The network for 'mitochondrial genome maintenance' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

mitochondrial genome maintenance

The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
TIM23 Tim23p 0.328
GEP3 Gep3p 0.300
DNM1 Dnm1p 0.246
TIM44 Tim44p 0.245
YTA12 Yta12p 0.223
FCJ1 Fcj1p 0.217
HMI1 Hmi1p 0.181
RRG8 Rrg8p 0.174
MRPL20 Mrpl20p 0.168
RRG1 Rrg1p 0.162
FIS1 Fis1p 0.157
MRS2 Mrs2p 0.128
PIF1 Pif1p 0.125
CCM1 Ccm1p 0.114
LEU2 Leu2p 0.113
NUM1 Num1p 0.112
AIM34 Aim34p 0.111
MDJ1 Mdj1p 0.106
ERG10 Erg10p 0.105
IRC19 Irc19p 0.097
ACH1 Ach1p 0.096
RNR3 Rnr3p 0.095
AFG3 Afg3p 0.089
UBC13 Ubc13p 0.088
GDH1 Gdh1p 0.082
MDM38 Mdm38p 0.077
MSH1 Msh1p 0.077
IMG1 Img1p 0.076
OCT1 Oct1p 0.073
IDP1 Idp1p 0.071
MGM1 Mgm1p 0.070
IFM1 Ifm1p 0.069
MDM32 Mdm32p 0.065
APN1 Apn1p 0.063
PET309 Pet309p 0.062
SLS1 Sls1p 0.061
MEF2 Mef2p 0.060
MTG2 Mtg2p 0.059
AIM22 Aim22p 0.059
MRS3 Mrs3p 0.057
KDX1 Kdx1p 0.057
YME1 Yme1p 0.053
TOS4 Tos4p 0.053
CNB1 Cnb1p 0.052
MDH1 Mdh1p 0.052
SKG6 Skg6p 0.051
AHA1 Aha1p 0.051
CYC3 Cyc3p 0.051
GLG2 Glg2p 0.050
MDM10 Mdm10p 0.050
MRPL16 Mrpl16p 0.049
RAD14 Rad14p 0.049
UPS2 Ups2p 0.048
MIP1 Mip1p 0.047
YHR080C hypothetical protein 0.046
OLI1 F0-ATP synthase subunit c (ATPase-associated proteolipid), encoded on the mitochondrial genome; mutation confers oligomycin resistance; expression is specifically dependent on the nuclear genes AEP1 and AEP2 0.046
SUV3 Suv3p 0.045
GUT2 Gut2p 0.044
OAC1 Oac1p 0.043
MGM101 Mgm101p 0.041
AEP1 Aep1p 0.040
ADH2 Adh2p 0.040
COQ1 Coq1p 0.040
MSS116 Mss116p 0.040
PMP2 Pmp2p 0.040
MRC1 Mrc1p 0.039
FZO1 Fzo1p 0.039
RPL2B Rpl2bp 0.039
KCS1 Kcs1p 0.038
PST1 Pst1p 0.038
ARP10 Arp10p 0.038
MSG5 Msg5p 0.038
SWI1 Swi1p 0.037
AIM38 Aim38p 0.037
ICS2 Ics2p 0.037
UPS3 Ups3p 0.037
CCW14 Ccw14p 0.036
UGO1 Ugo1p 0.036
YLR419W hypothetical protein 0.036
APN2 Apn2p 0.036
LYS9 Lys9p 0.036
RSM22 Rsm22p 0.035
NST1 Nst1p 0.035
FMP30 Fmp30p 0.035
ASN1 Asn1p 0.035
GEP5 Gep5p 0.034
YLR264C-A hypothetical protein 0.034
VPS9 Vps9p 0.034
MSR1 Msr1p 0.034
YER121W hypothetical protein 0.034
TOM5 Tom5p 0.033
SRD1 Srd1p 0.033
YGR205W hypothetical protein 0.033
CEM1 Cem1p 0.033
ALG11 Alg11p 0.033
YNL234W hypothetical protein 0.033
YER039C-A hypothetical protein 0.033
YLR253W hypothetical protein 0.033
ILV3 Ilv3p 0.032
HSP150 Hsp150p 0.032
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
guk-1 Protein GUK-1 0.018
dna-2 Protein DNA-2 0.017
ruvb-2 Protein RUVB-2 0.014
ent-5 Protein ENT-5 0.013
cee-1 Protein CEE-1 0.012
C56G2.7 Protein C56G2.7 0.010
mrp-4 Protein MRP-4 0.010
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 0.019
KIF23 kinesin family member 23 0.014
USP1 ubiquitin specific peptidase 1 0.014
MCM4 minichromosome maintenance complex component 4 0.013
CENPF centromere protein F, 350/400kDa (mitosin) 0.012
MELK maternal embryonic leucine zipper kinase 0.012
HMMR hyaluronan-mediated motility receptor (RHAMM) 0.011
FBL fibrillarin 0.011
ADRM1 adhesion regulating molecule 1 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Pten phosphatase and tensin homolog 0.903
Trp53 transformation related protein 53 0.327
Hdac4 histone deacetylase 4 0.280
Mef2c myocyte enhancer factor 2C 0.141
Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.124
Mef2d myocyte enhancer factor 2D 0.070
Rb1 retinoblastoma 1 0.059
Hdac5 histone deacetylase 5 0.057
Ulk1 Unc-51 like kinase 1 (C. elegans) 0.055
Esr1 estrogen receptor 1 (alpha) 0.051
Apc adenomatosis polyposis coli 0.040
Terf1 telomeric repeat binding factor 1 0.039
Ppp3ca protein phosphatase 3, catalytic subunit, alpha isoform 0.039
Sqstm1 sequestosome 1 0.038
Qk quaking 0.037
Prkacb protein kinase, cAMP dependent, catalytic, beta 0.034
Ncoa3 nuclear receptor coactivator 3 0.034
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.033
Txndc16 thioredoxin domain containing 16 0.030
Hmgb2 high mobility group box 2 0.028
Mdm2 transformed mouse 3T3 cell double minute 2 0.028
Fnip1 folliculin interacting protein 1 0.026
D4Wsu53e DNA segment, Chr 4, Wayne State University 53, expressed 0.026
Ubl3 ubiquitin-like 3 0.025
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.024
Dhx16 DEAH (Asp-Glu-Ala-His) box polypeptide 16 0.023
Xpr1 xenotropic and polytropic retrovirus receptor 1 0.023
Spnb2 spectrin beta 2 0.023
Mdm4 transformed mouse 3T3 cell double minute 4 0.023
Smn1 survival motor neuron 1 0.022
Hmbs hydroxymethylbilane synthase 0.022
Skp2 S-phase kinase-associated protein 2 (p45) 0.021
Brca1 breast cancer 1 0.020
Hells helicase, lymphoid specific 0.020
Pwp2 PWP2 periodic tryptophan protein homolog (yeast) 0.020
Klhl24 kelch-like 24 (Drosophila) 0.020
Zmynd11 zinc finger, MYND domain containing 11 0.020
Wdr55 WD repeat domain 55 0.020
Bcl2 B-cell leukemia/lymphoma 2 0.019
Ppan peter pan homolog (Drosophila) 0.019
Zeb2 zinc finger E-box binding homeobox 2 0.018
Kif1b kinesin family member 1B 0.017
Emx1 empty spiracles homolog 1 (Drosophila) 0.017
Parl presenilin associated, rhomboid-like 0.017
Sesn1 sestrin 1 0.016
Xpc xeroderma pigmentosum, complementation group C 0.016
Trpc2 transient receptor potential cation channel, subfamily C, member 2 0.016
Htatip2 HIV-1 tat interactive protein 2, homolog (human) 0.015
Pparg peroxisome proliferator activated receptor gamma 0.015
Nr1d2 nuclear receptor subfamily 1, group D, member 2 0.015
Pitpnc1 phosphatidylinositol transfer protein, cytoplasmic 1 0.015
Brca2 breast cancer 2 0.014
Elavl1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.014
A930001N09Rik RIKEN cDNA A930001N09 gene 0.014
Sos2 son of sevenless homolog 2 (Drosophila) 0.014
Prkdc protein kinase, DNA activated, catalytic polypeptide 0.014
Mef2a myocyte enhancer factor 2A 0.014
Mrps2 mitochondrial ribosomal protein S2 0.013
Ikbkg inhibitor of kappaB kinase gamma 0.013
Cdx2 caudal type homeobox 2 0.013
Rtn4ip1 reticulon 4 interacting protein 1 0.013
Myo5a myosin VA 0.013
Hdac9 histone deacetylase 9 0.013
Ulk2 Unc-51 like kinase 2 (C. elegans) 0.013
Irf6 interferon regulatory factor 6 0.013
Mgea5 meningioma expressed antigen 5 (hyaluronidase) 0.013
Npc1 Niemann Pick type C1 0.013
Cdca7 cell division cycle associated 7 0.013
Hspa9 heat shock protein 9 0.012
Klf7 Kruppel-like factor 7 (ubiquitous) 0.012
Iqcb1 IQ calmodulin-binding motif containing 1 0.012
Ate1 arginyltransferase 1 0.012
Inpp5k inositol polyphosphate 5-phosphatase K 0.012
Pptc7 PTC7 protein phosphatase homolog (S. cerevisiae) 0.012
Hhat hedgehog acyltransferase 0.012
Mecp2 methyl CpG binding protein 2 0.012
Fam134b family with sequence similarity 134, member B 0.012
Ccdc137 coiled-coil domain containing 137 0.012
Lims1 LIM and senescent cell antigen-like domains 1 0.012
Rbl1 retinoblastoma-like 1 (p107) 0.012
Fbxo31 F-box protein 31 0.012
Huwe1 HECT, UBA and WWE domain containing 1 0.011
Ncoa1 nuclear receptor coactivator 1 0.011
Aktip thymoma viral proto-oncogene 1 interacting protein 0.011
Dtl denticleless homolog (Drosophila) 0.011
Cpeb2 cytoplasmic polyadenylation element binding protein 2 0.011
Zfp187 zinc finger protein 187 0.011
Gucy1a3 guanylate cyclase 1, soluble, alpha 3 0.011
Myc myelocytomatosis oncogene 0.011
Sfn stratifin 0.011
Uqcc ubiquinol-cytochrome c reductase complex chaperone, CBP3 homolog (yeast) 0.011
Hivep2 human immunodeficiency virus type I enhancer binding protein 2 0.011
Mbnl1 muscleblind-like 1 (Drosophila) 0.011
Tars2 threonyl-tRNA synthetase 2, mitochondrial (putative) 0.010
Braf Braf transforming gene 0.010
Setdb1 SET domain, bifurcated 1 0.010
Rnmtl1 RNA methyltransferase like 1 0.010
Dcp1a DCP1 decapping enzyme homolog A (S. cerevisiae) 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism