bfa1p 0.040
CIN1 Cin1p 0.040
YKL075C hypothetical protein 0.038
RAD61 Rad61p 0.038
PTI1 Pti1p 0.038
NBL1 Nbl1p 0.036
CRP1 Crp1p 0.035
MYO1 Myo1p 0.035
MAM1 Mam1p 0.034
IRC15 Irc15p 0.033
GLC7 Glc7p 0.031
YNL144C hypothetical protein 0.030
SRD1 Srd1p 0.030
SGO1 Sgo1p 0.028
TGL2 Tgl2p 0.028
YOR059C hypothetical protein 0.028
CAB3 Cab3p 0.027
SMC5 Smc5p 0.027
IME4 Ime4p 0.027
SPO12 Spo12p 0.026
CLB1 Clb1p 0.026
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
rnr-1 Protein RNR-1 0.022
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
CycB3 Cyclin B3 0.796
Mcm10 Sensitized chromosome inheritance modifier 19 0.757
gwl greatwall 0.646
CycA Cyclin A 0.643
Iswi Imitation SWI 0.563
CycB Cyclin B 0.563
Pp1-87B Protein phosphatase 1 at 87B 0.543
cdc16 CG6759 gene product from transcript CG6759-RA 0.518
Dref DNA replication-related element factor 0.462
Klp61F Kinesin-like protein at 61F 0.451
cmet CENP-meta 0.426
hpo hippo 0.423
ncd non-claret disjunctional 0.409
tefu telomere fusion 0.376
fzy fizzy 0.374
polo CG12306 gene product from transcript CG12306-RA 0.356
SMC2 CG10212 gene product from transcript CG10212-RA 0.312
pav pavarotti 0.282
ida imaginal discs arrested 0.267
dup double parked 0.253
stg string 0.208
Sse Separase 0.203
flfl falafel 0.194
Cap-G CG34438 gene product from transcript CG34438-RF 0.174
pim pimples 0.160
nbs CG6754 gene product from transcript CG6754-RC 0.158
Cdc37 CG12019 gene product from transcript CG12019-RA 0.150
brat brain tumor 0.133
BubR1 Bub1-related kinase 0.130
mars CG17064 gene product from transcript CG17064-RB 0.100
Rpd3 CG7471 gene product from transcript CG7471-RA 0.099
ball ballchen 0.098
cav caravaggio 0.095
Myb Myb oncogene-like 0.090
thr three rows 0.087
prod proliferation disrupter 0.081
cdc2 CG5363 gene product from transcript CG5363-RA 0.080
Cenp-C CG31258 gene product from transcript CG31258-RA 0.073
NiPp1 Nuclear inhibitor of Protein phosphatase 1 0.073
gammaTub23C gamma-Tubulin at 23C 0.069
pie pineapple eye 0.068
CG9772 CG9772 gene product from transcript CG9772-RB 0.066
asp abnormal spindle 0.062
pasha partner of drosha 0.061
cid centromere identifier 0.060
Cks30A Cyclin-dependent kinase subunit 30A 0.060
Orc2 Origin recognition complex subunit 2 0.060
Kmn1 kinetochore Mis12-Ndc80 network component 1 0.057
Bj1 Bj1 protein 0.055
Spc105R Spc105-related 0.055
NELF-B CG32721 gene product from transcript CG32721-RA 0.052
Su(H) Suppressor of Hairless 0.051
borr borealin-related 0.050
vtd verthandi 0.048
pita CG3941 gene product from transcript CG3941-RA 0.044
east enhanced adult sensory threshold 0.043
Nuf2 CG8902 gene product from transcript CG8902-RA 0.043
DNApol-alpha60 DNA polymerase alpha 60kD 0.042
Dcr-1 Dicer-1 0.041
Incenp Inner centromere protein 0.040
Rab23 CG2108 gene product from transcript CG2108-RA 0.038
Akt1 CG4006 gene product from transcript CG4006-RA 0.037
RnrS Ribonucleoside diphosphate reductase small subunit 0.036
betaTub60D beta-Tubulin at 60D 0.034
nod no distributive disjunction 0.034
asl asterless 0.033
zwilch CG18729 gene product from transcript CG18729-RA 0.033
cutlet CG33122 gene product from transcript CG33122-RA 0.033
UbcD2 Ubiquitin conjugating enzyme 2 0.032
I-2 Inhibitor-2 0.032
sle slender lobes 0.031
CG4332 CG4332 gene product from transcript CG4332-RA 0.031
Grip75 CG6176 gene product from transcript CG6176-RA 0.031
msps mini spindles 0.031
gammaTub37C gamma-Tubulin at 37C 0.031
Cks85A Cyclin-dependent kinase subunit 85A 0.030
kuk kugelkern 0.030
Rpb4 CG33520 gene product from transcript CG33520-RF 0.030
lds lodestar 0.030
Eps-15 Epidermal growth factor receptor pathway substrate clone 15 0.029
alphaTub67C alpha-Tubulin at 67C 0.029
CG8378 CG8378 gene product from transcript CG8378-RA 0.029
E(z) Enhancer of zeste 0.029
shtd shattered 0.028
Det Deterin 0.028
CG6962 CG6962 gene product from transcript CG6962-RA 0.028
CG13625 CG13625 gene product from transcript CG13625-RA 0.027
Ras85D Ras oncogene at 85D 0.027
KP78b CG17216 gene product from transcript CG17216-RB 0.027
Psa Puromycin sensitive aminopeptidase 0.027
nxf2 nuclear RNA export factor 2 0.027
atms antimeros 0.027
mus301 mutagen-sensitive 301 0.027
mad2 CG17498 gene product from transcript CG17498-RA 0.026
Ptp69D Protein tyrosine phosphatase 69D 0.026
wisp wispy 0.026
Trf4-1 CG11265 gene product from transcript CG11265-RE 0.025
Su(var)2-10 Suppressor of variegation 2-10 0.025
dap dacapo 0.025
Orc6 Origin recognition complex subunit 6 0.024
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Homo sapiens
Name Description Probability Func Analog Organism
CDC20 cell division cycle 20 homolog (S. cerevisiae) 0.999
CDC27 cell division cycle 27 homolog (S. cerevisiae) 0.999
CDK2 cyclin-dependent kinase 2 0.995
BUB1B budding uninhibited by benzimidazoles 1 homolog beta (yeast) 0.994
ANAPC7 anaphase promoting complex subunit 7 0.972
BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast) 0.969
CCNA2 cyclin A2 0.954
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 0.910
ANAPC4 anaphase promoting complex subunit 4 0.896
CCNB1 cyclin B1 0.874
CDC23 cell division cycle 23 homolog (S. cerevisiae) 0.836
BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) 0.799
CCT8 chaperonin containing TCP1, subunit 8 (theta) 0.743
RB1 retinoblastoma 1 0.738
CKS1B CDC28 protein kinase regulatory subunit 1B 0.597
SKP2 S-phase kinase-associated protein 2 (p45) 0.568
CHAF1A chromatin assembly factor 1, subunit A (p150) 0.479
ANAPC11 anaphase promoting complex subunit 11 0.444
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) 0.431
SMC6 structural maintenance of chromosomes 6 0.405
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.395
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.387
RAD21 RAD21 homolog (S. pombe) 0.368
CDC26 cell division cycle 26 homolog (S. cerevisiae) 0.305
ORC1 origin recognition complex, subunit 1 0.301
RBL1 retinoblastoma-like 1 (p107) 0.295
CUL2 cullin 2 0.236
CCNE1 cyclin E1 0.231
CREBBP CREB binding protein 0.213
RBX1 ring-box 1, E3 ubiquitin protein ligase 0.210
NSMCE1 non-SMC element 1 homolog (S. cerevisiae) 0.210
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.205
CUL1 cullin 1 0.194
AURKB aurora kinase B 0.193
CBX5 chromobox homolog 5 0.187
CCNB2 cyclin B2 0.158
CDC16 cell division cycle 16 homolog (S. cerevisiae) 0.155
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.154
COPS5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) 0.146
SMC3 structural maintenance of chromosomes 3 0.131
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.131
CDKN3 cyclin-dependent kinase inhibitor 3 0.123
SKP1 S-phase kinase-associated protein 1 0.114
TFDP1 transcription factor Dp-1 0.111
VHL von Hippel-Lindau tumor suppressor 0.103
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.099
CKS2 CDC28 protein kinase regulatory subunit 2 0.091
CDT1 chromatin licensing and DNA replication factor 1 0.091
PLK1 polo-like kinase 1 0.078
SKA1 spindle and kinetochore associated complex subunit 1 0.075
ANAPC1 anaphase promoting complex subunit 1 0.071
DOT1L DOT1-like, histone H3 methyltransferase (S. cerevisiae) 0.068
STAG1 stromal antigen 1 0.065
CCND1 cyclin D1 0.064
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.058
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha 0.055
PPP2R1B protein phosphatase 2, regulatory subunit A, beta 0.055
SKA3 spindle and kinetochore associated complex subunit 3 0.053
PTTG1 pituitary tumor-transforming 1 0.053
E2F1 E2F transcription factor 1 0.052
RBL2 retinoblastoma-like 2 (p130) 0.050
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 0.049
NEK9 NIMA (never in mitosis gene a)- related kinase 9 0.049
SPC24 SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae) 0.049
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) 0.048
BRCA1 breast cancer 1, early onset 0.045
FXR2 fragile X mental retardation, autosomal homolog 2 0.045
MYST1 MYST histone acetyltransferase 1 0.045
SMC4 structural maintenance of chromosomes 4 0.044
BRCA2 breast cancer 2, early onset 0.043
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.043
BIRC5 baculoviral IAP repeat containing 5 0.043
CDK1 cyclin-dependent kinase 1 0.043
NDC80 NDC80 homolog, kinetochore complex component (S. cerevisiae) 0.042
KIF18A kinesin family member 18A 0.041
NSMCE4A non-SMC element 4 homolog A (S. cerevisiae) 0.040
HERC2 hect domain and RLD 2 0.040
BTRC beta-transducin repeat containing 0.038
SKA2 spindle and kinetochore associated complex subunit 2 0.038
UHRF1 ubiquitin-like with PHD and ring finger domains 1 0.037
COMMD1 copper metabolism (Murr1) domain containing 1 0.037
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.037
INCENP inner centromere protein antigens 135/155kDa 0.036
PARP3 poly (ADP-ribose) polymerase family, member 3 0.036
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.036
COPS4 COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis) 0.036
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.035
ATMIN ATM interactor 0.035
SGOL2 shugoshin-like 2 (S. pombe) 0.034
CASC5 cancer susceptibility candidate 5 0.033
LRR1 leucine rich repeat protein 1 0.033
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) 0.032
SIRT2 sirtuin 2 0.032
PPME1 protein phosphatase methylesterase 1 0.032
ANKRD52 ankyrin repeat domain 52 0.032
CUL5 cullin 5 0.030
PRRC2C proline-rich coiled-coil 2C 0.030
ARIH2 ariadne homolog 2 (Drosophila) 0.030
FBXO5 F-box protein 5 0.029
RBBP8 retinoblastoma binding protein 8 0.029
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Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 0.989
Ctnnb1 catenin (cadherin associated protein), beta 1 0.701
Ccne1 cyclin E1 0.626
Ccnb1 cyclin B1 0.483
Prc1 protein regulator of cytokinesis 1 0.371
Brca1 breast cancer 1 0.334
Cdk1 cyclin-dependent kinase 1 0.272
Cdk2 cyclin-dependent kinase 2 0.256
Cenpe centromere protein E 0.215
Ccna2 cyclin A2 0.204
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.183
Spag5 sperm associated antigen 5 0.182
Pten phosphatase and tensin homolog 0.172
Brca2 breast cancer 2 0.160
Kif2c kinesin family member 2C 0.145
Sgol1 shugoshin-like 1 (S. pombe) 0.134
Kif20a kinesin family member 20A 0.115
Ccnb2 cyclin B2 0.087
Asf1b ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.085
Nek2 NIMA (never in mitosis gene a)-related expressed kinase 2 0.082
Ooep oocyte expressed protein homolog (dog) 0.082
Apc adenomatosis polyposis coli 0.079
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.079
Melk maternal embryonic leucine zipper kinase 0.071
Hmmr hyaluronan mediated motility receptor (RHAMM) 0.066
Ube2c ubiquitin-conjugating enzyme E2C 0.056
Nbn nibrin 0.051
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.049
Sgol2 shugoshin-like 2 (S. pombe) 0.045
Dlgap5 discs, large (Drosophila) homolog-associated protein 5 0.045
Kif4 kinesin family member 4 0.041
Suz12 suppressor of zeste 12 homolog (Drosophila) 0.040
Ncapd2 non-SMC condensin I complex, subunit D2 0.040
Rad51ap1 RAD51 associated protein 1 0.039
Bub1b budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) 0.039
Mis18bp1 MIS18 binding protein 1 0.037
Ccnf cyclin F 0.036
C330027C09Rik RIKEN cDNA C330027C09 gene 0.036
Cdc25c cell division cycle 25 homolog C (S. pombe) 0.036
Birc5 baculoviral IAP repeat-containing 5 0.036
Plk1 polo-like kinase 1 (Drosophila) 0.035
Chek1 checkpoint kinase 1 homolog (S. pombe) 0.035
Cdca8 cell division cycle associated 8 0.035
Kif11 kinesin family member 11 0.033
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.033
Cenpn centromere protein N 0.032
Blm Bloom syndrome, RecQ helicase-like 0.031
Kif22 kinesin family member 22 0.029
Kntc1 kinetochore associated 1 0.028
Axin1 axin 1 0.028
Cenpk centromere protein K 0.025
Tmpo thymopoietin 0.025
E2f8 E2F transcription factor 8 0.025
Ppp1ca protein phosphatase 1, catalytic subunit, alpha isoform 0.023
Cdkn2d cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) 0.021
Cenpf centromere protein F 0.021
Psen1 presenilin 1 0.021
Wdhd1 WD repeat and HMG-box DNA binding protein 1 0.021
Aurkb aurora kinase B 0.021
Lin9 lin-9 homolog (C. elegans) 0.021
Gtse1 G two S phase expressed protein 1 0.021
Gsk3b glycogen synthase kinase 3 beta 0.020
Ect2 ect2 oncogene 0.020
Uhrf1 ubiquitin-like, containing PHD and RING finger domains, 1 0.020
Suv39h2 suppressor of variegation 3-9 homolog 2 (Drosophila) 0.020
Acd adrenocortical dysplasia 0.020
6720463M24Rik RIKEN cDNA 6720463M24 gene 0.020
Ckap2 cytoskeleton associated protein 2 0.019
Ncapd3 non-SMC condensin II complex, subunit D3 0.019
Mdm4 transformed mouse 3T3 cell double minute 4 0.019
2810417H13Rik RIKEN cDNA 2810417H13 gene 0.018
Mybl2 myeloblastosis oncogene-like 2 0.018
Cdca5 cell division cycle associated 5 0.018
Ndc80 NDC80 homolog, kinetochore complex component (S. cerevisiae) 0.018
Aurka aurora kinase A 0.017
Cdkn3 cyclin-dependent kinase inhibitor 3 0.017
Hist1h2aa histone cluster 1, H2aa 0.016
Mdm2 transformed mouse 3T3 cell double minute 2 0.016
Fignl1 fidgetin-like 1 0.016
Cbx1 chromobox homolog 1 (Drosophila HP1 beta) 0.016
Braf Braf transforming gene 0.016
Trp73 transformation related protein 73 0.016
Dtl denticleless homolog (Drosophila) 0.015
Cul4a cullin 4A 0.015
Hist2h4 histone cluster 2, H4 0.014
Prkdc protein kinase, DNA activated, catalytic polypeptide 0.014
Exo1 exonuclease 1 0.014
Ercc6l excision repair cross-complementing rodent repair deficiency complementation group 6 - like 0.014
Rb1 retinoblastoma 1 0.014
Kiss1 KiSS-1 metastasis-suppressor 0.014
Tk1 thymidine kinase 1 0.014
Mns1 meiosis-specific nuclear structural protein 1 0.014
Stil Scl/Tal1 interrupting locus 0.013
Gsg2 germ cell-specific gene 2 0.013
Orc1 origin recognition complex, subunit 1 0.013
Ube2n ubiquitin-conjugating enzyme E2N 0.013
Lig4 ligase IV, DNA, ATP-dependent 0.013
Ube2t ubiquitin-conjugating enzyme E2T (putative) 0.012
Msh2 mutS homolog 2 (E. coli) 0.012
Usp9x ubiquitin specific peptidase 9, X chromosome 0.012
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Rattus norvegicus
Name Description Probability Func Analog Organism