The network for 'double strand break repair via nonhomologous end joining' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

double strand break repair via nonhomologous end joining

The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends.

Name Description Probability Func Analog Organism
RAD52 Rad52p 0.224
LEO1 Leo1p 0.205
TPD3 Tpd3p 0.176
XRS2 Xrs2p 0.165
PSY4 Psy4p 0.127
ASF1 Asf1p 0.123
POL30 Pol30p 0.086
RAD5 Rad5p 0.084
HHO1 Hho1p 0.080
RAD53 Rad53p 0.079
MRE11 Mre11p 0.076
EST1 Est1p 0.066
REV3 Rev3p 0.063
EAF7 Eaf7p 0.062
VPS71 Vps71p 0.060
RSC1 Rsc1p 0.056
EXO1 Exo1p 0.052
TOP1 Top1p 0.052
MMS1 Mms1p 0.051
VPS75 Vps75p 0.050
EST2 Est2p 0.047
RAD54 Rad54p 0.047
HHT2 Hht2p 0.047
PRI1 Pri1p 0.042
EPL1 Epl1p 0.042
RSC30 Rsc30p 0.041
RSC3 Rsc3p 0.040
GCN5 Gcn5p 0.040
TIP41 Tip41p 0.038
SAE2 Sae2p 0.038
MRC1 Mrc1p 0.038
RSC2 Rsc2p 0.037
RHO5 Rho5p 0.036
RAD1 Rad1p 0.034
POL2 Pol2p 0.034
HUL5 Hul5p 0.034
RSC4 Rsc4p 0.033
DDC1 Ddc1p 0.032
BDF1 Bdf1p 0.031
MLH3 Mlh3p 0.031
RAD59 Rad59p 0.030
EAF1 Eaf1p 0.030
NPR2 Npr2p 0.029
PSO2 Pso2p 0.029
CTF4 Ctf4p 0.028
PHO23 Pho23p 0.028
YDL156W hypothetical protein 0.028
YLR257W hypothetical protein 0.028
PDS5 Pds5p 0.027
ARE2 Are2p 0.027
DIA2 Dia2p 0.026
YLR422W hypothetical protein 0.026
HAL5 Hal5p 0.026
ARG82 Arg82p 0.026
SWC4 Swc4p 0.026
SRS2 Srs2p 0.026
SWC7 Swc7p 0.025
MLH2 Mlh2p 0.025
ZEO1 Zeo1p 0.025
RAD9 Rad9p 0.025
CTK3 Ctk3p 0.024
TEL1 Tel1p 0.024
SEM1 Sem1p 0.024
TYE7 Tye7p 0.024
SIZ1 Siz1p 0.024
IML1 Iml1p 0.024
STE18 Ste18p 0.024
LIF1 Lif1p 0.023
ADI1 Adi1p 0.023
RTT109 Rtt109p 0.023
UBP2 Ubp2p 0.023
MMS22 Mms22p 0.023
RCO1 Rco1p 0.023
PRE2 Pre2p 0.023
TOF1 Tof1p 0.023
SRD1 Srd1p 0.023
HDA2 Hda2p 0.023
SMC6 Smc6p 0.023
MLP1 Mlp1p 0.023
BUR6 Bur6p 0.023
HST3 Hst3p 0.023
CRZ1 Crz1p 0.023
PDS1 Pds1p 0.022
YLR264C-A hypothetical protein 0.022
HST1 Hst1p 0.022
IXR1 Ixr1p 0.022
STH1 Sth1p 0.022
CUP1-1 Cup1-1p 0.022
UBP6 Ubp6p 0.022
OAF1 Oaf1p 0.022
RAD2 Rad2p 0.021
CRP1 Crp1p 0.021
SLX8 Slx8p 0.021
RNH201 Rnh201p 0.021
YNL144C hypothetical protein 0.021
YOL038C-A hypothetical protein 0.021
YLR162W hypothetical protein 0.021
UFD2 Ufd2p 0.021
LEU2 Leu2p 0.021
GPB2 Gpb2p 0.021
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
rrm1 ribonucleotide reductase M1 polypeptide 0.630
slbp stem-loop binding protein 0.581
mybl2 myeloblastosis oncogene-like 2 0.209
msh2 mutS homolog 2 (E. coli) 0.132
ipo9 importin 9 0.116
hells helicase, lymphoid-specific 0.105
pola1 polymerase (DNA directed), alpha 1 0.097
hat1 histone acetyltransferase 1 0.093
mcm4 MCM4 minichromosome maintenance deficient 4, mitotin (S. cerevisiae) 0.092
wdhd1 WD repeat and HMG-box DNA binding protein 1 0.090
mcm5 MCM5 minichromosome maintenance deficient 5 (S. cerevisiae) 0.087
LOC100537814 kinetochore-associated protein 1-like 0.085
dnmt1 DNA (cytosine-5-)-methyltransferase 1 0.077
anp32b acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.075
nasp nuclear autoantigenic sperm protein (histone-binding) 0.061
rfc1 replication factor C (activator 1) 1 0.060
ppm1g protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform 0.058
fen1 flap structure-specific endonuclease 1 0.057
mcmbp minichromosome maintenance complex binding protein 0.048
prim1 primase polypeptide 1 0.047
zgc:110113 zgc:110113 0.047
rbb4 retinoblastoma binding protein 4 0.047
rpa1 replication protein A1 0.045
pds5b PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) 0.038
ubr7 ubiquitin protein ligase E3 component n-recognin 7 0.036
zgc:92648 zgc:92648 0.036
dut dUTP pyrophosphatase 0.034
rfc5 replication factor C (activator 1) 5 0.033
rbb4l retinoblastoma binding protein 4, like 0.032
pcna proliferating cell nuclear antigen 0.032
LOC563669 cohesin subunit SA-3-like 0.032
zgc:110540 zgc:110540 0.031
whsc1 Wolf-Hirschhorn syndrome candidate 1 0.028
hirip3 HIRA interacting protein 3 0.027
cdk2 cyclin-dependent kinase 2 0.022
zgc:113210 zgc:113210 0.021
asf1bb ASF1 anti-silencing function 1 homolog Bb 0.021
acvr2a activin receptor IIa 0.020
orc6 origin recognition complex, subunit 6 0.020
anp32a acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.018
mbd3b methyl-CpG binding domain protein 3b 0.018
usp1 ubiquitin specific protease 1 0.018
sae1 SUMO1 activating enzyme subunit 1 0.018
rpa3 replication protein A3 0.017
ptpn11a protein tyrosine phosphatase, non-receptor type 11, a 0.016
si:ch1073-351m12.1 si:ch1073-351m12.1 0.015
mcm7 MCM7 minichromosome maintenance deficient 7 (S. cerevisiae) 0.015
msh6 mutS homolog 6 (E. coli) 0.014
ezh2 enhancer of zeste homolog 2 (Drosophila) 0.014
rrm2 ribonucleotide reductase M2 polypeptide 0.013
wnt8a wingless-type MMTV integration site family, member 8a 0.013
myst2 MYST histone acetyltransferase 2 0.013
cpsf2 cleavage and polyadenylation specific factor 2 0.013
ncapd2 non-SMC condensin I complex, subunit D2 0.012
parp2 poly (ADP-ribose) polymerase family, member 2 0.012
snrpa small nuclear ribonucleoprotein polypeptide A 0.011
ccne2 cyclin E2 0.011
wu:fc85c01 wu:fc85c01 0.011
pola2 polymerase (DNA directed), alpha 2 0.011
zgc:113183 zgc:113183 0.010
zgc:100817 zgc:100817 0.010
elavl1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.010
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
mus205 mutagen-sensitive 205 0.998
lok loki 0.994
mus101 mutagen-sensitive 101 0.986
CG5524 CG5524 gene product from transcript CG5524-RA 0.985
DNApol-eta CG7143 gene product from transcript CG7143-RA 0.977
Brca2 Breast cancer 2, early onset homolog 0.969
okr okra 0.920
spn-A spindle A 0.895
Klp3A Kinesin-like protein at 3A 0.879
mus309 mutagen-sensitive 309 0.869
mus308 mutagen-sensitive 308 0.839
RPA2 Replication protein A2 0.819
Irbp Inverted repeat-binding protein 0.788
mus301 mutagen-sensitive 301 0.716
Mcm3 Minichromosome maintenance 3 0.622
Rev1 CG12189 gene product from transcript CG12189-RA 0.622
rad50 CG6339 gene product from transcript CG6339-RD 0.589
mus201 mutagen-sensitive 201 0.525
mei-9 meiotic 9 0.394
spn-B spindle B 0.380
mus304 mutagen-sensitive 304 0.366
RecQ5 homolog of RecQ 0.309
Mcm7 Minichromosome maintenance 7 0.286
mus312 mutagen-sensitive 312 0.239
RnrL Ribonucleoside diphosphate reductase large subunit 0.227
Lig4 Ligase4 0.224
mei-41 meiotic 41 0.179
CycJ Cyclin J 0.169
RpA-70 Replication Protein A 70 0.114
CDC45L CG3658 gene product from transcript CG3658-RA 0.098
RfC4 Replication factor C subunit 4 0.098
DNApol-delta DNA-polymerase-delta 0.096
CG13350 CG13350 gene product from transcript CG13350-RA 0.085
Ercc1 CG10215 gene product from transcript CG10215-RA 0.082
Ssrp Structure specific recognition protein 0.079
RecQ4 CG7487 gene product from transcript CG7487-RA 0.075
mus210 mutagen-sensitive 210 0.063
MCPH1 Microcephalin 0.058
CG5384 CG5384 gene product from transcript CG5384-RA 0.058
Smc5 CG32438 gene product from transcript CG32438-RE 0.057
spn-E spindle E 0.053
Ku80 CG18801 gene product from transcript CG18801-RA 0.051
CG7376 CG7376 gene product from transcript CG7376-RA 0.050
hay haywire 0.034
CG5857 CG5857 gene product from transcript CG5857-RA 0.034
Ddx1 Dead-box-1 0.031
feo fascetto 0.031
Orc4 Origin recognition complex subunit 4 0.029
Mcm5 Minichromosome maintenance 5 0.027
Hira CG12153 gene product from transcript CG12153-RA 0.027
CG9576 CG9576 gene product from transcript CG9576-RA 0.025
nbs CG6754 gene product from transcript CG6754-RC 0.024
CG7457 CG7457 gene product from transcript CG7457-RA 0.023
CG10722 CG10722 gene product from transcript CG10722-RA 0.023
CG2694 CG2694 gene product from transcript CG2694-RA 0.020
Mlh1 CG11482 gene product from transcript CG11482-RA 0.020
His2Av Histone H2A variant 0.017
DNApol-alpha73 DNA polymerase alpha 73kD 0.015
CG6049 CG6049 gene product from transcript CG6049-RC 0.014
Chrac-14 CG13399 gene product from transcript CG13399-RA 0.013
Atu Another transcription unit 0.012
CG4680 CG4680 gene product from transcript CG4680-RA 0.012
armi armitage 0.011
WRNexo WRN exonuclease 0.010
rump rumpelstiltskin 0.010
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
BRCA1 breast cancer 1, early onset 0.967
H2AFX H2A histone family, member X 0.948
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.945
PARP1 poly (ADP-ribose) polymerase 1 0.941
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.929
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 0.831
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.810
RPA1 replication protein A1, 70kDa 0.767
MDC1 mediator of DNA-damage checkpoint 1 0.721
MSH6 mutS homolog 6 (E. coli) 0.640
BLM Bloom syndrome, RecQ helicase-like 0.492
NBN nibrin 0.410
APLF aprataxin and PNKP like factor 0.367
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.310
FANCD2 Fanconi anemia, complementation group D2 0.296
WRN Werner syndrome, RecQ helicase-like 0.266
PCNA proliferating cell nuclear antigen 0.235
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 0.208
CDK2 cyclin-dependent kinase 2 0.192
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.131
RAD51 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) 0.117
BRCA2 breast cancer 2, early onset 0.112
CHEK1 CHK1 checkpoint homolog (S. pombe) 0.110
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.108
SMC1A structural maintenance of chromosomes 1A 0.094
CHAF1A chromatin assembly factor 1, subunit A (p150) 0.087
RAD50 RAD50 homolog (S. cerevisiae) 0.078
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 0.077
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.068
MSH2 mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) 0.053
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.050
TP53 tumor protein p53 0.044
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.043
APTX aprataxin 0.038
PNKP polynucleotide kinase 3'-phosphatase 0.038
CSNK2A1 casein kinase 2, alpha 1 polypeptide 0.035
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 0.030
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 0.026
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.026
POLD3 polymerase (DNA-directed), delta 3, accessory subunit 0.026
ATM ataxia telangiectasia mutated 0.025
RBBP8 retinoblastoma binding protein 8 0.025
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 0.025
RBM10 RNA binding motif protein 10 0.025
MCM3 minichromosome maintenance complex component 3 0.025
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.024
TOP2A topoisomerase (DNA) II alpha 170kDa 0.024
ATR ataxia telangiectasia and Rad3 related 0.023
LIG4 ligase IV, DNA, ATP-dependent 0.022
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 0.021
POMP proteasome maturation protein 0.021
MLH1 mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) 0.019
ORC1 origin recognition complex, subunit 1 0.019
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 0.017
RPA2 replication protein A2, 32kDa 0.017
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 0.016
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2 0.016
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 0.016
FANCA Fanconi anemia, complementation group A 0.015
CHEK2 CHK2 checkpoint homolog (S. pombe) 0.015
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.015
DHX30 DEAH (Asp-Glu-Ala-His) box polypeptide 30 0.014
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.014
TIMELESS timeless homolog (Drosophila) 0.014
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.014
RB1 retinoblastoma 1 0.014
RAD21 RAD21 homolog (S. pombe) 0.014
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 0.013
SSRP1 structure specific recognition protein 1 0.012
POLA2 polymerase (DNA directed), alpha 2 (70kD subunit) 0.012
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 0.012
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 0.012
E2F1 E2F transcription factor 1 0.011
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.011
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 0.011
FANCG Fanconi anemia, complementation group G 0.011
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 0.011
HMGA1 high mobility group AT-hook 1 0.010
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 0.937
Atm ataxia telangiectasia mutated homolog (human) 0.917
Prim1 DNA primase, p49 subunit 0.866
Brca2 breast cancer 2 0.726
Hdac1 histone deacetylase 1 0.631
Mcm3 minichromosome maintenance deficient 3 (S. cerevisiae) 0.568
Rpa1 replication protein A1 0.480
Prim2 DNA primase, p58 subunit 0.431
Suds3 suppressor of defective silencing 3 homolog (S. cerevisiae) 0.419
Nbn nibrin 0.394
Cdt1 chromatin licensing and DNA replication factor 1 0.328
Mlh1 mutL homolog 1 (E. coli) 0.312
Prkdc protein kinase, DNA activated, catalytic polypeptide 0.295
Cdc6 cell division cycle 6 homolog (S. cerevisiae) 0.277
Mcm4 minichromosome maintenance deficient 4 homolog (S. cerevisiae) 0.275
Msh2 mutS homolog 2 (E. coli) 0.273
Mcm7 minichromosome maintenance deficient 7 (S. cerevisiae) 0.249
Pold1 polymerase (DNA directed), delta 1, catalytic subunit 0.242
Brca1 breast cancer 1 0.232
Ccne1 cyclin E1 0.211
Tipin timeless interacting protein 0.211
Hprt hypoxanthine guanine phosphoribosyl transferase 0.196
Pola2 polymerase (DNA directed), alpha 2 0.194
Hdac6 histone deacetylase 6 0.192
Ezh2 enhancer of zeste homolog 2 (Drosophila) 0.168
Dicer1 Dicer1, Dcr-1 homolog (Drosophila) 0.166
Dnajc9 DnaJ (Hsp40) homolog, subfamily C, member 9 0.166
Cdk4 cyclin-dependent kinase 4 0.143
Wdhd1 WD repeat and HMG-box DNA binding protein 1 0.140
Dnmt1 DNA methyltransferase (cytosine-5) 1 0.135
Ssrp1 structure specific recognition protein 1 0.123
Mcm2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae) 0.121
Parp2 poly (ADP-ribose) polymerase family, member 2 0.114
Hells helicase, lymphoid specific 0.109
Timeless timeless homolog (Drosophila) 0.103
2700029M09Rik RIKEN cDNA 2700029M09 gene 0.097
Igh immunoglobulin heavy chain complex 0.093
Rad50 RAD50 homolog (S. cerevisiae) 0.081
Nup85 nucleoporin 85 0.073
Mdm2 transformed mouse 3T3 cell double minute 2 0.068
Pcna proliferating cell nuclear antigen 0.065
Lmnb1 lamin B1 0.062
Hdac2 histone deacetylase 2 0.058
Pole2 polymerase (DNA directed), epsilon 2 (p59 subunit) 0.057
Rnaseh2b ribonuclease H2, subunit B 0.054
Rfc2 replication factor C (activator 1) 2 0.053
Cpsf3 cleavage and polyadenylation specificity factor 3 0.051
Xrcc6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.051
Haus1 HAUS augmin-like complex, subunit 1 0.051
Rfc1 replication factor C (activator 1) 1 0.050
Gins1 GINS complex subunit 1 (Psf1 homolog) 0.047
Gmnn geminin 0.046
Ccna2 cyclin A2 0.045
Lrrc40 leucine rich repeat containing 40 0.045
Pold3 polymerase (DNA-directed), delta 3, accessory subunit 0.043
Hspa14 heat shock protein 14 0.042
Rfc5 replication factor C (activator 1) 5 0.041
Mcm5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) 0.040
Hat1 histone aminotransferase 1 0.040
Blm Bloom syndrome, RecQ helicase-like 0.039
H2afx H2A histone family, member X 0.038
Ccz1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae) 0.036
Vrk1 vaccinia related kinase 1 0.036
Atad5 ATPase family, AAA domain containing 5 0.036
Nup88 nucleoporin 88 0.036
Lig1 ligase I, DNA, ATP-dependent 0.035
Mtbp Mdm2, transformed 3T3 cell double minute p53 binding protein 0.035
Th1l TH1-like homolog (Drosophila) 0.033
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.033
Rfc4 replication factor C (activator 1) 4 0.032
Smarcc1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.031
Tcfcp2l1 transcription factor CP2-like 1 0.031
Chd1l chromodomain helicase DNA binding protein 1-like 0.030
Rpa2 replication protein A2 0.030
Polr2b polymerase (RNA) II (DNA directed) polypeptide B 0.029
Orc6 origin recognition complex, subunit 6 0.028
Nup107 nucleoporin 107 0.026
Tcrb T-cell receptor beta chain 0.026
Xrcc5 X-ray repair complementing defective repair in Chinese hamster cells 5 0.026
Pms2 postmeiotic segregation increased 2 (S. cerevisiae) 0.025
Nup93 nucleoporin 93 0.025
Syce2 synaptonemal complex central element protein 2 0.025
Ncapd3 non-SMC condensin II complex, subunit D3 0.025
Mdm4 transformed mouse 3T3 cell double minute 4 0.025
Parn poly(A)-specific ribonuclease (deadenylation nuclease) 0.025
Tcrd T-cell receptor delta chain 0.024
Nasp nuclear autoantigenic sperm protein (histone-binding) 0.023
Ncaph non-SMC condensin I complex, subunit H 0.023
Topbp1 topoisomerase (DNA) II binding protein 1 0.023
Tada2a transcriptional adaptor 2A 0.023
Cenpn centromere protein N 0.023
Asf1b ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.022
Lars leucyl-tRNA synthetase 0.022
Rad51 RAD51 homolog (S. cerevisiae) 0.021
Dclre1c DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae) 0.021
Rrm1 ribonucleotide reductase M1 0.021
Ttc27 tetratricopeptide repeat domain 27 0.021
Mad2l1 MAD2 mitotic arrest deficient-like 1 (yeast) 0.020
Ckap5 cytoskeleton associated protein 5 0.020
Creb1 cAMP responsive element binding protein 1 0.019
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism