The network for 'response to oxidative stress' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to oxidative stress

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
PRX1 Prx1p 0.814
PHO85 Pho85p 0.742
TRX2 Trx2p 0.595
SOD1 Sod1p 0.571
TRR1 Trr1p 0.509
AFT1 Aft1p 0.500
CTT1 Ctt1p 0.471
YAP1 Yap1p 0.440
AHP1 Ahp1p 0.415
SNF1 Snf1p 0.387
AIM17 Aim17p 0.384
TSA1 Tsa1p 0.346
HOG1 Hog1p 0.328
SLT2 Slt2p 0.307
CUP1-1 Cup1-1p 0.289
RFS1 Rfs1p 0.286
ACS2 Acs2p 0.264
ZWF1 Zwf1p 0.255
CUP1-2 Cup1-2p 0.243
KSS1 Kss1p 0.229
CRM1 Crm1p 0.221
HMX1 Hmx1p 0.220
SSL2 Ssl2p 0.220
GLR1 Glr1p 0.216
YCF1 Ycf1p 0.209
MOB1 Mob1p 0.202
GLN3 Gln3p 0.197
DDR48 Ddr48p 0.187
APN2 Apn2p 0.183
ALD4 Ald4p 0.181
POG1 Pog1p 0.179
GRX2 Grx2p 0.176
HOP1 Hop1p 0.174
GCY1 Gcy1p 0.171
YSA1 Ysa1p 0.170
RHO1 Rho1p 0.169
NDE1 Nde1p 0.168
TSA2 Tsa2p 0.165
SKO1 Sko1p 0.161
VMA5 Vma5p 0.161
SIR2 Sir2p 0.160
IDP2 Idp2p 0.154
HST3 Hst3p 0.153
ALD6 Ald6p 0.153
TSL1 Tsl1p 0.153
CRZ1 Crz1p 0.148
NTH2 Nth2p 0.145
RAD16 Rad16p 0.144
GRE2 Gre2p 0.143
GRE3 Gre3p 0.143
HYR1 Hyr1p 0.141
DBF20 Dbf20p 0.141
YOL087C hypothetical protein 0.140
CNB1 Cnb1p 0.139
YNL134C hypothetical protein 0.138
STR3 Str3p 0.138
TRX3 Trx3p 0.137
RAD51 Rad51p 0.136
STE11 Ste11p 0.135
HSF1 Hsf1p 0.135
MIG2 Mig2p 0.135
GFA1 Gfa1p 0.133
HRP1 Hrp1p 0.133
XBP1 Xbp1p 0.133
STI1 Sti1p 0.131
FAR11 Far11p 0.130
SAC7 Sac7p 0.129
CAT2 Cat2p 0.128
GAT2 Gat2p 0.127
CYC8 Cyc8p 0.126
FPK1 Fpk1p 0.125
RBK1 Rbk1p 0.125
SCH9 Sch9p 0.119
CBK1 Cbk1p 0.119
ARE1 Are1p 0.119
RSC6 Rsc6p 0.118
SOD2 Sod2p 0.118
VAC7 Vac7p 0.117
ROM2 Rom2p 0.116
RED1 Red1p 0.116
TPS1 Tps1p 0.116
ITC1 Itc1p 0.113
KAP122 Kap122p 0.112
ECM38 Ecm38p 0.112
YAK1 Yak1p 0.111
CCS1 Ccs1p 0.107
MIG3 Mig3p 0.107
PPH3 Pph3p 0.107
PET10 Pet10p 0.106
GPA2 Gpa2p 0.105
YPL150W hypothetical protein 0.104
HYP2 Hyp2p 0.104
GSH1 Gsh1p 0.104
OM45 Om45p 0.103
PPG1 Ppg1p 0.103
SLM1 Slm1p 0.102
RPN4 Rpn4p 0.102
RGS2 Rgs2p 0.101
MSN2 Msn2p 0.101
GSP2 Gsp2p 0.100
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
itr-1 Protein ITR-1 0.038
acdh-3 Protein ACDH-3 0.035
mat-3 Protein MAT-3 0.035
K11H12.8 Protein K11H12.8 0.029
ppk-3 Protein PPK-3 0.029
hlh-2 Protein HLH-2 0.025
nhr-67 Protein NHR-67 0.024
bath-42 Protein BATH-42 0.022
lpin-1 Protein LPIN-1 0.022
gsr-1 Protein GSR-1 0.021
zyg-8 Protein ZYG-8 0.021
sem-5 Protein SEM-5 0.021
cye-1 Protein CYE-1 0.021
cri-3 Protein CRI-3 0.021
F35G2.2 Protein F35G2.2 0.020
cat-1 Protein CAT-1 0.020
tomm-20 Protein TOMM-20 0.019
pek-1 Protein PEK-1 0.019
nhr-34 Protein NHR-34 0.019
gst-7 Protein GST-7 0.019
gei-4 Protein GEI-4 0.018
Y22D7AL.10 Protein Y22D7AL.10 0.018
CELE_C27D8.2 Protein C27D8.2 0.018
prdx-2 Protein PRDX-2 0.018
egl-18 Protein EGL-18 0.018
cam-1 Protein CAM-1 0.018
vav-1 Protein VAV-1 0.018
K07C11.4 Protein K07C11.4 0.018
W01A11.1 Protein W01A11.1 0.017
prdx-3 Protein PRDX-3 0.017
let-60 Protein LET-60 0.017
nhr-120 Protein NHR-120 0.017
C18B2.5 Protein C18B2.5 0.017
vps-16 Protein VPS-16 0.017
pdfr-1 Protein PDFR-1 0.017
pes-1 Protein PES-1 0.017
smf-3 Protein SMF-3 0.016
vrk-1 Protein VRK-1 0.016
ubr-1 Protein UBR-1 0.016
egl-8 Protein EGL-8 0.016
har-1 Protein HAR-1 0.016
F48E8.3 Protein F48E8.3 0.016
pmk-1 Protein PMK-1 0.016
mrp-1 Protein MRP-1 0.016
F43H9.4 Protein F43H9.4 0.016
T23F4.2 Protein T23F4.2 0.015
smf-2 Protein SMF-2 0.015
mpz-2 Protein MPZ-2 0.015
F33H2.3 Protein F33H2.3 0.015
npp-13 Protein NPP-13 0.015
bli-4 Protein BLI-4 0.015
gei-8 Protein GEI-8 0.015
C34F6.10 Protein C34F6.10 0.015
E04A4.5 Protein E04A4.5 0.015
cin-4 Protein CIN-4 0.015
ZC449.5 Protein ZC449.5 0.015
eat-16 Protein EAT-16 0.015
hlh-1 Protein HLH-1 0.015
apa-2 Protein APA-2 0.015
eif-3.K Protein EIF-3.K 0.014
rpia-1 Protein RPIA-1 0.014
hlh-14 Protein HLH-14 0.014
lpd-9 Protein LPD-9 0.014
F21A10.2 Protein F21A10.2 0.014
sym-4 Protein SYM-4 0.014
T08G11.1 Protein T08G11.1 0.014
nuo-2 Protein NUO-2 0.014
R05F9.6 Protein R05F9.6 0.014
CELE_F20D1.3 Protein F20D1.3 0.014
fln-2 Protein FLN-2 0.014
nipi-3 Protein NIPI-3 0.014
C24A1.3 Protein C24A1.3 0.014
acs-19 Protein ACS-19 0.014
btbd-10 Protein BTBD-10 0.014
tct-1 Protein TCT-1 0.014
glit-1 Protein GLIT-1 0.014
mig-5 Protein MIG-5 0.014
scc-1 Protein SCC-1 0.014
sax-7 Protein SAX-7 0.014
T05F1.2 Protein T05F1.2 0.013
nhr-49 Protein NHR-49 0.013
plc-3 Protein PLC-3 0.013
syd-9 Protein SYD-9 0.013
plc-1 Protein PLC-1 0.013
Y51H1A.3 Protein Y51H1A.3 0.013
T19D12.5 Protein T19D12.5 0.013
soc-2 Protein SOC-2 0.013
ced-3 Protein CED-3 0.013
lag-1 Protein LAG-1 0.013
alh-3 Protein ALH-3 0.013
C30H6.7 Protein C30H6.7 0.013
F21F3.6 Protein F21F3.6 0.013
C23H3.3 Protein C23H3.3 0.013
mcm-3 Protein MCM-3 0.013
aldo-2 Protein ALDO-2 0.013
D1043.1 Protein D1043.1 0.013
let-23 Protein LET-23 0.013
C50F2.5 Protein C50F2.5 0.013
M57.2 Protein M57.2 0.013
ant-1.1 Protein ANT-1.1 0.013
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
mapk1 mitogen-activated protein kinase 1 0.773
bcl2l1 bcl2-like 1 0.712
per2 period homolog 2 (Drosophila) 0.426
pitx3 paired-like homeodomain transcription factor 3 0.339
jun jun proto-oncogene 0.305
per3 period homolog 3 (Drosophila) 0.295
tp53 tumor protein p53 0.287
copeb core promoter element binding protein 0.268
igf1rb insulin-like growth factor 1b receptor 0.263
adipor2 adiponectin receptor 2 0.259
cry1a cryptochrome 1a 0.251
cry2b cryptochrome 2b 0.227
pafah1b1a platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit a 0.186
stmn2b stathmin-like 2b 0.181
mapk3 mitogen-activated protein kinase 3 0.176
sgk1 serum/glucocorticoid regulated kinase 1 0.172
ptf1a pancreas specific transcription factor, 1a 0.167
nr3c1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.140
ef1a elongation factor 1-alpha 0.132
cyp3c1 cytochrome P450, family 3, subfamily c, polypeptide 1 0.129
trim13 tripartite motif-containing 13 0.128
idh1 isocitrate dehydrogenase 1 (NADP+), soluble 0.125
tardbp TAR DNA binding protein 0.124
ddb2 damage-specific DNA binding protein 2 0.114
sod1 superoxide dismutase 1, soluble 0.111
pafah1b1b platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b 0.110
odc1 ornithine decarboxylase 1 0.105
tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.103
qk quaking 0.102
elovl5 ELOVL family member 5, elongation of long chain fatty acids (yeast) 0.097
ctsba cathepsin B, a 0.096
gadd45ba growth arrest and DNA-damage-inducible, beta a 0.095
hif1ab hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b 0.093
pcsk1 proprotein convertase subtilisin/kexin type 1 0.092
cry3 cryptochrome 3 0.088
pgd phosphogluconate hydrogenase 0.087
atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.084
bmp4 bone morphogenetic protein 4 0.079
gstp1 glutathione S-transferase pi 0.077
cdh23 cadherin-like 23 0.075
prdx2 peroxiredoxin 2 0.072
aplp2 amyloid beta (A4) precursor-like protein 2 0.071
prdx3 peroxiredoxin 3 0.069
smad2 MAD homolog 2 (Drosophila) 0.069
slc5a5 solute carrier family 5 (sodium iodide symporter), member 5 0.068
abcc5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 0.068
hspd1 heat shock 60kD protein 1 (chaperonin) 0.066
trpv6 transient receptor potential cation channel, subfamily V, member 6 0.065
sepw1 selenoprotein W, 1 0.064
junbl jun B proto-oncogene, like 0.062
runx1 runt-related transcription factor 1 0.060
cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) 0.057
bbc3 BCL2 binding component 3 0.056
gclc glutamate-cysteine ligase, catalytic subunit 0.056
chat choline acetyltransferase 0.054
adipoql adiponectin, C1Q and collagen domain containing, like 0.054
pcsk2 proprotein convertase subtilisin/kexin type 2 0.053
nr1h3 nuclear receptor subfamily 1, group H, member 3 0.053
fos v-fos FBJ murine osteosarcoma viral oncogene homolog 0.051
sdha succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.050
bactin1 bactin1 0.050
stac3 SH3 and cysteine rich domain 3 0.049
ndufb8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8 0.047
igfbp1a insulin-like growth factor binding protein 1a 0.046
pdlim1 PDZ and LIM domain 1 (elfin) 0.045
zbtb4 zinc finger and BTB domain containing 4 0.044
evx1 even-skipped homeobox 1 0.044
myhc4 myosin heavy chain 4 0.044
pikfyve phosphoinositide kinase, FYVE finger containing 0.044
prox1 prospero-related homeobox gene 1 0.044
zgc:101071 zgc:101071 0.043
cdh1 cadherin 1, epithelial 0.043
grb10a growth factor receptor-bound protein 10a 0.042
zgc:64133 zgc:64133 0.042
gpx4b glutathione peroxidase 4b 0.041
tnni1al troponin I, skeletal, slow like 0.041
col4a5 collagen, type IV, alpha 5 (Alport syndrome) 0.041
fam60al family with sequence similarity 60, member A, like 0.040
nfkbiab nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b 0.039
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.038
rpsa ribosomal protein SA 0.038
appa amyloid beta (A4) precursor protein a 0.037
hsd3b7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 0.037
rpz rapunzel 0.037
col12a1 collagen, type XII, alpha 1 0.037
tpma alpha-tropomyosin 0.037
ikzf1 IKAROS family zinc finger 1 (Ikaros) 0.036
mdm2 transformed 3T3 cell double minute 2 homolog (mouse) 0.035
btg1 B-cell translocation gene 1 0.035
arl6 ADP-ribosylation factor-like 6 0.034
hbaa1 hemoglobin alpha adult-1 0.033
dvl3 dishevelled, dsh homolog 3 (Drosophila) 0.033
tbx20 T-box 20 0.032
mapk7 mitogen-activated protein kinase 7 0.031
smc1al structural maintenance of chromosomes 1A, like 0.031
gapdhs glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 0.030
cyp1a cytochrome P450, family 1, subfamily A 0.030
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.030
tkt transketolase 0.030
mstnb myostatin b 0.029
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Sod Superoxide dismutase 1.000
Trx-2 thioredoxin-2 0.998
Cat Catalase 0.997
Sod2 Superoxide dismutase 2 (Mn) 0.987
MTF-1 Metal response element-binding Transcription Factor-1 0.980
Mpk2 CG5475 gene product from transcript CG5475-RB 0.977
Pink1 PTEN-induced putative kinase 1 0.975
p38b CG7393 gene product from transcript CG7393-RA 0.959
shi shibire 0.946
NLaz Neural Lazarillo 0.933
PHGPx CG12013 gene product from transcript CG12013-RC 0.910
SdhB Succinate dehydrogenase B 0.906
l(3)82Fd CG32464 gene product from transcript CG32464-RR 0.905
Jafrac1 thioredoxin peroxidase 1 0.885
mth methuselah 0.881
drk downstream of receptor kinase 0.857
CG6783 CG6783 gene product from transcript CG6783-RC 0.846
InR Insulin-like receptor 0.825
dj-1beta CG1349 gene product from transcript CG1349-RA 0.747
Tpi Triose phosphate isomerase 0.731
Prx5 Peroxiredoxin 5 0.723
Itp-r83A Inositol 1,4,5,-tris-phosphate receptor 0.721
dco discs overgrown 0.695
p120ctn Adherens junction protein p120 0.661
ben bendless 0.642
chico CG5686 gene product from transcript CG5686-RB 0.607
Mer Merlin 0.601
Gyc-89Da Guanylyl cyclase at 89Da 0.599
C3G CG42328 gene product from transcript CG42328-RC 0.578
Thor CG8846 gene product from transcript CG8846-RA 0.568
stai stathmin 0.567
lok loki 0.566
Atf-2 Activating transcription factor-2 0.547
Pi3K68D Phosphotidylinositol 3 kinase 68D 0.517
mei-41 meiotic 41 0.513
Dcr-2 Dicer-2 0.498
tefu telomere fusion 0.495
cert ceramide transfer protein 0.487
MAN1 CG3167 gene product from transcript CG3167-RA 0.483
CG5362 CG5362 gene product from transcript CG5362-RA 0.473
GLaz Glial Lazarillo 0.464
wts warts 0.449
Trxr-1 Thioredoxin reductase-1 0.447
Aldh Aldehyde dehydrogenase 0.442
Atg13 Autophagy-specific gene 13 0.410
pan pangolin 0.407
kermit CG11546 gene product from transcript CG11546-RB 0.389
shg shotgun 0.385
Hsp27 Heat shock protein 27 0.380
t tan 0.373
Mekk1 CG7717 gene product from transcript CG7717-RB 0.366
Vps4 Vacuolar protein sorting 4 0.346
key kenny 0.344
rdgB retinal degeneration B 0.341
ImpL2 Ecdysone-inducible gene L2 0.331
Lnk CG17367 gene product from transcript CG17367-RC 0.327
Snoo Sno oncogene 0.327
Hsp22 Heat shock protein 22 0.326
awd abnormal wing discs 0.323
Akt1 CG4006 gene product from transcript CG4006-RA 0.315
mus201 mutagen-sensitive 201 0.311
fzy fizzy 0.304
Gyc-89Db Guanylyl cyclase at 89Db 0.302
hep hemipterous 0.300
Dredd Death related ced-3/Nedd2-like protein 0.289
EcR Ecdysone receptor 0.283
Ca-P60A Calcium ATPase at 60A 0.282
Trap1 CG3152 gene product from transcript CG3152-RA 0.272
sev sevenless 0.268
eag ether a go-go 0.267
CG8036 CG8036 gene product from transcript CG8036-RB 0.266
Dab Disabled 0.257
p53 CG33336 gene product from transcript CG33336-RB 0.249
CG13604 CG13604 gene product from transcript CG13604-RD 0.246
CG8993 CG8993 gene product from transcript CG8993-RA 0.246
Cng Cyclic-nucleotide-gated ion channel protein 0.243
Ric Ras which interacts with Calmodulin 0.242
Indy I'm not dead yet 0.241
Rac1 CG2248 gene product from transcript CG2248-RA 0.241
CG3683 CG3683 gene product from transcript CG3683-RC 0.239
Eip71CD Ecdysone-induced protein 28/29kD 0.227
mus209 mutagen-sensitive 209 0.227
foxo forkhead box, sub-group O 0.222
Act57B Actin 57B 0.216
maf-S CG9954 gene product from transcript CG9954-RA 0.216
Hsp68 Heat shock protein 68 0.215
CrebB-17A Cyclic-AMP response element binding protein B at 17A 0.215
bves CG32513 gene product from transcript CG32513-RA 0.214
AnnX Annexin X 0.213
Lectin-galC1 Galactose-specific C-type lectin 0.212
G-salpha60A G protein salpha 60A 0.212
Tsp42Ef Tetraspanin 42Ef 0.210
Ras85D Ras oncogene at 85D 0.201
CG42630 CG42630 gene product from transcript CG42630-RA 0.197
rhea CG6831 gene product from transcript CG6831-RA 0.197
cln3 CG5582 gene product from transcript CG5582-RA 0.196
gig gigas 0.195
l(3)L1231 lethal (3) L1231 0.191
Sos Son of sevenless 0.187
dnc dunce 0.179
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
JUN jun proto-oncogene 0.997
TP53 tumor protein p53 0.997
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.994
DUSP1 dual specificity phosphatase 1 0.988
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.984
EGFR epidermal growth factor receptor 0.979
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.973
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.934
BCL2 B-cell CLL/lymphoma 2 0.928
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.891
BCL2L1 BCL2-like 1 0.872
PML promyelocytic leukemia 0.855
CREBBP CREB binding protein 0.831
EPAS1 endothelial PAS domain protein 1 0.823
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.819
FYN FYN oncogene related to SRC, FGR, YES 0.780
SOCS3 suppressor of cytokine signaling 3 0.775
MAPK14 mitogen-activated protein kinase 14 0.761
HSPB1 heat shock 27kDa protein 1 0.735
PRDX1 peroxiredoxin 1 0.735
ATF4 activating transcription factor 4 (tax-responsive enhancer element B67) 0.719
IL1R1 interleukin 1 receptor, type I 0.715
CRYAB crystallin, alpha B 0.684
FHL1 four and a half LIM domains 1 0.666
INSR insulin receptor 0.652
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.649
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.645
MAPK8 mitogen-activated protein kinase 8 0.643
UBC ubiquitin C 0.642
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.637
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.634
SMAD3 SMAD family member 3 0.631
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa 0.618
FHL2 four and a half LIM domains 2 0.602
AKR1C2 aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III) 0.601
RING1 ring finger protein 1 0.583
SOD1 superoxide dismutase 1, soluble 0.581
ESR1 estrogen receptor 1 0.557
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.547
TTR transthyretin 0.535
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.534
IL1B interleukin 1, beta 0.524
GCLM glutamate-cysteine ligase, modifier subunit 0.523
ATF2 activating transcription factor 2 0.521
PLAUR plasminogen activator, urokinase receptor 0.518
CAV1 caveolin 1, caveolae protein, 22kDa 0.501
HDAC6 histone deacetylase 6 0.497
GAB1 GRB2-associated binding protein 1 0.488
ZNF746 zinc finger protein 746 0.480
LAT linker for activation of T cells 0.474
ARRB1 arrestin, beta 1 0.455
BBS10 Bardet-Biedl syndrome 10 0.450
AKR1C1 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) 0.438
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.432
GRB2 growth factor receptor-bound protein 2 0.427
ARRB2 arrestin, beta 2 0.421
PDCD6IP programmed cell death 6 interacting protein 0.415
PTK2 PTK2 protein tyrosine kinase 2 0.410
MYD88 myeloid differentiation primary response gene (88) 0.410
TIMP2 TIMP metallopeptidase inhibitor 2 0.408
BID BH3 interacting domain death agonist 0.405
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.395
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.390
STRN4 striatin, calmodulin binding protein 4 0.385
NCOR2 nuclear receptor corepressor 2 0.377
ABI2 abl-interactor 2 0.376
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.372
LTBP2 latent transforming growth factor beta binding protein 2 0.369
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 0.368
CCR5 chemokine (C-C motif) receptor 5 0.366
TKT transketolase 0.362
RHOA ras homolog gene family, member A 0.362
PRDX2 peroxiredoxin 2 0.358
HDAC2 histone deacetylase 2 0.354
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 0.350
APP amyloid beta (A4) precursor protein 0.344
TRIB3 tribbles homolog 3 (Drosophila) 0.342
NFE2L2 nuclear factor (erythroid-derived 2)-like 2 0.339
DAXX death-domain associated protein 0.338
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.338
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.337
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.333
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.329
SP1 Sp1 transcription factor 0.329
FOS FBJ murine osteosarcoma viral oncogene homolog 0.325
MPDZ multiple PDZ domain protein 0.323
H2AFX H2A histone family, member X 0.316
JUNB jun B proto-oncogene 0.314
IDE insulin-degrading enzyme 0.304
AKR1C3 aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) 0.293
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 0.293
UBQLN4 ubiquilin 4 0.285
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.282
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.281
TSC22D3 TSC22 domain family, member 3 0.274
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.272
MAFG v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian) 0.263
HBG2 hemoglobin, gamma G 0.263
TXN thioredoxin 0.259
CFL1 cofilin 1 (non-muscle) 0.256
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 0.995
Pten phosphatase and tensin homolog 0.992
Mapk14 mitogen-activated protein kinase 14 0.957
Shc1 src homology 2 domain-containing transforming protein C1 0.947
Hbb-b1 hemoglobin, beta adult major chain 0.942
Rnf2 ring finger protein 2 0.921
Kit kit oncogene 0.891
Fbn1 fibrillin 1 0.886
Rybp RING1 and YY1 binding protein 0.864
Tgfbr1 transforming growth factor, beta receptor I 0.847
Ptgs2 prostaglandin-endoperoxide synthase 2 0.846
Ctnnb1 catenin (cadherin associated protein), beta 1 0.821
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.799
Prkce protein kinase C, epsilon 0.789
Ltbp2 latent transforming growth factor beta binding protein 2 0.783
Igh immunoglobulin heavy chain complex 0.776
Grb2 growth factor receptor bound protein 2 0.765
Tgfbr2 transforming growth factor, beta receptor II 0.748
Dusp1 dual specificity phosphatase 1 0.745
Jun Jun oncogene 0.744
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.722
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.706
Fos FBJ osteosarcoma oncogene 0.692
Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha 0.686
Elavl1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.682
Tlr4 toll-like receptor 4 0.676
Thbs1 thrombospondin 1 0.668
Insr insulin receptor 0.665
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.660
Mapk8 mitogen-activated protein kinase 8 0.656
Clock circadian locomotor output cycles kaput 0.650
Skil SKI-like 0.649
Atf2 activating transcription factor 2 0.643
C1qa complement component 1, q subcomponent, alpha polypeptide 0.641
Lox lysyl oxidase 0.638
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.631
Arhgef7 Rho guanine nucleotide exchange factor (GEF7) 0.623
Msh2 mutS homolog 2 (E. coli) 0.586
Klf4 Kruppel-like factor 4 (gut) 0.581
Gclm glutamate-cysteine ligase, modifier subunit 0.578
Slc10a6 solute carrier family 10 (sodium/bile acid cotransporter family), member 6 0.569
Atp5b ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit 0.556
Prnp prion protein 0.549
Bax BCL2-associated X protein 0.537
Mapkapk2 MAP kinase-activated protein kinase 2 0.524
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.520
Slc40a1 solute carrier family 40 (iron-regulated transporter), member 1 0.519
Nf1 neurofibromatosis 1 0.519
Slc4a1 solute carrier family 4 (anion exchanger), member 1 0.515
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.505
Ep300 E1A binding protein p300 0.497
Mapk1 mitogen-activated protein kinase 1 0.496
Src Rous sarcoma oncogene 0.479
Ccl2 chemokine (C-C motif) ligand 2 0.470
Rhob ras homolog gene family, member B 0.467
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.465
C1qc complement component 1, q subcomponent, C chain 0.464
Nos1 nitric oxide synthase 1, neuronal 0.460
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.440
Mcl1 myeloid cell leukemia sequence 1 0.436
Col1a2 collagen, type I, alpha 2 0.430
Tenc1 tensin like C1 domain-containing phosphatase 0.428
Ikbkg inhibitor of kappaB kinase gamma 0.415
Apoe apolipoprotein E 0.414
Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) 0.407
E2f1 E2F transcription factor 1 0.398
Btg2 B-cell translocation gene 2, anti-proliferative 0.395
Stat3 signal transducer and activator of transcription 3 0.392
Gclc glutamate-cysteine ligase, catalytic subunit 0.389
Fbxl5 F-box and leucine-rich repeat protein 5 0.380
Mknk2 MAP kinase-interacting serine/threonine kinase 2 0.377
Lat linker for activation of T cells 0.366
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.363
C1qb complement component 1, q subcomponent, beta polypeptide 0.358
Met met proto-oncogene 0.358
Vcp valosin containing protein 0.342
Cyld cylindromatosis (turban tumor syndrome) 0.341
Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.335
Fgfr1 fibroblast growth factor receptor 1 0.332
Eef1a1 eukaryotic translation elongation factor 1 alpha 1 0.323
Bicc1 bicaudal C homolog 1 (Drosophila) 0.319
Sgpl1 sphingosine phosphate lyase 1 0.318
C3ar1 complement component 3a receptor 1 0.309
Duox2 dual oxidase 2 0.309
Ppia peptidylprolyl isomerase A 0.304
Mmp2 matrix metallopeptidase 2 0.297
Rac1 RAS-related C3 botulinum substrate 1 0.296
Tiparp TCDD-inducible poly(ADP-ribose) polymerase 0.293
Ptk2 PTK2 protein tyrosine kinase 2 0.291
Zfp36l1 zinc finger protein 36, C3H type-like 1 0.291
Thbs2 thrombospondin 2 0.284
Col3a1 collagen, type III, alpha 1 0.282
Ahr aryl-hydrocarbon receptor 0.281
Pkd1 polycystic kidney disease 1 homolog 0.279
Dsg4 desmoglein 4 0.276
Kpna1 karyopherin (importin) alpha 1 0.276
Suz12 suppressor of zeste 12 homolog (Drosophila) 0.273
Htra3 HtrA serine peptidase 3 0.270
Cav1 caveolin 1, caveolae protein 0.269
Psen1 presenilin 1 0.263
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Errfi1 ERBB receptor feedback inhibitor 1 0.849
Col3a1 collagen, type III, alpha 1 0.740
COX2 COXII 0.661
Nr4a3 nuclear receptor subfamily 4, group A, member 3 0.634
Il6 interleukin 6 0.611
Hbb hemoglobin, beta 0.570
Ppp1r15a protein phosphatase 1, regulatory (inhibitor) subunit 15A 0.547
Flt1 FMS-related tyrosine kinase 1 0.541
Junb jun B proto-oncogene 0.517
Hoxa2 homeo box A2 0.509
Gadd45a growth arrest and DNA-damage-inducible, alpha 0.495
Gpx4 glutathione peroxidase 4 0.485
Ftl ferritin, light polypeptide 0.484
Vim vimentin 0.470
CYTB cytochrome b 0.469
Pebp1 phosphatidylethanolamine binding protein 1 0.459
LOC100134871 beta globin minor gene 0.450
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.431
Bgn biglycan 0.415
Gzmb granzyme B 0.404
Ccl3 chemokine (C-C motif) ligand 3 0.400
Prlhr prolactin releasing hormone receptor 0.384
Mgst2 microsomal glutathione S-transferase 2 0.380
Gapdh glyceraldehyde-3-phosphate dehydrogenase 0.375
Col1a1 collagen, type I, alpha 1 0.360
Pgam1 phosphoglycerate mutase 1 (brain) 0.356
Abcb11 ATP-binding cassette, subfamily B (MDR/TAP), member 11 0.342
Il13ra1 interleukin 13 receptor, alpha 1 0.338
ND2 NADH dehydrogenase subunit 2 0.334
Cryab crystallin, alpha B 0.333
Alas2 aminolevulinate, delta-, synthase 2 0.330
Hes2 hairy and enhancer of split 2 (Drosophila) 0.329
Htr5b 5-hydroxytryptamine (serotonin) receptor 5B 0.320
Il18 interleukin 18 0.320
Shc3 SHC (Src homology 2 domain containing) transforming protein 3 0.318
Jak1 Janus kinase 1 0.314
LOC689064 beta-globin 0.314
Cd46 CD46 molecule, complement regulatory protein 0.313
Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 0.311
Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.304
Scamp2 secretory carrier membrane protein 2 0.295
Prdx1 peroxiredoxin 1 0.294
Sell selectin L 0.290
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.289
Gja1 gap junction protein, alpha 1 0.288
Il1rap interleukin 1 receptor accessory protein 0.284
Elf1 E74-like factor 1 0.282
Pgk1 phosphoglycerate kinase 1 0.275
Gpr182 G protein-coupled receptor 182 0.273
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.272
Il2rb interleukin 2 receptor, beta 0.265
Casp3 caspase 3 0.260
Dusp1 dual specificity phosphatase 1 0.260
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.256
Zyx zyxin 0.255
Mosc2 MOCO sulphurase C-terminal domain containing 2 0.252
RGD1564664 similar to LOC387763 protein 0.251
Tpm3 tropomyosin 3, gamma 0.249
Kmo kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.242
Nme2 non-metastatic cells 2, protein (NM23B) expressed in 0.241
Apoa2 apolipoprotein A-II 0.240
Chrm1 cholinergic receptor, muscarinic 1 0.238
St13 suppression of tumorigenicity 13 0.238
Clic4 chloride intracellular channel 4 0.236
Plau plasminogen activator, urokinase 0.234
Klk8 kallikrein related-peptidase 8 0.232
Gstp1 glutathione S-transferase pi 1 0.230
Sult1b1 sulfotransferase family, cytosolic, 1B, member 1 0.230
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.217
Col1a2 collagen, type I, alpha 2 0.217
Cyp2d3 cytochrome P450, family 2, subfamily d, polypeptide 3 0.217
Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.216
Homer3 homer homolog 3 (Drosophila) 0.215
Jun Jun oncogene 0.215
Il1a interleukin 1 alpha 0.215
Ccnl1 cyclin L1 0.215
Gclm glutamate cysteine ligase, modifier subunit 0.215
Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 0.212
Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 0.211
Smad1 SMAD family member 1 0.210
Col5a2 collagen, type V, alpha 2 0.208
Pkm2 pyruvate kinase, muscle 0.207
Lamp2 lysosomal-associated membrane protein 2 0.206
Rara retinoic acid receptor, alpha 0.204
Foxd3 forkhead box D3 0.202
Ptgs2 prostaglandin-endoperoxide synthase 2 0.201
Egfr epidermal growth factor receptor 0.198
Epas1 endothelial PAS domain protein 1 0.198
Crygd crystallin, gamma D 0.197
Egr2 early growth response 2 0.197
Socs3 suppressor of cytokine signaling 3 0.196
Clec4f C-type lectin domain family 4, member f 0.196
Hspe1 heat shock protein 1 (chaperonin 10) 0.195
Nr4a1 nuclear receptor subfamily 4, group A, member 1 0.195
Klf4 Kruppel-like factor 4 (gut) 0.192
Ces2c carboxylesterase 2C 0.191
Ugt1a6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.190
Txnrd1 thioredoxin reductase 1 0.190
Fabp5 fatty acid binding protein 5, epidermal 0.189
Grm7 glutamate receptor, metabotropic 7 0.186