The network for 'amino acid activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

amino acid activation

The modification of an amino acid to an active form, for incorporation into a peptide, protein or other macromolecule.

Name Description Probability Func Analog Organism
ILS1 Ils1p 0.994
VAS1 Vas1p 0.980
CDC60 Cdc60p 0.978
SES1 Ses1p 0.975
GUS1 Gus1p 0.953
SLM5 Slm5p 0.942
DYS1 Dys1p 0.908
DED81 Ded81p 0.898
PET112 Pet112p 0.871
KRS1 Krs1p 0.827
GRS1 Grs1p 0.804
THS1 Ths1p 0.751
FRS2 Frs2p 0.750
IFM1 Ifm1p 0.749
YHR020W hypothetical protein 0.588
GLN4 Gln4p 0.557
KAP104 Kap104p 0.479
MSF1 Msf1p 0.457
MSE1 Mse1p 0.446
TYS1 Tys1p 0.404
MES1 Mes1p 0.403
GCN20 Gcn20p 0.402
SUP35 Sup35p 0.375
ALA1 Ala1p 0.356
YNL247W hypothetical protein 0.340
HTS1 Hts1p 0.339
YDR341C hypothetical protein 0.337
FRS1 Frs1p 0.295
ASN2 Asn2p 0.289
AIM10 Aim10p 0.284
YFH7 Yfh7p 0.270
KEL3 Kel3p 0.270
SUB2 Sub2p 0.215
RRF1 Rrf1p 0.199
MSY1 Msy1p 0.196
ISM1 Ism1p 0.170
MRF1 Mrf1p 0.170
TCM62 Tcm62p 0.142
CTM1 Ctm1p 0.135
GYL1 Gyl1p 0.131
CYM1 Cym1p 0.131
GUA1 Gua1p 0.128
MEF2 Mef2p 0.118
COQ1 Coq1p 0.114
MSD1 Msd1p 0.097
RPS20 Rps20p 0.087
MRP20 Mrp20p 0.078
YHB1 Yhb1p 0.076
OCT1 Oct1p 0.072
PRO2 Pro2p 0.071
ART10 Art10p 0.060
MST1 Mst1p 0.058
ADE6 Ade6p 0.057
PET494 Pet494p 0.055
ILV3 Ilv3p 0.054
YLR264C-A hypothetical protein 0.052
CCM1 Ccm1p 0.052
AEP3 Aep3p 0.051
RSM23 Rsm23p 0.051
SRD1 Srd1p 0.051
URA4 Ura4p 0.051
MAP2 Map2p 0.050
MDN1 Mdn1p 0.046
ARC1 Arc1p 0.046
EFT1 Eft1p 0.045
ARP10 Arp10p 0.044
ASN1 Asn1p 0.044
GUF1 Guf1p 0.043
YOL038C-A hypothetical protein 0.042
ISA2 Isa2p 0.042
YLR162W hypothetical protein 0.042
IBA57 Iba57p 0.042
URA2 Ura2p 0.041
AAP1 Aap1p 0.040
CYS4 Cys4p 0.038
MER1 Mer1p 0.037
IMD2 Imd2p 0.037
EFR3 Efr3p 0.037
SHM1 Shm1p 0.037
NAM2 Nam2p 0.037
RSM19 Rsm19p 0.036
RPS5 Rps5p 0.036
LEU2 Leu2p 0.036
MKC7 Mkc7p 0.035
EMC1 Emc1p 0.034
ATP6 Atp6p 0.034
CUP1-1 Cup1-1p 0.034
AIM33 Aim33p 0.034
LYS21 Lys21p 0.034
CPD1 Cpd1p 0.032
YPR157W hypothetical protein 0.032
PRS2 Prs2p 0.031
URA3 Ura3p 0.031
AGC1 Agc1p 0.031
ZPS1 Zps1p 0.030
YAR068W hypothetical protein 0.030
OPT2 Opt2p 0.030
CCT2 Cct2p 0.030
YRB1 Yrb1p 0.029
HXT3 Hxt3p 0.029
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Aats-leu Leucyl-tRNA synthetase 0.637
Aats-thr Threonyl-tRNA synthetase 0.576
Aats-asn Asparaginyl-tRNA synthetase 0.466
Aats-tyr Tyrosyl-tRNA synthetase 0.323
Srp68 CG5064 gene product from transcript CG5064-RA 0.271
Aats-asp Aspartyl-tRNA synthetase 0.264
CG1703 CG1703 gene product from transcript CG1703-RA 0.178
CG17259 CG17259 gene product from transcript CG17259-RA 0.129
Hsc70-5 Heat shock protein cognate 5 0.068
Srp54k Signal recognition particle protein 54k 0.054
Aats-met Methionyl-tRNA synthetase 0.038
Aats-trp Tryptophanyl-tRNA synthetase 0.034
Drp1 Dynamin related protein 1 0.034
CG33123 CG33123 gene product from transcript CG33123-RA 0.027
Xbp1 X box binding protein-1 0.027
CG12264 CG12264 gene product from transcript CG12264-RA 0.025
Aats-glupro Glutamyl-prolyl-tRNA synthetase 0.025
Aats-gly Glycyl-tRNA synthetase 0.023
Aats-pro Prolyl-tRNA synthetase 0.023
Aats-ala Alanyl-tRNA synthetase 0.022
l(2)k01209 lethal (2) k01209 0.020
beta'Cop beta'-coatomer protein 0.018
CG11771 CG11771 gene product from transcript CG11771-RA 0.018
Aats-his Histidyl-tRNA synthetase 0.017
ATP7 CG1886 gene product from transcript CG1886-RB 0.014
Aats-val Valyl-tRNA synthetase 0.014
l(2)37Cc lethal (2) 37Cc 0.014
Trxr-1 Thioredoxin reductase-1 0.014
CG15100 CG15100 gene product from transcript CG15100-RA 0.013
eIF2B-epsilon CG3806 gene product from transcript CG3806-RB 0.013
Gcn2 CG1609 gene product from transcript CG1609-RA 0.013
CG42630 CG42630 gene product from transcript CG42630-RA 0.013
JhI-1 Juvenile hormone-inducible protein 1 0.012
CG8417 CG8417 gene product from transcript CG8417-RA 0.011
eIF3-S8 CG4954 gene product from transcript CG4954-RA 0.011
Aats-cys Cysteinyl-tRNA synthetase 0.011
SrpRbeta Signal recognition particle receptor beta 0.011
CG4679 CG4679 gene product from transcript CG4679-RA 0.011
drosha CG8730 gene product from transcript CG8730-RA 0.011
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
GARS glycyl-tRNA synthetase 1.000
IARS isoleucyl-tRNA synthetase 1.000
EPRS glutamyl-prolyl-tRNA synthetase 1.000
AARS alanyl-tRNA synthetase 1.000
MARS methionyl-tRNA synthetase 1.000
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.999
CARS cysteinyl-tRNA synthetase 0.998
YARS tyrosyl-tRNA synthetase 0.998
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 0.992
NARS asparaginyl-tRNA synthetase 0.992
LARS leucyl-tRNA synthetase 0.833
RARS arginyl-tRNA synthetase 0.829
SARS seryl-tRNA synthetase 0.766
TARS threonyl-tRNA synthetase 0.756
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 0.657
KARS lysyl-tRNA synthetase 0.592
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 0.326
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase 0.269
ECSIT ECSIT homolog (Drosophila) 0.239
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.193
MRPS27 mitochondrial ribosomal protein S27 0.187
LONP1 lon peptidase 1, mitochondrial 0.085
XPOT exportin, tRNA (nuclear export receptor for tRNAs) 0.084
DARS aspartyl-tRNA synthetase 0.080
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 0.069
PSAT1 phosphoserine aminotransferase 1 0.066
KRT8 keratin 8 0.061
CNO cappuccino homolog (mouse) 0.057
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.052
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 0.044
MRRF mitochondrial ribosome recycling factor 0.037
ATF4 activating transcription factor 4 (tax-responsive enhancer element B67) 0.037
LARS2 leucyl-tRNA synthetase 2, mitochondrial 0.035
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial 0.032
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase 0.032
EIF3CL eukaryotic translation initiation factor 3, subunit C-like 0.031
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma 0.031
ATP13A1 ATPase type 13A1 0.029
C12orf44 chromosome 12 open reading frame 44 0.025
MINA MYC induced nuclear antigen 0.025
OTUD5 OTU domain containing 5 0.025
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa 0.023
RPTOR regulatory associated protein of MTOR, complex 1 0.022
DPH5 DPH5 homolog (S. cerevisiae) 0.020
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.020
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative) 0.018
TRAP1 TNF receptor-associated protein 1 0.018
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 0.018
ARMC6 armadillo repeat containing 6 0.017
HMBS hydroxymethylbilane synthase 0.017
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2) 0.016
PHGDH phosphoglycerate dehydrogenase 0.016
GOT1 glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) 0.016
BCS1L BCS1-like (S. cerevisiae) 0.016
PFAS phosphoribosylformylglycinamidine synthase 0.015
GCDH glutaryl-CoA dehydrogenase 0.015
TRIB3 tribbles homolog 3 (Drosophila) 0.015
LIG3 ligase III, DNA, ATP-dependent 0.014
XPO5 exportin 5 0.014
DLAT dihydrolipoamide S-acetyltransferase 0.014
THG1L tRNA-histidine guanylyltransferase 1-like (S. cerevisiae) 0.013
WARS tryptophanyl-tRNA synthetase 0.013
GPS1 G protein pathway suppressor 1 0.013
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 0.013
LIAS lipoic acid synthetase 0.013
BMS1 BMS1 homolog, ribosome assembly protein (yeast) 0.013
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11 0.013
TH1L TH1-like (Drosophila) 0.012
HOXB7 homeobox B7 0.012
TSFM Ts translation elongation factor, mitochondrial 0.012
GUF1 GUF1 GTPase homolog (S. cerevisiae) 0.012
TRMT1 TRM1 tRNA methyltransferase 1 homolog (S. cerevisiae) 0.011
RTN4IP1 reticulon 4 interacting protein 1 0.011
MRPL1 mitochondrial ribosomal protein L1 0.011
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 0.011
METTL8 methyltransferase like 8 0.011
SCFD2 sec1 family domain containing 2 0.011
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.010
POLRMT polymerase (RNA) mitochondrial (DNA directed) 0.010
DEAF1 deformed epidermal autoregulatory factor 1 (Drosophila) 0.010
EIF2D eukaryotic translation initiation factor 2D 0.010
GMDS GDP-mannose 4,6-dehydratase 0.010
WDR46 WD repeat domain 46 0.010
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Gars glycyl-tRNA synthetase 0.984
Nars asparaginyl-tRNA synthetase 0.978
Lars leucyl-tRNA synthetase 0.934
Aars alanyl-tRNA synthetase 0.816
Yars tyrosyl-tRNA synthetase 0.707
Eif3d eukaryotic translation initiation factor 3, subunit D 0.623
Eif3c eukaryotic translation initiation factor 3, subunit C 0.611
Iars isoleucine-tRNA synthetase 0.578
Tars threonyl-tRNA synthetase 0.500
Mars methionine-tRNA synthetase 0.449
Rars arginyl-tRNA synthetase 0.306
Eprs glutamyl-prolyl-tRNA synthetase 0.286
Sars seryl-aminoacyl-tRNA synthetase 0.257
Asns asparagine synthetase 0.218
Farsb phenylalanyl-tRNA synthetase, beta subunit 0.143
Nop56 NOP56 ribonucleoprotein homolog (yeast) 0.130
Wdr74 WD repeat domain 74 0.102
Nsun2 NOL1/NOP2/Sun domain family member 2 0.094
Eif3g eukaryotic translation initiation factor 3, subunit G 0.087
Dus1l dihydrouridine synthase 1-like (S. cerevisiae) 0.083
Mthfd2 methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase 0.051
Rrp12 ribosomal RNA processing 12 homolog (S. cerevisiae) 0.051
Srp68 signal recognition particle 68 0.049
Elac2 elaC homolog 2 (E. coli) 0.036
Mrps18b mitochondrial ribosomal protein S18B 0.034
Lrrc59 leucine rich repeat containing 59 0.034
Ddx1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 0.033
Lsg1 large subunit GTPase 1 homolog (S. cerevisiae) 0.033
Atf4 activating transcription factor 4 0.031
Cars cysteinyl-tRNA synthetase 0.030
Eif2b4 eukaryotic translation initiation factor 2B, subunit 4 delta 0.029
Pus1 pseudouridine synthase 1 0.029
Ddx56 DEAD (Asp-Glu-Ala-Asp) box polypeptide 56 0.028
Lonp1 lon peptidase 1, mitochondrial 0.026
Ddx54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 0.026
Aatf apoptosis antagonizing transcription factor 0.025
Gtf2f1 general transcription factor IIF, polypeptide 1 0.025
Abcf1 ATP-binding cassette, sub-family F (GCN20), member 1 0.022
Vcp valosin containing protein 0.022
Ncbp1 nuclear cap binding protein subunit 1 0.021
Wdr36 WD repeat domain 36 0.020
Xpot exportin, tRNA (nuclear export receptor for tRNAs) 0.019
Ftsj3 FtsJ homolog 3 (E. coli) 0.019
Psat1 phosphoserine aminotransferase 1 0.018
Drg2 developmentally regulated GTP binding protein 2 0.018
Larp1 La ribonucleoprotein domain family, member 1 0.017
Slc3a2 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 0.017
Mybbp1a MYB binding protein (P160) 1a 0.017
Nop14 NOP14 nucleolar protein homolog (yeast) 0.017
Fam98a family with sequence similarity 98, member A 0.014
Eif2b3 eukaryotic translation initiation factor 2B, subunit 3 0.014
Cct5 chaperonin containing Tcp1, subunit 5 (epsilon) 0.014
Las1l LAS1-like (S. cerevisiae) 0.014
Eif3b eukaryotic translation initiation factor 3, subunit B 0.014
Fam192a family with sequence similarity 192, member A 0.013
Hspa9 heat shock protein 9 0.013
Trmt5 TRM5 tRNA methyltransferase 5 homolog (S. cerevisiae) 0.013
Dohh deoxyhypusine hydroxylase/monooxygenase 0.012
Bms1 BMS1 homolog, ribosome assembly protein (yeast) 0.011
Clpb ClpB caseinolytic peptidase B homolog (E. coli) 0.011
Psph phosphoserine phosphatase 0.010
Nolc1 nucleolar and coiled-body phosphoprotein 1 0.010
Lrpprc leucine-rich PPR-motif containing 0.010
Ttc4 tetratricopeptide repeat domain 4 0.010
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Yars tyrosyl-tRNA synthetase 0.922
Mars methionine-tRNA synthetase 0.484
Eif3c eukaryotic translation initiation factor 3, subunit C 0.387
Aars alanyl-tRNA synthetase 0.373
Sars seryl-tRNA synthetase 0.344
Gars glycyl-tRNA synthetase 0.235
Eif3d eukaryotic translation initiation factor 3, subunit D 0.222
Tars threonyl-tRNA synthetase 0.222
Eif3b eukaryotic translation initiation factor 3, subunit B 0.130
Pno1 partner of NOB1 homolog (S. cerevisiae) 0.128
Cars cysteinyl-tRNA synthetase 0.093
Nsfl1c NSFL1 (p97) cofactor (p47) 0.050
Eif2d eukaryotic translation initiation factor 2D 0.038
Aatf apoptosis antagonizing transcription factor 0.032
LOC100360406 rCG34104-like 0.031
Ddx1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 0.030
Dym dymeclin 0.030
Psmd12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.030
Cpsf3 cleavage and polyadenylation specificity factor 3 0.029
Nmt1 N-myristoyltransferase 1 0.027
Eprs glutamyl-prolyl-tRNA synthetase 0.025
Cct3 chaperonin containing Tcp1, subunit 3 (gamma) 0.024
Psmc6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.022
Psmd2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.022
Eef1d eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.022
Hax1 HCLS1 associated protein X-1 0.019
Cirh1a cirrhosis, autosomal recessive 1A (cirhin) 0.017
Wars tryptophanyl-tRNA synthetase 0.014
Dmap1 DNA methyltransferase 1-associated protein 1 0.014
Rpl19 ribosomal protein L19 0.014
Ciao1 cytosolic iron-sulfur protein assembly 1 homolog (S. cerevisiae) 0.014
Tcp1 t-complex 1 0.013
Ppp2r2d protein phosphatase 2, regulatory subunit B, delta isoform 0.013
Prmt1 protein arginine methyltransferase 1 0.013
Uba5 ubiquitin-like modifier activating enzyme 5 0.012
Farsb phenylalanyl-tRNA synthetase, beta subunit 0.012
Abcf1 ATP-binding cassette, subfamily F (GCN20), member 1 0.012
Rpl3 ribosomal protein L3 0.011
Psmc4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.011
Anapc5 anaphase-promoting complex subunit 5 0.011
Psmc3 proteasome (prosome, macropain) 26S subunit, ATPase 3 0.011