The network for 'double strand break repair' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

double strand break repair

The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
RAD53 Rad53p 0.999
CTF4 Ctf4p 0.995
RAD52 Rad52p 0.992
RAD9 Rad9p 0.991
RFA1 Rfa1p 0.983
SLD5 Sld5p 0.980
SMC6 Smc6p 0.972
SRS2 Srs2p 0.969
MCM5 Mcm5p 0.969
RAD54 Rad54p 0.965
MRC1 Mrc1p 0.964
XRS2 Xrs2p 0.957
MCM4 Mcm4p 0.949
CDC45 Cdc45p 0.948
POL30 Pol30p 0.938
RDH54 Rdh54p 0.937
RTT107 Rtt107p 0.931
RAD50 Rad50p 0.926
TOF1 Tof1p 0.926
ELG1 Elg1p 0.910
SLX4 Slx4p 0.903
SIR2 Sir2p 0.887
MRE11 Mre11p 0.886
POL3 Pol3p 0.886
MCM6 Mcm6p 0.882
MSH6 Msh6p 0.877
LIF1 Lif1p 0.875
DDC1 Ddc1p 0.861
MCM3 Mcm3p 0.842
POL2 Pol2p 0.842
RAD1 Rad1p 0.839
MCM2 Mcm2p 0.825
RSC1 Rsc1p 0.815
RAD5 Rad5p 0.812
SHU1 Shu1p 0.808
MMS1 Mms1p 0.793
PSF1 Psf1p 0.791
MCM7 Mcm7p 0.786
SMC3 Smc3p 0.784
MSH2 Msh2p 0.778
ASF1 Asf1p 0.777
POL12 Pol12p 0.772
RAD24 Rad24p 0.752
SLX8 Slx8p 0.750
TOP1 Top1p 0.745
TEL1 Tel1p 0.734
ARP4 Arp4p 0.727
POL1 Pol1p 0.722
INO80 Ino80p 0.715
SGS1 Sgs1p 0.714
PSY3 Psy3p 0.709
MEC1 Mec1p 0.691
DPB11 Dpb11p 0.662
CSM3 Csm3p 0.659
DBF4 Dbf4p 0.643
ARP9 Arp9p 0.630
MCM10 Mcm10p 0.628
MMS21 Mms21p 0.621
RSC2 Rsc2p 0.620
IES3 Ies3p 0.609
RAD18 Rad18p 0.603
RAD27 Rad27p 0.588
DNL4 Dnl4p 0.582
SCC2 Scc2p 0.570
DMC1 Dmc1p 0.558
PPH21 Pph21p 0.557
SLD2 Sld2p 0.552
RSC8 Rsc8p 0.551
RAD10 Rad10p 0.546
POB3 Pob3p 0.538
PSF2 Psf2p 0.530
YAF9 Yaf9p 0.527
EST2 Est2p 0.509
SHU2 Shu2p 0.505
REV7 Rev7p 0.491
RAD59 Rad59p 0.475
IES1 Ies1p 0.470
NPL6 Npl6p 0.466
CSM2 Csm2p 0.461
NUP120 Nup120p 0.438
PSF3 Psf3p 0.433
HHF1 Hhf1p 0.410
MMS22 Mms22p 0.395
EPL1 Epl1p 0.387
NUP85 Nup85p 0.368
PSY4 Psy4p 0.367
DCC1 Dcc1p 0.360
FUN30 Fun30p 0.336
POL31 Pol31p 0.335
EST1 Est1p 0.331
SLX5 Slx5p 0.327
SAE2 Sae2p 0.323
MUS81 Mus81p 0.316
MEC3 Mec3p 0.312
HST3 Hst3p 0.298
RFA2 Rfa2p 0.292
TPD3 Tpd3p 0.284
RMI1 Rmi1p 0.282
PPH3 Pph3p 0.281
STH1 Sth1p 0.280
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
knl-1 Protein KNL-1 0.103
smc-5 Protein SMC-5 0.060
F54E12.2 Protein F54E12.2 0.043
gon-4 Protein GON-4 0.042
zyg-9 Protein ZYG-9 0.032
glh-4 Protein GLH-4 0.027
coh-3 Protein COH-3 0.027
M01A10.1 Protein M01A10.1 0.023
msh-6 Protein MSH-6 0.022
pas-1 Protein PAS-1 0.021
ndc-80 Protein NDC-80 0.021
mcm-6 Protein MCM-6 0.020
Y47D3A.29 Protein Y47D3A.29 0.020
mes-4 Protein MES-4 0.020
icp-1 Protein ICP-1 0.018
acly-2 Protein ACLY-2 0.018
T19A5.1 Protein T19A5.1 0.016
wago-9 Protein WAGO-9 0.016
gei-14 Protein GEI-14 0.015
drh-3 Protein DRH-3 0.015
klc-1 Protein KLC-1 0.015
nmy-2 Protein NMY-2 0.014
orc-5 Protein ORC-5 0.014
pme-3 Protein PME-3 0.013
polq-1 Protein POLQ-1 0.013
npl-4.2 Protein NPL-4.2 0.012
F52B5.3 Protein F52B5.3 0.012
nra-1 Protein NRA-1 0.012
bath-19 Protein BATH-19 0.012
rpa-1 Protein RPA-1 0.012
ima-2 Protein IMA-2 0.011
chk-1 Protein CHK-1 0.011
met-2 Protein MET-2 0.011
C27A12.7 Protein C27A12.7 0.011
spd-2 Protein SPD-2 0.010
F10C2.4 Protein F10C2.4 0.010
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
pola2 polymerase (DNA directed), alpha 2 0.852
fen1 flap structure-specific endonuclease 1 0.810
chtf18 CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae) 0.648
nasp nuclear autoantigenic sperm protein (histone-binding) 0.598
wdhd1 WD repeat and HMG-box DNA binding protein 1 0.555
hirip3 HIRA interacting protein 3 0.462
pcna proliferating cell nuclear antigen 0.457
mybl2 myeloblastosis oncogene-like 2 0.377
zgc:92139 zgc:92139 0.356
palb2 partner and localizer of BRCA2 0.343
hells helicase, lymphoid-specific 0.337
gins2 GINS complex subunit 2 0.316
rbb4 retinoblastoma binding protein 4 0.307
dnmt1 DNA (cytosine-5-)-methyltransferase 1 0.280
pold1 polymerase (DNA directed), delta 1, catalytic subunit 0.267
pola1 polymerase (DNA directed), alpha 1 0.237
zgc:92648 zgc:92648 0.229
hat1 histone acetyltransferase 1 0.228
slbp stem-loop binding protein 0.225
cdc45 CDC45 cell division cycle 45 homolog (S. cerevisiae) 0.221
zgc:154089 zgc:154089 0.216
mus81 MUS81 endonuclease homolog (yeast) 0.200
suv39h1b suppressor of variegation 3-9 homolog 1b 0.198
zgc:55943 zgc:55943 0.192
prim1 primase polypeptide 1 0.189
smc2 structural maintenance of chromosomes 2 0.189
lrrc42 leucine rich repeat containing 42 0.188
dut dUTP pyrophosphatase 0.180
sass6 spindle assembly 6 homolog (C. elegans) 0.180
zgc:92661 zgc:92661 0.162
atad5a ATPase family, AAA domain containing 5a 0.147
esco2 establishment of cohesion 1 homolog 2 0.146
mcm4 MCM4 minichromosome maintenance deficient 4, mitotin (S. cerevisiae) 0.145
cdc7 cell division cycle 7 homolog (S. cerevisiae) 0.136
rpa1 replication protein A1 0.131
zgc:56197 zgc:56197 0.125
ncapd2 non-SMC condensin I complex, subunit D2 0.122
pds5b PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) 0.120
cuedc2 CUE domain containing 2 0.119
cdk2 cyclin-dependent kinase 2 0.119
zgc:174506 zgc:174506 0.108
nipblb novel protein similar to vertebrate Nipped-B homolog and nipped-b homolog b (Drosophila) 0.107
msh2 mutS homolog 2 (E. coli) 0.107
trip13 thyroid hormone receptor interactor 13 0.106
chaf1b chromatin assembly factor 1, subunit B 0.106
dnmt5 DNA (cytosine-5-)-methyltransferase 5 0.103
rfc4 replication factor C (activator 1) 4 0.102
traip TRAF-interacting protein 0.102
zgc:73100 zgc:73100 0.101
wdr76 WD repeat domain 76 0.096
maf1 MAF1 homolog (S. cerevisiae) 0.094
spc24 SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae) 0.092
si:ch211-218c6.5 si:ch211-218c6.5 0.091
ddx39b DEAD (Asp-Glu-Ala-Asp) box polypeptide 39b 0.091
neil3 nei endonuclease VIII-like 3 (E. coli) 0.090
paxip1 PAX interacting (with transcription-activation domain) protein 1 0.089
si:ch211-215h6.2 si:ch211-215h6.2 0.085
pspc1 paraspeckle component 1 0.084
si:dkeyp-35b8.5 si:dkeyp-35b8.5 0.084
hnrnpa0 heterogeneous nuclear ribonucleoprotein A0 0.083
pole2 polymerase (DNA directed), epsilon 2 0.082
LOC100333229 PCNA-associated factor-like 0.080
rap1a RAP1A, member of RAS oncogene family 0.077
ck2b casein kinase 2 beta 0.076
usp5 ubiquitin specific protease 5 0.076
rfc5 replication factor C (activator 1) 5 0.075
si:ch211-239j15.4 si:ch211-239j15.4 0.074
ppp2cb protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform 0.071
lppr3b lipid phosphate phosphatase-related protein type 3b 0.069
dhfr dihydrofolate reductase 0.069
ssrp1a structure specific recognition protein 1a 0.068
orc6 origin recognition complex, subunit 6 0.068
zgc:110540 zgc:110540 0.067
rpa2 replication protein A2 0.066
orc1 origin recognition complex, subunit 1 0.066
cbx1a chromobox homolog 1a (HP1 beta homolog Drosophila) 0.065
usf1 upstream transcription factor 1 0.064
im:6898523 im:6898523 0.064
hnrnpul1 heterogeneous nuclear ribonucleoprotein U-like 1 0.064
eif3ja eukaryotic translation initiation factor 3, subunit Ja 0.064
tyms thymidylate synthase 0.064
calm3b calmodulin 3b (phosphorylase kinase, delta) 0.064
nuf2 NUF2, NDC80 kinetochore complex component, homolog 0.063
hmgb2b high-mobility group box 2b 0.062
cse1l chromosome segregation 1-like (S. cerevisiae) 0.060
rnaseh2a ribonuclease H2, subunit A 0.060
syap1 synapse associated protein 1 0.059
pdcd8 programmed cell death 8 (apoptosis-inducing factor) 0.058
morf4l1 mortality factor 4 like 1 0.057
ung uracil-DNA glycosylase 0.056
zgc:101661 zgc:101661 0.055
zgc:103440 zgc:103440 0.053
zgc:92172 zgc:92172 0.051
smc4 structural maintenance of chromosomes 4 0.050
rad51c rad51 homolog C (S. cerevisiae) 0.050
brca2 breast cancer 2, early onset 0.049
lztfl1 leucine zipper transcription factor-like 1 0.048
hdac1 histone deacetylase 1 0.048
tial1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.047
zgc:113143 zgc:113143 0.047
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
mus205 mutagen-sensitive 205 0.999
okr okra 0.998
lok loki 0.996
DNApol-eta CG7143 gene product from transcript CG7143-RA 0.992
Irbp Inverted repeat-binding protein 0.987
Mcm2 Minichromosome maintenance 2 0.984
mus308 mutagen-sensitive 308 0.975
RpA-70 Replication Protein A 70 0.964
mei-9 meiotic 9 0.960
tefu telomere fusion 0.952
mus101 mutagen-sensitive 101 0.948
p53 CG33336 gene product from transcript CG33336-RB 0.944
spn-A spindle A 0.938
Brca2 Breast cancer 2, early onset homolog 0.937
CG5524 CG5524 gene product from transcript CG5524-RA 0.937
rad50 CG6339 gene product from transcript CG6339-RD 0.936
mus301 mutagen-sensitive 301 0.889
hay haywire 0.888
mus201 mutagen-sensitive 201 0.856
mus210 mutagen-sensitive 210 0.856
RfC4 Replication factor C subunit 4 0.789
mre11 meiotic recombination 11 0.775
RecQ5 homolog of RecQ 0.743
Rev1 CG12189 gene product from transcript CG12189-RA 0.741
mus309 mutagen-sensitive 309 0.727
Cks30A Cyclin-dependent kinase subunit 30A 0.727
Mcm3 Minichromosome maintenance 3 0.673
mus304 mutagen-sensitive 304 0.652
spn-B spindle B 0.635
mei-41 meiotic 41 0.618
RecQ4 CG7487 gene product from transcript CG7487-RA 0.601
Mcm6 Minichromosome maintenance 6 0.562
Ercc1 CG10215 gene product from transcript CG10215-RA 0.501
E(z) Enhancer of zeste 0.484
RnrL Ribonucleoside diphosphate reductase large subunit 0.476
CG13350 CG13350 gene product from transcript CG13350-RA 0.423
CDC45L CG3658 gene product from transcript CG3658-RA 0.392
Mcm5 Minichromosome maintenance 5 0.391
CG8142 CG8142 gene product from transcript CG8142-RA 0.385
CG9576 CG9576 gene product from transcript CG9576-RA 0.327
cutlet CG33122 gene product from transcript CG33122-RA 0.323
RfC3 Replication factor C subunit 3 0.293
CSN4 COP9 complex homolog subunit 4 0.288
CG16908 CG16908 gene product from transcript CG16908-RA 0.281
CG2694 CG2694 gene product from transcript CG2694-RA 0.269
Smc5 CG32438 gene product from transcript CG32438-RE 0.263
CG5857 CG5857 gene product from transcript CG5857-RA 0.260
Mcm7 Minichromosome maintenance 7 0.249
rasp CG11495 gene product from transcript CG11495-RA 0.216
spn-E spindle E 0.203
CycH Cyclin H 0.186
nbs CG6754 gene product from transcript CG6754-RC 0.179
WRNexo WRN exonuclease 0.155
Lig4 Ligase4 0.148
mus312 mutagen-sensitive 312 0.143
CG8247 CG8247 gene product from transcript CG8247-RB 0.128
pie pineapple eye 0.128
defl deflated 0.120
mit(1)15 mitotic 15 0.120
RPA2 Replication protein A2 0.112
CG2982 CG2982 gene product from transcript CG2982-RB 0.105
CG5745 CG5745 gene product from transcript CG5745-RA 0.105
pasha partner of drosha 0.097
MAGE CG10059 gene product from transcript CG10059-RA 0.095
Mlh1 CG11482 gene product from transcript CG11482-RA 0.092
Su(var)2-HP2 CG12864 gene product from transcript CG12864-RB 0.090
CG7099 CG7099 gene product from transcript CG7099-RA 0.088
Gnf1 Germ line transcription factor 1 0.086
Shc SHC-adaptor protein 0.084
ash2 absent, small, or homeotic discs 2 0.082
Caf1 Chromatin assembly factor 1 subunit 0.081
Nup75 Nucleoporin 75 0.078
cmet CENP-meta 0.076
CG12391 CG12391 gene product from transcript CG12391-RA 0.073
wdn wings down 0.072
CG13349 CG13349 gene product from transcript CG13349-RA 0.071
Mcm10 Sensitized chromosome inheritance modifier 19 0.067
DNApol-alpha50 DNA polymerase alpha 50kD 0.066
Top2 Topoisomerase 2 0.065
Uba1 Ubiquitin activating enzyme 1 0.065
DNApol-alpha73 DNA polymerase alpha 73kD 0.063
stwl stonewall 0.063
png pan gu 0.062
Pms2 CG8169 gene product from transcript CG8169-RA 0.062
mof males absent on the first 0.062
ida imaginal discs arrested 0.061
Caf1-105 CG12892 gene product from transcript CG12892-RA 0.060
Cka Connector of kinase to AP-1 0.060
CG8963 CG8963 gene product from transcript CG8963-RB 0.054
Rpn3 Regulatory particle non-ATPase 3 0.054
fs(2)ltoPP43 female sterile (2) ltoPP43 0.054
l(2)dtl lethal-(2)-denticleless 0.053
CG9772 CG9772 gene product from transcript CG9772-RB 0.052
AGO3 Argonaute 3 0.052
DNApol-delta DNA-polymerase-delta 0.051
D12 CG13400 gene product from transcript CG13400-RA 0.050
scny scrawny 0.050
hang hangover 0.049
Rpn1 CG7762 gene product from transcript CG7762-RA 0.049
desat1 CG5887 gene product from transcript CG5887-RA 0.048
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
BRCA1 breast cancer 1, early onset 1.000
RAD51 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) 1.000
H2AFX H2A histone family, member X 1.000
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 1.000
PRKDC protein kinase, DNA-activated, catalytic polypeptide 1.000
RPA1 replication protein A1, 70kDa 1.000
BLM Bloom syndrome, RecQ helicase-like 1.000
MSH2 mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) 1.000
NBN nibrin 1.000
MDC1 mediator of DNA-damage checkpoint 1 1.000
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.999
RAD18 RAD18 homolog (S. cerevisiae) 0.999
PARP1 poly (ADP-ribose) polymerase 1 0.999
MSH6 mutS homolog 6 (E. coli) 0.998
PCNA proliferating cell nuclear antigen 0.998
BRCA2 breast cancer 2, early onset 0.996
CHEK1 CHK1 checkpoint homolog (S. pombe) 0.996
C19orf39 chromosome 19 open reading frame 39 0.995
TP53 tumor protein p53 0.994
CHEK2 CHK2 checkpoint homolog (S. pombe) 0.993
RAD51C RAD51 homolog C (S. cerevisiae) 0.993
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.991
FANCD2 Fanconi anemia, complementation group D2 0.991
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.986
WRN Werner syndrome, RecQ helicase-like 0.986
HDAC1 histone deacetylase 1 0.984
MCM2 minichromosome maintenance complex component 2 0.981
RAD51L3 RAD51-like 3 (S. cerevisiae) 0.980
RAD50 RAD50 homolog (S. cerevisiae) 0.980
SMC1A structural maintenance of chromosomes 1A 0.980
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 0.979
BRCC3 BRCA1/BRCA2-containing complex, subunit 3 0.978
RAD21 RAD21 homolog (S. pombe) 0.970
GINS2 GINS complex subunit 2 (Psf2 homolog) 0.970
RAD1 RAD1 homolog (S. pombe) 0.967
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.947
CDK2 cyclin-dependent kinase 2 0.946
MCM3 minichromosome maintenance complex component 3 0.934
FAM175A family with sequence similarity 175, member A 0.923
E2F1 E2F transcription factor 1 0.919
RPA2 replication protein A2, 32kDa 0.918
SMC3 structural maintenance of chromosomes 3 0.913
MMS22L MMS22-like, DNA repair protein 0.910
ASF1B ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.897
SMC6 structural maintenance of chromosomes 6 0.888
MCM6 minichromosome maintenance complex component 6 0.885
PLK1 polo-like kinase 1 0.882
MCM5 minichromosome maintenance complex component 5 0.878
INO80 INO80 homolog (S. cerevisiae) 0.873
MCM4 minichromosome maintenance complex component 4 0.869
APLF aprataxin and PNKP like factor 0.849
ATM ataxia telangiectasia mutated 0.846
ACTL6A actin-like 6A 0.834
CCNE1 cyclin E1 0.832
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 0.821
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 0.820
GINS4 GINS complex subunit 4 (Sld5 homolog) 0.803
DTL denticleless homolog (Drosophila) 0.798
MCM7 minichromosome maintenance complex component 7 0.797
RB1 retinoblastoma 1 0.773
DTX3L deltex 3-like (Drosophila) 0.765
POLE2 polymerase (DNA directed), epsilon 2 (p59 subunit) 0.756
RPA3 replication protein A3, 14kDa 0.721
SLX4 SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) 0.706
APTX aprataxin 0.689
CHD4 chromodomain helicase DNA binding protein 4 0.679
UBE2N ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) 0.660
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.641
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 125kDa 0.630
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 0.623
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.618
RAD52 RAD52 homolog (S. cerevisiae) 0.614
BRE brain and reproductive organ-expressed (TNFRSF1A modulator) 0.602
CHAF1A chromatin assembly factor 1, subunit A (p150) 0.598
FEN1 flap structure-specific endonuclease 1 0.597
PALB2 partner and localizer of BRCA2 0.595
ORC1 origin recognition complex, subunit 1 0.568
LRP1 low density lipoprotein receptor-related protein 1 0.565
MSH3 mutS homolog 3 (E. coli) 0.560
ATR ataxia telangiectasia and Rad3 related 0.556
RAD54L RAD54-like (S. cerevisiae) 0.550
WAPAL wings apart-like homolog (Drosophila) 0.550
EXO1 exonuclease 1 0.539
SP1 Sp1 transcription factor 0.525
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 0.521
INO80E INO80 complex subunit E 0.518
MRFAP1 Morf4 family associated protein 1 0.516
PARP9 poly (ADP-ribose) polymerase family, member 9 0.515
EME1 essential meiotic endonuclease 1 homolog 1 (S. pombe) 0.510
MUS81 MUS81 endonuclease homolog (S. cerevisiae) 0.497
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.483
RNF11 ring finger protein 11 0.480
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.473
TERF2 telomeric repeat binding factor 2 0.460
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium) 0.460
CDC45 cell division cycle 45 homolog (S. cerevisiae) 0.456
RAD51AP1 RAD51 associated protein 1 0.454
RECQL4 RecQ protein-like 4 0.448
POLA2 polymerase (DNA directed), alpha 2 (70kD subunit) 0.443
TONSL tonsoku-like, DNA repair protein 0.424
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Brca1 breast cancer 1 0.999
Brca2 breast cancer 2 0.999
Trp53 transformation related protein 53 0.998
Pou5f1 POU domain, class 5, transcription factor 1 0.994
Cdt1 chromatin licensing and DNA replication factor 1 0.987
Mcm3 minichromosome maintenance deficient 3 (S. cerevisiae) 0.980
Prkdc protein kinase, DNA activated, catalytic polypeptide 0.958
Hells helicase, lymphoid specific 0.944
Atm ataxia telangiectasia mutated homolog (human) 0.939
Mcm2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae) 0.916
Cdc6 cell division cycle 6 homolog (S. cerevisiae) 0.855
Orc1 origin recognition complex, subunit 1 0.852
Rad51 RAD51 homolog (S. cerevisiae) 0.844
Pola1 polymerase (DNA directed), alpha 1 0.840
Prim1 DNA primase, p49 subunit 0.839
Wdhd1 WD repeat and HMG-box DNA binding protein 1 0.826
Smc2 structural maintenance of chromosomes 2 0.813
Smc3 structural maintenace of chromosomes 3 0.729
Gmnn geminin 0.702
E2f1 E2F transcription factor 1 0.701
Mlh1 mutL homolog 1 (E. coli) 0.693
Timeless timeless homolog (Drosophila) 0.691
Rttn rotatin 0.691
Mybl2 myeloblastosis oncogene-like 2 0.683
Pcna proliferating cell nuclear antigen 0.673
Hdac1 histone deacetylase 1 0.671
Mdm4 transformed mouse 3T3 cell double minute 4 0.659
Sgol1 shugoshin-like 1 (S. pombe) 0.657
Nbn nibrin 0.634
Chek1 checkpoint kinase 1 homolog (S. pombe) 0.599
Sin3a transcriptional regulator, SIN3A (yeast) 0.569
Mcm4 minichromosome maintenance deficient 4 homolog (S. cerevisiae) 0.567
Smc1a structural maintenance of chromosomes 1A 0.541
Mecp2 methyl CpG binding protein 2 0.539
Terf1 telomeric repeat binding factor 1 0.529
Mcm5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) 0.502
Pold1 polymerase (DNA directed), delta 1, catalytic subunit 0.497
Mcm7 minichromosome maintenance deficient 7 (S. cerevisiae) 0.458
Bub1 budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) 0.455
Ttk Ttk protein kinase 0.411
Rfc2 replication factor C (activator 1) 2 0.408
Lrr1 leucine rich repeat protein 1 0.402
Tipin timeless interacting protein 0.401
Hdac2 histone deacetylase 2 0.400
Cdca5 cell division cycle associated 5 0.393
Mre11a meiotic recombination 11 homolog A (S. cerevisiae) 0.392
Pold3 polymerase (DNA-directed), delta 3, accessory subunit 0.390
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.388
Mms22l MMS22-like, DNA repair protein 0.369
Ccne1 cyclin E1 0.369
Rrm1 ribonucleotide reductase M1 0.360
Rfc1 replication factor C (activator 1) 1 0.357
2700029M09Rik RIKEN cDNA 2700029M09 gene 0.347
Ccnf cyclin F 0.346
Smarcc1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.342
Atrx alpha thalassemia/mental retardation syndrome X-linked homolog (human) 0.337
Haus6 HAUS augmin-like complex, subunit 6 0.332
Fancd2 Fanconi anemia, complementation group D2 0.331
Cenpn centromere protein N 0.314
Cdca7 cell division cycle associated 7 0.305
Ezh2 enhancer of zeste homolog 2 (Drosophila) 0.297
Nek2 NIMA (never in mitosis gene a)-related expressed kinase 2 0.291
Pole polymerase (DNA directed), epsilon 0.290
Rbl1 retinoblastoma-like 1 (p107) 0.278
Ncapd3 non-SMC condensin II complex, subunit D3 0.263
Msh2 mutS homolog 2 (E. coli) 0.262
Lig1 ligase I, DNA, ATP-dependent 0.257
Rfc4 replication factor C (activator 1) 4 0.251
Rfc3 replication factor C (activator 1) 3 0.241
Mcm8 minichromosome maintenance deficient 8 (S. cerevisiae) 0.238
Kntc1 kinetochore associated 1 0.237
Arid1b AT rich interactive domain 1B (SWI-like) 0.235
Dkc1 dyskeratosis congenita 1, dyskerin homolog (human) 0.226
Mcm6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae) 0.225
Dtl denticleless homolog (Drosophila) 0.215
Kif4 kinesin family member 4 0.205
Stil Scl/Tal1 interrupting locus 0.201
Pole2 polymerase (DNA directed), epsilon 2 (p59 subunit) 0.199
Creb1 cAMP responsive element binding protein 1 0.194
Rad50 RAD50 homolog (S. cerevisiae) 0.192
E2f8 E2F transcription factor 8 0.188
Mis18bp1 MIS18 binding protein 1 0.188
Dicer1 Dicer1, Dcr-1 homolog (Drosophila) 0.179
Pola2 polymerase (DNA directed), alpha 2 0.178
Ccdc99 coiled-coil domain containing 99 0.176
Gins1 GINS complex subunit 1 (Psf1 homolog) 0.175
Polh polymerase (DNA directed), eta (RAD 30 related) 0.175
Hdac6 histone deacetylase 6 0.174
Hat1 histone aminotransferase 1 0.174
Dhfr dihydrofolate reductase 0.169
Xrcc5 X-ray repair complementing defective repair in Chinese hamster cells 5 0.167
Cbx5 chromobox homolog 5 (Drosophila HP1a) 0.164
Exo1 exonuclease 1 0.159
Pms2 postmeiotic segregation increased 2 (S. cerevisiae) 0.157
Blm Bloom syndrome, RecQ helicase-like 0.155
Plk4 polo-like kinase 4 (Drosophila) 0.153
Topbp1 topoisomerase (DNA) II binding protein 1 0.152
Nup85 nucleoporin 85 0.151
Melk maternal embryonic leucine zipper kinase 0.150
Cdca7l cell division cycle associated 7 like 0.148
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Psmd2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.616
Nsfl1c NSFL1 (p97) cofactor (p47) 0.606
Top2a topoisomerase (DNA) II alpha 0.386
Tcfe2a transcription factor E2a 0.234
Spc25 SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) 0.167
LOC100364212 heterogeneous nuclear ribonucleoprotein K-like 0.154
Ccne1 cyclin E1 0.150
Melk maternal embryonic leucine zipper kinase 0.143
Vcp valosin-containing protein 0.140
Dscc1 defective in sister chromatid cohesion 1 homolog (S. cerevisiae) 0.127
Ppp1cb protein phosphatase 1, catalytic subunit, beta isoform 0.120
Gtf2e2 general transcription factor IIE, polypeptide 2, beta 0.118
Zc3h15 zinc finger CCCH-type containing 15 0.117
Rad23b RAD23 homolog B (S. cerevisiae) 0.099
Chd4 chromodomain helicase DNA binding protein 4 0.099
Smc3 structural maintenance of chromosomes 3 0.098
Tyms thymidylate synthetase 0.096
Timeless timeless homolog (Drosophila) 0.095
Psmd11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.094
Psmd1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.077
Bub1b budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) 0.076
Psmc5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.076
Kifc1 kinesin family member C1 0.075
Mcm6 minichromosome maintenance complex component 6 0.074
Wdfy3 WD repeat and FYVE domain containing 3 0.073
Ccnb1 cyclin B1 0.073
Ufd1l ubiquitin fusion degradation 1 like (yeast) 0.071
Psmc6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.070
Rfc4 replication factor C (activator 1) 4 0.070
Hist1h1a histone cluster 1, H1a 0.069
Psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.068
Ect2 epithelial cell transforming sequence 2 oncogene 0.068
Asf1b ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.065
Prim1 DNA primase, p49 subunit 0.063
Cenpi centromere protein I 0.062
Ppp5c protein phosphatase 5, catalytic subunit 0.061
Nudcd2 NudC domain containing 2 0.059
Cand1 cullin-associated and neddylation-dissociated 1 0.057
Gins4 GINS complex subunit 4 (Sld5 homolog) 0.055
Psmd7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 0.055
Mcm5 minichromosome maintenance complex component 5 0.054
Exoc7 exocyst complex component 7 0.054
Cct8 chaperonin containing Tcp1, subunit 8 (theta) 0.054
Stip1 stress-induced phosphoprotein 1 0.052
Ns5atp9 NS5A (hepatitis C virus) transactivated protein 9 0.051
Nploc4 nuclear protein localization 4 homolog (S. cerevisiae) 0.048
Pfdn2 prefoldin subunit 2 0.047
Nrd1 nardilysin 1 0.046
Ubtf upstream binding transcription factor, RNA polymerase I 0.046
Chek1 CHK1 checkpoint homolog (S. pombe) 0.045
Psmc1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.044
Cenpk centromere protein K 0.043
Cad carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase 0.043
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.039
Plk4 polo-like kinase 4 (Drosophila) 0.039
Ddx50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 0.039
Psmd4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.038
Strap serine/threonine kinase receptor associated protein 0.038
Csde1 cold shock domain containing E1, RNA binding 0.038
Fkbp3 FK506 binding protein 3 0.038
Gart phosphoribosylglycinamide formyltransferase 0.037
Mars methionine-tRNA synthetase 0.037
Rbm25 RNA binding motif protein 25 0.036
Ube2t ubiquitin-conjugating enzyme E2T (putative) 0.036
Arhgap11a Rho GTPase activating protein 11A 0.035
Fam195b family with sequence similarity 195, member B 0.035
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.034
Depdc1 DEP domain containing 1 0.034
Ccdc97 coiled-coil domain containing 97 0.034
Aqr aquarius homolog (mouse) 0.033
Safb scaffold attachment factor B 0.033
Dtx3 deltex homolog 3 (Drosophila) 0.033
Lbr lamin B receptor 0.033
Rpa2 replication protein A2 0.032
Tfpt TCF3 (E2A) fusion partner 0.032
Aurkb aurora kinase B 0.032
Ppp2r2a protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform 0.032
Psmd3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 0.032
Smarcb1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 0.031
Dnajc21 DnaJ (Hsp40) homolog, subfamily C, member 21 0.031
Psmd12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.031
Dhfr dihydrofolate reductase 0.030
Psmd6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.030
Psmc3 proteasome (prosome, macropain) 26S subunit, ATPase 3 0.030
Kif4 kinesin family member 4 0.030
Sf3b2 splicing factor 3b, subunit 2 0.030
Ppm1a protein phosphatase 1A, magnesium dependent, alpha isoform 0.029
Prim2 primase, DNA, polypeptide 2 0.029
RGD1304693 similar to CG14803-PA 0.029
Wrap53 WD repeat containing, antisense to TP53 0.029
Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase 0.028
Ccna2 cyclin A2 0.028
Nars asparaginyl-tRNA synthetase 0.028
Cdc45l CDC45 cell division cycle 45-like (S. cerevisiae) 0.028
Narg1 NMDA receptor regulated 1 0.027
Rbm18 RNA binding motif protein 18 0.027
Mcm2 minichromosome maintenance complex component 2 0.027
Ezh2 enhancer of zeste homolog 2 (Drosophila) 0.026
Usp47 ubiquitin specific peptidase 47 0.026
Bard1 BRCA1 associated RING domain 1 0.026