The network for 'histone h3 k4 trimethylation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

histone h3 k4 trimethylation

The modification of histone H3 by addition of three methyl groups to lysine at position 4 of the histone.

Name Description Probability Func Analog Organism
SDC1 Sdc1p 0.765
SET1 Set1p 0.659
SWD3 Swd3p 0.566
SWD1 Swd1p 0.344
SHG1 Shg1p 0.171
BRE2 Bre2p 0.113
RTF1 Rtf1p 0.091
SPP1 Spp1p 0.079
SET2 Set2p 0.056
PTI1 Pti1p 0.048
CTR9 Ctr9p 0.042
SRD1 Srd1p 0.031
LEU2 Leu2p 0.029
YLR264C-A hypothetical protein 0.026
POB3 Pob3p 0.024
YLR162W hypothetical protein 0.024
MER1 Mer1p 0.023
YOL038C-A hypothetical protein 0.023
ARP10 Arp10p 0.020
HXT3 Hxt3p 0.020
YLR042C hypothetical protein 0.019
YAR068W hypothetical protein 0.019
ARG8 Arg8p 0.018
YPR157W hypothetical protein 0.018
BAT2 Bat2p 0.018
TFA1 Tfa1p 0.017
ATP6 Atp6p 0.017
CUP1-1 Cup1-1p 0.017
ZPS1 Zps1p 0.016
AUA1 Aua1p 0.016
PRS2 Prs2p 0.015
FMT1 Fmt1p 0.015
YBR013C hypothetical protein 0.015
YIL151C hypothetical protein 0.015
URA3 Ura3p 0.015
YIR035C hypothetical protein 0.014
HO Hop 0.014
PAF1 Paf1p 0.014
OPT2 Opt2p 0.014
HPF1 Hpf1p 0.014
BSC1 Bsc1p 0.014
YJL181W hypothetical protein 0.014
IZH4 Izh4p 0.014
YLR040C hypothetical protein 0.014
WWM1 Wwm1p 0.014
SCM4 Scm4p 0.014
CHA1 Cha1p 0.014
SPL2 Spl2p 0.013
TYE7 Tye7p 0.013
DIC1 Dic1p 0.013
YOL013W-A hypothetical protein 0.013
ADH2 Adh2p 0.013
YAR066W hypothetical protein 0.013
YPR096C hypothetical protein 0.013
RKR1 Rkr1p 0.013
MF(ALPHA)2 Mf(alpha)2p 0.012
ARR2 Arr2p 0.012
COS12 Cos12p 0.012
YKR075C hypothetical protein 0.012
RRN5 Rrn5p 0.012
YAL037C-A hypothetical protein 0.012
SWC7 Swc7p 0.012
BNA4 Bna4p 0.011
CPD1 Cpd1p 0.011
YAL064W hypothetical protein 0.011
MET8 Met8p 0.011
YPL067C hypothetical protein 0.011
ALT2 Alt2p 0.011
CRP1 Crp1p 0.011
YDR222W hypothetical protein 0.010
UPS3 Ups3p 0.010
YNL058C hypothetical protein 0.010
YGL006W-A hypothetical protein 0.010
NRG2 Nrg2p 0.010
RNP1 Rnp1p 0.010
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
cec-3 Protein CEC-3 0.017
F41G3.6 Protein F41G3.6 0.015
mom-2 Protein MOM-2 0.013
rnr-2 Protein RNR-2 0.013
patr-1 Protein PATR-1 0.012
bath-42 Protein BATH-42 0.011
C35D10.7 Protein C35D10.7 0.011
CELE_C08F8.3 Protein C08F8.3 0.010
F10E9.3 Protein F10E9.3 0.010
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
WDR5 WD repeat domain 5 0.991
MLL myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.876
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila) 0.400
RBBP5 retinoblastoma binding protein 5 0.316
HCFC1 host cell factor C1 (VP16-accessory protein) 0.199
MYST3 MYST histone acetyltransferase (monocytic leukemia) 3 0.199
LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.177
MEN1 multiple endocrine neoplasia I 0.142
CXXC1 CXXC finger protein 1 0.042
MYST1 MYST histone acetyltransferase 1 0.038
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.036
CHD8 chromodomain helicase DNA binding protein 8 0.034
MLL2 myeloid/lymphoid or mixed-lineage leukemia 2 0.021
SETD1A SET domain containing 1A 0.016
AFF1 AF4/FMR2 family, member 1 0.013
HCFC2 host cell factor C2 0.013
MGEA5 meningioma expressed antigen 5 (hyaluronidase) 0.012
AFF4 AF4/FMR2 family, member 4 0.011
NCOA6 nuclear receptor coactivator 6 0.011
HIST1H3B histone cluster 1, H3b 0.011
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 0.011
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Mus musculus
Name Description Probability Func Analog Organism
Arid4b AT rich interactive domain 4B (RBP1-like) 0.989
Arid1a AT rich interactive domain 1A (SWI-like) 0.731
Rictor RPTOR independent companion of MTOR, complex 2 0.636
Ccnt2 cyclin T2 0.531
Mll1 myeloid/lymphoid or mixed-lineage leukemia 1 0.501
Mll3 myeloid/lymphoid or mixed-lineage leukemia 3 0.442
Sfrs18 serine/arginine-rich splicing factor 18 0.383
Zmym2 zinc finger, MYM-type 2 0.360
Fnbp4 formin binding protein 4 0.226
Sfswap splicing factor, suppressor of white-apricot homolog (Drosophila) 0.221
Pten phosphatase and tensin homolog 0.198
Rbm5 RNA binding motif protein 5 0.170
Zfp445 zinc finger protein 445 0.160
Clk1 CDC-like kinase 1 0.156
Arid4a AT rich interactive domain 4A (RBP1-like) 0.137
Fam48a family with sequence similarity 48, member A 0.132
Nipbl Nipped-B homolog (Drosophila) 0.110
Fam193b family with sequence similarity 193, member B 0.110
Crebzf CREB/ATF bZIP transcription factor 0.109
Ppp1r12a protein phosphatase 1, regulatory (inhibitor) subunit 12A 0.106
Chd2 chromodomain helicase DNA binding protein 2 0.103
Atrx alpha thalassemia/mental retardation syndrome X-linked homolog (human) 0.103
Ttc14 tetratricopeptide repeat domain 14 0.102
Zmym5 zinc finger, MYM-type 5 0.101
Usp9x ubiquitin specific peptidase 9, X chromosome 0.099
Ncbp2 nuclear cap binding protein subunit 2 0.096
Rsf1 remodeling and spacing factor 1 0.096
Msl1 male-specific lethal 1 homolog (Drosophila) 0.096
Ddx17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 0.094
Ankrd16 ankyrin repeat domain 16 0.081
Tet2 tet oncogene family member 2 0.080
Zfc3h1 zinc finger, C3H1-type containing 0.079
Nktr natural killer tumor recognition sequence 0.076
Brwd1 bromodomain and WD repeat domain containing 1 0.071
Crebbp CREB binding protein 0.069
Clk4 CDC like kinase 4 0.068
Mysm1 myb-like, SWIRM and MPN domains 1 0.067
Tnrc6c trinucleotide repeat containing 6C 0.065
Mgea5 meningioma expressed antigen 5 (hyaluronidase) 0.063
Rere arginine glutamic acid dipeptide (RE) repeats 0.061
Braf Braf transforming gene 0.056
A430102J17Rik RIKEN cDNA A430102J17 gene 0.055
D4Wsu53e DNA segment, Chr 4, Wayne State University 53, expressed 0.053
4921513D23Rik RIKEN cDNA 4921513D23 gene 0.051
Macf1 microtubule-actin crosslinking factor 1 0.050
BC018507 cDNA sequence BC018507 0.050
Smg1 SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans) 0.049
2810046L04Rik RIKEN cDNA 2810046L04 gene 0.049
Rapgef6 Rap guanine nucleotide exchange factor (GEF) 6 0.049
Mbtd1 mbt domain containing 1 0.049
Tia1 cytotoxic granule-associated RNA binding protein 1 0.046
Phf21a PHD finger protein 21A 0.044
Ep300 E1A binding protein p300 0.043
Tnrc6b trinucleotide repeat containing 6b 0.043
1700081L11Rik RIKEN cDNA 1700081L11 gene 0.041
Ccnl2 cyclin L2 0.039
Clk2 CDC-like kinase 2 0.038
Fam76b family with sequence similarity 76, member B 0.038
Ylpm1 YLP motif containing 1 0.038
Ash1l ash1 (absent, small, or homeotic)-like (Drosophila) 0.037
Rfx7 regulatory factor X, 7 0.037
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.035
Rnf44 ring finger protein 44 0.034
Dmtf1 cyclin D binding myb-like transcription factor 1 0.034
Mapk8 mitogen-activated protein kinase 8 0.031
Son Son DNA binding protein 0.030
Zcchc11 zinc finger, CCHC domain containing 11 0.029
Pds5a PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae) 0.028
Ythdf1 YTH domain family 1 0.027
Atf2 activating transcription factor 2 0.027
Akt3 thymoma viral proto-oncogene 3 0.027
Leng8 leukocyte receptor cluster (LRC) member 8 0.027
Tnrc6a trinucleotide repeat containing 6a 0.026
Spen SPEN homolog, transcriptional regulator (Drosophila) 0.026
Med13l mediator complex subunit 13-like 0.025
Wbp7 WW domain binding protein 7 0.025
Zfml zinc finger, matrin-like 0.024
Hdac2 histone deacetylase 2 0.024
Brd8 bromodomain containing 8 0.024
Med12 mediator of RNA polymerase II transcription, subunit 12 homolog (yeast) 0.023
Top2b topoisomerase (DNA) II beta 0.023
0610009D07Rik RIKEN cDNA 0610009D07 gene 0.023
Prpf39 PRP39 pre-mRNA processing factor 39 homolog (yeast) 0.022
Klhl24 kelch-like 24 (Drosophila) 0.022
Zfp740 zinc finger protein 740 0.022
Trim39 tripartite motif-containing 39 0.022
Pik3c3 phosphoinositide-3-kinase, class 3 0.022
Atm ataxia telangiectasia mutated homolog (human) 0.021
Sin3a transcriptional regulator, SIN3A (yeast) 0.021
Zfp292 zinc finger protein 292 0.020
Phf12 PHD finger protein 12 0.020
Casc3 cancer susceptibility candidate 3 0.020
Ankrd12 ankyrin repeat domain 12 0.020
Hcfc1 host cell factor C1 0.020
Ubp1 upstream binding protein 1 0.019
Zfp329 zinc finger protein 329 0.019
Fbxl3 F-box and leucine-rich repeat protein 3 0.019
Senp7 SUMO1/sentrin specific peptidase 7 0.019
Lime1 Lck interacting transmembrane adaptor 1 0.018
Ccnt1 cyclin T1 0.018
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Rattus norvegicus
Name Description Probability Func Analog Organism