The network for 'cell death' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cell death

Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as \

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
SLT2 Slt2p 0.418
SSA1 Ssa1p 0.168
RPT6 Rpt6p 0.124
RPS6B Rps6bp 0.121
RPS3 Rps3p 0.109
RPL10 Rpl10p 0.099
RPG1 Rpg1p 0.086
CCT2 Cct2p 0.086
HHT1 Hht1p 0.081
TIF35 Tif35p 0.079
HYP2 Hyp2p 0.070
CDC55 Cdc55p 0.064
STI1 Sti1p 0.063
CMD1 Cmd1p 0.062
TEF4 Tef4p 0.061
BFR1 Bfr1p 0.060
HTB1 Htb1p 0.059
RPS7A Rps7ap 0.054
RPL19B Rpl19bp 0.053
MSN5 Msn5p 0.052
SBA1 Sba1p 0.051
RPS1A Rps1ap 0.051
ARB1 Arb1p 0.050
KAR2 Kar2p 0.049
EMW1 Emw1p 0.049
CCT3 Cct3p 0.046
PEP4 Pep4p 0.045
RPN12 Rpn12p 0.044
AQY2 Aqy2p 0.043
DSK2 Dsk2p 0.043
IDH2 Idh2p 0.042
PRT1 Prt1p 0.042
MSH3 Msh3p 0.039
RPL13A Rpl13ap 0.038
CCR4 Ccr4p 0.038
STE5 Ste5p 0.037
HMO1 Hmo1p 0.037
SSA3 Ssa3p 0.036
OYE2 Oye2p 0.036
BCK1 Bck1p 0.036
RPL3 Rpl3p 0.035
RPL5 Rpl5p 0.035
PIL1 Pil1p 0.034
BMH1 Bmh1p 0.034
SEC26 Sec26p 0.033
HSP82 Hsp82p 0.032
SOD2 Sod2p 0.032
SUR1 Sur1p 0.031
SCH9 Sch9p 0.031
RPS1B Rps1bp 0.031
CDC37 Cdc37p 0.030
LSP1 Lsp1p 0.030
PBS2 Pbs2p 0.030
YHR033W hypothetical protein 0.029
YGL242C hypothetical protein 0.029
TRA1 Tra1p 0.029
TIF5 Tif5p 0.029
LYS20 Lys20p 0.029
SGT2 Sgt2p 0.028
PRK1 Prk1p 0.028
LSM8 Lsm8p 0.028
RAD23 Rad23p 0.028
RPT1 Rpt1p 0.028
BMH2 Bmh2p 0.028
RTS1 Rts1p 0.027
SNO3 Sno3p 0.027
KSS1 Kss1p 0.027
HCR1 Hcr1p 0.027
MKT1 Mkt1p 0.027
MAD1 Mad1p 0.026
TOR1 Tor1p 0.026
ERP2 Erp2p 0.026
RPL25 Rpl25p 0.026
CKB1 Ckb1p 0.026
PET9 Pet9p 0.026
UFO1 Ufo1p 0.026
RPS11A Rps11ap 0.026
DNM1 Dnm1p 0.025
ALD6 Ald6p 0.025
MCK1 Mck1p 0.025
CDC20 Cdc20p 0.025
RPL32 Rpl32p 0.025
GET3 Get3p 0.024
GUT2 Gut2p 0.024
TPD3 Tpd3p 0.024
DCS2 Dcs2p 0.024
YPK2 Ypk2p 0.024
RPS5 Rps5p 0.024
MIS1 Mis1p 0.024
KSP1 Ksp1p 0.024
RPT3 Rpt3p 0.024
CCT6 Cct6p 0.024
ATG3 Atg3p 0.023
YOL098C hypothetical protein 0.023
TEF1 Tef1p 0.023
MYO5 Myo5p 0.023
GAD1 Gad1p 0.023
RPL21A Rpl21ap 0.023
SHE3 She3p 0.023
MDV1 Mdv1p 0.023
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
hsp-1 Protein HSP-1 0.895
lmn-1 Protein LMN-1 0.878
icd-1 Protein ICD-1 0.852
egl-18 Protein EGL-18 0.846
ceh-20 Protein CEH-20 0.754
pdfr-1 Protein PDFR-1 0.737
H21P03.2 Protein H21P03.2 0.710
mua-6 Protein MUA-6 0.703
pdr-1 Protein PDR-1 0.678
rpl-18 Protein RPL-18 0.664
par-5 Protein PAR-5 0.660
pbs-6 Protein PBS-6 0.648
cam-1 Protein CAM-1 0.642
prmt-1 Protein PRMT-1 0.632
uba-1 Protein UBA-1 0.630
kle-2 Protein KLE-2 0.606
rps-2 Protein RPS-2 0.606
egg-6 Protein EGG-6 0.605
pas-6 Protein PAS-6 0.596
sem-5 Protein SEM-5 0.593
mig-5 Protein MIG-5 0.590
rps-5 Protein RPS-5 0.585
ceh-44 Protein CEH-44 0.585
gex-3 Protein GEX-3 0.578
vha-8 Protein VHA-8 0.558
vab-3 Protein VAB-3 0.557
his-68 Protein HIS-68 0.550
imp-2 Protein IMP-2 0.547
pac-1 Protein PAC-1 0.543
C34E10.8 Protein C34E10.8 0.541
jmjd-1.2 Protein JMJD-1.2 0.541
C32D5.11 Protein C32D5.11 0.539
pas-1 Protein PAS-1 0.530
inx-8 Protein INX-8 0.526
glp-1 Protein GLP-1 0.523
nhr-2 Protein NHR-2 0.519
lsm-5 Protein LSM-5 0.518
rme-2 Protein RME-2 0.510
nol-9 Protein NOL-9 0.508
unc-60 Protein UNC-60 0.506
dlc-1 Protein DLC-1 0.502
nrde-2 Protein NRDE-2 0.498
set-1 Protein SET-1 0.497
cids-2 Protein CIDS-2 0.494
cif-1 Protein CIF-1 0.492
D2085.3 Protein D2085.3 0.491
rps-0 Protein RPS-0 0.490
rpl-16 Protein RPL-16 0.482
emb-5 Protein EMB-5 0.476
pmk-1 Protein PMK-1 0.470
act-4 Protein ACT-4 0.467
mec-2 Protein MEC-2 0.461
nasp-2 Protein NASP-2 0.461
zip-4 Protein ZIP-4 0.461
skr-8 Protein SKR-8 0.460
cct-1 Protein CCT-1 0.450
crt-1 Protein CRT-1 0.447
rad-23 Protein RAD-23 0.447
rars-1 Protein RARS-1 0.446
drp-1 Protein DRP-1 0.445
rpn-3 Protein RPN-3 0.440
dpy-23 Protein DPY-23 0.440
rpl-12 Protein RPL-12 0.440
mes-3 Protein MES-3 0.439
act-5 Protein ACT-5 0.438
him-1 Protein HIM-1 0.438
clic-1 Protein CLIC-1 0.437
unc-32 Protein UNC-32 0.436
T19D12.4 Protein T19D12.4 0.433
mat-3 Protein MAT-3 0.432
mei-1 Protein MEI-1 0.432
jtr-1 Protein JTR-1 0.430
rpn-6.1 Protein RPN-6.1 0.426
eat-6 Protein EAT-6 0.423
let-23 Protein LET-23 0.421
mut-16 Protein MUT-16 0.418
snr-3 Protein SNR-3 0.416
eef-1B.1 Protein EEF-1B.1 0.415
tba-4 Protein TBA-4 0.415
sax-7 Protein SAX-7 0.412
mag-1 Protein MAG-1 0.409
cra-1 Protein CRA-1 0.407
tars-1 Protein TARS-1 0.406
eef-1A.1 Protein EEF-1A.1 0.405
plp-1 Protein PLP-1 0.404
F39B2.1 Protein F39B2.1 0.404
dnj-25 Protein DNJ-25 0.402
rpt-2 Protein RPT-2 0.401
gly-7 Protein GLY-7 0.400
snr-4 Protein SNR-4 0.399
rpl-11.1 Protein RPL-11.1 0.399
pbs-5 Protein PBS-5 0.399
exos-2 Protein EXOS-2 0.398
rpl-13 Protein RPL-13 0.397
eef-1G Protein EEF-1G 0.393
ddl-1 Protein DDL-1 0.393
klp-15 Protein KLP-15 0.391
T27A3.1 Protein T27A3.1 0.387
atn-1 Protein ATN-1 0.387
let-70 Protein LET-70 0.383
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Danio rerio
Name Description Probability Func Analog Organism
tp53 tumor protein p53 0.961
pax2a paired box gene 2a 0.816
cdh1 cadherin 1, epithelial 0.809
atp6v1ba ATPase, H+ transporting, lysosomal, V1 subunit B, member a 0.776
tbx1 T-box 1 0.741
tbx20 T-box 20 0.730
pkd2 polycystic kidney disease 2 0.726
kdrl kinase insert domain receptor like 0.711
ntn1a netrin 1a 0.656
wnt11r wingless-type MMTV integration site family, member 11, related 0.562
bmp4 bone morphogenetic protein 4 0.560
rpl18a ribosomal protein L18a 0.530
runx2b runt-related transcription factor 2b 0.500
csnk1da casein kinase 1, delta a 0.498
gli1 GLI-Kruppel family member 1 0.487
fgfr1a fibroblast growth factor receptor 1a 0.483
nrg2a neuregulin 2a 0.481
runx1 runt-related transcription factor 1 0.475
kif23 kinesin family member 23 0.472
bbc3 BCL2 binding component 3 0.464
wnt4a wingless-type MMTV integration site family, member 4a 0.452
fn1 fibronectin 1 0.450
hspa5 heat shock protein 5 0.446
rpsa ribosomal protein SA 0.440
cse1l chromosome segregation 1-like (S. cerevisiae) 0.433
nrg1 neuregulin 1 0.426
wnt1 wingless-type MMTV integration site family, member 1 0.410
baxa bcl2-associated X protein, a 0.403
sox32 SRY-box containing gene 32 0.387
fgf3 fibroblast growth factor 3 0.384
cmyb transcription factor cmyb 0.384
rpl19 ribosomal protein L19 0.382
ptpra protein tyrosine phosphatase, receptor type, A 0.377
nrp2b neuropilin 2b 0.370
ywhabl tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like 0.370
efnb2a ephrin B2a 0.363
rpl13 ribosomal protein L13 0.362
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.361
spry4 sprouty (Drosophila) homolog 4 0.357
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.354
gnb2l1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 0.353
eif3d eukaryotic translation initiation factor 3, subunit D 0.345
bmp2b bone morphogenetic protein 2b 0.338
fgf8a fibroblast growth factor 8 a 0.337
sox9a SRY-box containing gene 9a 0.336
notch3 notch homolog 3 0.333
lhx1a LIM homeobox 1a 0.327
evx1 even-skipped homeobox 1 0.322
pea3 ETS-domain transcription factor pea3 0.319
atp6v1h ATPase, H+ transporting, lysosomal, V1 subunit H 0.318
tia1l cytotoxic granule-associated RNA binding protein 1, like 0.309
th tyrosine hydroxylase 0.308
cct7 chaperonin containing TCP1, subunit 7 (eta) 0.301
ctsl1a cathepsin L, 1 a 0.299
ca8 carbonic anhydrase VIII 0.297
tcp1 t-complex polypeptide 1 0.295
zgc:92237 zgc:92237 0.295
atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.294
raraa retinoic acid receptor, alpha a 0.294
pcna proliferating cell nuclear antigen 0.290
gpr126 G protein-coupled receptor 126 0.290
osr1 odd-skipped related 1 (Drosophila) 0.285
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.278
itgb1b integrin, beta 1b 0.275
wnt8b wingless-type MMTV integration site family, member 8b 0.270
otpa orthopedia homolog a 0.270
alcamb activated leukocyte cell adhesion molecule b 0.265
plxnb2a plexin b2a 0.259
lhx2b LIM homeobox 2b 0.254
nf1a neurofibromin 1a 0.250
bdnf brain-derived neurotrophic factor 0.250
lcp1 lymphocyte cytosolic plastin 1 0.248
cdc42 cell division cycle 42 0.246
cct6a chaperonin containing TCP1, subunit 6A (zeta 1) 0.245
foxo3b forkhead box O3b 0.245
kita kit receptor a 0.245
wls wntless homolog (Drosophila) 0.243
tgfb3 transforming growth factor, beta 3 0.241
faua Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed a 0.238
ptpn11a protein tyrosine phosphatase, non-receptor type 11, a 0.235
etf1 eukaryotic translation termination factor 1 0.235
egr1 early growth response 1 0.234
mib mind bomb 0.231
atp6v0ca ATPase, H+ transporting, lysosomal, V0 subunit c, a 0.230
neo1 neogenin 1 0.230
hand2 heart and neural crest derivatives expressed transcript 2 0.229
bcl2l1 bcl2-like 1 0.226
cnr1 cannabinoid receptor 1 0.226
cnn2 calponin 2 0.224
eif3ha eukaryotic translation initiation factor 3, subunit H, a 0.224
prpf8 pre-mRNA processing factor 8 0.222
tp63 tumor protein p63 0.222
ikzf1 IKAROS family zinc finger 1 (Ikaros) 0.221
tgif1 TGFB-induced factor homeobox 1 0.220
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.219
ahcyl1 S-adenosylhomocysteine hydrolase-like 1 0.218
mcm7 MCM7 minichromosome maintenance deficient 7 (S. cerevisiae) 0.218
sox2 SRY-box containing gene 2 0.217
pax7a paired box gene 7a 0.216
ptpro protein tyrosine phosphatase, receptor type, O 0.211
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Drosophila melanogaster
Name Description Probability Func Analog Organism
nej nejire 0.999
Akt1 CG4006 gene product from transcript CG4006-RA 0.997
ci cubitus interruptus 0.996
slmb supernumerary limbs 0.992
Atg1 Autophagy-specific gene 1 0.987
hep hemipterous 0.984
CG11347 CG11347 gene product from transcript CG11347-RE 0.957
Aos1 CG12276 gene product from transcript CG12276-RA 0.953
Atpalpha Na pump alpha subunit 0.950
wg wingless 0.940
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.939
sax saxophone 0.925
B52 CG10851 gene product from transcript CG10851-RB 0.920
dm diminutive 0.919
InR Insulin-like receptor 0.919
rpr reaper 0.892
Dcp-1 Death caspase-1 0.892
Dsp1 Dorsal switch protein 1 0.890
puc puckered 0.882
S6k RPS6-p70-protein kinase 0.879
Atg18 Autophagy-specific gene 18 0.872
tsr twinstar 0.865
eIF-4a Eukaryotic initiation factor 4a 0.861
shn schnurri 0.843
phl pole hole 0.835
Trip1 CG8882 gene product from transcript CG8882-RA 0.822
tkv thickveins 0.817
Itp-r83A Inositol 1,4,5,-tris-phosphate receptor 0.810
dnc dunce 0.804
ago archipelago 0.798
RASSF8 CG5053 gene product from transcript CG5053-RA 0.795
Rm62 CG10279 gene product from transcript CG10279-RD 0.788
alpha-Cat alpha Catenin 0.771
rap retina aberrant in pattern 0.765
jar jaguar 0.764
gig gigas 0.741
so sine oculis 0.737
Nop60B Nucleolar protein at 60B 0.728
Sema-2a CG4700 gene product from transcript CG4700-RC 0.721
kay kayak 0.720
bel belle 0.716
Pak PAK-kinase 0.711
Eip93F CG18389 gene product from transcript CG18389-RB 0.709
Gyc76C Guanylyl cyclase at 76C 0.707
Hel25E Helicase at 25E 0.706
Sir2 CG5216 gene product from transcript CG5216-RA 0.698
klu klumpfuss 0.696
kis kismet 0.688
trn tartan 0.687
Pten CG5671 gene product from transcript CG5671-RB 0.684
Pvr PDGF- and VEGF-receptor related 0.679
Stat92E Signal-transducer and activator of transcription protein at 92E 0.672
polo CG12306 gene product from transcript CG12306-RA 0.665
Eip74EF Ecdysone-induced protein 74EF 0.658
abd-A abdominal A 0.641
shi shibire 0.638
numb CG3779 gene product from transcript CG3779-RB 0.636
RpL14 Ribosomal protein L14 0.634
Pi3K21B CG2699 gene product from transcript CG2699-RA 0.621
jing CG9397 gene product from transcript CG9397-RI 0.618
drk downstream of receptor kinase 0.616
rut rutabaga 0.614
Ser Serrate 0.612
drpr draper 0.609
rl rolled 0.600
Lis-1 Lissencephaly-1 0.594
eIF-4E Eukaryotic initiation factor 4E 0.591
crol crooked legs 0.587
Sox14 Sox box protein 14 0.587
Khc Kinesin heavy chain 0.584
Iswi Imitation SWI 0.582
mrn marionette 0.581
Rpn2 CG11888 gene product from transcript CG11888-RA 0.580
ftz-f1 ftz transcription factor 1 0.580
Ef2b Elongation factor 2b 0.575
Atg8a Autophagy-specific gene 8a 0.570
Atg9 Autophagy-specific gene 9 0.568
Mad Mothers against dpp 0.559
egr eiger 0.558
msn misshapen 0.556
p53 CG33336 gene product from transcript CG33336-RB 0.550
put punt 0.546
TER94 CG2331 gene product from transcript CG2331-RA 0.543
hiw highwire 0.540
Top2 Topoisomerase 2 0.538
skpA CG16983 gene product from transcript CG16983-RD 0.535
gro groucho 0.534
CkIIalpha Casein kinase II alpha subunit 0.533
Mer Merlin 0.522
Mlf Myelodysplasia/myeloid leukemia factor 0.521
ss spineless 0.518
mus209 mutagen-sensitive 209 0.515
l(2)37Cc lethal (2) 37Cc 0.513
E(z) Enhancer of zeste 0.513
cathD CG1548 gene product from transcript CG1548-RA 0.511
foxo forkhead box, sub-group O 0.511
Rel Relish 0.510
Su(H) Suppressor of Hairless 0.506
lwr lesswright 0.504
SoxN SoxNeuro 0.498
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism