The network for 'mitochondrion degradation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

mitochondrion degradation

The autophagic process in which mitochondria are delivered to the vacuole and degraded in response to changing cellular conditions.

Name Description Probability Func Analog Organism
ATG1 Atg1p 0.989
ATG12 Atg12p 0.987
ATG8 Atg8p 0.981
ATG29 Atg29p 0.978
ATG4 Atg4p 0.943
ATG11 Atg11p 0.938
ATG3 Atg3p 0.937
ATG7 Atg7p 0.935
ATG21 Atg21p 0.925
ATG16 Atg16p 0.915
ATG13 Atg13p 0.902
ATG5 Atg5p 0.848
SNX4 Snx4p 0.777
ATG2 Atg2p 0.673
ATG9 Atg9p 0.638
ATG23 Atg23p 0.624
CIS1 Cis1p 0.563
ATG17 Atg17p 0.532
ATG14 Atg14p 0.313
STP2 Stp2p 0.269
ATG10 Atg10p 0.256
HSV2 Hsv2p 0.139
LAT1 Lat1p 0.127
YIL165C hypothetical protein 0.097
UBX3 Ubx3p 0.095
SPG3 Spg3p 0.093
ATG20 Atg20p 0.084
HIT1 Hit1p 0.079
ATG18 Atg18p 0.071
ATG32 Atg32p 0.060
YLR031W hypothetical protein 0.059
PPM1 Ppm1p 0.059
RRD1 Rrd1p 0.058
PCL5 Pcl5p 0.053
VPS41 Vps41p 0.047
MFM1 Mfm1p 0.046
MDM10 Mdm10p 0.046
YLR211C hypothetical protein 0.045
NGL2 Ngl2p 0.045
ABM1 Abm1p 0.041
GSH1 Gsh1p 0.040
VPS30 Vps30p 0.039
PSR1 Psr1p 0.038
ATG26 Atg26p 0.035
SLG1 Slg1p 0.034
NFT1 Nft1p 0.033
DNM1 Dnm1p 0.033
PTC6 Ptc6p 0.033
MUB1 Mub1p 0.032
SRD1 Srd1p 0.032
MPT5 Mpt5p 0.031
APN2 Apn2p 0.031
ARP10 Arp10p 0.031
KGD1 Kgd1p 0.030
YLR407W hypothetical protein 0.029
HSP60 Hsp60p 0.028
CRP1 Crp1p 0.027
YLR264C-A hypothetical protein 0.026
MER1 Mer1p 0.026
UPS3 Ups3p 0.026
SCW4 Scw4p 0.026
YLR162W hypothetical protein 0.026
SSP1 Ssp1p 0.025
PRM9 Prm9p 0.025
LEU2 Leu2p 0.025
YBR296C-A hypothetical protein 0.025
HXT3 Hxt3p 0.025
ALT2 Alt2p 0.025
SWC7 Swc7p 0.024
MKS1 Mks1p 0.024
ICS2 Ics2p 0.024
YNL190W hypothetical protein 0.024
YOL038C-A hypothetical protein 0.023
DOA4 Doa4p 0.023
KRE1 Kre1p 0.023
CHA1 Cha1p 0.023
AZF1 Azf1p 0.022
SPL2 Spl2p 0.022
YHR140W hypothetical protein 0.022
VPS36 Vps36p 0.022
CYT2 Cyt2p 0.022
FMP23 Fmp23p 0.021
PHD1 Phd1p 0.021
HSP31 Hsp31p 0.021
TYE7 Tye7p 0.021
PEP4 Pep4p 0.021
ACH1 Ach1p 0.020
YLR042C hypothetical protein 0.020
YJL185C hypothetical protein 0.020
TIP1 Tip1p 0.020
CUP1-1 Cup1-1p 0.020
ARG82 Arg82p 0.020
YAP1 Yap1p 0.020
YBR013C hypothetical protein 0.020
REV1 Rev1p 0.020
OPT2 Opt2p 0.020
MOD5 Mod5p 0.019
REE1 Ree1p 0.019
CCW14 Ccw14p 0.019
STB3 Stb3p 0.019
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Marf Mitochondrial assembly regulatory factor 0.630
park parkin 0.568
Pink1 PTEN-induced putative kinase 1 0.420
CG8443 CG8443 gene product from transcript CG8443-RA 0.148
porin CG6647 gene product from transcript CG6647-RA 0.133
p38b CG7393 gene product from transcript CG7393-RA 0.130
Dcr-2 Dicer-2 0.076
Lasp CG3849 gene product from transcript CG3849-RB 0.059
Taz Tafazzin 0.058
opa1-like optic atrophy 1-like 0.056
Atg9 Autophagy-specific gene 9 0.047
trpml transient receptor potential mucolipin 0.035
Tom34 Translocase of outer membrane 34 0.034
Rheb CG1081 gene product from transcript CG1081-RA 0.032
Cul-5 Cullin-5 0.031
sra sarah 0.030
Miro Mitochondrial Rho 0.030
SNF1A SNF1A/AMP-activated protein kinase 0.029
pix pixie 0.026
Drp1 Dynamin related protein 1 0.024
Lrrk Leucine-rich repeat kinase 0.023
Pi3K59F Phosphotidylinositol 3 kinase 59F 0.021
maf-S CG9954 gene product from transcript CG9954-RA 0.021
Atg18 Autophagy-specific gene 18 0.021
ref(2)P refractory to sigma P 0.020
Atg7 Autophagy-specific gene 7 0.020
SdhB Succinate dehydrogenase B 0.019
drd drop dead 0.019
rho-7 rhomboid-7 0.018
dm diminutive 0.018
twin CG31137 gene product from transcript CG31137-RB 0.018
mei-41 meiotic 41 0.016
pelo pelota 0.016
Dredd Death related ced-3/Nedd2-like protein 0.016
chico CG5686 gene product from transcript CG5686-RB 0.015
PHGPx CG12013 gene product from transcript CG12013-RC 0.015
vas vasa 0.014
Syx17 Syntaxin 17 0.014
Ptp61F Protein tyrosine phosphatase 61F 0.014
HtrA2 CG8464 gene product from transcript CG8464-RA 0.013
Atg8a Autophagy-specific gene 8a 0.013
Ppat-Dpck Bifunctional Phosphopantetheine adenylyltransferase - Dephospho-CoA kinase 0.013
bor belphegor 0.013
bdg bedraggled 0.012
cmet CENP-meta 0.012
CG31033 CG31033 gene product from transcript CG31033-RC 0.012
alphaTub84B alpha-Tubulin at 84B 0.011
Letm1 CG4589 gene product from transcript CG4589-RB 0.011
por porcupine 0.011
CG31133 CG31133 gene product from transcript CG31133-RA 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.917
GABARAP GABA(A) receptor-associated protein 0.785
NBR1 neighbor of BRCA1 gene 1 0.697
PINK1 PTEN induced putative kinase 1 0.626
GABARAPL2 GABA(A) receptor-associated protein-like 2 0.382
ATG3 ATG3 autophagy related 3 homolog (S. cerevisiae) 0.105
GABARAPL1 GABA(A) receptor-associated protein like 1 0.062
FBXO7 F-box protein 7 0.061
ZNF746 zinc finger protein 746 0.043
SQSTM1 sequestosome 1 0.042
ATG5 ATG5 autophagy related 5 homolog (S. cerevisiae) 0.039
ATG7 ATG7 autophagy related 7 homolog (S. cerevisiae) 0.035
ARL15 ADP-ribosylation factor-like 15 0.030
ULK1 unc-51-like kinase 1 (C. elegans) 0.028
ATG13 ATG13 autophagy related 13 homolog (S. cerevisiae) 0.025
NSF N-ethylmaleimide-sensitive factor 0.025
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.021
OPTN optineurin 0.017
UBR1 ubiquitin protein ligase E3 component n-recognin 1 0.012
ATG10 ATG10 autophagy related 10 homolog (S. cerevisiae) 0.010
PRDX6 peroxiredoxin 6 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 0.959
Atg12 autophagy-related 12 (yeast) 0.927
Pten phosphatase and tensin homolog 0.901
Mdm2 transformed mouse 3T3 cell double minute 2 0.599
Emx1 empty spiracles homolog 1 (Drosophila) 0.297
Hspd1 heat shock protein 1 (chaperonin) 0.292
Mdm4 transformed mouse 3T3 cell double minute 4 0.278
Trp53inp2 transformation related protein 53 inducible nuclear protein 2 0.271
Trp73 transformation related protein 73 0.268
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.247
Rara retinoic acid receptor, alpha 0.196
Mapre3 microtubule-associated protein, RP/EB family, member 3 0.178
Dnaja3 DnaJ (Hsp40) homolog, subfamily A, member 3 0.135
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.116
Nphp1 nephronophthisis 1 (juvenile) homolog (human) 0.108
Sqstm1 sequestosome 1 0.107
Cycs cytochrome c, somatic 0.102
Kit kit oncogene 0.102
Trp63 transformation related protein 63 0.084
Hr hairless 0.083
Eif4a2 eukaryotic translation initiation factor 4A2 0.077
Mfn2 mitofusin 2 0.068
Wwox WW domain-containing oxidoreductase 0.061
Hif1an hypoxia-inducible factor 1, alpha subunit inhibitor 0.061
Ubxn6 UBX domain protein 6 0.060
Atg5 autophagy-related 5 (yeast) 0.056
Ypel3 yippee-like 3 (Drosophila) 0.054
Sfn stratifin 0.052
Yipf4 Yip1 domain family, member 4 0.050
Tprgl transformation related protein 63 regulated like 0.050
Yap1 yes-associated protein 1 0.048
Hagh hydroxyacyl glutathione hydrolase 0.047
Dnajb2 DnaJ (Hsp40) homolog, subfamily B, member 2 0.046
Cript cysteine-rich PDZ-binding protein 0.046
Fam103a1 family with sequence similarity 103, member A1 0.045
Atp6v1d ATPase, H+ transporting, lysosomal V1 subunit D 0.045
Brp44 brain protein 44 0.042
Hhat hedgehog acyltransferase 0.041
Wdr45 WD repeat domain 45 0.041
Rab28 RAB28, member RAS oncogene family 0.041
Irf6 interferon regulatory factor 6 0.040
Ghitm growth hormone inducible transmembrane protein 0.039
Paip2 polyadenylate-binding protein-interacting protein 2 0.039
Csde1 cold shock domain containing E1, RNA binding 0.039
Lrpprc leucine-rich PPR-motif containing 0.039
Atg7 autophagy-related 7 (yeast) 0.038
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.038
Rb1 retinoblastoma 1 0.038
Apc adenomatosis polyposis coli 0.036
2310061I04Rik RIKEN cDNA 2310061I04 gene 0.034
Rab18 RAB18, member RAS oncogene family 0.034
Trpc2 transient receptor potential cation channel, subfamily C, member 2 0.034
Gabarapl1 gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1 0.033
Htatip2 HIV-1 tat interactive protein 2, homolog (human) 0.033
Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 0.033
Isca1 iron-sulfur cluster assembly 1 homolog (S. cerevisiae) 0.033
Tcta T-cell leukemia translocation altered gene 0.031
Maf1 MAF1 homolog (S. cerevisiae) 0.031
Ndufaf4 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4 0.031
March5 membrane-associated ring finger (C3HC4) 5 0.030
Nudt9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 0.030
Foxo3 forkhead box O3 0.030
Tmem70 transmembrane protein 70 0.030
Pdk2 pyruvate dehydrogenase kinase, isoenzyme 2 0.030
Ahr aryl-hydrocarbon receptor 0.029
Sgca sarcoglycan, alpha (dystrophin-associated glycoprotein) 0.029
Slmo2 slowmo homolog 2 (Drosophila) 0.029
Mgll monoglyceride lipase 0.029
Afg3l2 AFG3(ATPase family gene 3)-like 2 (yeast) 0.028
Gfm1 G elongation factor, mitochondrial 1 0.027
Sucla2 succinate-Coenzyme A ligase, ADP-forming, beta subunit 0.027
Huwe1 HECT, UBA and WWE domain containing 1 0.027
Mapk14 mitogen-activated protein kinase 14 0.026
Lias lipoic acid synthetase 0.026
Ctnnb1 catenin (cadherin associated protein), beta 1 0.026
Rab11a RAB11a, member RAS oncogene family 0.025
Polb polymerase (DNA directed), beta 0.025
Lamc2 laminin, gamma 2 0.025
Braf Braf transforming gene 0.025
Macrod1 MACRO domain containing 1 0.025
Dmd dystrophin, muscular dystrophy 0.024
Gm3244 predicted pseudogene 3244 0.024
Ndufs1 NADH dehydrogenase (ubiquinone) Fe-S protein 1 0.024
Gde1 glycerophosphodiester phosphodiesterase 1 0.024
Abtb1 ankyrin repeat and BTB (POZ) domain containing 1 0.024
Slc25a33 solute carrier family 25, member 33 0.024
Sgcb sarcoglycan, beta (dystrophin-associated glycoprotein) 0.024
Brca1 breast cancer 1 0.024
Optn optineurin 0.024
Lap3 leucine aminopeptidase 3 0.024
Hsbp1 heat shock factor binding protein 1 0.023
Reep5 receptor accessory protein 5 0.023
Hspa8 heat shock protein 8 0.023
Ubc ubiquitin C 0.022
Dctn2 dynactin 2 0.022
Chchd7 coiled-coil-helix-coiled-coil-helix domain containing 7 0.022
Hprt hypoxanthine guanine phosphoribosyl transferase 0.022
Rint1 RAD50 interactor 1 0.022
Tmem66 transmembrane protein 66 0.022
Cables1 CDK5 and Abl enzyme substrate 1 0.022
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Rattus norvegicus
Name Description Probability Func Analog Organism