The network for 'protein catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

protein catabolic process

The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
CDC48 Cdc48p 0.999
RPT1 Rpt1p 0.989
RAD23 Rad23p 0.981
KAR2 Kar2p 0.981
HRD1 Hrd1p 0.976
UFD2 Ufd2p 0.972
RPN10 Rpn10p 0.970
RPT4 Rpt4p 0.969
PRE1 Pre1p 0.963
ECM29 Ecm29p 0.953
SKP1 Skp1p 0.950
PPH22 Pph22p 0.944
RPT6 Rpt6p 0.942
CDC53 Cdc53p 0.941
DSK2 Dsk2p 0.936
VPS36 Vps36p 0.899
RKR1 Rkr1p 0.894
OTU1 Otu1p 0.871
PRE2 Pre2p 0.864
DOC1 Doc1p 0.850
RPN11 Rpn11p 0.848
PRE6 Pre6p 0.847
SPT16 Spt16p 0.843
MAD2 Mad2p 0.841
RPT2 Rpt2p 0.840
PUP1 Pup1p 0.839
YPT1 Ypt1p 0.836
CDC16 Cdc16p 0.825
MND2 Mnd2p 0.819
SHP1 Shp1p 0.812
RPN6 Rpn6p 0.800
PPH21 Pph21p 0.781
CDC27 Cdc27p 0.777
SSE2 Sse2p 0.765
RPN9 Rpn9p 0.760
UBC7 Ubc7p 0.753
RPN7 Rpn7p 0.751
FYV10 Fyv10p 0.739
DFM1 Dfm1p 0.725
PRE10 Pre10p 0.725
UBP6 Ubp6p 0.720
RPT3 Rpt3p 0.720
RPN4 Rpn4p 0.712
UBC4 Ubc4p 0.711
CDC23 Cdc23p 0.704
SCJ1 Scj1p 0.704
PRE7 Pre7p 0.699
RPN8 Rpn8p 0.698
PUP2 Pup2p 0.698
MUB1 Mub1p 0.693
GID7 Gid7p 0.693
UBR1 Ubr1p 0.683
NPL4 Npl4p 0.680
VID30 Vid30p 0.677
APC5 Apc5p 0.665
CDC20 Cdc20p 0.663
HRD3 Hrd3p 0.661
RPN13 Rpn13p 0.649
KSP1 Ksp1p 0.648
APC2 Apc2p 0.647
STE5 Ste5p 0.642
MON2 Mon2p 0.630
UBC13 Ubc13p 0.622
CKA1 Cka1p 0.620
UFD4 Ufd4p 0.619
MGR1 Mgr1p 0.618
RPN1 Rpn1p 0.606
BUB3 Bub3p 0.602
UBP3 Ubp3p 0.592
SSM4 Ssm4p 0.588
CDC4 Cdc4p 0.581
CTF13 Ctf13p 0.573
GLC7 Glc7p 0.571
PRE4 Pre4p 0.568
UFD1 Ufd1p 0.563
CKA2 Cka2p 0.562
APC9 Apc9p 0.552
PRE3 Pre3p 0.549
PRE8 Pre8p 0.548
RPN5 Rpn5p 0.548
RPT5 Rpt5p 0.546
HRT1 Hrt1p 0.542
BCK1 Bck1p 0.535
BMH2 Bmh2p 0.530
UBP15 Ubp15p 0.525
BRE5 Bre5p 0.525
RPN2 Rpn2p 0.523
APC11 Apc11p 0.517
PRE9 Pre9p 0.500
UBX2 Ubx2p 0.494
RMD5 Rmd5p 0.490
SNX4 Snx4p 0.483
SWM1 Swm1p 0.459
PUP3 Pup3p 0.456
PRE5 Pre5p 0.455
MOT2 Mot2p 0.450
MET30 Met30p 0.448
PDS1 Pds1p 0.442
YNL155W hypothetical protein 0.442
RPN3 Rpn3p 0.438
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
rpt-2 Protein RPT-2 0.951
rpt-3 Protein RPT-3 0.925
egl-18 Protein EGL-18 0.875
rpn-7 Protein RPN-7 0.870
egl-30 Protein EGL-30 0.825
col-34 Protein COL-34 0.795
npl-4.2 Protein NPL-4.2 0.776
unc-52 Protein UNC-52 0.719
rpt-5 Protein RPT-5 0.690
npl-4.1 Protein NPL-4.1 0.688
rpn-12 Protein RPN-12 0.674
pbs-6 Protein PBS-6 0.652
col-14 Protein COL-14 0.629
inx-12 Protein INX-12 0.628
dpy-4 Protein DPY-4 0.623
pas-4 Protein PAS-4 0.608
sqt-1 Protein SQT-1 0.601
vps-53 Protein VPS-53 0.598
pas-6 Protein PAS-6 0.592
col-73 Protein COL-73 0.592
rpn-3 Protein RPN-3 0.585
col-144 Protein COL-144 0.567
daf-2 Protein DAF-2 0.561
cam-1 Protein CAM-1 0.539
col-146 Protein COL-146 0.527
goa-1 Protein GOA-1 0.525
col-2 Protein COL-2 0.523
cpr-4 Protein CPR-4 0.521
rpt-4 Protein RPT-4 0.512
unc-54 Protein UNC-54 0.511
pbs-3 Protein PBS-3 0.508
unc-23 Protein UNC-23 0.500
pbs-5 Protein PBS-5 0.500
pas-1 Protein PAS-1 0.493
lon-3 Protein LON-3 0.491
F31C3.2 Protein F31C3.2 0.479
pcaf-1 Protein PCAF-1 0.475
imb-2 Protein IMB-2 0.469
unc-27 Protein UNC-27 0.466
T12D8.9 Protein T12D8.9 0.464
col-173 Protein COL-173 0.455
par-5 Protein PAR-5 0.454
col-109 Protein COL-109 0.454
col-92 Protein COL-92 0.445
R90.1 Protein R90.1 0.429
ttyh-1 Protein TTYH-1 0.423
sqt-2 Protein SQT-2 0.421
ifa-1 Protein IFA-1 0.419
col-182 Protein COL-182 0.416
pal-1 Protein PAL-1 0.410
mig-2 Protein MIG-2 0.407
ifb-1 Protein IFB-1 0.406
stam-1 Protein STAM-1 0.406
daf-21 Protein DAF-21 0.402
egl-38 Protein EGL-38 0.392
col-157 Protein COL-157 0.391
daf-1 Protein DAF-1 0.387
F46C5.9 Protein F46C5.9 0.386
pes-22 Protein PES-22 0.376
hgrs-1 Protein HGRS-1 0.365
ceh-18 Protein CEH-18 0.358
col-43 Protein COL-43 0.357
col-180 Protein COL-180 0.355
vav-1 Protein VAV-1 0.353
rol-6 Protein ROL-6 0.347
twk-18 Protein TWK-18 0.343
cka-2 Protein CKA-2 0.343
col-133 Protein COL-133 0.343
ZK930.1 Protein ZK930.1 0.341
app-1 Protein APP-1 0.334
col-104 Protein COL-104 0.334
myo-3 Protein MYO-3 0.327
rnr-1 Protein RNR-1 0.316
mup-2 Protein MUP-2 0.315
sli-1 Protein SLI-1 0.314
rpa-1 Protein RPA-1 0.312
rsbp-1 Protein RSBP-1 0.311
bli-2 Protein BLI-2 0.306
CELE_C18C4.5 Protein C18C4.5 0.304
vab-3 Protein VAB-3 0.303
tni-1 Protein TNI-1 0.302
dim-1 Protein DIM-1 0.302
mom-2 Protein MOM-2 0.300
sem-5 Protein SEM-5 0.297
col-84 Protein COL-84 0.294
syx-17 Protein SYX-17 0.294
ced-9 Protein CED-9 0.290
lev-11 Protein LEV-11 0.289
F26E4.3 Protein F26E4.3 0.286
dlc-1 Protein DLC-1 0.284
rpn-2 Protein RPN-2 0.280
gpr-2 Protein GPR-2 0.279
zyg-9 Protein ZYG-9 0.278
mec-2 Protein MEC-2 0.274
pry-1 Protein PRY-1 0.271
unc-86 Protein UNC-86 0.271
tag-322 Protein TAG-322 0.270
cdc-42 Protein CDC-42 0.270
dpy-13 Protein DPY-13 0.269
lin-7 Protein LIN-7 0.266
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
psmd6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.124
psmb1 proteasome (prosome, macropain) subunit, beta type, 1 0.109
fstl1b follistatin-like 1b 0.109
psmb3 proteasome (prosome, macropain) subunit, beta type, 3 0.079
psmd4b proteasome (prosome, macropain) 26S subunit, non-ATPase, 4b 0.077
chd chordin 0.075
zgc:92775 zgc:92775 0.072
psmc6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.071
ctnnb1 catenin (cadherin-associated protein), beta 1 0.067
psmd12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.061
psma6a proteasome (prosome, macropain) subunit, alpha type, 6a 0.060
psmb4 proteasome (prosome, macropain) subunit, beta type, 4 0.056
psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.054
fgf8a fibroblast growth factor 8 a 0.044
psmc1b proteasome (prosome, macropain) 26S subunit, ATPase, 1b 0.043
psmc5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.039
hmcn1 hemicentin 1 0.037
ccnb1 cyclin B1 0.033
psmd13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 0.033
psma8 proteasome (prosome, macropain) subunit, alpha type, 8 0.030
cdh1 cadherin 1, epithelial 0.028
ctsz cathepsin Z 0.028
mobkl3 MOB1, Mps One Binder kinase activator-like 3 (yeast) 0.026
psmd8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 0.026
kpna2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 0.025
wnt8b wingless-type MMTV integration site family, member 8b 0.024
snai1a snail homolog 1a (Drosophila) 0.023
efnb2a ephrin B2a 0.020
dynlrb1 dynein, light chain, roadblock-type 1 0.020
myhz2 myosin, heavy polypeptide 2, fast muscle specific 0.020
ppp1r12a protein phosphatase 1, regulatory (inhibitor) subunit 12A 0.020
eng1a engrailed 1a 0.019
snai1b snail homolog 1b (Drosophila) 0.019
bactin2 bactin2 0.018
ube2d1 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) 0.018
foxo3b forkhead box O3b 0.017
tia1l cytotoxic granule-associated RNA binding protein 1, like 0.017
psmb7 proteasome (prosome, macropain) subunit, beta type, 7 0.016
usp5 ubiquitin specific protease 5 0.016
bmpr1aa bone morphogenetic protein receptor, type 1aa 0.016
fras1 Fraser syndrome 1 0.015
kif23 kinesin family member 23 0.015
furinb furin (paired basic amino acid cleaving enzyme) b 0.014
cnot6 CCR4-NOT transcription complex, subunit 6 0.014
adrm1b adhesion regulating molecule 1b 0.014
dnm1l dynamin 1-like 0.014
LOC100330405 transmembrane protein 176B-like 0.014
psmd11a proteasome (prosome, macropain) 216S subunit, non-ATPase, 11a 0.014
psmb5 proteasome (prosome, macropain) subunit, beta type, 5 0.013
itgb1b integrin, beta 1b 0.013
sox32 SRY-box containing gene 32 0.013
fgfr1a fibroblast growth factor receptor 1a 0.013
actn3b actinin alpha 3b 0.012
frem2a Fras1 related extracellular matrix protein 2a 0.012
LOC100151531 zinc finger protein Gfi-1b-like 0.012
LOC553527 hypothetical protein LOC553527 0.012
psmd2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.012
fbn2b fibrillin 2b 0.012
sirt1 sirtuin (silent mating type information regulation 2 homolog) 1 0.012
psma4 proteasome (prosome, macropain) subunit, alpha type, 4 0.012
gbx2 gastrulation brain homeo box 2 0.012
her5 hairy-related 5 0.011
pcsk1 proprotein convertase subtilisin/kexin type 1 0.011
prdm1a PR domain containing 1a, with ZNF domain 0.011
tfap2a transcription factor AP-2 alpha 0.011
fmr1 fragile X mental retardation 1 0.011
col4a3 collagen, type IV, alpha 3 0.011
myl9 myosin, light polypeptide 9, regulatory 0.011
ck2b casein kinase 2 beta 0.011
tceb1b transcription elongation factor B (SIII), polypeptide 1b 0.011
pcdh8 protocadherin 8 0.011
lef1 lymphocyte enhancer binding factor 1 0.011
cds2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 0.011
atp1a2a ATPase, Na+/K+ transporting, alpha 2a polypeptide 0.011
gcm2 glial cells missing homolog 2 (Drosophila) 0.011
lmo4a LIM domain only 4a 0.011
ube2g2 ubiquitin-conjugating enzyme E2G 2 0.011
hhip hedgehog interacting protein 0.010
actn2 actinin, alpha 2 0.010
si:rp71-45k5.4 si:rp71-45k5.4 0.010
tp53bp2 tumor protein p53 binding protein, 2 0.010
bc2 putative breast adenocarcinoma marker 0.010
spns2 spinster homolog 2 (Drosophila) 0.010
zgc:123326 zgc:123326 0.010
frem1a Fras1 related extracellular matrix 1a 0.010
ppp6c protein phosphatase 6, catalytic subunit 0.010
itih2 inter-alpha (globulin) inhibitor H2 0.010
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
EcR Ecdysone receptor 0.943
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.816
Prosbeta2 Proteasome beta2 subunit 0.806
Ras85D Ras oncogene at 85D 0.784
skpA CG16983 gene product from transcript CG16983-RD 0.739
Pros26.4 Proteasome 26S subunit subunit 4 ATPase 0.681
Rel Relish 0.644
shi shibire 0.600
phl pole hole 0.572
CSN5 COP9 complex homolog subunit 5 0.572
CycE Cyclin E 0.562
dlg1 discs large 1 0.562
Cul-4 Cullin-4 0.559
UbcD2 Ubiquitin conjugating enzyme 2 0.558
CycB Cyclin B 0.551
tefu telomere fusion 0.542
Rpt4 CG3455 gene product from transcript CG3455-RA 0.540
Pros26 Proteasome 26kD subunit 0.514
wdb widerborst 0.477
Pros29 Proteasome 29kD subunit 0.474
Atpalpha Na pump alpha subunit 0.466
tws twins 0.463
Rpt3 CG16916 gene product from transcript CG16916-RA 0.456
rl rolled 0.453
wupA wings up A 0.445
Prosbeta5 Proteasome beta5 subunit 0.444
smo smoothened 0.441
ago archipelago 0.421
betaTub56D beta-Tubulin at 56D 0.419
CG13349 CG13349 gene product from transcript CG13349-RA 0.413
Tak1 TGF-beta activated kinase 1 0.409
Su(H) Suppressor of Hairless 0.404
ctp cut up 0.395
dos daughter of sevenless 0.391
lqf liquid facets 0.390
Stat92E Signal-transducer and activator of transcription protein at 92E 0.387
RhoGEF2 CG9635 gene product from transcript CG9635-RF 0.387
lsn larsen 0.386
Vps25 Vacuolar protein sorting 25 0.377
InR Insulin-like receptor 0.374
ptc patched 0.370
hpo hippo 0.361
Rpn2 CG11888 gene product from transcript CG11888-RA 0.352
gwl greatwall 0.325
chico CG5686 gene product from transcript CG5686-RB 0.313
Fcp1 CG12252 gene product from transcript CG12252-RA 0.309
Rpn9 CG10230 gene product from transcript CG10230-RB 0.307
TER94 CG2331 gene product from transcript CG2331-RA 0.304
ncd non-claret disjunctional 0.303
Rpt1 CG1341 gene product from transcript CG1341-RA 0.298
N Notch 0.297
fzy fizzy 0.295
brat brain tumor 0.293
Rpn1 CG7762 gene product from transcript CG7762-RA 0.284
Prosbeta7 Proteasome beta7 subunit 0.283
nej nejire 0.278
gig gigas 0.276
Rpn6 Proteasome p44.5 subunit 0.275
jar jaguar 0.271
Pros28.1 Proteasome 28kD subunit 1 0.271
Prosbeta1 Proteasome beta1 subunit 0.256
Prosalpha5 Proteasome alpha5 subunit 0.251
TSG101 tumor suppressor protein 101 0.249
Aos1 CG12276 gene product from transcript CG12276-RA 0.247
p53 CG33336 gene product from transcript CG33336-RB 0.240
CG32581 CG32581 gene product from transcript CG32581-RB 0.239
Prosbeta3 Proteasome beta3 subunit 0.238
CycD Cyclin D 0.235
wmd wing morphogenesis defect 0.233
fry furry 0.227
shg shotgun 0.226
CkIalpha Casein kinase Ialpha 0.225
th thread 0.225
Pros35 Proteasome 35kD subunit 0.225
CSN3 COP9 complex homolog subunit 3 0.223
Atg1 Autophagy-specific gene 1 0.221
G-salpha60A G protein salpha 60A 0.220
CG12321 CG12321 gene product from transcript CG12321-RA 0.217
scny scrawny 0.217
bel belle 0.214
endoA endophilin A 0.214
Mad Mothers against dpp 0.213
dsh dishevelled 0.208
lin19 lin-19-like 0.207
ph-p polyhomeotic proximal 0.203
Prosalpha7 Proteasome alpha7 subunit 0.203
CG17331 CG17331 gene product from transcript CG17331-RA 0.199
yki yorkie 0.199
l(2)k14710 lethal (2) k14710 0.197
Pros54 Proteasome 54kD subunit 0.196
Rac1 CG2248 gene product from transcript CG2248-RA 0.194
dco discs overgrown 0.193
LamC Lamin C 0.188
Rpd3 CG7471 gene product from transcript CG7471-RA 0.187
CG9135 CG9135 gene product from transcript CG9135-RB 0.185
CG8979 CG8979 gene product from transcript CG8979-RC 0.185
Smox Smad on X 0.185
key kenny 0.184
kis kismet 0.181
RagA CG11968 gene product from transcript CG11968-RA 0.180
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
UBC ubiquitin C 1.000
RNF11 ring finger protein 11 1.000
TP53 tumor protein p53 1.000
UBE2D3 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) 1.000
VCP valosin containing protein 1.000
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 1.000
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 1.000
CUL1 cullin 1 0.999
SKP1 S-phase kinase-associated protein 1 0.999
UBE2D2 ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) 0.998
SQSTM1 sequestosome 1 0.998
UBE2D1 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) 0.998
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 0.998
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 0.998
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 0.997
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.996
XIAP X-linked inhibitor of apoptosis 0.995
SNX9 sorting nexin 9 0.995
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.994
CUL2 cullin 2 0.994
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 0.993
BTRC beta-transducin repeat containing 0.993
CREBBP CREB binding protein 0.993
SMAD2 SMAD family member 2 0.993
SMAD3 SMAD family member 3 0.992
RB1 retinoblastoma 1 0.991
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 0.988
UBE2N ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) 0.987
HSPA8 heat shock 70kDa protein 8 0.987
CUL3 cullin 3 0.986
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.985
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 0.985
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.983
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2 0.983
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 0.983
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.982
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 0.980
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 0.980
RAD23A RAD23 homolog A (S. cerevisiae) 0.979
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.978
TRAF1 TNF receptor-associated factor 1 0.977
TRAF6 TNF receptor-associated factor 6 0.976
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.976
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.974
ARIH2 ariadne homolog 2 (Drosophila) 0.973
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 0.971
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.971
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.967
CDC27 cell division cycle 27 homolog (S. cerevisiae) 0.965
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.965
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.962
FBXW11 F-box and WD repeat domain containing 11 0.962
CDC20 cell division cycle 20 homolog (S. cerevisiae) 0.961
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.959
UBQLN1 ubiquilin 1 0.954
UFD1L ubiquitin fusion degradation 1 like (yeast) 0.953
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 0.949
POMP proteasome maturation protein 0.947
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.946
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.944
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1 0.941
RNF111 ring finger protein 111 0.936
BIRC2 baculoviral IAP repeat containing 2 0.933
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) 0.928
RBX1 ring-box 1, E3 ubiquitin protein ligase 0.928
COPS5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) 0.926
FASLG Fas ligand (TNF superfamily, member 6) 0.914
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.906
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.902
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.898
MAPK1 mitogen-activated protein kinase 1 0.898
DERL1 Der1-like domain family, member 1 0.896
PTK2 PTK2 protein tyrosine kinase 2 0.894
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 0.893
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.893
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.871
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.870
HDAC1 histone deacetylase 1 0.868
GABARAP GABA(A) receptor-associated protein 0.866
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.863
KPNA3 karyopherin alpha 3 (importin alpha 4) 0.862
HSPA4 heat shock 70kDa protein 4 0.861
UBE2B ubiquitin-conjugating enzyme E2B (RAD6 homolog) 0.859
PSAP prosaposin 0.855
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.853
TRIM39 tripartite motif containing 39 0.848
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 0.846
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.845
MOBKL3 MOB1, Mps One Binder kinase activator-like 3 (yeast) 0.843
PXN paxillin 0.843
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.841
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.837
USP9X ubiquitin specific peptidase 9, X-linked 0.834
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 0.833
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.820
PML promyelocytic leukemia 0.804
UBXN7 UBX domain protein 7 0.803
BRCA1 breast cancer 1, early onset 0.803
ANAPC4 anaphase promoting complex subunit 4 0.799
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.794
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Ctnnb1 catenin (cadherin associated protein), beta 1 1.000
Trp53 transformation related protein 53 0.999
Vcp valosin containing protein 0.994
Axin1 axin 1 0.992
Apc adenomatosis polyposis coli 0.991
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.991
Pten phosphatase and tensin homolog 0.987
Psmd4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.984
Traf6 TNF receptor-associated factor 6 0.937
Fgfr1 fibroblast growth factor receptor 1 0.934
Usp9x ubiquitin specific peptidase 9, X chromosome 0.915
Hif1a hypoxia inducible factor 1, alpha subunit 0.915
Col1a1 collagen, type I, alpha 1 0.908
Smad7 MAD homolog 7 (Drosophila) 0.908
Cdk1 cyclin-dependent kinase 1 0.896
Psen1 presenilin 1 0.895
Psma7 proteasome (prosome, macropain) subunit, alpha type 7 0.885
Rb1 retinoblastoma 1 0.885
Fgfr2 fibroblast growth factor receptor 2 0.884
Mdm2 transformed mouse 3T3 cell double minute 2 0.877
Psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.864
Psmb7 proteasome (prosome, macropain) subunit, beta type 7 0.841
Psmd14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.828
Gsk3b glycogen synthase kinase 3 beta 0.819
Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a 0.817
Nf1 neurofibromatosis 1 0.812
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.803
Psma5 proteasome (prosome, macropain) subunit, alpha type 5 0.798
Ccnb1 cyclin B1 0.796
Psma2 proteasome (prosome, macropain) subunit, alpha type 2 0.792
Ncoa3 nuclear receptor coactivator 3 0.762
Rac1 RAS-related C3 botulinum substrate 1 0.761
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.749
Dvl1 dishevelled, dsh homolog 1 (Drosophila) 0.741
Rbl2 retinoblastoma-like 2 0.738
Brca1 breast cancer 1 0.737
Psmc3 proteasome (prosome, macropain) 26S subunit, ATPase 3 0.736
Rxra retinoid X receptor alpha 0.731
Per2 period homolog 2 (Drosophila) 0.724
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.724
Fbn1 fibrillin 1 0.719
Mbd3 methyl-CpG binding domain protein 3 0.711
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.706
Ret ret proto-oncogene 0.706
Psma1 proteasome (prosome, macropain) subunit, alpha type 1 0.702
Psmb6 proteasome (prosome, macropain) subunit, beta type 6 0.699
Ilk integrin linked kinase 0.695
Amfr autocrine motility factor receptor 0.695
Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) 0.693
Cbl Casitas B-lineage lymphoma 0.691
Ubc ubiquitin C 0.681
Meox2 mesenchyme homeobox 2 0.673
Tab3 TGF-beta activated kinase 1/MAP3K7 binding protein 3 0.664
Thbs1 thrombospondin 1 0.662
Stat3 signal transducer and activator of transcription 3 0.662
Pbx1 pre B-cell leukemia transcription factor 1 0.660
Psmc6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.641
Cops5 COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana) 0.641
Trp53bp1 transformation related protein 53 binding protein 1 0.630
Prc1 protein regulator of cytokinesis 1 0.626
Tax1bp1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.619
Yap1 yes-associated protein 1 0.614
Vhl von Hippel-Lindau tumor suppressor 0.611
Ikbkg inhibitor of kappaB kinase gamma 0.610
Egfr epidermal growth factor receptor 0.605
Klk1b1 kallikrein 1-related peptidase b1 0.605
Ythdf3 YTH domain family 3 0.599
Clock circadian locomotor output cycles kaput 0.596
Per1 period homolog 1 (Drosophila) 0.594
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.587
Tjp1 tight junction protein 1 0.574
Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) 0.572
Nos1 nitric oxide synthase 1, neuronal 0.567
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.566
Birc5 baculoviral IAP repeat-containing 5 0.556
Psma6 proteasome (prosome, macropain) subunit, alpha type 6 0.554
Psma3 proteasome (prosome, macropain) subunit, alpha type 3 0.553
Cul3 cullin 3 0.551
Src Rous sarcoma oncogene 0.548
Ptgs2 prostaglandin-endoperoxide synthase 2 0.547
Cry2 cryptochrome 2 (photolyase-like) 0.545
Bmpr2 bone morphogenic protein receptor, type II (serine/threonine kinase) 0.545
Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 0.541
Arhgef7 Rho guanine nucleotide exchange factor (GEF7) 0.538
Dlg4 discs, large homolog 4 (Drosophila) 0.538
Bcl3 B-cell leukemia/lymphoma 3 0.535
Atf2 activating transcription factor 2 0.532
Csf1 colony stimulating factor 1 (macrophage) 0.528
Cry1 cryptochrome 1 (photolyase-like) 0.528
Tgfb1 transforming growth factor, beta 1 0.528
Bag6 BCL2-associated athanogene 6 0.525
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.523
Adam9 a disintegrin and metallopeptidase domain 9 (meltrin gamma) 0.512
Psmc5 protease (prosome, macropain) 26S subunit, ATPase 5 0.505
Homer1 homer homolog 1 (Drosophila) 0.502
Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 0.502
Psmd6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.502
Ccna2 cyclin A2 0.501
Ptk2 PTK2 protein tyrosine kinase 2 0.498
Smad4 MAD homolog 4 (Drosophila) 0.497
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Psma5 proteasome (prosome, macropain) subunit, alpha type 5 0.955
Dnaja2 DnaJ (Hsp40) homolog, subfamily A, member 2 0.909
Psma3 proteasome (prosome, macropain) subunit, alpha type 3 0.863
Psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.762
Psmb3 proteasome (prosome, macropain) subunit, beta type 3 0.706
Dnaja1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.643
Psmb6 proteasome (prosome, macropain) subunit, beta type 6 0.476
Psmb2 proteasome (prosome, macropain) subunit, beta type 2 0.365
Eef2 eukaryotic translation elongation factor 2 0.303
Psma4 proteasome (prosome, macropain) subunit, alpha type 4 0.299
Psmb7 proteasome (prosome, macropain) subunit, beta type 7 0.264
Psmd6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.220
Grin1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 0.219
Psmc1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.212
Canx calnexin 0.208
Psma2 proteasome (prosome, macropain) subunit, alpha type 2 0.206
Csnk1d casein kinase 1, delta 0.199
Mapre1 microtubule-associated protein, RP/EB family, member 1 0.193
Psma7 proteasome (prosome, macropain) subunit, alpha type 7 0.184
Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.179
Vcp valosin-containing protein 0.166
Psme2 proteasome (prosome, macropain) activator subunit 2 0.162
Ppp1cb protein phosphatase 1, catalytic subunit, beta isoform 0.144
Psmb4 proteasome (prosome, macropain) subunit, beta type 4 0.140
Eif4h eukaryotic translation initiation factor 4H 0.131
Gja1 gap junction protein, alpha 1 0.128
Psmd4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.114
Psmc4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.109
Cdc37 cell division cycle 37 homolog (S. cerevisiae) 0.109
Psmb5 proteasome (prosome, macropain) subunit, beta type 5 0.103
Psma1 proteasome (prosome, macropain) subunit, alpha type 1 0.100
Dbp D site of albumin promoter (albumin D-box) binding protein 0.096
Creld2 cysteine-rich with EGF-like domains 2 0.093
Hsph1 heat shock 105/110 protein 1 0.089
Ppm1b protein phosphatase 1B, magnesium dependent, beta isoform 0.085
Hal histidine ammonia lyase 0.084
Psmc3 proteasome (prosome, macropain) 26S subunit, ATPase 3 0.082
Fgfr1 Fibroblast growth factor receptor 1 0.078
Begain brain-enriched guanylate kinase-associated 0.078
Dlg4 discs, large homolog 4 (Drosophila) 0.073
Ptges3 prostaglandin E synthase 3 (cytosolic) 0.070
Musk muscle, skeletal, receptor tyrosine kinase 0.069
Grasp GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein 0.068
Manf mesencephalic astrocyte-derived neurotrophic factor 0.066
Dnajb9 DnaJ (Hsp40) homolog, subfamily B, member 9 0.065
Glg1 golgi apparatus protein 1 0.065
Ube2g1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) 0.065
P22k15 cystatin related protein 2 0.063
Stip1 stress-induced phosphoprotein 1 0.062
Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 0.061
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.061
Syngr2 synaptogyrin 2 0.060
Mprip myosin phosphatase Rho interacting protein 0.059
Zfp364 zinc finger protein 364 0.058
Usp15 ubiquitin specific peptidase 15 0.057
Axin1 axin 1 0.056
Caprin1 cell cycle associated protein 1 0.053
LOC100366237 prefoldin subunit 4-like 0.053
Prss3 protease, serine, 3 0.053
Cand1 cullin-associated and neddylation-dissociated 1 0.051
Clcn7 chloride channel 7 0.051
Ubc ubiquitin C 0.050
Map3k3 mitogen activated protein kinase kinase kinase 3 0.050
Ptp4a1 protein tyrosine phosphatase type IVA, member 1 0.049
Dr1 down-regulator of transcription 1 0.048
Zfand5 zinc finger, AN1-type domain 5 0.048
Ect2 epithelial cell transforming sequence 2 oncogene 0.048
Hprt1 hypoxanthine phosphoribosyltransferase 1 0.047
Hmmr hyaluronan mediated motility receptor (RHAMM) 0.046
Psmd14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.045
March5 membrane-associated ring finger (C3HC4) 5 0.045
Spc25 SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) 0.045
Psmb1 proteasome (prosome, macropain) subunit, beta type 1 0.045
Pten phosphatase and tensin homolog 0.045
Grina glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 0.044
Psmd3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 0.044
Cdh22 cadherin 22 0.044
Dctn4 dynactin 4 0.044
Pomp proteasome maturation protein 0.043
Eif4a2 eukaryotic translation initiation factor 4A, isoform 2 0.043
Pdia4 protein disulfide isomerase family A, member 4 0.042
Txnl1 thioredoxin-like 1 0.042
Pdia3 protein disulfide isomerase family A, member 3 0.041
Ube2d3 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) 0.041
Hk1 hexokinase 1 0.041
Mcam melanoma cell adhesion molecule 0.040
Vapa VAMP (vesicle-associated membrane protein)-associated protein A 0.040
Snx6 sorting nexin 6 0.039
Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) 0.039
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.039
Camk2a calcium/calmodulin-dependent protein kinase II alpha 0.039
Psmd1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.039
Smad7 SMAD family member 7 0.038
Usf2 upstream transcription factor 2, c-fos interacting 0.037
Grin2b glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.037
Nploc4 nuclear protein localization 4 homolog (S. cerevisiae) 0.037
Efhd2 EF-hand domain family, member D2 0.037
Ifitm3 interferon induced transmembrane protein 3 0.036
Nck1 NCK adaptor protein 1 0.036
Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) 0.036