The network for 'cell cycle checkpoint' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cell cycle checkpoint

A cell cycle process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
BMH1 Bmh1p 0.897
GLC7 Glc7p 0.860
RAD53 Rad53p 0.842
REG1 Reg1p 0.829
BIM1 Bim1p 0.767
SNF1 Snf1p 0.752
PPH22 Pph22p 0.665
CTF18 Ctf18p 0.659
RTS1 Rts1p 0.601
SPT5 Spt5p 0.585
PPH21 Pph21p 0.566
CDC20 Cdc20p 0.552
BUB1 Bub1p 0.537
PDS1 Pds1p 0.513
MRC1 Mrc1p 0.495
PLC1 Plc1p 0.495
RAD9 Rad9p 0.486
RED1 Red1p 0.472
PPH3 Pph3p 0.468
SLK19 Slk19p 0.460
GBP2 Gbp2p 0.453
MAD2 Mad2p 0.421
CLB5 Clb5p 0.421
ZIP1 Zip1p 0.402
CKA1 Cka1p 0.386
KSP1 Ksp1p 0.382
SDS22 Sds22p 0.353
EAF1 Eaf1p 0.352
CTF13 Ctf13p 0.318
GIC1 Gic1p 0.313
DBF4 Dbf4p 0.306
RRM3 Rrm3p 0.301
MEC1 Mec1p 0.270
CDC55 Cdc55p 0.266
BFA1 Bfa1p 0.242
CKS1 Cks1p 0.235
CLB6 Clb6p 0.232
SLG1 Slg1p 0.231
DIA2 Dia2p 0.227
RAD52 Rad52p 0.223
NOP6 Nop6p 0.212
KEL1 Kel1p 0.211
HTA1 Hta1p 0.210
DSN1 Dsn1p 0.201
CDC14 Cdc14p 0.200
CWC2 Cwc2p 0.196
MCM2 Mcm2p 0.192
RSP5 Rsp5p 0.192
BUB3 Bub3p 0.191
HHT1 Hht1p 0.188
MCM21 Mcm21p 0.185
BCK1 Bck1p 0.181
CDC28 Cdc28p 0.181
PIG2 Pig2p 0.180
CLB3 Clb3p 0.179
DUN1 Dun1p 0.177
DDC1 Ddc1p 0.176
HHT2 Hht2p 0.176
NBL1 Nbl1p 0.175
MCK1 Mck1p 0.175
CLF1 Clf1p 0.173
TOR1 Tor1p 0.171
ASF1 Asf1p 0.170
HOG1 Hog1p 0.170
MEK1 Mek1p 0.169
CSE4 Cse4p 0.168
LTE1 Lte1p 0.165
PSY2 Psy2p 0.165
RTS3 Rts3p 0.162
GPM2 Gpm2p 0.161
RTG3 Rtg3p 0.159
SGV1 Sgv1p 0.155
PAM1 Pam1p 0.155
BUD14 Bud14p 0.155
ALD6 Ald6p 0.154
TSA2 Tsa2p 0.151
RAD24 Rad24p 0.151
RPO26 Rpo26p 0.150
HSL1 Hsl1p 0.147
SWC4 Swc4p 0.145
MPS1 Mps1p 0.144
KIN3 Kin3p 0.143
DPB11 Dpb11p 0.138
CHL1 Chl1p 0.138
CIN8 Cin8p 0.137
SIC1 Sic1p 0.135
CDC25 Cdc25p 0.134
RAD27 Rad27p 0.133
CTF3 Ctf3p 0.131
TOP2 Top2p 0.129
HOP1 Hop1p 0.123
MCM10 Mcm10p 0.122
CDC37 Cdc37p 0.122
MCD1 Mcd1p 0.121
MMS22 Mms22p 0.120
KIN1 Kin1p 0.116
RAD54 Rad54p 0.114
POL30 Pol30p 0.114
PEX22 Pex22p 0.112
DPB2 Dpb2p 0.109
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
ccnb1 cyclin B1 0.114
ywhaqb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b 0.101
cry3 cryptochrome 3 0.094
pcna proliferating cell nuclear antigen 0.083
plk1 polo-like kinase 1 (Drosophila) 0.080
pafah1b1b platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b 0.075
kif23 kinesin family member 23 0.058
snrpc small nuclear ribonucleoprotein polypeptide C 0.055
brd2a bromodomain-containing 2a 0.053
zgc:111944 zgc:111944 0.052
ddb2 damage-specific DNA binding protein 2 0.048
ccnb2 cyclin B2 0.043
id2a inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a 0.042
pafah1b1a platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit a 0.040
ccna2 cyclin A2 0.040
si:ch211-244o22.2 si:ch211-244o22.2 0.037
fen1 flap structure-specific endonuclease 1 0.037
zff9 zinc finger protein 9 0.037
aurkb aurora kinase B 0.035
mcm5 MCM5 minichromosome maintenance deficient 5 (S. cerevisiae) 0.034
skp2 S-phase kinase-associated protein 2 (p45) 0.033
rtkn2 rhotekin 2 0.030
ywhaqa tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a 0.029
cstf1 cleavage stimulation factor, 3' pre-RNA, subunit 1 0.027
dtl denticleless homolog (Drosophila) 0.026
g2e3 G2/M-phase specific E3 ubiquitin ligase 0.026
sass6 spindle assembly 6 homolog (C. elegans) 0.024
cdt1 chromatin licensing and DNA replication factor 1 0.023
rqcd1 RCD1 required for cell differentiation1 homolog (S. pombe) 0.022
ccne cyclin E 0.022
smarcb1a SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1a 0.021
ncapg non-SMC condensin I complex, subunit G 0.020
gtdc1 glycosyltransferase-like domain containing 1 0.020
ppp2r5eb protein phosphatase 2, regulatory subunit B', epsilon isoform b 0.020
srsf1a serine/arginine-rich splicing factor 1a 0.020
ncapd2 non-SMC condensin I complex, subunit D2 0.019
zgc:101598 zgc:101598 0.019
sae1 SUMO1 activating enzyme subunit 1 0.018
odc1 ornithine decarboxylase 1 0.018
hdac3 histone deacetylase 3 0.018
btg2 B-cell translocation gene 2 0.018
ywhabb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b 0.018
wdr76 WD repeat domain 76 0.017
mapk3 mitogen-activated protein kinase 3 0.017
si:ch211-69g19.2 si:ch211-69g19.2 0.017
rpa3 replication protein A3 0.017
mdm2 transformed 3T3 cell double minute 2 homolog (mouse) 0.017
gmnn geminin, DNA replication inhibitor 0.017
mapk14a mitogen-activated protein kinase 14a 0.017
zgc:113346 zgc:113346 0.017
xrcc6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.017
tgif1 TGFB-induced factor homeobox 1 0.016
ube2g2 ubiquitin-conjugating enzyme E2G 2 0.016
slbp stem-loop binding protein 0.016
suv39h1b suppressor of variegation 3-9 homolog 1b 0.015
ybx1 Y box binding protein 1 0.015
celsr3 cadherin, EGF LAG seven-pass G-type receptor 3 0.014
zgc:55448 zgc:55448 0.014
zgc:66100 zgc:66100 0.014
zgc:174506 zgc:174506 0.014
tfam transcription factor A, mitochondrial 0.014
cand1 cullin-associated and neddylation-dissociated 1 0.013
zgc:113183 zgc:113183 0.013
orc6 origin recognition complex, subunit 6 0.013
cdk8 cyclin-dependent kinase 8 0.013
ywhaba tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a 0.012
stil TAL1 (SCL) interrupting locus 0.012
aurka aurora kinase A 0.012
rbpms2 RNA binding protein with multiple splicing 2 0.012
ywhae1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 0.012
zgc:56095 zgc:56095 0.012
chaf1b chromatin assembly factor 1, subunit B 0.012
per2 period homolog 2 (Drosophila) 0.012
lrwd1 leucine-rich repeats and WD repeat domain containing 1 0.011
gins3 GINS complex subunit 3 0.011
rbbp6 retinoblastoma binding protein 6 0.011
cx52.6 connexin 52.6 0.011
dvl3 dishevelled, dsh homolog 3 (Drosophila) 0.011
cct8 chaperonin containing TCP1, subunit 8 (theta) 0.011
mab21l1 mab-21-like 1 0.011
orc1 origin recognition complex, subunit 1 0.011
strap serine/threonine kinase receptor associated protein 0.011
cxcr4b chemokine (C-X-C motif), receptor 4b 0.011
bmp8a bone morphogenetic protein 8a 0.011
zgc:153910 zgc:153910 0.011
srsf2 serine/arginine-rich splicing factor 2 0.011
snrpd1 small nuclear ribonucleoprotein D1 polypeptide 0.011
dedd1 death effector domain-containing 1 0.011
klhl11 kelch-like 11 (Drosophila) 0.010
si:ch211-59d15.5 si:ch211-59d15.5 0.010
camkvb CaM kinase-like vesicle-associated b 0.010
esco2 establishment of cohesion 1 homolog 2 0.010
ppp4ca protein phosphatase 4 (formerly X), catalytic subunit a 0.010
cstf3 cleavage stimulation factor, 3' pre-RNA, subunit 3 0.010
nr3c1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
lok loki 0.982
RanGap Ran GTPase activating protein 0.978
CSN5 COP9 complex homolog subunit 5 0.899
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.871
Rpd3 CG7471 gene product from transcript CG7471-RA 0.826
Iswi Imitation SWI 0.811
spn-B spindle B 0.809
Dref DNA replication-related element factor 0.772
BRWD3 CG31132 gene product from transcript CG31132-RA 0.734
Caf1 Chromatin assembly factor 1 subunit 0.730
tefu telomere fusion 0.727
rad50 CG6339 gene product from transcript CG6339-RD 0.713
Pp2A-29B Protein phosphatase 2A at 29B 0.711
dre4 CG1828 gene product from transcript CG1828-RB 0.697
CkIIbeta Casein kinase II beta subunit 0.684
mei-9 meiotic 9 0.591
Nup153 Nucleoporin 153 0.569
MED6 Mediator complex subunit 6 0.537
cdm cadmus 0.525
CSN4 COP9 complex homolog subunit 4 0.501
Kap-alpha3 karyopherin alpha3 0.499
Akt1 CG4006 gene product from transcript CG4006-RA 0.497
mus209 mutagen-sensitive 209 0.493
cdc2c CG10498 gene product from transcript CG10498-RC 0.493
mus301 mutagen-sensitive 301 0.488
mus205 mutagen-sensitive 205 0.480
Hdac3 Histone deacetylase 3 0.478
mei-41 meiotic 41 0.458
Cdc37 CG12019 gene product from transcript CG12019-RA 0.457
hay haywire 0.456
imd immune deficiency 0.434
lin19 lin-19-like 0.427
Crag Calmodulin-binding protein related to a Rab3 GDP/GTP exchange protein 0.396
wee CG4488 gene product from transcript CG4488-RA 0.392
Su(var)2-HP2 CG12864 gene product from transcript CG12864-RB 0.392
Nup50 Nucleoporin 50 0.376
p53 CG33336 gene product from transcript CG33336-RB 0.374
alph alphabet 0.369
Myb Myb oncogene-like 0.360
CDC45L CG3658 gene product from transcript CG3658-RA 0.359
MED20 Mediator complex subunit 20 0.351
CSN3 COP9 complex homolog subunit 3 0.351
Bap55 Brahma associated protein 55kD 0.343
Mpk2 CG5475 gene product from transcript CG5475-RB 0.341
CG9772 CG9772 gene product from transcript CG9772-RB 0.340
Dredd Death related ced-3/Nedd2-like protein 0.337
Srp54 CG4602 gene product from transcript CG4602-RA 0.325
CG31301 CG31301 gene product from transcript CG31301-RA 0.316
Mcm10 Sensitized chromosome inheritance modifier 19 0.314
MED11 Mediator complex subunit 11 0.308
Cul-2 Cullin-2 0.307
mre11 meiotic recombination 11 0.300
okr okra 0.295
Su(var)2-10 Suppressor of variegation 2-10 0.294
Bap60 Brahma associated protein 60kD 0.289
Cap-G CG34438 gene product from transcript CG34438-RF 0.288
Top2 Topoisomerase 2 0.284
dah discontinuous actin hexagon 0.281
RASSF8 CG5053 gene product from transcript CG5053-RA 0.272
MED31 Mediator complex subunit 31 0.268
CSN6 COP9 complex homolog subunit 6 0.268
fs(1)h female sterile (1) homeotic 0.264
jumu jumeau 0.262
cnc cap-n-collar 0.253
Fcp1 CG12252 gene product from transcript CG12252-RA 0.242
mus312 mutagen-sensitive 312 0.241
scra scraps 0.237
Pp1-87B Protein phosphatase 1 at 87B 0.235
gw gawky 0.234
eEF1delta CG4912 gene product from transcript CG4912-RB 0.228
fzy fizzy 0.226
Cat Catalase 0.220
growl CG14648 gene product from transcript CG14648-RA 0.219
sxc super sex combs 0.218
wcd wicked 0.217
Bj1 Bj1 protein 0.216
spn-D spindle D 0.216
Mcm7 Minichromosome maintenance 7 0.208
Spc105R Spc105-related 0.206
Ice CG7788 gene product from transcript CG7788-RA 0.204
Irbp Inverted repeat-binding protein 0.203
Stim Stromal interaction molecule 0.198
gwl greatwall 0.196
CG10754 CG10754 gene product from transcript CG10754-RA 0.190
Gga CG3002 gene product from transcript CG3002-RB 0.188
RecQ4 CG7487 gene product from transcript CG7487-RA 0.188
Grip84 gamma-tubulin ring protein 84 0.188
CG10267 CG10267 gene product from transcript CG10267-RB 0.175
CG8159 CG8159 gene product from transcript CG8159-RB 0.175
pie pineapple eye 0.173
mus201 mutagen-sensitive 201 0.172
key kenny 0.172
CG34415 CG34415 gene product from transcript CG34415-RC 0.172
Hcf Host cell factor 0.171
RnrL Ribonucleoside diphosphate reductase large subunit 0.170
E2f2 E2F transcription factor 2 0.169
feo fascetto 0.166
cal1 chromosome alignment defect 1 0.164
Npc1a Niemann-Pick type C-1a 0.163
BG4 CG12297 gene product from transcript CG12297-RA 0.159
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Homo sapiens
Name Description Probability Func Analog Organism
TP53 tumor protein p53 1.000
H2AFX H2A histone family, member X 0.999
RB1 retinoblastoma 1 0.999
COPS5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) 0.997
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.993
BRCA1 breast cancer 1, early onset 0.983
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.975
CDK2 cyclin-dependent kinase 2 0.971
NBN nibrin 0.967
E2F1 E2F transcription factor 1 0.964
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.958
RAD51 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) 0.949
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.948
CUL2 cullin 2 0.943
MSH6 mutS homolog 6 (E. coli) 0.941
CHEK1 CHK1 checkpoint homolog (S. pombe) 0.928
MDC1 mediator of DNA-damage checkpoint 1 0.915
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.911
AURKB aurora kinase B 0.906
CDC20 cell division cycle 20 homolog (S. cerevisiae) 0.895
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.885
RAD50 RAD50 homolog (S. cerevisiae) 0.884
SKP2 S-phase kinase-associated protein 2 (p45) 0.881
MED1 mediator complex subunit 1 0.880
HDAC1 histone deacetylase 1 0.858
CUL1 cullin 1 0.839
FANCD2 Fanconi anemia, complementation group D2 0.829
RFWD2 ring finger and WD repeat domain 2 0.823
WDR5 WD repeat domain 5 0.817
MCM2 minichromosome maintenance complex component 2 0.811
CDK6 cyclin-dependent kinase 6 0.809
BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) 0.803
PCNA proliferating cell nuclear antigen 0.800
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.800
THOC4 THO complex 4 0.788
CLSPN claspin 0.759
XIAP X-linked inhibitor of apoptosis 0.759
BRCA2 breast cancer 2, early onset 0.740
ATM ataxia telangiectasia mutated 0.733
CCNA2 cyclin A2 0.717
TOPBP1 topoisomerase (DNA) II binding protein 1 0.717
BCL2 B-cell CLL/lymphoma 2 0.701
RBL2 retinoblastoma-like 2 (p130) 0.693
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.685
CHEK2 CHK2 checkpoint homolog (S. pombe) 0.676
TFDP1 transcription factor Dp-1 0.644
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 0.629
BRCC3 BRCA1/BRCA2-containing complex, subunit 3 0.609
CCT8 chaperonin containing TCP1, subunit 8 (theta) 0.590
CCNB1 cyclin B1 0.588
CDC25A cell division cycle 25 homolog A (S. pombe) 0.577
RBL1 retinoblastoma-like 1 (p107) 0.558
PLK1 polo-like kinase 1 0.545
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.538
COPS4 COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis) 0.529
UIMC1 ubiquitin interaction motif containing 1 0.521
TERF2 telomeric repeat binding factor 2 0.498
WRN Werner syndrome, RecQ helicase-like 0.493
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.492
RAD1 RAD1 homolog (S. pombe) 0.491
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.491
CSNK2B casein kinase 2, beta polypeptide 0.486
BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast) 0.484
CNOT3 CCR4-NOT transcription complex, subunit 3 0.477
HIST1H3D histone cluster 1, H3d 0.472
CASP2 caspase 2, apoptosis-related cysteine peptidase 0.465
BABAM1 BRISC and BRCA1 A complex member 1 0.463
CDC27 cell division cycle 27 homolog (S. cerevisiae) 0.463
TP53BP1 tumor protein p53 binding protein 1 0.462
TOP2A topoisomerase (DNA) II alpha 170kDa 0.443
EME1 essential meiotic endonuclease 1 homolog 1 (S. pombe) 0.433
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.430
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 0.426
DAXX death-domain associated protein 0.417
CCNE1 cyclin E1 0.416
FAM175A family with sequence similarity 175, member A 0.414
BRE brain and reproductive organ-expressed (TNFRSF1A modulator) 0.411
BCL2L1 BCL2-like 1 0.410
HIST1H2BG histone cluster 1, H2bg 0.403
CUL4A cullin 4A 0.402
THOC2 THO complex 2 0.401
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.387
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 0.378
UBXN7 UBX domain protein 7 0.377
PKM2 pyruvate kinase, muscle 0.371
CDC5L CDC5 cell division cycle 5-like (S. pombe) 0.370
PARP1 poly (ADP-ribose) polymerase 1 0.358
ORC2 origin recognition complex, subunit 2 0.358
ZW10 ZW10, kinetochore associated, homolog (Drosophila) 0.354
TTI1 Tel2 interacting protein 1 homolog (S. pombe) 0.343
BUB1B budding uninhibited by benzimidazoles 1 homolog beta (yeast) 0.338
RBBP8 retinoblastoma binding protein 8 0.335
RPA2 replication protein A2, 32kDa 0.335
PPP4C protein phosphatase 4, catalytic subunit 0.332
DDB1 damage-specific DNA binding protein 1, 127kDa 0.328
MAPK14 mitogen-activated protein kinase 14 0.324
RAD9A RAD9 homolog A (S. pombe) 0.322
DDB2 damage-specific DNA binding protein 2, 48kDa 0.319
POU5F1 POU class 5 homeobox 1 0.317
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.317
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Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 1.000
Brca1 breast cancer 1 0.996
Brca2 breast cancer 2 0.979
Cdk4 cyclin-dependent kinase 4 0.979
Pten phosphatase and tensin homolog 0.968
Atm ataxia telangiectasia mutated homolog (human) 0.898
Mdm2 transformed mouse 3T3 cell double minute 2 0.879
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.847
Mcm3 minichromosome maintenance deficient 3 (S. cerevisiae) 0.838
Rb1 retinoblastoma 1 0.794
Per2 period homolog 2 (Drosophila) 0.790
E2f1 E2F transcription factor 1 0.784
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.764
Mdm4 transformed mouse 3T3 cell double minute 4 0.728
Mapk14 mitogen-activated protein kinase 14 0.705
Nf1 neurofibromatosis 1 0.703
Mcm2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae) 0.664
Sirt1 sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae) 0.651
Clock circadian locomotor output cycles kaput 0.641
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.613
Skil SKI-like 0.613
Prim1 DNA primase, p49 subunit 0.606
Elavl1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.604
Nbn nibrin 0.596
Dtl denticleless homolog (Drosophila) 0.594
Crebbp CREB binding protein 0.582
Atf2 activating transcription factor 2 0.581
Kif11 kinesin family member 11 0.527
Hells helicase, lymphoid specific 0.511
Orc1 origin recognition complex, subunit 1 0.493
Prim2 DNA primase, p58 subunit 0.486
Ttk Ttk protein kinase 0.460
Cry1 cryptochrome 1 (photolyase-like) 0.457
Mcm4 minichromosome maintenance deficient 4 homolog (S. cerevisiae) 0.453
Lin9 lin-9 homolog (C. elegans) 0.450
Cdk1 cyclin-dependent kinase 1 0.446
Smc2 structural maintenance of chromosomes 2 0.441
Lsm2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.426
Cdc6 cell division cycle 6 homolog (S. cerevisiae) 0.391
Mybl2 myeloblastosis oncogene-like 2 0.371
Cdt1 chromatin licensing and DNA replication factor 1 0.371
Ccnf cyclin F 0.364
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.357
Cdk2 cyclin-dependent kinase 2 0.348
Cbl Casitas B-lineage lymphoma 0.342
Cenpk centromere protein K 0.325
Usp1 ubiquitin specific peptidase 1 0.324
Xpa xeroderma pigmentosum, complementation group A 0.322
Raf1 v-raf-leukemia viral oncogene 1 0.322
Ccnb1 cyclin B1 0.302
Plk4 polo-like kinase 4 (Drosophila) 0.291
Chek1 checkpoint kinase 1 homolog (S. pombe) 0.283
Trp73 transformation related protein 73 0.281
Wdhd1 WD repeat and HMG-box DNA binding protein 1 0.281
Cry2 cryptochrome 2 (photolyase-like) 0.278
Ndel1 nuclear distribution gene E-like homolog 1 (A. nidulans) 0.276
Ncoa3 nuclear receptor coactivator 3 0.270
C330027C09Rik RIKEN cDNA C330027C09 gene 0.267
Trp63 transformation related protein 63 0.266
Smad4 MAD homolog 4 (Drosophila) 0.265
Ezh2 enhancer of zeste homolog 2 (Drosophila) 0.259
Rad51ap1 RAD51 associated protein 1 0.255
Nek2 NIMA (never in mitosis gene a)-related expressed kinase 2 0.254
Plk1 polo-like kinase 1 (Drosophila) 0.253
Parp1 poly (ADP-ribose) polymerase family, member 1 0.253
Nasp nuclear autoantigenic sperm protein (histone-binding) 0.247
Kif20a kinesin family member 20A 0.242
Prc1 protein regulator of cytokinesis 1 0.242
Suz12 suppressor of zeste 12 homolog (Drosophila) 0.242
Rpa1 replication protein A1 0.239
Ruvbl2 RuvB-like protein 2 0.235
Nup107 nucleoporin 107 0.233
Haus6 HAUS augmin-like complex, subunit 6 0.233
Cdca7 cell division cycle associated 7 0.232
Bptf bromodomain PHD finger transcription factor 0.231
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.228
Pcna proliferating cell nuclear antigen 0.222
Rbl1 retinoblastoma-like 1 (p107) 0.221
Bub1 budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) 0.218
Kat2a K(lysine) acetyltransferase 2A 0.217
H2afx H2A histone family, member X 0.215
Smc3 structural maintenace of chromosomes 3 0.212
Nde1 nuclear distribution gene E homolog 1 (A nidulans) 0.210
Ptch1 patched homolog 1 0.209
Apc adenomatosis polyposis coli 0.206
Bub1b budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) 0.201
Ccne2 cyclin E2 0.201
Aurka aurora kinase A 0.183
Igh immunoglobulin heavy chain complex 0.183
Trip13 thyroid hormone receptor interactor 13 0.181
Kif22 kinesin family member 22 0.181
Rfc3 replication factor C (activator 1) 3 0.180
Asf1b ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.178
E2f8 E2F transcription factor 8 0.176
Terf1 telomeric repeat binding factor 1 0.176
Cul4a cullin 4A 0.175
Men1 multiple endocrine neoplasia 1 0.174
Sox4 SRY-box containing gene 4 0.172
Tcf3 transcription factor 3 0.172
Gps1 G protein pathway suppressor 1 0.164
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Pkm2 pyruvate kinase, muscle 0.343
Ube2c ubiquitin-conjugating enzyme E2C 0.315
Top2a topoisomerase (DNA) II alpha 0.192
Ppp1ca protein phosphatase 1, catalytic subunit, alpha isoform 0.183
Cdk4 cyclin-dependent kinase 4 0.175
Ccnb2 cyclin B2 0.161
Rrm2 ribonucleotide reductase M2 0.126
Spc25 SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) 0.122
Gpx4 glutathione peroxidase 4 0.109
Traf4af1 TRAF4 associated factor 1 0.108
Gapdh glyceraldehyde-3-phosphate dehydrogenase 0.105
Cdkn3 cyclin-dependent kinase inhibitor 3 0.103
Cdc42 cell division cycle 42 (GTP binding protein) 0.090
Ccnb1 cyclin B1 0.088
Cdk1 cyclin-dependent kinase 1 0.085
Rbbp7 retinoblastoma binding protein 7 0.080
Pdp1 pyruvate dehyrogenase phosphatase catalytic subunit 1 0.079
Atp5b ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide 0.078
Ptbp1 polypyrimidine tract binding protein 1 0.077
Ube2i ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.076
Ect2 epithelial cell transforming sequence 2 oncogene 0.074
Pttg1 pituitary tumor-transforming 1 0.071
Hmmr hyaluronan mediated motility receptor (RHAMM) 0.070
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.070
Aurkb aurora kinase B 0.064
Snrpa small nuclear ribonucleoprotein polypeptide A 0.064
Asf1b ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.064
Mif macrophage migration inhibitory factor 0.063
LOC100364212 heterogeneous nuclear ribonucleoprotein K-like 0.063
Dctn4 dynactin 4 0.061
Kif2c kinesin family member 2C 0.060
Cdca8 cell division cycle associated 8 0.059
Mdm2 Mdm2 p53 binding protein homolog (mouse) 0.059
Slc25a4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 0.059
Top2b topoisomerase (DNA) II beta 0.059
Pctk1 PCTAIRE protein kinase 1 0.057
Zfand5 zinc finger, AN1-type domain 5 0.052
Hmgb2 high mobility group box 2 0.052
Racgap1 Rac GTPase-activating protein 1 0.052
Depdc1 DEP domain containing 1 0.052
Dnaja2 DnaJ (Hsp40) homolog, subfamily A, member 2 0.052
Cdca3 cell division cycle associated 3 0.051
Oaz1 ornithine decarboxylase antizyme 1 0.050
Stub1 STIP1 homology and U-Box containing protein 1 0.049
Mcm6 minichromosome maintenance complex component 6 0.049
Cks2 CDC28 protein kinase regulatory subunit 2 0.048
Bak1 BCL2-antagonist/killer 1 0.048
Kif22 kinesin family member 22 0.046
Tle4 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) 0.045
Pcna proliferating cell nuclear antigen 0.045
Rb1 retinoblastoma 1 0.045
Rad51 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) 0.044
Mcm7 minichromosome maintenance complex component 7 0.044
H2afx H2A histone family, member X 0.043
Ap2s1 adaptor-related protein complex 2, sigma 1 subunit 0.043
Rpa2 replication protein A2 0.043
Cul3 cullin 3 0.043
Mapk6 mitogen-activated protein kinase 6 0.043
Vasp vasodilator-stimulated phosphoprotein 0.042
Akr1a1 aldo-keto reductase family 1, member A1 (aldehyde reductase) 0.040
Gpi glucose phosphate isomerase 0.040
Arpc1b actin related protein 2/3 complex, subunit 1B 0.040
Ccnd3 cyclin D3 0.039
Kif20b kinesin family member 20B 0.039
Cdca7 cell division cycle associated 7 0.038
Csnk1g2 casein kinase 1, gamma 2 0.038
March8 membrane-associated ring finger (C3HC4) 8 0.038
Parp1 poly (ADP-ribose) polymerase 1 0.037
Spag5 sperm associated antigen 5 0.037
Bad BCL2-associated agonist of cell death 0.037
Lmnb1 lamin B1 0.037
Tcp11l2 t-complex 11 (mouse) like 2 0.037
Birc5 baculoviral IAP repeat-containing 5 0.037
Csnk2b casein kinase 2, beta polypeptide 0.036
Pfn1 profilin 1 0.036
Troap trophinin associated protein 0.035
Eif4h eukaryotic translation initiation factor 4H 0.035
Cdkn2c cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.035
Ns5atp9 NS5A (hepatitis C virus) transactivated protein 9 0.035
Prc1 protein regulator of cytokinesis 1 0.035
Sf1 splicing factor 1 0.035
Daxx death-domain associated protein 0.034
Dhfr dihydrofolate reductase 0.034
Sumo3 SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae) 0.034
Ccng2 cyclin G2 0.034
Epn1 Epsin 1 0.033
Ogt O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) 0.033
Lbr lamin B receptor 0.033
Stxbp3 syntaxin binding protein 3 0.033
Psmb7 proteasome (prosome, macropain) subunit, beta type 7 0.033
Cc2d1b coiled-coil and C2 domain containing 1B 0.032
Rabac1 Rab acceptor 1 (prenylated) 0.032
Mki67 antigen identified by monoclonal antibody Ki-67 0.032
Chek1 CHK1 checkpoint homolog (S. pombe) 0.032
Aurka aurora kinase A 0.032
Tubb5 tubulin, beta 5 0.032
Bub1b budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) 0.032
Ckap2 cytoskeleton associated protein 2 0.031
Cbfb core-binding factor, beta subunit 0.031
Rcc2 regulator of chromosome condensation 2 0.031