The network for 'negative regulation of transcription dna templated' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of transcription dna templated

Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
RPD3 Rpd3p 0.999
RLF2 Rlf2p 0.998
SIR2 Sir2p 0.997
HDA1 Hda1p 0.994
RAP1 Rap1p 0.993
SIN3 Sin3p 0.991
HHT1 Hht1p 0.988
RCO1 Rco1p 0.978
RXT2 Rxt2p 0.976
HHF1 Hhf1p 0.975
SET1 Set1p 0.959
SDS3 Sds3p 0.957
PHO23 Pho23p 0.956
SUM1 Sum1p 0.951
HAT1 Hat1p 0.944
SIR4 Sir4p 0.927
ORC5 Orc5p 0.925
SET2 Set2p 0.923
CYC8 Cyc8p 0.920
CTI6 Cti6p 0.910
HDA3 Hda3p 0.890
SET3 Set3p 0.882
RIF1 Rif1p 0.881
NAT1 Nat1p 0.872
SPT16 Spt16p 0.870
PAP2 Pap2p 0.865
ADR1 Adr1p 0.859
GAL11 Gal11p 0.841
RPN4 Rpn4p 0.836
HTB1 Htb1p 0.819
HFI1 Hfi1p 0.809
ORC2 Orc2p 0.805
MED2 Med2p 0.792
HCM1 Hcm1p 0.790
RIM101 Rim101p 0.775
EAF3 Eaf3p 0.772
RSC2 Rsc2p 0.767
UME1 Ume1p 0.756
CHD1 Chd1p 0.751
GCR2 Gcr2p 0.745
FKH2 Fkh2p 0.740
SWD1 Swd1p 0.730
BDF1 Bdf1p 0.718
GCN5 Gcn5p 0.706
SIR3 Sir3p 0.703
SNT1 Snt1p 0.702
HSP82 Hsp82p 0.695
ISW2 Isw2p 0.695
PGD1 Pgd1p 0.694
DOA1 Doa1p 0.685
RTT106 Rtt106p 0.683
SPT10 Spt10p 0.681
NUP133 Nup133p 0.671
ADA2 Ada2p 0.667
YAK1 Yak1p 0.659
UBP8 Ubp8p 0.656
IES3 Ies3p 0.655
STP22 Stp22p 0.650
NHP6A Nhp6ap 0.645
SPP1 Spp1p 0.632
ORC6 Orc6p 0.630
SIN4 Sin4p 0.624
UME6 Ume6p 0.622
RPB2 Rpb2p 0.607
SWI4 Swi4p 0.601
DEP1 Dep1p 0.598
NRG1 Nrg1p 0.597
LGE1 Lge1p 0.588
YTA7 Yta7p 0.580
FOB1 Fob1p 0.577
DOT6 Dot6p 0.575
ASF1 Asf1p 0.570
RSC4 Rsc4p 0.570
SSN3 Ssn3p 0.563
TAF5 Taf5p 0.560
PHO4 Pho4p 0.558
ROX3 Rox3p 0.555
URE2 Ure2p 0.555
HMO1 Hmo1p 0.553
GLN3 Gln3p 0.549
CDC6 Cdc6p 0.538
PBS2 Pbs2p 0.533
STE7 Ste7p 0.531
CSE2 Cse2p 0.519
HAA1 Haa1p 0.514
MSN2 Msn2p 0.510
RGT1 Rgt1p 0.507
ISW1 Isw1p 0.503
HIR1 Hir1p 0.501
CTK1 Ctk1p 0.501
HTB2 Htb2p 0.500
MMS22 Mms22p 0.491
IXR1 Ixr1p 0.488
SDC1 Sdc1p 0.485
IZH4 Izh4p 0.484
HAT2 Hat2p 0.484
CTF18 Ctf18p 0.484
SCH9 Sch9p 0.479
HOS4 Hos4p 0.471
MCM2 Mcm2p 0.469
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
egl-18 Protein EGL-18 0.998
pha-4 Protein PHA-4 0.983
elt-6 Protein ELT-6 0.902
hlh-2 Protein HLH-2 0.849
his-1 Protein HIS-1 0.699
zip-7 Protein ZIP-7 0.685
his-16 Protein HIS-16 0.641
unc-62 Protein UNC-62 0.626
his-64 Protein HIS-64 0.589
nhr-67 Protein NHR-67 0.526
pry-1 Protein PRY-1 0.515
his-50 Protein HIS-50 0.472
his-5 Protein HIS-5 0.446
egl-46 Protein EGL-46 0.432
let-502 Protein LET-502 0.426
his-61 Protein HIS-61 0.391
his-3 Protein HIS-3 0.390
ceh-27 Protein CEH-27 0.371
eya-1 Protein EYA-1 0.360
his-46 Protein HIS-46 0.353
nhr-2 Protein NHR-2 0.346
mix-1 Protein MIX-1 0.338
sur-2 Protein SUR-2 0.336
wrm-1 Protein WRM-1 0.332
cnd-1 Protein CND-1 0.330
his-52 Protein HIS-52 0.307
mls-2 Protein MLS-2 0.288
hcp-3 Protein HCP-3 0.278
F10D7.5 Protein F10D7.5 0.277
daf-1 Protein DAF-1 0.273
CELE_F19F10.9 Protein F19F10.9 0.273
cam-1 Protein CAM-1 0.257
mab-5 Protein MAB-5 0.256
lin-17 Protein LIN-17 0.252
F39B2.1 Protein F39B2.1 0.251
hbl-1 Protein HBL-1 0.248
rad-26 Protein RAD-26 0.248
inx-3 Protein INX-3 0.242
orc-1 Protein ORC-1 0.242
his-51 Protein HIS-51 0.239
ztf-2 Protein ZTF-2 0.238
ran-1 Protein RAN-1 0.235
tam-1 Protein TAM-1 0.235
his-31 Protein HIS-31 0.235
zyg-1 Protein ZYG-1 0.234
hda-1 Protein HDA-1 0.229
his-38 Protein HIS-38 0.229
his-68 Protein HIS-68 0.225
mat-3 Protein MAT-3 0.225
peb-1 Protein PEB-1 0.224
his-29 Protein HIS-29 0.221
tbx-8 Protein TBX-8 0.218
pop-1 Protein POP-1 0.215
shn-1 Protein SHN-1 0.214
lin-53 Protein LIN-53 0.213
mcm-2 Protein MCM-2 0.202
nhr-25 Protein NHR-25 0.199
his-45 Protein HIS-45 0.190
zfp-1 Protein ZFP-1 0.186
drap-1 Protein DRAP-1 0.183
sel-7 Protein SEL-7 0.182
mep-1 Protein MEP-1 0.181
ceh-16 Protein CEH-16 0.181
pes-1 Protein PES-1 0.179
his-42 Protein HIS-42 0.172
efl-1 Protein EFL-1 0.171
mes-4 Protein MES-4 0.165
eor-1 Protein EOR-1 0.164
fkh-2 Protein FKH-2 0.163
D1081.8 Protein D1081.8 0.160
daf-12 Protein DAF-12 0.160
cfim-2 Protein CFIM-2 0.158
egl-38 Protein EGL-38 0.153
prp-8 Protein PRP-8 0.152
his-47 Protein HIS-47 0.148
ceh-34 Protein CEH-34 0.147
his-14 Protein HIS-14 0.145
unc-42 Protein UNC-42 0.142
daf-21 Protein DAF-21 0.139
R07E4.5 Protein R07E4.5 0.135
mom-4 Protein MOM-4 0.135
attf-2 Protein ATTF-2 0.133
bar-1 Protein BAR-1 0.133
hlh-1 Protein HLH-1 0.131
flt-1 Protein FLT-1 0.129
lsy-2 Protein LSY-2 0.128
lin-40 Protein LIN-40 0.127
npp-21 Protein NPP-21 0.127
npp-22 Protein NPP-22 0.127
fozi-1 Protein FOZI-1 0.126
Y82E9BR.13 Protein Y82E9BR.13 0.126
deb-1 Protein DEB-1 0.125
dpy-22 Protein DPY-22 0.122
hlh-14 Protein HLH-14 0.121
htz-1 Protein HTZ-1 0.119
CELE_T26A8.4 Protein T26A8.4 0.118
patr-1 Protein PATR-1 0.117
R05H5.5 Protein R05H5.5 0.114
pax-3 Protein PAX-3 0.113
cdt-2 Protein CDT-2 0.112
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
chd chordin 0.872
boc brother of CDO 0.830
jag2 jagged 2 0.746
pax2a paired box gene 2a 0.720
pcna proliferating cell nuclear antigen 0.700
snai1b snail homolog 1b (Drosophila) 0.692
gata6 GATA-binding protein 6 0.672
dlx2a distal-less homeobox gene 2a 0.643
dlx5a distal-less homeobox gene 5a 0.573
zic1 zic family member 1 (odd-paired homolog, Drosophila) 0.557
six3b sine oculis homeobox homolog 3b 0.546
rarab retinoic acid receptor, alpha b 0.532
pitx2 paired-like homeodomain transcription factor 2 0.499
ndr2 nodal-related 2 0.492
tbx1 T-box 1 0.489
mab21l2 mab-21-like 2 0.480
spry4 sprouty (Drosophila) homolog 4 0.461
fgf3 fibroblast growth factor 3 0.459
whsc1 Wolf-Hirschhorn syndrome candidate 1 0.454
bmp2b bone morphogenetic protein 2b 0.439
sox32 SRY-box containing gene 32 0.437
tp53 tumor protein p53 0.415
dlx3b distal-less homeobox gene 3b 0.414
mll myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.402
otx1b orthodenticle homolog 1b 0.394
runx2b runt-related transcription factor 2b 0.393
grem2 gremlin 2, cysteine knot superfamily 0.391
hoxd4a homeo box D4a 0.385
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.384
gli1 GLI-Kruppel family member 1 0.373
shhb sonic hedgehog b 0.370
nkx1.2la NK1 transcription factor related 2-like,a 0.365
tbx5a T-box 5a 0.359
meis2.1 myeloid ecotropic viral integration site 2.1 0.353
twist3 twist3 0.346
zic2a zic family member 2 (odd-paired homolog, Drosophila), a 0.345
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.338
ccnd1 cyclin D1 0.321
ascl1a achaete-scute complex-like 1a (Drosophila) 0.315
dlc deltaC 0.314
hmgb1a high-mobility group box 1a 0.314
ptf1a pancreas specific transcription factor, 1a 0.307
gbx2 gastrulation brain homeo box 2 0.295
sesn1 sestrin 1 0.293
irx7 iroquois homeobox protein 7 0.282
tfap2a transcription factor AP-2 alpha 0.278
flh floating head 0.274
hp1bp3 heterochromatin protein 1, binding protein 3 0.273
gata4 GATA-binding protein 4 0.268
foxa3 forkhead box A3 0.264
sox10 SRY-box containing gene 10 0.261
emx1 empty spiracles homeobox 1 0.261
notch1a notch homolog 1a 0.256
neurog1 neurogenin 1 0.252
sox9a SRY-box containing gene 9a 0.241
ripply1 ripply1 0.233
runx1 runt-related transcription factor 1 0.231
fgf19 fibroblast growth factor 19 0.220
hoxb1b homeo box B1b 0.217
foxi1 forkhead box I1 0.215
spaw southpaw 0.212
sox19a SRY-box containing gene 19a 0.211
nkx2.2a NK2 transcription factor related 2a 0.206
gata5 GATA-binding protein 5 0.205
dlx6a distal-less homeobox gene 6a 0.203
nkx2.5 NK2 transcription factor related 5 0.201
axin2 axin 2 (conductin, axil) 0.201
fezf2 FEZ family zinc finger 2 0.200
tll1 tolloid-like 1 0.199
msxc muscle segment homeobox C 0.196
hoxc4a homeo box C4a 0.196
vsx1 visual system homeobox 1 homolog, chx10-like 0.195
eomesa eomesodermin homolog a 0.190
hand2 heart and neural crest derivatives expressed transcript 2 0.190
pcdh18b protocadherin 18b 0.186
olig3 oligodendrocyte transcription factor 3 0.185
emx3 empty spiracles homeobox 3 0.184
dusp6 dual specificity phosphatase 6 0.184
gsc goosecoid 0.179
gbx1 gastrulation brain homeobox 1 0.178
lhx1a LIM homeobox 1a 0.177
dct dopachrome tautomerase 0.176
hmx1 H6 homeo box 1 0.175
dlx1a distal-less homeobox gene 1a 0.174
pou3f2 POU class 3 homeobox 2 0.174
dlx4a distal-less homeobox gene 4a 0.174
irx4b iroquois homeobox protein 4b 0.167
pax6a paired box gene 6a 0.167
pax8 paired box gene 8 0.166
sox19b SRY-box containing gene 19b 0.165
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.163
egr1 early growth response 1 0.162
neo1 neogenin 1 0.162
junb jun B proto-oncogene 0.159
meis3 myeloid ecotropic viral integration site 3 0.157
lhx5 LIM homeobox 5 0.155
etv2 ets variant gene 2 0.154
per2 period homolog 2 (Drosophila) 0.153
zfp36l1a zinc finger protein 36, C3H type-like 1a 0.153
pou3f3b POU class 3 homeobox 3b 0.153
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Snr1 Snf5-related 1 1.000
hep hemipterous 1.000
CTCF CG8591 gene product from transcript CG8591-RA 0.999
Pcl Polycomblike 0.999
mam mastermind 0.998
kay kayak 0.998
tll tailless 0.997
hth homothorax 0.997
Su(var)205 Suppressor of variegation 205 0.997
shn schnurri 0.994
ato atonal 0.993
ara araucan 0.993
slp1 sloppy paired 1 0.992
gpp grappa 0.991
bowl brother of odd with entrails limited 0.991
Pc Polycomb 0.991
Rpd3 CG7471 gene product from transcript CG7471-RA 0.991
brk brinker 0.989
Iswi Imitation SWI 0.988
ci cubitus interruptus 0.988
His2Av Histone H2A variant 0.986
salm spalt major 0.986
nub nubbin 0.986
gsb gooseberry 0.984
p53 CG33336 gene product from transcript CG33336-RB 0.984
D1 D1 chromosomal protein 0.983
HLHm7 E(spl) region transcript m7 0.981
kn knot 0.979
E(spl) Enhancer of split 0.978
trx trithorax 0.976
dco discs overgrown 0.975
Su(H) Suppressor of Hairless 0.974
eve even skipped 0.973
Ubx Ultrabithorax 0.973
h hairy 0.972
smt3 CG4494 gene product from transcript CG4494-RA 0.972
ftz fushi tarazu 0.972
tin tinman 0.972
abd-A abdominal A 0.968
cnc cap-n-collar 0.966
lwr lesswright 0.966
Kr Kruppel 0.965
lid little imaginal discs 0.964
yki yorkie 0.962
ash1 absent, small, or homeotic discs 1 0.958
Scm Sex comb on midleg 0.957
E(var)3-9 Enhancer of variegation 3-9 0.957
Nf-YC Nuclear factor Y-box C 0.957
Abd-B Abdominal B 0.956
tup tailup 0.956
hkb huckebein 0.954
nab CG33545 gene product from transcript CG33545-RC 0.950
CtBP C-terminal Binding Protein 0.949
prd paired 0.947
gro groucho 0.947
run runt 0.942
so sine oculis 0.938
pb proboscipedia 0.938
eya eyes absent 0.935
ph-p polyhomeotic proximal 0.934
tsh teashirt 0.933
sli slit 0.933
rpr reaper 0.930
ems empty spiracles 0.930
polybromo CG11375 gene product from transcript CG11375-RA 0.929
Spt5 CG7626 gene product from transcript CG7626-RA 0.927
BEAF-32 Boundary element-associated factor of 32kD 0.926
egg eggless 0.924
osa CG7467 gene product from transcript CG7467-RD 0.922
mirr mirror 0.919
kni knirps 0.918
Ser Serrate 0.909
mus209 mutagen-sensitive 209 0.907
svp seven up 0.904
Mad Mothers against dpp 0.902
rho rhomboid 0.896
al aristaless 0.895
Akt1 CG4006 gene product from transcript CG4006-RA 0.893
pros prospero 0.892
E2f2 E2F transcription factor 2 0.889
bin biniou 0.882
HGTX CG13475 gene product from transcript CG13475-RB 0.880
dac dachshund 0.879
ush u-shaped 0.876
btl breathless 0.869
dome domeless 0.866
eyg eyegone 0.857
pdm2 POU domain protein 2 0.852
Uba2 Smt3 activating enzyme 2 0.850
pan pangolin 0.848
EcR Ecdysone receptor 0.842
Sir2 CG5216 gene product from transcript CG5216-RA 0.839
slp2 sloppy paired 2 0.837
gcm glial cells missing 0.835
Hel25E Helicase at 25E 0.834
Tip60 CG6121 gene product from transcript CG6121-RA 0.833
MEP-1 CG1244 gene product from transcript CG1244-RG 0.829
sens senseless 0.827
hh hedgehog 0.827
dpn deadpan 0.823
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Jun Jun oncogene 0.945
Junb jun B proto-oncogene 0.825
Dusp1 dual specificity phosphatase 1 0.788
Fos FBJ osteosarcoma oncogene 0.713
Btg2 BTG family, member 2 0.634
Smad7 SMAD family member 7 0.588
Nfib nuclear factor I/B 0.543
Dbp D site of albumin promoter (albumin D-box) binding protein 0.488
Tcfe2a transcription factor E2a 0.400
Tgfbr2 transforming growth factor, beta receptor II 0.374
Ppp1r15a protein phosphatase 1, regulatory (inhibitor) subunit 15A 0.360
Rhob ras homolog gene family, member B 0.352
Klf6 Kruppel-like factor 6 0.350
Ubtf upstream binding transcription factor, RNA polymerase I 0.325
Nr1d2 nuclear receptor subfamily 1, group D, member 2 0.308
Ahr aryl hydrocarbon receptor 0.305
Pou3f2 POU class 3 homeobox 2 0.302
S100a8 S100 calcium binding protein A8 0.299
Trim28 tripartite motif-containing 28 0.294
Id1 inhibitor of DNA binding 1 0.292
Met met proto-oncogene 0.288
Grk1 G protein-coupled receptor kinase 1 0.276
Hoxb7 homeo box B7 0.269
Ier2 immediate early response 2 0.261
Myh9 myosin, heavy chain 9, non-muscle 0.260
Vim vimentin 0.248
S100a10 S100 calcium binding protein A10 0.245
Klf9 Kruppel-like factor 9 0.245
Tcf4 transcription factor 4 0.242
Ripk3 receptor-interacting serine-threonine kinase 3 0.236
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.235
S100a9 S100 calcium binding protein A9 0.233
Rara retinoic acid receptor, alpha 0.230
Atf3 activating transcription factor 3 0.222
Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.218
Bmp7 bone morphogenetic protein 7 0.212
Hoxc4 homeo box C4 0.211
Hes1 hairy and enhancer of split 1 (Drosophila) 0.211
Slc4a1 solute carrier family 4 (anion exchanger), member 1 0.206
Jak2 Janus kinase 2 0.196
Kdm6b lysine (K)-specific demethylase 6B 0.196
Foxi2 forkhead box I2 0.195
Myc myelocytomatosis oncogene 0.192
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.186
Tcp11 t-complex protein 11 0.185
Palm paralemmin 0.183
Hsd3b6 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6 0.182
Neurog1 neurogenin 1 0.178
Pcna proliferating cell nuclear antigen 0.178
Lpl lipoprotein lipase 0.177
Smad1 SMAD family member 1 0.173
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.170
Siah1a seven in absentia 1A 0.167
Slc5a1 solute carrier family 5 (sodium/glucose cotransporter), member 1 0.166
Fat2 FAT tumor suppressor homolog 2 (Drosophila) 0.166
Sp1 Sp1 transcription factor 0.166
Axin1 axin 1 0.163
Defb1 defensin beta 1 0.163
Errfi1 ERBB receptor feedback inhibitor 1 0.162
P2rx3 purinergic receptor P2X, ligand-gated ion channel, 3 0.161
Cntn4 contactin 4 0.161
Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.160
Otx1 orthodenticle homeobox 1 0.160
Dab2 disabled homolog 2 (Drosophila) 0.159
Ptbp1 polypyrimidine tract binding protein 1 0.158
Eif4h eukaryotic translation initiation factor 4H 0.155
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.155
Gast gastrin 0.154
Grin2d glutamate receptor, ionotropic, N-methyl D-aspartate 2D 0.154
Egr1 early growth response 1 0.150
Socs7 suppressor of cytokine signaling 7 0.149
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.149
Anxa2 annexin A2 0.148
Flt1 FMS-related tyrosine kinase 1 0.147
Sorbs3 sorbin and SH3 domain containing 3 0.145
Klf4 Kruppel-like factor 4 (gut) 0.144
Pds5b PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) 0.143
Adra2b adrenergic, alpha-2B-, receptor 0.141
Nr4a3 nuclear receptor subfamily 4, group A, member 3 0.141
Klf2 Kruppel-like factor 2 (lung) 0.139
Mapk9 mitogen-activated protein kinase 9 0.139
Ppp2cb protein phosphatase 2, catalytic subunit, beta isoform 0.138
Dchs1 dachsous 1 (Drosophila) 0.138
Jund jun D proto-oncogene 0.138
Msl1 male-specific lethal 1 homolog (Drosophila) 0.137
Foxe3 forkhead box E3 0.137
Nfya nuclear transcription factor-Y alpha 0.136
Synpo synaptopodin 0.135
Thbd thrombomodulin 0.134
A4galt alpha 1,4-galactosyltransferase 0.133
Zfp36l2 zinc finger protein 36, C3H type-like 2 0.133
Abcc1 ATP-binding cassette, subfamily C (CFTR/MRP), member 1 0.132
Shox2 short stature homeobox 2 0.131
Dnaja2 DnaJ (Hsp40) homolog, subfamily A, member 2 0.130
Lphn2 latrophilin 2 0.129
Lhx5 LIM homeobox 5 0.127
Pgam1 phosphoglycerate mutase 1 (brain) 0.127
Dlg1 discs, large homolog 1 (Drosophila) 0.127
Alx1 ALX homeobox 1 0.126
Uts2r urotensin 2 receptor 0.126