The network for 'negative regulation of meiotic cell cycle' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of meiotic cell cycle

Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
HXT4 Hxt4p 0.913
RED1 Red1p 0.834
SNT1 Snt1p 0.785
HXT2 Hxt2p 0.777
PPH22 Pph22p 0.685
MEK1 Mek1p 0.602
PSY2 Psy2p 0.485
MTH1 Mth1p 0.467
ZDS1 Zds1p 0.442
YCS4 Ycs4p 0.344
HOS4 Hos4p 0.322
HOP1 Hop1p 0.319
HOS2 Hos2p 0.212
PSY4 Psy4p 0.203
YAR028W hypothetical protein 0.189
HXT3 Hxt3p 0.181
RAD17 Rad17p 0.173
GIS1 Gis1p 0.154
GAL2 Gal2p 0.149
BRN1 Brn1p 0.148
MSN4 Msn4p 0.147
SIF2 Sif2p 0.143
CCT2 Cct2p 0.135
STE4 Ste4p 0.125
PSD2 Psd2p 0.122
THI22 Thi22p 0.116
URA8 Ura8p 0.113
HXT8 Hxt8p 0.112
PPH3 Pph3p 0.104
RAD9 Rad9p 0.094
HXT1 Hxt1p 0.093
YHR033W hypothetical protein 0.092
GIS4 Gis4p 0.091
PHO81 Pho81p 0.085
SCS7 Scs7p 0.083
CPR1 Cpr1p 0.082
NOC3 Noc3p 0.079
MRL1 Mrl1p 0.075
RAD24 Rad24p 0.072
HSL1 Hsl1p 0.067
SMC4 Smc4p 0.067
HOT1 Hot1p 0.066
ZIP1 Zip1p 0.062
YNR073C hypothetical protein 0.061
SRS2 Srs2p 0.058
TAX4 Tax4p 0.057
COS111 Cos111p 0.056
YMR279C hypothetical protein 0.055
PDS1 Pds1p 0.054
GPR1 Gpr1p 0.054
YMR259C hypothetical protein 0.053
PDR15 Pdr15p 0.053
CDC55 Cdc55p 0.053
CKA1 Cka1p 0.051
PPH21 Pph21p 0.050
GAL10 Gal10p 0.049
SMC2 Smc2p 0.048
UGA2 Uga2p 0.048
GLO3 Glo3p 0.046
HXT9 Hxt9p 0.046
RGC1 Rgc1p 0.046
AZF1 Azf1p 0.046
YMR315W hypothetical protein 0.045
HXT11 Hxt11p 0.045
YMR155W hypothetical protein 0.045
MPH3 Mph3p 0.044
MEC1 Mec1p 0.043
MNR2 Mnr2p 0.041
MIG2 Mig2p 0.041
IZH4 Izh4p 0.041
PWP1 Pwp1p 0.039
TPK2 Tpk2p 0.039
PCL1 Pcl1p 0.039
CMD1 Cmd1p 0.039
NUC1 Nuc1p 0.038
SLG1 Slg1p 0.038
CCC2 Ccc2p 0.038
IMA4 Ima4p 0.037
GUD1 Gud1p 0.037
RCO1 Rco1p 0.036
HXT10 Hxt10p 0.036
RIO2 Rio2p 0.036
POT1 Pot1p 0.035
ZIP2 Zip2p 0.035
HHO1 Hho1p 0.035
PHO84 Pho84p 0.034
DFM1 Dfm1p 0.034
PIG1 Pig1p 0.034
MOT3 Mot3p 0.034
SMA1 Sma1p 0.034
SIP2 Sip2p 0.033
POL30 Pol30p 0.033
SET3 Set3p 0.032
FRE7 Fre7p 0.032
SWT1 Swt1p 0.032
HXT7 Hxt7p 0.032
SOR1 Sor1p 0.032
BDH1 Bdh1p 0.031
CMK1 Cmk1p 0.031
KIN1 Kin1p 0.031
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
ung uracil-DNA glycosylase 0.074
ncapd2 non-SMC condensin I complex, subunit D2 0.057
med12 mediator of RNA polymerase II transcription, subunit 12 homolog 0.031
LOC554173 abnormal spindles 0.029
slbp stem-loop binding protein 0.026
mib mind bomb 0.023
ncapg non-SMC condensin I complex, subunit G 0.022
kpna2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 0.021
setd8a SET domain containing (lysine methyltransferase) 8a 0.021
smc4 structural maintenance of chromosomes 4 0.021
gins3 GINS complex subunit 3 0.020
rpa3 replication protein A3 0.020
tyms thymidylate synthase 0.019
whsc1 Wolf-Hirschhorn syndrome candidate 1 0.018
zgc:92648 zgc:92648 0.017
wdhd1 WD repeat and HMG-box DNA binding protein 1 0.017
dnmt1 DNA (cytosine-5-)-methyltransferase 1 0.016
rad21 RAD21 homolog (S. pombe) 0.015
lepr leptin receptor 0.015
orc6 origin recognition complex, subunit 6 0.014
zgc:110113 zgc:110113 0.014
pcsk2 proprotein convertase subtilisin/kexin type 2 0.014
pgr progesterone receptor 0.012
ezh2 enhancer of zeste homolog 2 (Drosophila) 0.012
smc3 structural maintenance of chromosomes 3 0.012
hdac1 histone deacetylase 1 0.012
zgc:55701 zgc:55701 0.012
esco2 establishment of cohesion 1 homolog 2 0.012
stil TAL1 (SCL) interrupting locus 0.011
suv39h1b suppressor of variegation 3-9 homolog 1b 0.011
msh2 mutS homolog 2 (E. coli) 0.011
dhfr dihydrofolate reductase 0.011
zgc:113210 zgc:113210 0.011
bon bonnie and clyde 0.011
dut dUTP pyrophosphatase 0.011
atad5a ATPase family, AAA domain containing 5a 0.011
chaf1b chromatin assembly factor 1, subunit B 0.010
smad5 MAD homolog 5 (Drosophila) 0.010
ints6 integrator complex subunit 6 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
mxc multi sex combs 0.369
nej nejire 0.253
CycA Cyclin A 0.207
Doa Darkener of apricot 0.204
RPA2 Replication protein A2 0.177
Sxl Sex lethal 0.129
His2Av Histone H2A variant 0.126
CycJ Cyclin J 0.122
Cap-G CG34438 gene product from transcript CG34438-RF 0.117
Aly CG1101 gene product from transcript CG1101-RA 0.106
cdc2c CG10498 gene product from transcript CG10498-RC 0.106
prod proliferation disrupter 0.104
Akt1 CG4006 gene product from transcript CG4006-RA 0.095
brat brain tumor 0.092
Rpd3 CG7471 gene product from transcript CG7471-RA 0.084
dap dacapo 0.080
RfC4 Replication factor C subunit 4 0.072
Taf6 TBP-associated factor 6 0.070
mus209 mutagen-sensitive 209 0.067
fzy fizzy 0.064
lok loki 0.063
MRG15 CG6363 gene product from transcript CG6363-RA 0.063
pUf68 poly U binding factor 68kD 0.056
Snr1 Snf5-related 1 0.055
Bj1 Bj1 protein 0.052
ecd ecdysoneless 0.052
caz cabeza 0.052
CkIIalpha Casein kinase II alpha subunit 0.051
Su(var)205 Suppressor of variegation 205 0.051
piwi CG6122 gene product from transcript CG6122-RA 0.051
mod(mdg4) modifier of mdg4 0.050
Kmn1 kinetochore Mis12-Ndc80 network component 1 0.049
Src64B Src oncogene at 64B 0.047
O-fut1 O-fucosyltransferase 1 0.044
CrebB-17A Cyclic-AMP response element binding protein B at 17A 0.044
rl rolled 0.042
tra2 transformer 2 0.042
SelD Selenide,water dikinase 0.042
DNApol-delta DNA-polymerase-delta 0.041
pzg putzig 0.040
feo fascetto 0.039
14-3-3epsilon CG31196 gene product from transcript CG31196-RA 0.039
Mcm6 Minichromosome maintenance 6 0.037
jumu jumeau 0.037
Dref DNA replication-related element factor 0.036
BEAF-32 Boundary element-associated factor of 32kD 0.034
mei-9 meiotic 9 0.034
CG9135 CG9135 gene product from transcript CG9135-RB 0.033
egg eggless 0.032
cmet CENP-meta 0.032
ovo CG6824 gene product from transcript CG6824-RE 0.031
Rbf Retinoblastoma-family protein 0.030
Taf1 TBP-associated factor 1 0.030
CycE Cyclin E 0.030
pav pavarotti 0.029
Su(var)2-10 Suppressor of variegation 2-10 0.029
cg combgap 0.029
sqd squid 0.028
pim pimples 0.028
CycH Cyclin H 0.028
gpp grappa 0.027
Map60 Microtubule-associated protein 60 0.026
CycB Cyclin B 0.026
Nop60B Nucleolar protein at 60B 0.026
Ote Otefin 0.025
Mcm7 Minichromosome maintenance 7 0.025
osk oskar 0.024
ph-p polyhomeotic proximal 0.024
Dsor1 Downstream of raf1 0.024
Cenp-C CG31258 gene product from transcript CG31258-RA 0.023
Sce Sex combs extra 0.023
CG10267 CG10267 gene product from transcript CG10267-RB 0.023
U2af50 U2 small nuclear riboprotein auxiliary factor 50 0.023
CG4973 CG4973 gene product from transcript CG4973-RA 0.023
TH1 CG9984 gene product from transcript CG9984-RA 0.022
Cul-5 Cullin-5 0.021
snRNP-U1-70K small ribonucleoprotein particle U1 subunit 70K 0.021
spn-B spindle B 0.021
l(1)G0095 lethal (1) G0095 0.021
Orc1 Origin recognition complex subunit 1 0.020
CycC Cyclin C 0.020
Bap55 Brahma associated protein 55kD 0.020
nos nanos 0.019
katanin-60 katanin 60 0.019
polo CG12306 gene product from transcript CG12306-RA 0.018
mus101 mutagen-sensitive 101 0.018
dsh dishevelled 0.018
CG5745 CG5745 gene product from transcript CG5745-RA 0.017
pie pineapple eye 0.017
cav caravaggio 0.017
alphaTub67C alpha-Tubulin at 67C 0.017
vas vasa 0.017
fu fused 0.017
heph hephaestus 0.016
mus301 mutagen-sensitive 301 0.016
barr barren 0.016
gfzf GST-containing FLYWCH zinc-finger protein 0.016
Vsx2 CG33980 gene product from transcript CG33980-RA 0.015
mus308 mutagen-sensitive 308 0.015
slmb supernumerary limbs 0.015
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Homo sapiens
Name Description Probability Func Analog Organism
PCNA proliferating cell nuclear antigen 0.992
CCNA2 cyclin A2 0.983
NCAPH non-SMC condensin I complex, subunit H 0.980
CDC27 cell division cycle 27 homolog (S. cerevisiae) 0.882
CDK1 cyclin-dependent kinase 1 0.801
SKP2 S-phase kinase-associated protein 2 (p45) 0.796
CCNB1 cyclin B1 0.796
SMC4 structural maintenance of chromosomes 4 0.730
CDC20 cell division cycle 20 homolog (S. cerevisiae) 0.420
NCAPD2 non-SMC condensin I complex, subunit D2 0.270
HUS1 HUS1 checkpoint homolog (S. pombe) 0.262
ANAPC4 anaphase promoting complex subunit 4 0.209
NCAPG2 non-SMC condensin II complex, subunit G2 0.208
BUB1B budding uninhibited by benzimidazoles 1 homolog beta (yeast) 0.202
ANAPC7 anaphase promoting complex subunit 7 0.189
ANAPC1 anaphase promoting complex subunit 1 0.165
CKS2 CDC28 protein kinase regulatory subunit 2 0.143
RBBP8 retinoblastoma binding protein 8 0.103
SMC2 structural maintenance of chromosomes 2 0.100
CKS1B CDC28 protein kinase regulatory subunit 1B 0.099
AKAP11 A kinase (PRKA) anchor protein 11 0.095
CCNE1 cyclin E1 0.094
RPA1 replication protein A1, 70kDa 0.092
CDK2 cyclin-dependent kinase 2 0.090
ANAPC5 anaphase promoting complex subunit 5 0.085
MCM6 minichromosome maintenance complex component 6 0.083
CDC23 cell division cycle 23 homolog (S. cerevisiae) 0.080
CDC6 cell division cycle 6 homolog (S. cerevisiae) 0.075
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.070
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) 0.063
AKIP1 A kinase (PRKA) interacting protein 1 0.063
MSH6 mutS homolog 6 (E. coli) 0.059
RYR2 ryanodine receptor 2 (cardiac) 0.055
CCNE2 cyclin E2 0.053
SIP1 survival of motor neuron protein interacting protein 1 0.052
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 0.049
ORC1 origin recognition complex, subunit 1 0.044
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.042
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta 0.042
NCAPD3 non-SMC condensin II complex, subunit D3 0.041
NCAPH2 non-SMC condensin II complex, subunit H2 0.039
MSH2 mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) 0.034
CDC26 cell division cycle 26 homolog (S. cerevisiae) 0.034
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.032
CDC7 cell division cycle 7 homolog (S. cerevisiae) 0.031
DSN1 DSN1, MIND kinetochore complex component, homolog (S. cerevisiae) 0.031
RFC3 replication factor C (activator 1) 3, 38kDa 0.031
HDAC3 histone deacetylase 3 0.029
CENPQ centromere protein Q 0.028
CDT1 chromatin licensing and DNA replication factor 1 0.028
CDC16 cell division cycle 16 homolog (S. cerevisiae) 0.028
CCNB2 cyclin B2 0.028
ATAD2 ATPase family, AAA domain containing 2 0.027
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 0.027
NCAPG non-SMC condensin I complex, subunit G 0.027
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 0.025
MCM2 minichromosome maintenance complex component 2 0.024
PRPS1 phosphoribosyl pyrophosphate synthetase 1 0.024
MSH3 mutS homolog 3 (E. coli) 0.023
TMEM194A transmembrane protein 194A 0.021
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.020
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa 0.020
DONSON downstream neighbor of SON 0.019
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B 0.019
UNG uracil-DNA glycosylase 0.018
CCT8 chaperonin containing TCP1, subunit 8 (theta) 0.018
MUS81 MUS81 endonuclease homolog (S. cerevisiae) 0.017
MCM3 minichromosome maintenance complex component 3 0.017
SMC1A structural maintenance of chromosomes 1A 0.017
DBF4 DBF4 homolog (S. cerevisiae) 0.016
C13orf27 chromosome 13 open reading frame 27 0.016
RAD21 RAD21 homolog (S. pombe) 0.016
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 0.016
RFWD3 ring finger and WD repeat domain 3 0.016
C13orf34 chromosome 13 open reading frame 34 0.015
RFC1 replication factor C (activator 1) 1, 145kDa 0.014
NUSAP1 nucleolar and spindle associated protein 1 0.014
GPSM2 G-protein signaling modulator 2 0.014
ANAPC11 anaphase promoting complex subunit 11 0.014
PLK4 polo-like kinase 4 0.014
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha 0.014
MAPK3 mitogen-activated protein kinase 3 0.014
ZNF207 zinc finger protein 207 0.013
KIF18A kinesin family member 18A 0.013
MCM4 minichromosome maintenance complex component 4 0.013
TFDP1 transcription factor Dp-1 0.013
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa 0.013
ASF1A ASF1 anti-silencing function 1 homolog A (S. cerevisiae) 0.013
WASF2 WAS protein family, member 2 0.013
RPA2 replication protein A2, 32kDa 0.013
FBXO5 F-box protein 5 0.013
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.012
CCDC99 coiled-coil domain containing 99 0.012
EVI5 ecotropic viral integration site 5 0.012
IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) 0.012
SETD7 SET domain containing (lysine methyltransferase) 7 0.012
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 0.012
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta 0.011
STK17A serine/threonine kinase 17a 0.011
SORBS3 sorbin and SH3 domain containing 3 0.011
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Mus musculus
Name Description Probability Func Analog Organism
Ccna2 cyclin A2 0.452
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.344
Pcna proliferating cell nuclear antigen 0.279
Ccnb1 cyclin B1 0.222
Trim59 tripartite motif-containing 59 0.098
Plk4 polo-like kinase 4 (Drosophila) 0.079
Prc1 protein regulator of cytokinesis 1 0.070
Smc4 structural maintenance of chromosomes 4 0.069
Cdca8 cell division cycle associated 8 0.060
Ccne1 cyclin E1 0.060
Top2a topoisomerase (DNA) II alpha 0.058
Cdk1 cyclin-dependent kinase 1 0.058
Tmpo thymopoietin 0.053
Erg avian erythroblastosis virus E-26 (v-ets) oncogene related 0.052
Ccnb2 cyclin B2 0.051
Cenpj centromere protein J 0.049
Birc5 baculoviral IAP repeat-containing 5 0.048
Anln anillin, actin binding protein 0.041
C330027C09Rik RIKEN cDNA C330027C09 gene 0.040
Kif20a kinesin family member 20A 0.039
Cnot1 CCR4-NOT transcription complex, subunit 1 0.036
Kif11 kinesin family member 11 0.035
Pou5f1 POU domain, class 5, transcription factor 1 0.034
Ncoa3 nuclear receptor coactivator 3 0.033
Pias1 protein inhibitor of activated STAT 1 0.032
Nasp nuclear autoantigenic sperm protein (histone-binding) 0.032
Hmgb2 high mobility group box 2 0.032
Sufu suppressor of fused homolog (Drosophila) 0.032
Pola1 polymerase (DNA directed), alpha 1 0.031
Prkar2b protein kinase, cAMP dependent regulatory, type II beta 0.030
Kif23 kinesin family member 23 0.029
Mad2l1 MAD2 mitotic arrest deficient-like 1 (yeast) 0.028
Ckap2 cytoskeleton associated protein 2 0.023
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.021
Lin9 lin-9 homolog (C. elegans) 0.021
Hmmr hyaluronan mediated motility receptor (RHAMM) 0.021
Atad2 ATPase family, AAA domain containing 2 0.020
Racgap1 Rac GTPase-activating protein 1 0.020
Hells helicase, lymphoid specific 0.019
2610039C10Rik RIKEN cDNA 2610039C10 gene 0.019
Kif22 kinesin family member 22 0.018
Arpc4 actin related protein 2/3 complex, subunit 4 0.018
Mki67 antigen identified by monoclonal antibody Ki 67 0.018
Aurka aurora kinase A 0.017
C1qtnf5 C1q and tumor necrosis factor related protein 5 0.017
Ncaph non-SMC condensin I complex, subunit H 0.017
Cdk4 cyclin-dependent kinase 4 0.017
Ect2 ect2 oncogene 0.016
Lsm2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.016
H1 histocompatibility 1 0.016
G2e3 G2/M-phase specific E3 ubiquitin ligase 0.016
Gnb2 guanine nucleotide binding protein (G protein), beta 2 0.016
Trp53 transformation related protein 53 0.016
Prkar1a protein kinase, cAMP dependent regulatory, type I, alpha 0.015
Cdk2 cyclin-dependent kinase 2 0.015
Zfp101 zinc finger protein 101 0.015
Ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform 0.015
Bub1 budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) 0.015
Adrb1 adrenergic receptor, beta 1 0.015
Rrm1 ribonucleotide reductase M1 0.014
Aspm asp (abnormal spindle)-like, microcephaly associated (Drosophila) 0.014
Arhgdia Rho GDP dissociation inhibitor (GDI) alpha 0.014
Nusap1 nucleolar and spindle associated protein 1 0.014
Pds5b PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) 0.013
Mcm4 minichromosome maintenance deficient 4 homolog (S. cerevisiae) 0.013
Cenpa centromere protein A 0.013
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.013
Dtl denticleless homolog (Drosophila) 0.013
Guca2b guanylate cyclase activator 2b (retina) 0.012
Pkd1 polycystic kidney disease 1 homolog 0.012
Mdm4 transformed mouse 3T3 cell double minute 4 0.012
Atp2c2 ATPase, Ca++ transporting, type 2C, member 2 0.011
Kif2c kinesin family member 2C 0.011
Terf1 telomeric repeat binding factor 1 0.011
Zfp42 zinc finger protein 42 0.011
Add1 adducin 1 (alpha) 0.011
Cwh43 cell wall biogenesis 43 C-terminal homolog (S. cerevisiae) 0.010
Aurkb aurora kinase B 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism