The network for 'cellular response to dna damage stimulus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular response to dna damage stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
HHF1 Hhf1p 0.999
RAD50 Rad50p 0.999
RAD9 Rad9p 0.999
SRS2 Srs2p 0.999
RAD18 Rad18p 0.999
RAD24 Rad24p 0.998
RFA1 Rfa1p 0.998
RAD54 Rad54p 0.997
RAD1 Rad1p 0.997
RAD52 Rad52p 0.996
SMC6 Smc6p 0.995
POL30 Pol30p 0.994
RAD23 Rad23p 0.990
RAD5 Rad5p 0.988
RAD53 Rad53p 0.984
RAD57 Rad57p 0.981
MEC1 Mec1p 0.980
MSH6 Msh6p 0.980
SGS1 Sgs1p 0.979
DDC1 Ddc1p 0.977
YAP1 Yap1p 0.976
RAD10 Rad10p 0.974
YAF9 Yaf9p 0.974
EAF1 Eaf1p 0.971
MSH2 Msh2p 0.970
RAD14 Rad14p 0.970
CDC45 Cdc45p 0.969
PRE2 Pre2p 0.968
SIC1 Sic1p 0.966
RAD4 Rad4p 0.965
MCM4 Mcm4p 0.963
ARP4 Arp4p 0.959
XRS2 Xrs2p 0.955
PIF1 Pif1p 0.953
CTF4 Ctf4p 0.951
PMS1 Pms1p 0.951
RTF1 Rtf1p 0.947
ELG1 Elg1p 0.946
RAD27 Rad27p 0.945
MLH1 Mlh1p 0.941
MRC1 Mrc1p 0.940
REV3 Rev3p 0.938
HHO1 Hho1p 0.934
KCS1 Kcs1p 0.928
CLB3 Clb3p 0.927
RPN1 Rpn1p 0.920
ARP8 Arp8p 0.920
DMC1 Dmc1p 0.915
RPN10 Rpn10p 0.904
TEL1 Tel1p 0.902
MUS81 Mus81p 0.899
RPT6 Rpt6p 0.893
SMC5 Smc5p 0.890
RRP6 Rrp6p 0.885
POL31 Pol31p 0.881
RAD17 Rad17p 0.876
RFA2 Rfa2p 0.873
RAD16 Rad16p 0.870
PPH22 Pph22p 0.868
RAD51 Rad51p 0.867
POL3 Pol3p 0.865
DIA2 Dia2p 0.860
SWC4 Swc4p 0.852
TOR2 Tor2p 0.849
ESA1 Esa1p 0.847
MRE11 Mre11p 0.836
DUN1 Dun1p 0.835
SEM1 Sem1p 0.834
PSF1 Psf1p 0.830
UBR1 Ubr1p 0.829
MCM6 Mcm6p 0.828
POL2 Pol2p 0.822
RAD30 Rad30p 0.821
RTT109 Rtt109p 0.819
APN1 Apn1p 0.814
EAF5 Eaf5p 0.814
SLX4 Slx4p 0.808
RAD26 Rad26p 0.802
DCC1 Dcc1p 0.795
RPN12 Rpn12p 0.792
RAD59 Rad59p 0.788
NSE3 Nse3p 0.786
PSY2 Psy2p 0.775
HPR1 Hpr1p 0.774
RRM3 Rrm3p 0.772
SIR2 Sir2p 0.771
MEC3 Mec3p 0.769
CDC4 Cdc4p 0.768
POL32 Pol32p 0.764
RPT3 Rpt3p 0.746
GBP2 Gbp2p 0.743
EPL1 Epl1p 0.737
RPT1 Rpt1p 0.730
DPB11 Dpb11p 0.728
RSC2 Rsc2p 0.720
SLX8 Slx8p 0.715
NTG2 Ntg2p 0.714
PUP1 Pup1p 0.714
RAD3 Rad3p 0.713
MMS21 Mms21p 0.713
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
his-16 Protein HIS-16 0.843
rpt-5 Protein RPT-5 0.668
his-3 Protein HIS-3 0.647
his-45 Protein HIS-45 0.576
rpn-12 Protein RPN-12 0.440
rpt-3 Protein RPT-3 0.426
his-29 Protein HIS-29 0.421
his-59 Protein HIS-59 0.420
his-1 Protein HIS-1 0.350
his-5 Protein HIS-5 0.339
his-47 Protein HIS-47 0.328
CELE_Y41E3.11 Protein Y41E3.11 0.304
his-52 Protein HIS-52 0.296
acly-2 Protein ACLY-2 0.294
F52B5.3 Protein F52B5.3 0.289
his-42 Protein HIS-42 0.269
rpn-2 Protein RPN-2 0.247
his-51 Protein HIS-51 0.244
npp-15 Protein NPP-15 0.242
npl-4.2 Protein NPL-4.2 0.230
rrf-3 Protein RRF-3 0.220
rpn-5 Protein RPN-5 0.216
rpn-10 Protein RPN-10 0.211
dcr-1 Protein DCR-1 0.207
pas-2 Protein PAS-2 0.206
zyg-9 Protein ZYG-9 0.203
his-39 Protein HIS-39 0.200
mat-3 Protein MAT-3 0.199
pas-4 Protein PAS-4 0.195
pme-1 Protein PME-1 0.192
F10C2.4 Protein F10C2.4 0.189
D1081.8 Protein D1081.8 0.184
rpn-3 Protein RPN-3 0.183
mcm-2 Protein MCM-2 0.182
chk-1 Protein CHK-1 0.179
his-48 Protein HIS-48 0.171
rpt-2 Protein RPT-2 0.167
D2030.8 Protein D2030.8 0.166
his-31 Protein HIS-31 0.163
prpf-4 Protein PRPF-4 0.157
larp-5 Protein LARP-5 0.156
his-61 Protein HIS-61 0.154
htz-1 Protein HTZ-1 0.153
gpr-2 Protein GPR-2 0.153
dnj-5 Protein DNJ-5 0.151
F54E12.2 Protein F54E12.2 0.150
sas-5 Protein SAS-5 0.150
srgp-1 Protein SRGP-1 0.145
let-502 Protein LET-502 0.145
his-4 Protein HIS-4 0.144
akt-1 Protein AKT-1 0.143
atl-1 Protein ATL-1 0.142
his-64 Protein HIS-64 0.142
vab-1 Protein VAB-1 0.141
pabp-2 Protein PABP-2 0.139
ndc-80 Protein NDC-80 0.137
his-30 Protein HIS-30 0.136
capg-2 Protein CAPG-2 0.135
egl-18 Protein EGL-18 0.135
pbs-5 Protein PBS-5 0.134
ucr-2.3 Protein UCR-2.3 0.133
his-63 Protein HIS-63 0.128
his-2 Protein HIS-2 0.126
ima-2 Protein IMA-2 0.126
hda-1 Protein HDA-1 0.125
Y55D9A.2 Protein Y55D9A.2 0.123
CELE_F17C11.10 Protein F17C11.10 0.121
H21P03.2 Protein H21P03.2 0.121
C30A5.3 Protein C30A5.3 0.118
mis-12 Protein MIS-12 0.117
mcm-5 Protein MCM-5 0.116
R04F11.3 Protein R04F11.3 0.115
npp-9 Protein NPP-9 0.115
prp-3 Protein PRP-3 0.114
sid-1 Protein SID-1 0.114
set-1 Protein SET-1 0.114
his-6 Protein HIS-6 0.113
cdc-48.1 Protein CDC-48.1 0.113
his-50 Protein HIS-50 0.112
R148.3 Protein R148.3 0.111
Y110A7A.9 Protein Y110A7A.9 0.111
retr-1 Protein RETR-1 0.111
pbs-7 Protein PBS-7 0.109
F10B5.8 Protein F10B5.8 0.107
lea-1 Protein LEA-1 0.107
rpn-7 Protein RPN-7 0.107
F22H10.3 Protein F22H10.3 0.106
R186.7 Protein R186.7 0.104
mop-25.3 Protein MOP-25.3 0.103
mdt-8 Protein MDT-8 0.103
B0432.13 Protein B0432.13 0.102
gpb-1 Protein GPB-1 0.101
pri-2 Protein PRI-2 0.100
CELE_Y69A2AR.16 Protein Y69A2AR.16 0.096
nasp-1 Protein NASP-1 0.094
R11A8.7 Protein R11A8.7 0.094
cku-80 Protein CKU-80 0.093
dpf-3 Protein DPF-3 0.093
CELE_D1054.3 Protein D1054.3 0.093
tag-307 Protein TAG-307 0.093
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
fanci Fanconi anemia, complementation group I 0.454
mapk14a mitogen-activated protein kinase 14a 0.422
fzd7a frizzled homolog 7a 0.257
ccnd1 cyclin D1 0.227
psma6a proteasome (prosome, macropain) subunit, alpha type, 6a 0.219
ywhaqb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b 0.208
psmb3 proteasome (prosome, macropain) subunit, beta type, 3 0.207
brca2 breast cancer 2, early onset 0.203
psmd6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.193
pafah1b1a platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit a 0.193
tgif1 TGFB-induced factor homeobox 1 0.189
pola2 polymerase (DNA directed), alpha 2 0.187
psma8 proteasome (prosome, macropain) subunit, alpha type, 8 0.183
psmb2 proteasome (prosome, macropain) subunit, beta type, 2 0.174
wls wntless homolog (Drosophila) 0.166
ppp4ca protein phosphatase 4 (formerly X), catalytic subunit a 0.159
tagln2 transgelin 2 0.153
aaas achalasia, adrenocortical insufficiency, alacrimia 0.152
hmgb2b high-mobility group box 2b 0.146
nfkbiab nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b 0.146
psmd13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 0.146
pafah1b1b platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b 0.142
celf1 cugbp, Elav-like family member 1 0.136
mcm5 MCM5 minichromosome maintenance deficient 5 (S. cerevisiae) 0.135
hat1 histone acetyltransferase 1 0.130
fen1 flap structure-specific endonuclease 1 0.128
cxcr4b chemokine (C-X-C motif), receptor 4b 0.121
rasl11b RAS-like, family 11, member B 0.116
nasp nuclear autoantigenic sperm protein (histone-binding) 0.114
psmb1 proteasome (prosome, macropain) subunit, beta type, 1 0.114
bcl2l1 bcl2-like 1 0.113
anp32a acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.112
brd2a bromodomain-containing 2a 0.112
nr2f2 nuclear receptor subfamily 2, group F, member 2 0.111
mapk3 mitogen-activated protein kinase 3 0.110
psma4 proteasome (prosome, macropain) subunit, alpha type, 4 0.107
hug HuG 0.105
psmc1b proteasome (prosome, macropain) 26S subunit, ATPase, 1b 0.105
ppm1g protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform 0.104
ccnl1 cyclin L1 0.104
psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.095
mmp9 matrix metalloproteinase 9 0.092
psmc6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.091
baxa bcl2-associated X protein, a 0.091
ddb2 damage-specific DNA binding protein 2 0.087
psma2 proteasome (prosome, macropain) subunit, alpha type, 2 0.086
smc3 structural maintenance of chromosomes 3 0.085
cry5 cryptochrome 5 0.084
csnk1da casein kinase 1, delta a 0.083
efnb2a ephrin B2a 0.083
id2a inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a 0.083
si:ch211-1n9.7 si:ch211-1n9.7 0.080
stc1l stanniocalcin 1, like 0.079
asf1bb ASF1 anti-silencing function 1 homolog Bb 0.079
mcl1a myeloid cell leukemia sequence 1a 0.078
spry2 sprouty homolog 2 0.078
psma5 proteasome (prosome, macropain) subunit, alpha type,5 0.076
rfc4 replication factor C (activator 1) 4 0.075
gadd45aa growth arrest and DNA-damage-inducible, alpha, a 0.074
psmd12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.073
dusp1 dual specificity phosphatase 1 0.071
smndc1 survival motor neuron domain containing 1 0.068
cdh1 cadherin 1, epithelial 0.067
zgc:113143 zgc:113143 0.066
naa20 N(alpha)-acetyltransferase 20, NatB catalytic subunit 0.063
dab1a disabled homolog 1a (Drosophila) 0.063
fancd2 Fanconi anemia, complementation group D2 0.061
ywhabb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b 0.061
chek1 CHK1 checkpoint homolog (S. pombe) 0.060
pak2a p21 (CDKN1A)-activated kinase 2a 0.060
bcl2 B-cell leukemia/lymphoma 2 0.059
cdc25 cell division cycle 25 homolog 0.059
myca myelocytomatosis oncogene a 0.059
ccdc94 coiled-coil domain containing 94 0.058
mmp2 matrix metalloproteinase 2 0.058
eif4e eukaryotic translation initiation factor 4e 0.058
fabp7a fatty acid binding protein 7, brain, a 0.057
wdhd1 WD repeat and HMG-box DNA binding protein 1 0.056
sox4a SRY-box containing gene 4a 0.056
mlh1 mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) 0.055
rnaseh2a ribonuclease H2, subunit A 0.054
psmb4 proteasome (prosome, macropain) subunit, beta type, 4 0.054
plxnb2a plexin b2a 0.054
abcf1 ATP-binding cassette, sub-family F (GCN20), member 1 0.054
rplp2 ribosomal protein, large P2 0.054
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.053
per2 period homolog 2 (Drosophila) 0.053
dnmt5 DNA (cytosine-5-)-methyltransferase 5 0.053
ywhaba tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a 0.052
caprin1a cell cycle associated protein 1a 0.052
sox7 SRY-box containing gene 7 0.052
zgc:92648 zgc:92648 0.052
zgc:123326 zgc:123326 0.052
cand1 cullin-associated and neddylation-dissociated 1 0.052
prdm9 PR domain containing 9 0.052
dusp6 dual specificity phosphatase 6 0.052
hs3st3b1b heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1b 0.052
aurkb aurora kinase B 0.051
snrpd1 small nuclear ribonucleoprotein D1 polypeptide 0.050
stmn1b stathmin 1b 0.050
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
lok loki 1.000
mus205 mutagen-sensitive 205 0.998
tefu telomere fusion 0.997
skpA CG16983 gene product from transcript CG16983-RD 0.991
p53 CG33336 gene product from transcript CG33336-RB 0.991
Caf1 Chromatin assembly factor 1 subunit 0.989
hay haywire 0.988
DNApol-eta CG7143 gene product from transcript CG7143-RA 0.984
mre11 meiotic recombination 11 0.976
Pros26.4 Proteasome 26S subunit subunit 4 ATPase 0.969
rad50 CG6339 gene product from transcript CG6339-RD 0.967
Pros29 Proteasome 29kD subunit 0.953
CSN4 COP9 complex homolog subunit 4 0.949
CDC45L CG3658 gene product from transcript CG3658-RA 0.944
okr okra 0.939
mus308 mutagen-sensitive 308 0.930
Rpn9 CG10230 gene product from transcript CG10230-RB 0.927
sxc super sex combs 0.904
S6k RPS6-p70-protein kinase 0.897
Prosbeta2 Proteasome beta2 subunit 0.888
RpA-70 Replication Protein A 70 0.883
Dcr-2 Dicer-2 0.867
RfC4 Replication factor C subunit 4 0.864
kis kismet 0.862
Rbf Retinoblastoma-family protein 0.857
BRWD3 CG31132 gene product from transcript CG31132-RA 0.852
mus210 mutagen-sensitive 210 0.835
HLHm7 E(spl) region transcript m7 0.832
E(spl) Enhancer of split 0.831
spn-B spindle B 0.818
nbs CG6754 gene product from transcript CG6754-RC 0.812
Prosbeta3 Proteasome beta3 subunit 0.812
Brca2 Breast cancer 2, early onset homolog 0.804
Prosbeta5 Proteasome beta5 subunit 0.787
Prosbeta1 Proteasome beta1 subunit 0.786
CkIIbeta Casein kinase II beta subunit 0.772
Akt1 CG4006 gene product from transcript CG4006-RA 0.771
Iswi Imitation SWI 0.766
mus101 mutagen-sensitive 101 0.766
bsk basket 0.765
Jafrac1 thioredoxin peroxidase 1 0.762
smt3 CG4494 gene product from transcript CG4494-RA 0.757
da daughterless 0.754
mei-9 meiotic 9 0.749
Su(H) Suppressor of Hairless 0.747
Pp2A-29B Protein phosphatase 2A at 29B 0.740
Sin3A CG8815 gene product from transcript CG8815-RC 0.729
mus201 mutagen-sensitive 201 0.729
Pros26 Proteasome 26kD subunit 0.720
Mnn1 Menin 1 0.715
RecQ5 homolog of RecQ 0.694
RASSF8 CG5053 gene product from transcript CG5053-RA 0.684
mus301 mutagen-sensitive 301 0.684
pan pangolin 0.683
His2Av Histone H2A variant 0.672
Prosalpha7 Proteasome alpha7 subunit 0.665
mof males absent on the first 0.655
ebi CG4063 gene product from transcript CG4063-RA 0.654
Mer Merlin 0.652
phl pole hole 0.651
MED17 Mediator complex subunit 17 0.647
CG9772 CG9772 gene product from transcript CG9772-RB 0.637
Dp DP transcription factor 0.632
Rev1 CG12189 gene product from transcript CG12189-RA 0.627
nej nejire 0.625
Nipped-A CG33554 gene product from transcript CG33554-RE 0.625
sno strawberry notch 0.623
Rpt1 CG1341 gene product from transcript CG1341-RA 0.611
esc extra sexcombs 0.603
CG5524 CG5524 gene product from transcript CG5524-RA 0.592
mei-41 meiotic 41 0.591
CG5794 CG5794 gene product from transcript CG5794-RB 0.588
Rca1 Regulator of cyclin A1 0.579
rept reptin 0.579
Mcm7 Minichromosome maintenance 7 0.567
CG7288 CG7288 gene product from transcript CG7288-RA 0.564
DNApol-alpha73 DNA polymerase alpha 73kD 0.553
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.550
key kenny 0.539
CycD Cyclin D 0.533
lin19 lin-19-like 0.530
Rpn11 CG18174 gene product from transcript CG18174-RA 0.529
Sir2 CG5216 gene product from transcript CG5216-RA 0.525
RpII215 RNA polymerase II 215kD subunit 0.523
Su(var)2-10 Suppressor of variegation 2-10 0.520
MBD-R2 CG10042 gene product from transcript CG10042-RB 0.520
Rpt4 CG3455 gene product from transcript CG3455-RA 0.515
Chrac-14 CG13399 gene product from transcript CG13399-RA 0.509
Su(var)2-HP2 CG12864 gene product from transcript CG12864-RB 0.509
CSN6 COP9 complex homolog subunit 6 0.507
Ssrp Structure specific recognition protein 0.498
Spn Spinophilin 0.493
Pk61C Protein kinase 61C 0.491
Nf1 Neurofibromin 1 0.489
CG1240 CG1240 gene product from transcript CG1240-RA 0.484
pr-set7 CG3307 gene product from transcript CG3307-RC 0.481
babo baboon 0.481
Incenp Inner centromere protein 0.475
Prosalpha5 Proteasome alpha5 subunit 0.473
dre4 CG1828 gene product from transcript CG1828-RB 0.460
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
TP53 tumor protein p53 1.000
BRCA1 breast cancer 1, early onset 1.000
MDM2 Mdm2 p53 binding protein homolog (mouse) 1.000
PCNA proliferating cell nuclear antigen 1.000
H2AFX H2A histone family, member X 1.000
CHEK1 CHK1 checkpoint homolog (S. pombe) 1.000
RB1 retinoblastoma 1 1.000
BLM Bloom syndrome, RecQ helicase-like 1.000
PRKDC protein kinase, DNA-activated, catalytic polypeptide 1.000
CDK2 cyclin-dependent kinase 2 1.000
RAD51 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) 1.000
RPA1 replication protein A1, 70kDa 1.000
CHEK2 CHK2 checkpoint homolog (S. pombe) 1.000
CREBBP CREB binding protein 1.000
HDAC1 histone deacetylase 1 1.000
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 1.000
RAD50 RAD50 homolog (S. cerevisiae) 1.000
MSH2 mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) 1.000
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 1.000
PARP1 poly (ADP-ribose) polymerase 1 1.000
MSH6 mutS homolog 6 (E. coli) 0.999
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.999
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.999
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.999
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.999
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.999
NBN nibrin 0.999
E2F1 E2F transcription factor 1 0.999
MDC1 mediator of DNA-damage checkpoint 1 0.999
WRN Werner syndrome, RecQ helicase-like 0.998
CSNK2A1 casein kinase 2, alpha 1 polypeptide 0.998
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.997
BRCA2 breast cancer 2, early onset 0.997
EGFR epidermal growth factor receptor 0.996
SLX4 SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) 0.995
CCNE1 cyclin E1 0.995
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.995
MAPK14 mitogen-activated protein kinase 14 0.994
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.993
EP300 E1A binding protein p300 0.993
TOPBP1 topoisomerase (DNA) II binding protein 1 0.992
ATM ataxia telangiectasia mutated 0.991
RBBP8 retinoblastoma binding protein 8 0.991
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 0.990
FANCA Fanconi anemia, complementation group A 0.990
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.990
RAD1 RAD1 homolog (S. pombe) 0.989
XIAP X-linked inhibitor of apoptosis 0.987
SUMO1 SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) 0.987
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.987
HIST1H3D histone cluster 1, H3d 0.986
PML promyelocytic leukemia 0.986
RAD18 RAD18 homolog (S. cerevisiae) 0.985
UBC ubiquitin C 0.985
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 0.984
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.984
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.984
CCND1 cyclin D1 0.983
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 0.982
NCOA3 nuclear receptor coactivator 3 0.982
DDB1 damage-specific DNA binding protein 1, 127kDa 0.982
RPA3 replication protein A3, 14kDa 0.981
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.981
DTL denticleless homolog (Drosophila) 0.981
ATR ataxia telangiectasia and Rad3 related 0.980
CDC5L CDC5 cell division cycle 5-like (S. pombe) 0.979
COPS5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) 0.979
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.978
CDK4 cyclin-dependent kinase 4 0.977
BCL2L1 BCL2-like 1 0.977
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.977
HIST1H2BF histone cluster 1, H2bf 0.977
RAD51C RAD51 homolog C (S. cerevisiae) 0.976
CHAF1A chromatin assembly factor 1, subunit A (p150) 0.973
CCND3 cyclin D3 0.973
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 0.973
CHUK conserved helix-loop-helix ubiquitous kinase 0.970
MCM2 minichromosome maintenance complex component 2 0.970
TERF2 telomeric repeat binding factor 2 0.969
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.969
HIST1H2BD histone cluster 1, H2bd 0.966
TOP1 topoisomerase (DNA) I 0.964
SMC1A structural maintenance of chromosomes 1A 0.964
SIRT1 sirtuin 1 0.961
HIST1H1C histone cluster 1, H1c 0.960
HIST1H2BG histone cluster 1, H2bg 0.960
MDM4 Mdm4 p53 binding protein homolog (mouse) 0.960
TFDP1 transcription factor Dp-1 0.959
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.957
DHX9 DEAH (Asp-Glu-Ala-His) box polypeptide 9 0.955
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.954
STK4 serine/threonine kinase 4 0.953
SUMO2 SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) 0.952
SMC6 structural maintenance of chromosomes 6 0.950
FEN1 flap structure-specific endonuclease 1 0.950
BCL2 B-cell CLL/lymphoma 2 0.949
RPA2 replication protein A2, 32kDa 0.947
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.947
UBE2N ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) 0.946
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.945
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 1.000
Mdm2 transformed mouse 3T3 cell double minute 2 1.000
Pten phosphatase and tensin homolog 1.000
Brca2 breast cancer 2 1.000
Brca1 breast cancer 1 1.000
Rb1 retinoblastoma 1 1.000
Atm ataxia telangiectasia mutated homolog (human) 0.999
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.999
Mdm4 transformed mouse 3T3 cell double minute 4 0.999
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.998
Igh immunoglobulin heavy chain complex 0.997
E2f1 E2F transcription factor 1 0.997
Ctnnb1 catenin (cadherin associated protein), beta 1 0.994
Tcf3 transcription factor 3 0.993
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.993
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.992
Suz12 suppressor of zeste 12 homolog (Drosophila) 0.991
Msh2 mutS homolog 2 (E. coli) 0.988
Pcna proliferating cell nuclear antigen 0.988
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.987
Nbn nibrin 0.986
Mcm2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae) 0.985
Apc adenomatosis polyposis coli 0.983
Tnf tumor necrosis factor 0.980
Cdt1 chromatin licensing and DNA replication factor 1 0.976
Timeless timeless homolog (Drosophila) 0.975
Mcm7 minichromosome maintenance deficient 7 (S. cerevisiae) 0.973
Cdk4 cyclin-dependent kinase 4 0.972
Prkdc protein kinase, DNA activated, catalytic polypeptide 0.962
Pold1 polymerase (DNA directed), delta 1, catalytic subunit 0.960
Mcm4 minichromosome maintenance deficient 4 homolog (S. cerevisiae) 0.958
Sirt1 sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae) 0.953
Mybl2 myeloblastosis oncogene-like 2 0.949
Cdk1 cyclin-dependent kinase 1 0.936
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.935
Mtor mechanistic target of rapamycin (serine/threonine kinase) 0.932
Ash2l ash2 (absent, small, or homeotic)-like (Drosophila) 0.932
Ikzf1 IKAROS family zinc finger 1 0.927
Rev1 REV1 homolog (S. cerevisiae) 0.927
Wrn Werner syndrome homolog (human) 0.925
Psma5 proteasome (prosome, macropain) subunit, alpha type 5 0.924
Clock circadian locomotor output cycles kaput 0.916
Prim1 DNA primase, p49 subunit 0.897
Parp1 poly (ADP-ribose) polymerase family, member 1 0.895
Rnf2 ring finger protein 2 0.894
Xpa xeroderma pigmentosum, complementation group A 0.892
Stag1 stromal antigen 1 0.891
Mapk8 mitogen-activated protein kinase 8 0.889
Braf Braf transforming gene 0.885
Blm Bloom syndrome, RecQ helicase-like 0.877
Mcl1 myeloid cell leukemia sequence 1 0.876
Bax BCL2-associated X protein 0.875
Vegfa vascular endothelial growth factor A 0.875
Psma4 proteasome (prosome, macropain) subunit, alpha type 4 0.874
Usp1 ubiquitin specific peptidase 1 0.872
Mcm5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) 0.869
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.862
Psma7 proteasome (prosome, macropain) subunit, alpha type 7 0.860
Cdk2 cyclin-dependent kinase 2 0.854
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.851
Uhrf1 ubiquitin-like, containing PHD and RING finger domains, 1 0.846
Psmb4 proteasome (prosome, macropain) subunit, beta type 4 0.841
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.840
Orc1 origin recognition complex, subunit 1 0.835
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.833
Trim28 tripartite motif-containing 28 0.832
Psmb7 proteasome (prosome, macropain) subunit, beta type 7 0.830
Hprt hypoxanthine guanine phosphoribosyl transferase 0.829
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.829
Psmb2 proteasome (prosome, macropain) subunit, beta type 2 0.823
Notch1 Notch gene homolog 1 (Drosophila) 0.821
Skil SKI-like 0.819
Per1 period homolog 1 (Drosophila) 0.818
Atf2 activating transcription factor 2 0.817
Psma2 proteasome (prosome, macropain) subunit, alpha type 2 0.816
Tsc1 tuberous sclerosis 1 0.813
Cry1 cryptochrome 1 (photolyase-like) 0.804
Per2 period homolog 2 (Drosophila) 0.800
Brd4 bromodomain containing 4 0.798
Terf1 telomeric repeat binding factor 1 0.798
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.792
Ctcf CCCTC-binding factor 0.791
Vasp vasodilator-stimulated phosphoprotein 0.790
Rbl1 retinoblastoma-like 1 (p107) 0.783
Myc myelocytomatosis oncogene 0.782
Hat1 histone aminotransferase 1 0.780
Hells helicase, lymphoid specific 0.779
Chek1 checkpoint kinase 1 homolog (S. pombe) 0.776
Ccne1 cyclin E1 0.775
Foxo3 forkhead box O3 0.773
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.773
Smad4 MAD homolog 4 (Drosophila) 0.772
Psma1 proteasome (prosome, macropain) subunit, alpha type 1 0.771
Crebbp CREB binding protein 0.770
Pold3 polymerase (DNA-directed), delta 3, accessory subunit 0.759
Ikbkb inhibitor of kappaB kinase beta 0.758
Wdhd1 WD repeat and HMG-box DNA binding protein 1 0.758
Ncoa6 nuclear receptor coactivator 6 0.756
Hmgb1 high mobility group box 1 0.756
Rbl2 retinoblastoma-like 2 0.747
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Psmc1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.231
Psmb3 proteasome (prosome, macropain) subunit, beta type 3 0.119
Psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.099
Ptbp1 polypyrimidine tract binding protein 1 0.086
Psme2 proteasome (prosome, macropain) activator subunit 2 0.080
Psmb2 proteasome (prosome, macropain) subunit, beta type 2 0.064
Dnaja2 DnaJ (Hsp40) homolog, subfamily A, member 2 0.055
Cdk4 cyclin-dependent kinase 4 0.045
Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) 0.040
Psma4 proteasome (prosome, macropain) subunit, alpha type 4 0.036
Psmc5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.033
Rfc4 replication factor C (activator 1) 4 0.032
Psmd13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 0.031
Timeless timeless homolog (Drosophila) 0.029
Gapdh glyceraldehyde-3-phosphate dehydrogenase 0.027
Oaz1 ornithine decarboxylase antizyme 1 0.027
Stip1 stress-induced phosphoprotein 1 0.027
Mapk1 mitogen activated protein kinase 1 0.026
Kifc1 kinesin family member C1 0.026
Taok1 TAO kinase 1 0.025
Cdk2 cyclin dependent kinase 2 0.025
Icam1 intercellular adhesion molecule 1 0.025
Arf6 ADP-ribosylation factor 6 0.025
Top2a topoisomerase (DNA) II alpha 0.024
Tmpo thymopoietin 0.024
Atf2 activating transcription factor 2 0.023
Psmd7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 0.023
Psmb7 proteasome (prosome, macropain) subunit, beta type 7 0.022
Psmc3 proteasome (prosome, macropain) 26S subunit, ATPase 3 0.022
Asf1b ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.022
Eif4a2 eukaryotic translation initiation factor 4A, isoform 2 0.021
Ptges3 prostaglandin E synthase 3 (cytosolic) 0.020
Rrm2 ribonucleotide reductase M2 0.020
Irf1 interferon regulatory factor 1 0.020
Ube2c ubiquitin-conjugating enzyme E2C 0.019
Rpa2 replication protein A2 0.018
Nsfl1c NSFL1 (p97) cofactor (p47) 0.018
Creb1 cAMP responsive element binding protein 1 0.018
Arnt aryl hydrocarbon receptor nuclear translocator 0.017
Psmc4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.017
Cherp calcium homeostasis endoplasmic reticulum protein 0.017
Ppp1ca protein phosphatase 1, catalytic subunit, alpha isoform 0.016
Sf1 splicing factor 1 0.016
Mdm2 Mdm2 p53 binding protein homolog (mouse) 0.016
Cxcl16 chemokine (C-X-C motif) ligand 16 0.016
Foxm1 forkhead box M1 0.016
Cand1 cullin-associated and neddylation-dissociated 1 0.015
Tyms thymidylate synthetase 0.015
Usp47 ubiquitin specific peptidase 47 0.015
Ppp2ca protein phosphatase 2, catalytic subunit, alpha isoform 0.015
Spc25 SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) 0.015
Lmnb1 lamin B1 0.015
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.015
Psmb4 proteasome (prosome, macropain) subunit, beta type 4 0.014
Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 0.014
Psma5 proteasome (prosome, macropain) subunit, alpha type 5 0.014
Psma7 proteasome (prosome, macropain) subunit, alpha type 7 0.014
Actb actin, beta 0.014
Pfn1 profilin 1 0.014
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.014
Zfp36 zinc finger protein 36 0.014
Ppp1cb protein phosphatase 1, catalytic subunit, beta isoform 0.014
Ifi30 interferon gamma inducible protein 30 0.014
Top2b topoisomerase (DNA) II beta 0.014
Psmd6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.013
Vcp valosin-containing protein 0.013
Ifitm3 interferon induced transmembrane protein 3 0.013
Myo1b myosin Ib 0.013
Psmd1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.013
Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) 0.013
Txnrd1 thioredoxin reductase 1 0.013
Zc3h15 zinc finger CCCH-type containing 15 0.013
Psmd4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.013
Psmd12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.013
Lbr lamin B receptor 0.013
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.013
Tp53 tumor protein p53 0.013
Timp1 TIMP metallopeptidase inhibitor 1 0.013
Errfi1 ERBB receptor feedback inhibitor 1 0.012
Usp9x ubiquitin specific peptidase 9, X-linked 0.012
Mcm6 minichromosome maintenance complex component 6 0.012
Racgap1 Rac GTPase-activating protein 1 0.012
Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha isoform 0.012
Lgals3bp lectin, galactoside-binding, soluble, 3 binding protein 0.012
Tmsb4x thymosin beta 4, X-linked 0.012
Sumo1 SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) 0.012
B3gat1 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) 0.012
Ube2g1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) 0.011
Zfand6 zinc finger, AN1-type domain 6 0.011
Socs3 suppressor of cytokine signaling 3 0.011
Ssrp1 structure specific recognition protein 1 0.011
Apex1 APEX nuclease (multifunctional DNA repair enzyme) 1 0.011
Ireb2 iron responsive element binding protein 2 0.011
Mark2 MAP/microtubule affinity-regulating kinase 2 0.011
Actg1 actin, gamma 1 0.011
Cops6 COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis) 0.010
Ubc ubiquitin C 0.010
Actr10 actin-related protein 10 homolog (S. cerevisiae) 0.010
Exoc5 exocyst complex component 5 0.010
Raf1 v-raf-leukemia viral oncogene 1 0.010