The network for 'ubiquitin dependent protein catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

ubiquitin dependent protein catabolic process

The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
CDC48 Cdc48p 1.000
RPT1 Rpt1p 0.999
RPT6 Rpt6p 0.999
KAR2 Kar2p 0.998
SKP1 Skp1p 0.996
RAD23 Rad23p 0.993
UBP6 Ubp6p 0.988
RPN10 Rpn10p 0.983
RPT4 Rpt4p 0.982
PRE1 Pre1p 0.982
UFD4 Ufd4p 0.974
SEM1 Sem1p 0.973
RPT3 Rpt3p 0.967
PRE5 Pre5p 0.964
RPT2 Rpt2p 0.964
PPH22 Pph22p 0.958
RPN9 Rpn9p 0.956
MAD2 Mad2p 0.955
APC5 Apc5p 0.954
CDC53 Cdc53p 0.947
SCJ1 Scj1p 0.943
MUB1 Mub1p 0.940
RPN12 Rpn12p 0.934
PRE10 Pre10p 0.933
ECM29 Ecm29p 0.932
PRE2 Pre2p 0.922
UBX2 Ubx2p 0.917
MND2 Mnd2p 0.915
RPN6 Rpn6p 0.913
PRE9 Pre9p 0.902
PRE4 Pre4p 0.887
RPT5 Rpt5p 0.884
CDC23 Cdc23p 0.869
PUP2 Pup2p 0.862
UFD2 Ufd2p 0.862
DOC1 Doc1p 0.857
UBR1 Ubr1p 0.848
VPS36 Vps36p 0.844
UMP1 Ump1p 0.843
UFD1 Ufd1p 0.836
RPN3 Rpn3p 0.830
RPN11 Rpn11p 0.825
APC2 Apc2p 0.825
FYV10 Fyv10p 0.824
DSK2 Dsk2p 0.820
VPS60 Vps60p 0.815
PRE6 Pre6p 0.814
NPL4 Npl4p 0.804
CDC27 Cdc27p 0.800
VID30 Vid30p 0.795
TRE1 Tre1p 0.768
DER1 Der1p 0.767
CDC16 Cdc16p 0.767
SWM1 Swm1p 0.763
PRE7 Pre7p 0.748
OTU1 Otu1p 0.744
CDC4 Cdc4p 0.739
RPN7 Rpn7p 0.734
CDC31 Cdc31p 0.724
RPN8 Rpn8p 0.723
CDC20 Cdc20p 0.708
HSM3 Hsm3p 0.693
CUR1 Cur1p 0.680
BRE5 Bre5p 0.664
RKR1 Rkr1p 0.663
MET30 Met30p 0.658
PUP1 Pup1p 0.656
CDC26 Cdc26p 0.649
UBC4 Ubc4p 0.648
GID7 Gid7p 0.646
DFM1 Dfm1p 0.642
SCL1 Scl1p 0.639
CTF13 Ctf13p 0.608
UBX7 Ubx7p 0.602
HRT1 Hrt1p 0.600
PUP3 Pup3p 0.597
HRD3 Hrd3p 0.586
APC4 Apc4p 0.571
SSE2 Sse2p 0.570
YPI1 Ypi1p 0.563
PRE3 Pre3p 0.560
RPN2 Rpn2p 0.557
RPN1 Rpn1p 0.547
DDI1 Ddi1p 0.547
RPN13 Rpn13p 0.546
ELC1 Elc1p 0.535
UBC13 Ubc13p 0.531
GRR1 Grr1p 0.524
RPN4 Rpn4p 0.524
HRD1 Hrd1p 0.520
DMA1 Dma1p 0.514
PMT1 Pmt1p 0.514
CUE1 Cue1p 0.512
MTW1 Mtw1p 0.502
YOS9 Yos9p 0.497
KSP1 Ksp1p 0.490
GPB2 Gpb2p 0.484
FES1 Fes1p 0.482
APC1 Apc1p 0.470
APP1 App1p 0.466
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
rpn-7 Protein RPN-7 0.896
rpn-12 Protein RPN-12 0.847
rpt-5 Protein RPT-5 0.705
rpt-3 Protein RPT-3 0.681
pas-2 Protein PAS-2 0.674
pas-4 Protein PAS-4 0.642
rpt-2 Protein RPT-2 0.630
npl-4.2 Protein NPL-4.2 0.626
rpn-6.1 Protein RPN-6.1 0.615
rpn-3 Protein RPN-3 0.595
npl-4.1 Protein NPL-4.1 0.499
rpn-2 Protein RPN-2 0.499
pas-1 Protein PAS-1 0.466
pbs-6 Protein PBS-6 0.447
rpt-4 Protein RPT-4 0.433
atx-3 Protein ATX-3 0.431
rpn-11 Protein RPN-11 0.360
rnr-1 Protein RNR-1 0.335
pbs-2 Protein PBS-2 0.332
pbs-5 Protein PBS-5 0.312
hgrs-1 Protein HGRS-1 0.290
tba-2 Protein TBA-2 0.285
app-1 Protein APP-1 0.227
pas-6 Protein PAS-6 0.210
E04D5.1 Protein E04D5.1 0.205
pbs-3 Protein PBS-3 0.196
rpn-9 Protein RPN-9 0.189
pbs-1 Protein PBS-1 0.184
sas-5 Protein SAS-5 0.180
rpa-1 Protein RPA-1 0.168
usp-46 Protein USP-46 0.151
pbs-7 Protein PBS-7 0.122
pas-5 Protein PAS-5 0.122
pas-7 Protein PAS-7 0.122
kle-2 Protein KLE-2 0.117
Y71H2AM.20 Protein Y71H2AM.20 0.117
skr-1 Protein SKR-1 0.116
usp-14 Protein USP-14 0.109
mom-2 Protein MOM-2 0.107
T20B12.7 Protein T20B12.7 0.103
ubc-25 Protein UBC-25 0.098
pbs-4 Protein PBS-4 0.098
F56D12.6 Protein F56D12.6 0.098
mig-5 Protein MIG-5 0.097
zen-4 Protein ZEN-4 0.096
pcn-1 Protein PCN-1 0.093
rpn-10 Protein RPN-10 0.092
K08E3.5 Protein K08E3.5 0.090
bub-1 Protein BUB-1 0.088
rpn-5 Protein RPN-5 0.084
atg-18 Protein ATG-18 0.084
T22F3.2 Protein T22F3.2 0.083
hcp-1 Protein HCP-1 0.082
his-45 Protein HIS-45 0.082
egl-18 Protein EGL-18 0.081
ZK507.6 Protein ZK507.6 0.080
smk-1 Protein SMK-1 0.076
F46F11.6 Protein F46F11.6 0.074
stam-1 Protein STAM-1 0.074
gpr-1 Protein GPR-1 0.072
cul-1 Protein CUL-1 0.072
tag-353 Protein TAG-353 0.068
syx-5 Protein SYX-5 0.065
ykt-6 Protein YKT-6 0.064
syx-17 Protein SYX-17 0.064
cdc-48.2 Protein CDC-48.2 0.063
ZK1055.7 Protein ZK1055.7 0.062
CELE_C25A1.4 Protein C25A1.4 0.062
CELE_R102.5 Protein R102.5 0.061
bmk-1 Protein BMK-1 0.060
hda-1 Protein HDA-1 0.060
rpt-1 Protein RPT-1 0.059
sec-12 Protein SEC-12 0.059
rpt-6 Protein RPT-6 0.059
ubxn-4 Protein UBXN-4 0.059
dpy-30 Protein DPY-30 0.058
miro-1 Protein MIRO-1 0.058
K02B2.1 Protein K02B2.1 0.057
imb-2 Protein IMB-2 0.055
CELE_T10C6.6 Protein T10C6.6 0.055
csn-3 Protein CSN-3 0.054
mat-3 Protein MAT-3 0.054
taf-5 Protein TAF-5 0.054
lin-23 Protein LIN-23 0.053
pup-2 Protein PUP-2 0.053
W09D10.1 Protein W09D10.1 0.052
rod-1 Protein ROD-1 0.052
gyg-2 Protein GYG-2 0.052
T01G9.2 Protein T01G9.2 0.051
tbb-1 Protein TBB-1 0.051
prp-31 Protein PRP-31 0.051
vpr-1 Protein VPR-1 0.051
asb-1 Protein ASB-1 0.050
gei-11 Protein GEI-11 0.050
vps-53 Protein VPS-53 0.049
ceh-38 Protein CEH-38 0.049
ZK809.5 Protein ZK809.5 0.049
lin-3 Protein LIN-3 0.049
rab-6.1 Protein RAB-6.1 0.049
par-5 Protein PAR-5 0.048
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
psmd6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.974
psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.935
psmb1 proteasome (prosome, macropain) subunit, beta type, 1 0.929
zgc:92775 zgc:92775 0.916
psmb7 proteasome (prosome, macropain) subunit, beta type, 7 0.911
psma8 proteasome (prosome, macropain) subunit, alpha type, 8 0.875
psma6a proteasome (prosome, macropain) subunit, alpha type, 6a 0.782
psmd4b proteasome (prosome, macropain) 26S subunit, non-ATPase, 4b 0.775
psmb3 proteasome (prosome, macropain) subunit, beta type, 3 0.745
vcp valosin containing protein 0.742
psmd1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.742
psmc1b proteasome (prosome, macropain) 26S subunit, ATPase, 1b 0.719
psmd12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.712
psmc5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.684
psmb2 proteasome (prosome, macropain) subunit, beta type, 2 0.681
psmb5 proteasome (prosome, macropain) subunit, beta type, 5 0.676
ccnb1 cyclin B1 0.653
usp5 ubiquitin specific protease 5 0.630
ck2b casein kinase 2 beta 0.598
psmc4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.595
psma1 proteasome (prosome, macropain) subunit, alpha type, 1 0.550
psmc6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.547
kif23 kinesin family member 23 0.513
bc2 putative breast adenocarcinoma marker 0.509
supt5h suppressor of Ty 5 homolog (S. cerevisiae) 0.506
hyou1 hypoxia up-regulated 1 0.496
evx1 even-skipped homeobox 1 0.495
wnt4a wingless-type MMTV integration site family, member 4a 0.481
aurkb aurora kinase B 0.474
ywhabb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b 0.474
ube2d1 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) 0.463
arf2 ADP-ribosylation factor 2 0.460
baxa bcl2-associated X protein, a 0.457
adrm1b adhesion regulating molecule 1b 0.444
psmb6 proteasome (prosome, macropain) subunit, beta type, 6 0.418
rab1a RAB1A, member RAS oncogene family 0.416
hspa4b heat shock protein 4b 0.412
chuk conserved helix-loop-helix ubiquitous kinase 0.412
cdc20 cell division cycle 20 homolog 0.399
psmd13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 0.397
tmed2 transmembrane emp24 domain trafficking protein 2 0.365
zgc:123326 zgc:123326 0.362
plk1 polo-like kinase 1 (Drosophila) 0.362
zgc:86903 zgc:86903 0.357
max myc-associated factor X 0.355
sirt1 sirtuin (silent mating type information regulation 2 homolog) 1 0.340
cnot6 CCR4-NOT transcription complex, subunit 6 0.333
ddx42 DEAD (Asp-Glu-Ala-Asp) box polypeptide 42 0.306
btg2 B-cell translocation gene 2 0.305
syvn1 synovial apoptosis inhibitor 1, synoviolin 0.296
zgc:153910 zgc:153910 0.295
zgc:55448 zgc:55448 0.293
si:ch211-69g19.2 si:ch211-69g19.2 0.291
psmd3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 0.288
psmb4 proteasome (prosome, macropain) subunit, beta type, 4 0.288
ccna2 cyclin A2 0.282
psma4 proteasome (prosome, macropain) subunit, alpha type, 4 0.279
zgc:110116 zgc:110116 0.275
nploc4 nuclear protein localization 4 homolog (S. cerevisiae) 0.271
ubin ataxin-1 ubiquitin-like interacting protein 0.271
lancl1 LanC antibiotic synthetase component C-like 1 (bacterial) 0.270
si:ch211-239j15.4 si:ch211-239j15.4 0.268
psmc1a proteasome (prosome, macropain) 26S subunit, ATPase, 1a 0.268
ube2g2 ubiquitin-conjugating enzyme E2G 2 0.267
csnk1db casein kinase 1, delta b 0.265
psmc3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 0.263
eif1b eukaryotic translation initiation factor 1B 0.257
ccnb2 cyclin B2 0.256
dnm1l dynamin 1-like 0.254
flii flightless I homolog (Drosophila) 0.253
rqcd1 RCD1 required for cell differentiation1 homolog (S. pombe) 0.251
kpna4 karyopherin alpha 4 (importin alpha 3) 0.251
faf2 Fas associated factor family member 2 0.251
psmd2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.248
srsf11 serine/arginine-rich splicing factor 11 0.248
lratb lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b) 0.246
gdi2 GDP dissociation inhibitor 2 0.244
suv39h1b suppressor of variegation 3-9 homolog 1b 0.240
tia1l cytotoxic granule-associated RNA binding protein 1, like 0.234
trim55b tripartite motif-containing 55b 0.234
capn2b calpain 2, (m/II) large subunit b 0.231
gins3 GINS complex subunit 3 0.213
zgc:174506 zgc:174506 0.213
psmd11a proteasome (prosome, macropain) 216S subunit, non-ATPase, 11a 0.212
nexn nexilin (F actin binding protein) 0.211
cnot8 CCR4-NOT transcription complex, subunit 8 0.208
fbxw11a F-box and WD-40 domain protein 11a 0.208
smndc1 survival motor neuron domain containing 1 0.207
psmd11b proteasome (prosome, macropain) 216S subunit, non-ATPase, 11b 0.205
foxb1.2 forkhead box B1.2 0.203
lama4 laminin, alpha 4 0.203
cdt1 chromatin licensing and DNA replication factor 1 0.203
ciapin1 cytokine induced apoptosis inhibitor 1 0.199
zgc:56200 zgc:56200 0.199
birc5a baculoviral IAP repeat-containing 5a 0.199
atxn2l ataxin 2-like 0.199
pxn paxillin 0.199
arpp19a cAMP-regulated phosphoprotein 19a 0.197
zgc:103652 zgc:103652 0.195
srsf1a serine/arginine-rich splicing factor 1a 0.194
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Pros29 Proteasome 29kD subunit 0.965
Prosbeta2 Proteasome beta2 subunit 0.939
CycB Cyclin B 0.935
tefu telomere fusion 0.887
Prosbeta3 Proteasome beta3 subunit 0.871
CG13349 CG13349 gene product from transcript CG13349-RA 0.845
brm brahma 0.840
Mov34 CG3416 gene product from transcript CG3416-RA 0.778
Ras85D Ras oncogene at 85D 0.757
Rpt1 CG1341 gene product from transcript CG1341-RA 0.706
Rpt4 CG3455 gene product from transcript CG3455-RA 0.694
Rpt3 CG16916 gene product from transcript CG16916-RA 0.677
Pros26.4 Proteasome 26S subunit subunit 4 ATPase 0.661
CycE Cyclin E 0.585
CSN5 COP9 complex homolog subunit 5 0.574
Rpn6 Proteasome p44.5 subunit 0.545
ncd non-claret disjunctional 0.541
Pros35 Proteasome 35kD subunit 0.538
CG9772 CG9772 gene product from transcript CG9772-RB 0.535
polo CG12306 gene product from transcript CG12306-RA 0.534
Prosbeta1 Proteasome beta1 subunit 0.534
hpo hippo 0.529
lqf liquid facets 0.514
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.501
dco discs overgrown 0.499
Rpn2 CG11888 gene product from transcript CG11888-RA 0.487
smo smoothened 0.480
Pros26 Proteasome 26kD subunit 0.476
Rpn1 CG7762 gene product from transcript CG7762-RA 0.471
Rpn9 CG10230 gene product from transcript CG10230-RB 0.464
Uba1 Ubiquitin activating enzyme 1 0.426
krz kurtz 0.422
barr barren 0.415
Pros54 Proteasome 54kD subunit 0.413
Vps25 Vacuolar protein sorting 25 0.384
Rpn7 CG5378 gene product from transcript CG5378-RA 0.372
Sara Smad anchor for receptor activation 0.346
lin19 lin-19-like 0.337
cdc23 CG2508 gene product from transcript CG2508-RA 0.317
Cul-5 Cullin-5 0.315
CSN3 COP9 complex homolog subunit 3 0.313
Cap-G CG34438 gene product from transcript CG34438-RF 0.302
UbcD2 Ubiquitin conjugating enzyme 2 0.301
CG12321 CG12321 gene product from transcript CG12321-RA 0.282
Rpn5 CG1100 gene product from transcript CG1100-RA 0.274
Akt1 CG4006 gene product from transcript CG4006-RA 0.273
msps mini spindles 0.271
mts microtubule star 0.271
wdb widerborst 0.263
jub Ajuba LIM protein 0.258
swm second mitotic wave missing 0.250
Tak1 TGF-beta activated kinase 1 0.246
Top1 Topoisomerase 1 0.246
Sce Sex combs extra 0.239
Fcp1 CG12252 gene product from transcript CG12252-RA 0.237
Pros28.1 Proteasome 28kD subunit 1 0.235
milt milton 0.233
cact cactus 0.231
CycD Cyclin D 0.229
RhoGEF2 CG9635 gene product from transcript CG9635-RF 0.228
Rpn3 Regulatory particle non-ATPase 3 0.228
skpA CG16983 gene product from transcript CG16983-RD 0.223
CG32581 CG32581 gene product from transcript CG32581-RB 0.223
Fs(2)Ket Female sterile (2) Ketel 0.210
Cul-4 Cullin-4 0.208
brat brain tumor 0.206
Hsp83 Heat shock protein 83 0.205
Incenp Inner centromere protein 0.203
CG17331 CG17331 gene product from transcript CG17331-RA 0.197
Prosalpha5 Proteasome alpha5 subunit 0.197
eff effete 0.192
Doa Darkener of apricot 0.186
Vps28 Vacuolar protein sorting 28 0.186
Prp8 pre-mRNA processing factor 8 0.186
Rab1 Rab-protein 1 0.173
dik diskette 0.172
CSN6 COP9 complex homolog subunit 6 0.171
dsh dishevelled 0.167
slmb supernumerary limbs 0.166
fzy fizzy 0.165
Rpn11 CG18174 gene product from transcript CG18174-RA 0.162
CG8979 CG8979 gene product from transcript CG8979-RC 0.159
egr eiger 0.151
osk oskar 0.150
step steppke 0.146
gish gilgamesh 0.144
Rel Relish 0.142
Tbp-1 Tat-binding protein-1 0.142
tos tosca 0.142
CycG Cyclin G 0.142
Mad Mothers against dpp 0.141
CG5555 CG5555 gene product from transcript CG5555-RA 0.141
dom domino 0.141
ph-p polyhomeotic proximal 0.141
Su(H) Suppressor of Hairless 0.141
RagA CG11968 gene product from transcript CG11968-RA 0.140
ida imaginal discs arrested 0.139
Kap-alpha3 karyopherin alpha3 0.139
CG2046 CG2046 gene product from transcript CG2046-RA 0.138
CG15141 CG15141 gene product from transcript CG15141-RA 0.137
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
UBC ubiquitin C 1.000
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 1.000
SKP1 S-phase kinase-associated protein 1 1.000
UBE2D2 ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) 1.000
XIAP X-linked inhibitor of apoptosis 1.000
CUL1 cullin 1 1.000
VCP valosin containing protein 1.000
UBE2D1 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) 1.000
UBE2D3 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) 1.000
UBE2N ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) 1.000
RNF11 ring finger protein 11 1.000
CDC20 cell division cycle 20 homolog (S. cerevisiae) 1.000
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 1.000
CDC27 cell division cycle 27 homolog (S. cerevisiae) 0.999
UBQLN1 ubiquilin 1 0.999
SMAD2 SMAD family member 2 0.999
COPS5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) 0.999
CUL3 cullin 3 0.999
RB1 retinoblastoma 1 0.998
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.998
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.997
RBX1 ring-box 1, E3 ubiquitin protein ligase 0.996
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.996
TP53 tumor protein p53 0.995
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.994
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 0.993
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.989
SKP2 S-phase kinase-associated protein 2 (p45) 0.986
SQSTM1 sequestosome 1 0.984
OTUB1 OTU domain, ubiquitin aldehyde binding 1 0.983
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.981
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.981
ATXN3 ataxin 3 0.980
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 0.980
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 0.979
PTK2 PTK2 protein tyrosine kinase 2 0.979
CCNA2 cyclin A2 0.978
CCNB1 cyclin B1 0.978
BUB1B budding uninhibited by benzimidazoles 1 homolog beta (yeast) 0.978
RNF5 ring finger protein 5 0.978
TRAF6 TNF receptor-associated factor 6 0.977
ZNRF1 zinc and ring finger 1 0.974
BRCA1 breast cancer 1, early onset 0.969
BTRC beta-transducin repeat containing 0.969
ANAPC4 anaphase promoting complex subunit 4 0.967
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.966
FBXW11 F-box and WD repeat domain containing 11 0.966
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.964
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 0.962
CDK2 cyclin-dependent kinase 2 0.962
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.962
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.961
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.961
SIAH1 seven in absentia homolog 1 (Drosophila) 0.960
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 0.959
PLK1 polo-like kinase 1 0.958
CDC16 cell division cycle 16 homolog (S. cerevisiae) 0.958
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.954
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) 0.952
POMP proteasome maturation protein 0.951
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.948
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.945
CKS1B CDC28 protein kinase regulatory subunit 1B 0.940
UBE3A ubiquitin protein ligase E3A 0.939
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 0.936
FBXO5 F-box protein 5 0.935
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.934
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.934
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2 0.933
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.932
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.927
UBE2B ubiquitin-conjugating enzyme E2B (RAD6 homolog) 0.918
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 0.917
UBA1 ubiquitin-like modifier activating enzyme 1 0.916
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.905
RNF111 ring finger protein 111 0.904
SMAD3 SMAD family member 3 0.902
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.897
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 0.895
MARCH7 membrane-associated ring finger (C3HC4) 7 0.893
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 0.892
ARIH2 ariadne homolog 2 (Drosophila) 0.888
TRIM39 tripartite motif containing 39 0.883
SYVN1 synovial apoptosis inhibitor 1, synoviolin 0.882
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.882
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.878
ANAPC11 anaphase promoting complex subunit 11 0.876
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.873
PSEN1 presenilin 1 0.869
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.863
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 0.860
HSPA8 heat shock 70kDa protein 8 0.857
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) 0.855
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.849
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 0.843
HSPA4 heat shock 70kDa protein 4 0.835
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 0.825
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 0.824
UFD1L ubiquitin fusion degradation 1 like (yeast) 0.823
UBXN7 UBX domain protein 7 0.820
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 1.000
Ctnnb1 catenin (cadherin associated protein), beta 1 0.998
Psen1 presenilin 1 0.994
Axin1 axin 1 0.994
Mdm2 transformed mouse 3T3 cell double minute 2 0.989
Psmb7 proteasome (prosome, macropain) subunit, beta type 7 0.982
Per2 period homolog 2 (Drosophila) 0.974
Gsk3b glycogen synthase kinase 3 beta 0.972
Psma7 proteasome (prosome, macropain) subunit, alpha type 7 0.972
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.964
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.958
Psma3 proteasome (prosome, macropain) subunit, alpha type 3 0.952
Psma1 proteasome (prosome, macropain) subunit, alpha type 1 0.947
Cdk1 cyclin-dependent kinase 1 0.943
Ccnb1 cyclin B1 0.931
Rnf111 ring finger 111 0.928
Ncstn nicastrin 0.926
Pten phosphatase and tensin homolog 0.909
Apc adenomatosis polyposis coli 0.906
Cry2 cryptochrome 2 (photolyase-like) 0.905
Ccnb2 cyclin B2 0.897
App amyloid beta (A4) precursor protein 0.897
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.887
Psma5 proteasome (prosome, macropain) subunit, alpha type 5 0.886
Psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.877
Psma2 proteasome (prosome, macropain) subunit, alpha type 2 0.872
Clock circadian locomotor output cycles kaput 0.869
Psma6 proteasome (prosome, macropain) subunit, alpha type 6 0.868
Psmb6 proteasome (prosome, macropain) subunit, beta type 6 0.844
Dvl1 dishevelled, dsh homolog 1 (Drosophila) 0.839
Per1 period homolog 1 (Drosophila) 0.838
Psmc3 proteasome (prosome, macropain) 26S subunit, ATPase 3 0.818
Csnk1e casein kinase 1, epsilon 0.804
Rnf2 ring finger protein 2 0.782
Smad7 MAD homolog 7 (Drosophila) 0.778
Pomp proteasome maturation protein 0.772
Ccna2 cyclin A2 0.765
Mdm4 transformed mouse 3T3 cell double minute 4 0.764
Traf6 TNF receptor-associated factor 6 0.742
Cops2 COP9 (constitutive photomorphogenic) homolog, subunit 2 (Arabidopsis thaliana) 0.716
Rnf19a ring finger protein 19A 0.711
Aamp angio-associated migratory protein 0.705
Psmd6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.701
Ncoa3 nuclear receptor coactivator 3 0.701
Birc5 baculoviral IAP repeat-containing 5 0.691
Rrm2 ribonucleotide reductase M2 0.682
Mgea5 meningioma expressed antigen 5 (hyaluronidase) 0.675
Skil SKI-like 0.665
Vcp valosin containing protein 0.649
Psmd4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.647
Vdac3 voltage-dependent anion channel 3 0.647
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.645
Tax1bp1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.638
Git1 G protein-coupled receptor kinase-interactor 1 0.636
Pias2 protein inhibitor of activated STAT 2 0.631
Sap18 Sin3-associated polypeptide 18 0.629
Arrb2 arrestin, beta 2 0.618
E2f8 E2F transcription factor 8 0.609
Smurf2 SMAD specific E3 ubiquitin protein ligase 2 0.604
Ect2 ect2 oncogene 0.600
Cry1 cryptochrome 1 (photolyase-like) 0.599
Arid1b AT rich interactive domain 1B (SWI-like) 0.597
C330027C09Rik RIKEN cDNA C330027C09 gene 0.596
Kif20a kinesin family member 20A 0.593
Csnk1d casein kinase 1, delta 0.588
Arrb1 arrestin, beta 1 0.581
Aurka aurora kinase A 0.579
Arhgef7 Rho guanine nucleotide exchange factor (GEF7) 0.575
Mbd3 methyl-CpG binding domain protein 3 0.573
Anapc2 anaphase promoting complex subunit 2 0.562
Cyld cylindromatosis (turban tumor syndrome) 0.556
Psmd3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 0.536
Ranbp9 RAN binding protein 9 0.536
Psmb4 proteasome (prosome, macropain) subunit, beta type 4 0.534
Prc1 protein regulator of cytokinesis 1 0.533
Csnk1g2 casein kinase 1, gamma 2 0.533
Atf4 activating transcription factor 4 0.526
Tsc2 tuberous sclerosis 2 0.526
Yap1 yes-associated protein 1 0.523
Add1 adducin 1 (alpha) 0.522
Fgfr1 fibroblast growth factor receptor 1 0.510
Pcna proliferating cell nuclear antigen 0.484
Uhrf1 ubiquitin-like, containing PHD and RING finger domains, 1 0.482
Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) 0.478
Tab3 TGF-beta activated kinase 1/MAP3K7 binding protein 3 0.474
Ppp2ca protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform 0.464
Rbl2 retinoblastoma-like 2 0.448
Dctn1 dynactin 1 0.445
Nuf2 NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae) 0.442
H2afx H2A histone family, member X 0.431
Cops5 COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana) 0.425
Psmd12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.413
Hmmr hyaluronan mediated motility receptor (RHAMM) 0.411
Mki67 antigen identified by monoclonal antibody Ki 67 0.411
Manf mesencephalic astrocyte-derived neurotrophic factor 0.409
Mpp5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) 0.405
Ptch1 patched homolog 1 0.404
Agap3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 0.398
Crb2 crumbs homolog 2 (Drosophila) 0.390
Gnb2 guanine nucleotide binding protein (G protein), beta 2 0.390
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Psma5 proteasome (prosome, macropain) subunit, alpha type 5 0.993
Psmb3 proteasome (prosome, macropain) subunit, beta type 3 0.886
Psma4 proteasome (prosome, macropain) subunit, alpha type 4 0.722
Psmb6 proteasome (prosome, macropain) subunit, beta type 6 0.658
Psmb4 proteasome (prosome, macropain) subunit, beta type 4 0.609
Psma3 proteasome (prosome, macropain) subunit, alpha type 3 0.495
Psmc1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.487
Psma7 proteasome (prosome, macropain) subunit, alpha type 7 0.483
Psmc4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.346
Psme2 proteasome (prosome, macropain) activator subunit 2 0.305
Psmd6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.293
Psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.276
Psmb10 proteasome (prosome, macropain) subunit, beta type 10 0.265
Dnaja2 DnaJ (Hsp40) homolog, subfamily A, member 2 0.232
Psmd7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 0.206
Psmd13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 0.205
Ppp1cb protein phosphatase 1, catalytic subunit, beta isoform 0.199
Psmd4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.187
Cand1 cullin-associated and neddylation-dissociated 1 0.174
Psmb2 proteasome (prosome, macropain) subunit, beta type 2 0.171
Psmb7 proteasome (prosome, macropain) subunit, beta type 7 0.152
Txnl1 thioredoxin-like 1 0.132
Ube2d3 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) 0.130
Psma2 proteasome (prosome, macropain) subunit, alpha type 2 0.130
Zfand5 zinc finger, AN1-type domain 5 0.113
Nploc4 nuclear protein localization 4 homolog (S. cerevisiae) 0.101
Psma6 proteasome (prosome, macropain) subunit, alpha type 6 0.099
Senp2 Sumo1/sentrin/SMT3 specific peptidase 2 0.099
Nsfl1c NSFL1 (p97) cofactor (p47) 0.088
Cnbp CCHC-type zinc finger, nucleic acid binding protein 0.079
Psmb5 proteasome (prosome, macropain) subunit, beta type 5 0.079
Ube2i ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.074
LOC362855 P55 0.065
Cdc37 cell division cycle 37 homolog (S. cerevisiae) 0.061
Psmb1 proteasome (prosome, macropain) subunit, beta type 1 0.061
Dctn4 dynactin 4 0.060
Pomp proteasome maturation protein 0.058
Vcp valosin-containing protein 0.057
Pfn1 profilin 1 0.056
Psmd14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.054
Alkbh5 alkB, alkylation repair homolog 5 (E. coli) 0.053
Eif2s2 eukaryotic translation initiation factor 2, subunit 2 beta 0.053
Ppm1a protein phosphatase 1A, magnesium dependent, alpha isoform 0.053
Mapre1 microtubule-associated protein, RP/EB family, member 1 0.052
Mgat2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase 0.051
Dnajb9 DnaJ (Hsp40) homolog, subfamily B, member 9 0.048
Herpud1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.045
Bub1b budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) 0.043
Serp1 stress-associated endoplasmic reticulum protein 1 0.043
Rab21 RAB21, member RAS oncogene family 0.042
Psma1 proteasome (prosome, macropain) subunit, alpha type 1 0.041
Usp47 ubiquitin specific peptidase 47 0.041
Brcc3 BRCA1/BRCA2-containing complex, subunit 3 0.040
Ppp1r2 protein phosphatase 1, regulatory (inhibitor) subunit 2 0.040
Tax1bp1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.040
Psmd1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.040
Tollip toll interacting protein 0.039
Ccnb1 cyclin B1 0.038
Psmc3 proteasome (prosome, macropain) 26S subunit, ATPase 3 0.038
Phax phosphorylated adaptor for RNA export 0.037
Pdia3 protein disulfide isomerase family A, member 3 0.037
Ubc ubiquitin C 0.036
RGD1309102 similar to TRS85 homolog 0.035
Socs6 suppressor of cytokine signaling 6 0.035
Asf1b ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.033
Dnajb11 DnaJ (Hsp40) homolog, subfamily B, member 11 0.033
Zfp364 zinc finger protein 364 0.033
Ufd1l ubiquitin fusion degradation 1 like (yeast) 0.033
March5 membrane-associated ring finger (C3HC4) 5 0.031
Lsm14a LSM14A, SCD6 homolog A (S. cerevisiae) 0.031
Rnf2 ring finger protein 2 0.031
Ndfip2 Nedd4 family interacting protein 2 0.029
Foxm1 forkhead box M1 0.028
Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) 0.028
Mdm2 Mdm2 p53 binding protein homolog (mouse) 0.027
Irf1 interferon regulatory factor 1 0.027
Eif4a2 eukaryotic translation initiation factor 4A, isoform 2 0.027
Dnpep aspartyl aminopeptidase 0.026
Usp15 ubiquitin specific peptidase 15 0.026
Rbbp7 retinoblastoma binding protein 7 0.026
Pdia4 protein disulfide isomerase family A, member 4 0.026
Txnrd1 thioredoxin reductase 1 0.025
Ptges3 prostaglandin E synthase 3 (cytosolic) 0.024
Ifi35 interferon-induced protein 35 0.023
Rybp RING1 and YY1 binding protein 0.023
Vapa VAMP (vesicle-associated membrane protein)-associated protein A 0.023
LOC100364212 heterogeneous nuclear ribonucleoprotein K-like 0.023
Canx calnexin 0.022
Pttg1 pituitary tumor-transforming 1 0.022
Usp14 ubiquitin specific peptidase 14 0.022
Tbcb tubulin folding cofactor B 0.022
Rab11a RAB11a, member RAS oncogene family 0.021
Rps5 ribosomal protein S5 0.021
Slc35b1 solute carrier family 35, member B1 0.021
Cmtm6 CKLF-like MARVEL transmembrane domain containing 6 0.021
Ergic3 ERGIC and golgi 3 0.021
Slmap sarcolemma associated protein 0.020
Psmd3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 0.020
Stx12 syntaxin 12 0.020
Dnajc21 DnaJ (Hsp40) homolog, subfamily C, member 21 0.019