The network for 'small gtpase mediated signal transduction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

small gtpase mediated signal transduction

Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
RHO1 Rho1p 0.941
ROM2 Rom2p 0.941
IRA1 Ira1p 0.454
PKC1 Pkc1p 0.450
RAS2 Ras2p 0.367
AKL1 Akl1p 0.343
GYL1 Gyl1p 0.330
BNI1 Bni1p 0.311
MKK1 Mkk1p 0.306
SEC3 Sec3p 0.285
YKR017C hypothetical protein 0.277
GDI1 Gdi1p 0.272
KSS1 Kss1p 0.260
CDC50 Cdc50p 0.217
CDC25 Cdc25p 0.216
TPK2 Tpk2p 0.198
STE11 Ste11p 0.197
YIP3 Yip3p 0.191
REG1 Reg1p 0.175
SEC2 Sec2p 0.152
GPB2 Gpb2p 0.145
CDC42 Cdc42p 0.141
MYO3 Myo3p 0.133
YOL087C hypothetical protein 0.133
VPS15 Vps15p 0.131
RIM15 Rim15p 0.130
SPA2 Spa2p 0.122
VPS27 Vps27p 0.119
FAR1 Far1p 0.119
FYV8 Fyv8p 0.118
BUD6 Bud6p 0.118
KOG1 Kog1p 0.118
RGD1 Rgd1p 0.105
UBR1 Ubr1p 0.099
SHE4 She4p 0.095
AVO1 Avo1p 0.086
PEP5 Pep5p 0.086
SSK2 Ssk2p 0.086
TRS65 Trs65p 0.085
SLT2 Slt2p 0.085
TCA17 Tca17p 0.081
KDX1 Kdx1p 0.079
GSH1 Gsh1p 0.078
CDC24 Cdc24p 0.076
MKS1 Mks1p 0.075
GEA2 Gea2p 0.074
INP53 Inp53p 0.074
SLG1 Slg1p 0.072
GIC2 Gic2p 0.072
APP1 App1p 0.072
RIM21 Rim21p 0.068
MSG5 Msg5p 0.067
BUD14 Bud14p 0.066
RHO3 Rho3p 0.065
AIM20 Aim20p 0.064
CDC12 Cdc12p 0.064
WSC4 Wsc4p 0.062
RTG3 Rtg3p 0.062
RDI1 Rdi1p 0.061
BET3 Bet3p 0.060
YPK1 Ypk1p 0.059
SAC7 Sac7p 0.059
SLM1 Slm1p 0.059
NUP192 Nup192p 0.058
EXO84 Exo84p 0.057
YPT53 Ypt53p 0.057
BEM3 Bem3p 0.056
SAC6 Sac6p 0.056
PTP2 Ptp2p 0.055
SAK1 Sak1p 0.054
SIA1 Sia1p 0.054
AFI1 Afi1p 0.054
STI1 Sti1p 0.054
SGE1 Sge1p 0.053
YLR049C hypothetical protein 0.053
STE5 Ste5p 0.053
SKM1 Skm1p 0.053
BPT1 Bpt1p 0.053
TCO89 Tco89p 0.052
RFC1 Rfc1p 0.052
SCP1 Scp1p 0.051
VPS21 Vps21p 0.051
NHA1 Nha1p 0.050
YPL066W hypothetical protein 0.050
STT4 Stt4p 0.049
FUS3 Fus3p 0.049
TRS31 Trs31p 0.048
YAP1801 hypothetical protein 0.048
CYR1 Cyr1p 0.048
ECM25 Ecm25p 0.047
PFK26 Pfk26p 0.047
APM2 Apm2p 0.046
UBA4 Uba4p 0.045
FAA2 Faa2p 0.045
YFR039C hypothetical protein 0.044
DCD1 Dcd1p 0.044
TSC11 Tsc11p 0.044
CMK1 Cmk1p 0.043
RIM101 Rim101p 0.042
GPR1 Gpr1p 0.042
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
egl-18 Protein EGL-18 0.819
eor-1 Protein EOR-1 0.476
sur-2 Protein SUR-2 0.465
let-60 Protein LET-60 0.414
smp-1 Protein SMP-1 0.373
bet-2 Protein BET-2 0.340
sem-5 Protein SEM-5 0.271
unc-73 Protein UNC-73 0.238
skn-1 Protein SKN-1 0.227
hsr-9 Protein HSR-9 0.220
etr-1 Protein ETR-1 0.219
lin-25 Protein LIN-25 0.211
cdf-1 Protein CDF-1 0.205
eor-2 Protein EOR-2 0.197
CELE_F47G4.4 Protein F47G4.4 0.196
dab-1 Protein DAB-1 0.193
C11E4.6 Protein C11E4.6 0.173
klp-10 Protein KLP-10 0.164
plc-1 Protein PLC-1 0.158
mac-1 Protein MAC-1 0.155
gld-1 Protein GLD-1 0.146
pig-1 Protein PIG-1 0.146
lin-45 Protein LIN-45 0.141
lag-1 Protein LAG-1 0.141
rpn-6.1 Protein RPN-6.1 0.138
pxf-1 Protein PXF-1 0.135
daf-19 Protein DAF-19 0.124
sam-10 Protein SAM-10 0.123
fzr-1 Protein FZR-1 0.121
R90.1 Protein R90.1 0.120
srgp-1 Protein SRGP-1 0.120
symk-1 Protein SYMK-1 0.119
goa-1 Protein GOA-1 0.116
zfp-3 Protein ZFP-3 0.115
let-607 Protein LET-607 0.114
F33H1.4 Protein F33H1.4 0.113
unc-14 Protein UNC-14 0.113
CELE_F14E5.2 Protein F14E5.2 0.112
ubq-1 Protein UBQ-1 0.108
T04F8.6 Protein T04F8.6 0.108
cdt-1 Protein CDT-1 0.106
num-1 Protein NUM-1 0.105
lst-4 Protein LST-4 0.104
snf-1 Protein SNF-1 0.104
bed-1 Protein BED-1 0.101
F22D3.2 Protein F22D3.2 0.101
daf-3 Protein DAF-3 0.100
sax-3 Protein SAX-3 0.098
gop-1 Protein GOP-1 0.097
pqe-1 Protein PQE-1 0.095
ten-1 Protein TEN-1 0.092
ehs-1 Protein EHS-1 0.092
T23F11.1 Protein T23F11.1 0.092
nra-3 Protein NRA-3 0.092
K03H4.2 Protein K03H4.2 0.091
tam-1 Protein TAM-1 0.091
max-1 Protein MAX-1 0.090
egl-27 Protein EGL-27 0.090
pkn-1 Protein PKN-1 0.090
sma-6 Protein SMA-6 0.085
rig-6 Protein RIG-6 0.085
unc-94 Protein UNC-94 0.085
sym-4 Protein SYM-4 0.084
sax-7 Protein SAX-7 0.083
mom-5 Protein MOM-5 0.082
CELE_C46H3.2 Protein C46H3.2 0.082
cki-2 Protein CKI-2 0.082
daf-1 Protein DAF-1 0.082
rbc-1 Protein RBC-1 0.082
rgs-7 Protein RGS-7 0.078
atg-2 Protein ATG-2 0.078
ztf-20 Protein ZTF-20 0.078
ced-10 Protein CED-10 0.078
B0432.8 Protein B0432.8 0.077
tat-1 Protein TAT-1 0.077
ykt-6 Protein YKT-6 0.077
dpy-22 Protein DPY-22 0.077
itr-1 Protein ITR-1 0.076
pek-1 Protein PEK-1 0.076
gfi-2 Protein GFI-2 0.076
C46H11.2 Protein C46H11.2 0.075
let-23 Protein LET-23 0.075
git-1 Protein GIT-1 0.074
epg-2 Protein EPG-2 0.074
che-13 Protein CHE-13 0.074
aha-1 Protein AHA-1 0.074
cpf-2 Protein CPF-2 0.073
CELE_T05E11.3 Protein T05E11.3 0.072
fos-1 Protein FOS-1 0.072
hmg-1.2 Protein HMG-1.2 0.072
inx-1 Protein INX-1 0.072
C18B12.4 Protein C18B12.4 0.071
unc-71 Protein UNC-71 0.071
zfp-1 Protein ZFP-1 0.071
T14G11.1 Protein T14G11.1 0.071
rme-4 Protein RME-4 0.071
cgef-1 Protein CGEF-1 0.071
sup-17 Protein SUP-17 0.071
T19A5.1 Protein T19A5.1 0.070
pak-1 Protein PAK-1 0.070
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
gna12 guanine nucleotide binding protein (G protein) alpha 12 0.512
itgb1b.2 integrin, beta 1b.2 0.449
itgb1b integrin, beta 1b 0.369
actn1 actinin, alpha 1 0.367
gna13b guanine nucleotide binding protein (G protein), alpha 13b 0.339
si:dkeyp-22b2.3 si:dkeyp-22b2.3 0.311
tpm4 tropomyosin 4 0.299
pafah1b1b platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b 0.289
prickle1a prickle-like 1 (Drosophila) a 0.287
ywhai tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, iota polypeptide 0.282
cnn2 calponin 2 0.229
ywhabl tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like 0.215
pvrl1b poliovirus receptor-related 1b 0.208
ywhaqb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b 0.207
sumo3a SMT3 suppressor of mif two 3 homolog 3a 0.203
copeb core promoter element binding protein 0.179
gna13a guanine nucleotide binding protein (G protein), alpha 13a 0.172
yes1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 0.167
gnao1a guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a 0.166
ywhabb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b 0.156
nrg2a neuregulin 2a 0.151
pafah1b1a platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit a 0.141
cdkl1 cyclin-dependent kinase-like 1 (CDC2-related kinase) 0.140
chek1 CHK1 checkpoint homolog (S. pombe) 0.140
msna moesin a 0.133
hdac4 histone deacetylase 4 0.129
zgc:100942 zgc:100942 0.125
zgc:101761 zgc:101761 0.123
krt4 keratin 4 0.122
yap1 Yes-associated protein 1 0.122
rhoab ras homolog gene family, member Ab 0.121
nf1a neurofibromin 1a 0.120
pob partial optokinetic response b 0.113
unc5b unc-5 homolog B (C. elegans) 0.108
sf3b1 splicing factor 3b, subunit 1 0.106
zgc:123170 zgc:123170 0.106
appb amyloid beta (A4) precursor protein b 0.105
rad21 RAD21 homolog (S. pombe) 0.103
fzd3a frizzled homolog 3a 0.102
ywhae1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 0.097
arpc5b actin related protein 2/3 complex, subunit 5B 0.097
pkd2 polycystic kidney disease 2 0.097
sumo1 SMT3 suppressor of mif two 3 homolog 1 (yeast) 0.095
psen1 presenilin 1 0.095
gnai2l guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2, like 0.094
LOC100535549 cytoplasmic polyadenylation element-binding protein 4-like 0.094
ube2v2 ubiquitin-conjugating enzyme E2 variant 2 0.093
tmem2 transmembrane protein 2 0.092
bactin1 bactin1 0.092
znf711 zinc finger protein 711 0.090
gna11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 0.090
cdc42 cell division cycle 42 0.087
uba1 ubiquitin-like modifier activating enzyme 1 0.086
anxa2a annexin A2a 0.083
sox11b SRY-box containing gene 11b 0.083
vcp valosin containing protein 0.083
pabpc1a poly A binding protein, cytoplasmic 1 a 0.082
pycard PYD and CARD domain containing 0.082
ptrfb polymerase I and transcript release factor b 0.081
gng3 guanine nucleotide binding protein (G protein), gamma 3 0.080
sox4a SRY-box containing gene 4a 0.079
mapk3 mitogen-activated protein kinase 3 0.078
ap2a1 adaptor-related protein complex 2, alpha 1 subunit 0.077
mat2a methionine adenosyltransferase II, alpha 0.077
mmd2 progestin and adipoQ receptor 10 0.076
cd99l2 CD99 antigen-like 2 0.074
arf2 ADP-ribosylation factor 2 0.074
mfn2 mitofusin 2 0.072
ppm1aa protein phosphatase, Mg2+/Mn2+ dependent, 1Aa 0.072
si:ch211-232m7.1 si:ch211-232m7.1 0.071
ppp2r5ea protein phosphatase 2, regulatory subunit B', epsilon isoform a 0.070
rnps1 RNA binding protein S1, serine-rich domain 0.070
icn ictacalcin 0.070
esyt3 extended synaptotagmin-like protein 3 0.070
anxa1a annexin A1a 0.070
ptpro protein tyrosine phosphatase, receptor type, O 0.069
col1a1a collagen, type I, alpha 1a 0.069
fbn2b fibrillin 2b 0.069
ehd1 EH-domain containing 1 0.069
stmn1b stathmin 1b 0.068
s100a10b S100 calcium binding protein A10b 0.068
yrk Yes-related kinase 0.068
ctnnb1 catenin (cadherin-associated protein), beta 1 0.067
celsr1b cadherin EGF LAG seven-pass G-type receptor 1b 0.066
leo1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.066
ywhaba tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a 0.065
pard6gb par-6 partitioning defective 6 homolog gamma B (C. elegans) 0.065
dsc2l desmocollin 2 like 0.064
slc12a9 solute carrier family 12 (potassium/chloride transporters), member 9 0.063
LOC569128 hypothetical protein LOC569128 0.062
ddx42 DEAD (Asp-Glu-Ala-Asp) box polypeptide 42 0.062
spna2 spectrin alpha 2 0.061
usp1 ubiquitin specific protease 1 0.061
smc3 structural maintenance of chromosomes 3 0.061
bnc2 basonuclin 2 0.061
taldo1 transaldolase 1 0.060
med12 mediator of RNA polymerase II transcription, subunit 12 homolog 0.060
si:ch211-272f3.4 si:ch211-272f3.4 0.060
tbx1 T-box 1 0.060
gsna gelsolin a 0.060
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Rho1 CG8416 gene product from transcript CG8416-RB 0.981
Ras85D Ras oncogene at 85D 0.939
Sos Son of sevenless 0.920
Abi Abelson interacting protein 0.819
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.779
bun bunched 0.743
chic chickadee 0.733
Shc SHC-adaptor protein 0.712
Jra Jun-related antigen 0.635
Dsor1 Downstream of raf1 0.609
puc puckered 0.600
ttk tramtrack 0.600
put punt 0.594
Stat92E Signal-transducer and activator of transcription protein at 92E 0.593
plexB plexin B 0.567
flw flapwing 0.525
Akt1 CG4006 gene product from transcript CG4006-RA 0.522
rl rolled 0.499
Src64B Src oncogene at 64B 0.476
XNP CG4548 gene product from transcript CG4548-RA 0.438
rok Rho-kinase 0.433
14-3-3epsilon CG31196 gene product from transcript CG31196-RA 0.424
drk downstream of receptor kinase 0.423
gek genghis khan 0.418
tutl turtle 0.403
mask multiple ankyrin repeats single KH domain 0.381
Ephrin CG1862 gene product from transcript CG1862-RA 0.362
msn misshapen 0.358
aop anterior open 0.347
Mkp3 Mitogen-activated protein kinase phosphatase 3 0.342
lea leak 0.340
sty sprouty 0.337
trio CG18214 gene product from transcript CG18214-RA 0.332
mbt mushroom bodies tiny 0.322
p120ctn Adherens junction protein p120 0.319
Rac1 CG2248 gene product from transcript CG2248-RA 0.318
synj synaptojanin 0.290
phl pole hole 0.289
pnt pointed 0.285
Eip63E Ecdysone-induced protein 63E 0.275
sax saxophone 0.275
nwk nervous wreck 0.271
Rheb CG1081 gene product from transcript CG1081-RA 0.269
wts warts 0.262
insc inscuteable 0.262
Sra-1 specifically Rac1-associated protein 1 0.256
Cip4 CG15015 gene product from transcript CG15015-RA 0.255
Cdc42 CG12530 gene product from transcript CG12530-RA 0.250
CG5180 CG5180 gene product from transcript CG5180-RB 0.245
mri mrityu 0.240
stg string 0.240
alpha-Adaptin CG4260 gene product from transcript CG4260-RA 0.236
Pk61C Protein kinase 61C 0.236
Pkn Protein kinase related to protein kinase N 0.230
CG4751 CG4751 gene product from transcript CG4751-RA 0.230
MTF-1 Metal response element-binding Transcription Factor-1 0.228
Taf1 TBP-associated factor 1 0.225
ed echinoid 0.223
Lnk CG17367 gene product from transcript CG17367-RC 0.221
csw corkscrew 0.221
lqf liquid facets 0.217
pod1 CG4532 gene product from transcript CG4532-RF 0.216
mop myopic 0.215
pyd polychaetoid 0.214
Hnf4 Hepatocyte nuclear factor 4 0.213
Mad Mothers against dpp 0.211
Sbf SET domain binding factor 0.211
Apc APC-like 0.209
N Notch 0.206
Rca1 Regulator of cyclin A1 0.205
Bj1 Bj1 protein 0.204
S6k RPS6-p70-protein kinase 0.202
WASp CG1520 gene product from transcript CG1520-RA 0.199
Rap2l Ras-associated protein 2-like 0.196
siz schizo 0.195
raw CG12437 gene product from transcript CG12437-RB 0.193
shn schnurri 0.192
robo roundabout 0.192
baz bazooka 0.192
p130CAS CG1212 gene product from transcript CG1212-RA 0.190
Rala Ras-related protein 0.189
Dcr-1 Dicer-1 0.189
Arc-p34 CG10954 gene product from transcript CG10954-RA 0.185
CG7222 CG7222 gene product from transcript CG7222-RA 0.183
CG9797 CG9797 gene product from transcript CG9797-RA 0.180
yki yorkie 0.179
rap retina aberrant in pattern 0.177
kay kayak 0.173
Smg1 CG32743 gene product from transcript CG32743-RA 0.171
kuz kuzbanian 0.164
Cortactin CG3637 gene product from transcript CG3637-RA 0.162
didum dilute class unconventional myosin 0.162
simj simjang 0.161
mbc myoblast city 0.158
vav CG7893 gene product from transcript CG7893-RB 0.155
lgs legless 0.155
RhoGAP93B CG3421 gene product from transcript CG3421-RA 0.155
CG15609 CG15609 gene product from transcript CG15609-RE 0.153
Lis-1 Lissencephaly-1 0.152
AP-1sigma CG5864 gene product from transcript CG5864-RA 0.148
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 1.000
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 1.000
EGFR epidermal growth factor receptor 1.000
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 1.000
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.000
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 1.000
MDM2 Mdm2 p53 binding protein homolog (mouse) 1.000
SFN stratifin 1.000
GRB2 growth factor receptor-bound protein 2 1.000
RB1 retinoblastoma 1 1.000
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 1.000
MAPK14 mitogen-activated protein kinase 14 1.000
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.000
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 1.000
RHOA ras homolog gene family, member A 0.999
SOS1 son of sevenless homolog 1 (Drosophila) 0.999
MAPK1 mitogen-activated protein kinase 1 0.999
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.999
ABI1 abl-interactor 1 0.999
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.999
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.999
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.999
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.998
PTK2 PTK2 protein tyrosine kinase 2 0.998
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.998
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.998
IGF1R insulin-like growth factor 1 receptor 0.998
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.995
FGFR2 fibroblast growth factor receptor 2 0.995
SH3KBP1 SH3-domain kinase binding protein 1 0.994
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.994
SMAD2 SMAD family member 2 0.989
CCNE1 cyclin E1 0.989
TSC2 tuberous sclerosis 2 0.988
RICTOR RPTOR independent companion of MTOR, complex 2 0.985
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.985
CDK2 cyclin-dependent kinase 2 0.985
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.983
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.982
BRAF v-raf murine sarcoma viral oncogene homolog B1 0.981
HRAS v-Ha-ras Harvey rat sarcoma viral oncogene homolog 0.980
CBLB Cas-Br-M (murine) ecotropic retroviral transforming sequence b 0.980
MAP2K1 mitogen-activated protein kinase kinase 1 0.980
SH3BP2 SH3-domain binding protein 2 0.979
RACGAP1 Rac GTPase activating protein 1 0.979
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.979
GSK3B glycogen synthase kinase 3 beta 0.977
BAIAP2 BAI1-associated protein 2 0.976
IQGAP1 IQ motif containing GTPase activating protein 1 0.976
DOCK1 dedicator of cytokinesis 1 0.976
ESR1 estrogen receptor 1 0.976
JAG1 jagged 1 0.975
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 0.975
STK4 serine/threonine kinase 4 0.973
ITGB4 integrin, beta 4 0.972
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) 0.971
S100A6 S100 calcium binding protein A6 0.967
STK3 serine/threonine kinase 3 0.962
ARRB1 arrestin, beta 1 0.962
NCK1 NCK adaptor protein 1 0.960
PLCG1 phospholipase C, gamma 1 0.960
MARK3 MAP/microtubule affinity-regulating kinase 3 0.957
UBC ubiquitin C 0.953
ARHGAP1 Rho GTPase activating protein 1 0.952
LAT linker for activation of T cells 0.952
JUN jun proto-oncogene 0.951
MPRIP myosin phosphatase Rho interacting protein 0.950
NCKAP1 NCK-associated protein 1 0.949
MAPK3 mitogen-activated protein kinase 3 0.948
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.939
DUSP1 dual specificity phosphatase 1 0.935
S100A8 S100 calcium binding protein A8 0.934
S100A11 S100 calcium binding protein A11 0.924
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.924
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.921
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.921
COL4A1 collagen, type IV, alpha 1 0.920
RIN1 Ras and Rab interactor 1 0.920
NCK2 NCK adaptor protein 2 0.918
EIF4A3 eukaryotic translation initiation factor 4A3 0.916
GABARAPL1 GABA(A) receptor-associated protein like 1 0.914
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.913
SH3RF1 SH3 domain containing ring finger 1 0.911
S100B S100 calcium binding protein B 0.910
CSNK2A1 casein kinase 2, alpha 1 polypeptide 0.907
KIF23 kinesin family member 23 0.906
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.901
SRPK2 SRSF protein kinase 2 0.899
VAV1 vav 1 guanine nucleotide exchange factor 0.898
CD28 CD28 molecule 0.895
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 0.894
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.893
FMNL1 formin-like 1 0.890
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.886
WASF2 WAS protein family, member 2 0.886
SORBS3 sorbin and SH3 domain containing 3 0.884
CCND1 cyclin D1 0.883
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 0.882
PRKCA protein kinase C, alpha 0.879
PKM2 pyruvate kinase, muscle 0.879
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Grb2 growth factor receptor bound protein 2 0.999
Ephb2 Eph receptor B2 0.997
Cbl Casitas B-lineage lymphoma 0.996
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.993
Itsn1 intersectin 1 (SH3 domain protein 1A) 0.992
Efnb2 ephrin B2 0.992
Cdc42 cell division cycle 42 homolog (S. cerevisiae) 0.989
Ctnnb1 catenin (cadherin associated protein), beta 1 0.988
Nf1 neurofibromatosis 1 0.984
Lepr leptin receptor 0.983
Eln elastin 0.962
Mapk3 mitogen-activated protein kinase 3 0.958
Src Rous sarcoma oncogene 0.957
Plcg1 phospholipase C, gamma 1 0.955
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.948
Nckap1l NCK associated protein 1 like 0.947
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.945
Epha4 Eph receptor A4 0.930
Inpp5d inositol polyphosphate-5-phosphatase D 0.929
Apc adenomatosis polyposis coli 0.928
Tnks1bp1 tankyrase 1 binding protein 1 0.924
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.923
Pafah1b1 platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 0.916
Pnpla2 patatin-like phospholipase domain containing 2 0.914
Egfr epidermal growth factor receptor 0.909
Pxn paxillin 0.900
Dnm1 dynamin 1 0.898
Klk1b5 kallikrein 1-related peptidase b5 0.898
Trp53 transformation related protein 53 0.898
Col1a1 collagen, type I, alpha 1 0.898
Ednrb endothelin receptor type B 0.892
Git1 G protein-coupled receptor kinase-interactor 1 0.882
Braf Braf transforming gene 0.879
Sox10 SRY-box containing gene 10 0.867
Arrb2 arrestin, beta 2 0.864
Hmha1 histocompatibility (minor) HA-1 0.863
Ntf3 neurotrophin 3 0.853
2310014H01Rik RIKEN cDNA 2310014H01 gene 0.853
Flii flightless I homolog (Drosophila) 0.851
Cttn cortactin 0.848
Rac1 RAS-related C3 botulinum substrate 1 0.848
Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) 0.847
Raf1 v-raf-leukemia viral oncogene 1 0.838
Dok1 docking protein 1 0.836
Ccl2 chemokine (C-C motif) ligand 2 0.832
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.831
Vav1 vav 1 oncogene 0.827
Vav2 vav 2 oncogene 0.814
Klf7 Kruppel-like factor 7 (ubiquitous) 0.809
S1pr1 sphingosine-1-phosphate receptor 1 0.804
Dock1 dedicator of cytokinesis 1 0.802
Plxna1 plexin A1 0.796
Dok2 docking protein 2 0.792
Selplg selectin, platelet (p-selectin) ligand 0.788
Rictor RPTOR independent companion of MTOR, complex 2 0.788
Trp63 transformation related protein 63 0.779
Plxnd1 plexin D1 0.778
Ret ret proto-oncogene 0.778
Tgfb1 transforming growth factor, beta 1 0.773
Prkce protein kinase C, epsilon 0.771
Fbn1 fibrillin 1 0.763
Irs1 insulin receptor substrate 1 0.762
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.758
Shc1 src homology 2 domain-containing transforming protein C1 0.757
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.757
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.756
Sh3bp1 SH3-domain binding protein 1 0.751
Vasp vasodilator-stimulated phosphoprotein 0.747
Adam19 a disintegrin and metallopeptidase domain 19 (meltrin beta) 0.745
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.745
P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 0.743
Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) 0.739
Gab1 growth factor receptor bound protein 2-associated protein 1 0.735
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.732
Axin1 axin 1 0.732
Rasa1 RAS p21 protein activator 1 0.730
Fmnl1 formin-like 1 0.720
Itga3 integrin alpha 3 0.717
Gfra2 glial cell line derived neurotrophic factor family receptor alpha 2 0.715
Arhgef11 Rho guanine nucleotide exchange factor (GEF) 11 0.715
Wnt7a wingless-related MMTV integration site 7A 0.711
Pdgfb platelet derived growth factor, B polypeptide 0.706
Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.704
Lrrk2 leucine-rich repeat kinase 2 0.702
Rgs12 regulator of G-protein signaling 12 0.697
Cd2ap CD2-associated protein 0.695
Gab2 growth factor receptor bound protein 2-associated protein 2 0.690
Drd2 dopamine receptor D2 0.689
Jup junction plakoglobin 0.683
Shank3 SH3/ankyrin domain gene 3 0.678
Dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.678
Rasgrp2 RAS, guanyl releasing protein 2 0.677
Epb4.1l2 erythrocyte protein band 4.1-like 2 0.676
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.675
Mapk1 mitogen-activated protein kinase 1 0.675
Plekho2 pleckstrin homology domain containing, family O member 2 0.670
Laptm5 lysosomal-associated protein transmembrane 5 0.668
Rasgrp1 RAS guanyl releasing protein 1 0.667
Arhgef12 Rho guanine nucleotide exchange factor (GEF) 12 0.667
Ccr2 chemokine (C-C motif) receptor 2 0.667
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Rap1b RAP1B, member of RAS oncogene family 0.305
Ptafr platelet-activating factor receptor 0.222
Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.220
Rab7a RAB7A, member RAS oncogene family 0.217
Ube2g1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) 0.180
LOC100364212 heterogeneous nuclear ribonucleoprotein K-like 0.177
Tle4 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) 0.174
Ppp2ca protein phosphatase 2, catalytic subunit, alpha isoform 0.164
Jtb jumping translocation breakpoint 0.145
Lgals3 lectin, galactoside-binding, soluble, 3 0.136
Dbh dopamine beta-hydroxylase (dopamine beta-monooxygenase) 0.135
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.132
Arf6 ADP-ribosylation factor 6 0.131
Dlg3 discs, large homolog 3 (Drosophila) 0.130
Ppp2cb protein phosphatase 2, catalytic subunit, beta isoform 0.124
Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha isoform 0.119
Dag1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.117
Anxa2 annexin A2 0.114
Ppp1r12a protein phosphatase 1, regulatory (inhibitor) subunit 12A 0.114
Fkbp1a FK506 binding protein 1a 0.110
Grin2b glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.109
Kcnab1 potassium voltage-gated channel, shaker-related subfamily, beta member 1 0.106
Utrn utrophin 0.106
Rac1 ras-related C3 botulinum toxin substrate 1 0.106
Kit v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.102
Dlg1 discs, large homolog 1 (Drosophila) 0.097
Cdh6 cadherin 6 0.096
Golph3 golgi phosphoprotein 3 (coat-protein) 0.096
Exoc5 exocyst complex component 5 0.093
Irs1 insulin receptor substrate 1 0.092
Hk1 hexokinase 1 0.091
Adora2a adenosine A2a receptor 0.091
Slc23a2 solute carrier family 23 (nucleobase transporters), member 2 0.090
Fam135a family with sequence similarity 135, member A 0.090
Litaf lipopolysaccharide-induced TNF factor 0.089
Mapk1 mitogen activated protein kinase 1 0.089
Ccl2 chemokine (C-C motif) ligand 2 0.087
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.086
Csnk1g3 casein kinase 1, gamma 3 0.086
Mprip myosin phosphatase Rho interacting protein 0.086
LOC100360986 mCG1035404-like 0.086
Dock9 dedicator of cytokinesis 9 0.086
S100a4 S100 calcium-binding protein A4 0.085
Arf4 ADP-ribosylation factor 4 0.084
Dnaja2 DnaJ (Hsp40) homolog, subfamily A, member 2 0.084
Lcp2 lymphocyte cytosolic protein 2 0.084
Eif5 eukaryotic translation initiation factor 5 0.084
Ddx17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 0.084
Ubr5 ubiquitin protein ligase E3 component n-recognin 5 0.083
Col1a1 collagen, type I, alpha 1 0.083
Taok1 TAO kinase 1 0.083
Cfp complement factor properdin 0.081
Sirpa signal-regulatory protein alpha 0.081
Lphn2 latrophilin 2 0.080
Pfn1 profilin 1 0.080
Lrrc15 leucine rich repeat containing 15 0.080
Pde2a phosphodiesterase 2A, cGMP-stimulated 0.079
P2ry6 pyrimidinergic receptor P2Y, G-protein coupled, 6 0.079
Sfrp4 secreted frizzled-related protein 4 0.078
S100a10 S100 calcium binding protein A10 0.078
Dlgap1 discs, large (Drosophila) homolog-associated protein 1 0.078
Eif4a2 eukaryotic translation initiation factor 4A, isoform 2 0.078
Vim vimentin 0.077
Olr416 olfactory receptor 416 0.077
Mapk9 mitogen-activated protein kinase 9 0.077
Git1 G protein-coupled receptor kinase interacting ArfGAP 1 0.076
Inpp5d inositol polyphosphate-5-phosphatase D 0.076
Vamp3 vesicle-associated membrane protein 3 0.075
Jak1 Janus kinase 1 0.075
Syde1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans) 0.075
Camk2a calcium/calmodulin-dependent protein kinase II alpha 0.075
Ifitm3 interferon induced transmembrane protein 3 0.075
Folh1 folate hydrolase 1 0.074
Ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform 0.074
Snrk SNF related kinase 0.074
Jak2 Janus kinase 2 0.074
Cyb5r4 cytochrome b5 reductase 4 0.073
Prkch protein kinase C, eta 0.073
Shank3 SH3 and multiple ankyrin repeat domains 3 0.072
Mcpt2 mast cell protease 2 0.072
Cap1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.072
Ciita class II, major histocompatibility complex, transactivator 0.072
Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase 0.071
Sumo1 SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) 0.071
Rhoa ras homolog gene family, member A 0.071
Ppp1r13b protein phosphatase 1, regulatory (inhibitor) subunit 13B 0.071
Anxa1 annexin A1 0.070
Slc1a3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.070
Csnk1e casein kinase 1, epsilon 0.070
Mgea5 meningioma expressed antigen 5 (hyaluronidase) 0.069
Cugbp2 CUG triplet repeat, RNA binding protein 2 0.069
Ier5 immediate early response 5 0.068
Fnbp1 formin binding protein 1 0.068
Sox10 SRY (sex determining region Y)-box 10 0.068
Gng7 guanine nucleotide binding protein (G protein), gamma 7 0.068
Gnai3 guanine nucleotide binding protein (G protein), alpha inhibiting 3 0.068
Gata2 GATA binding protein 2 0.068
Myl12b myosin, light chain 12B, regulatory 0.068
Pak2 p21 protein (Cdc42/Rac)-activated kinase 2 0.068
Gabrg1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 0.067