The network for 'peptidyl lysine trimethylation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

peptidyl lysine trimethylation

The methylation of peptidyl-lysine to form peptidyl-N6,N6,N6-trimethyl-L-lysine.

Name Description Probability Func Analog Organism
RTF1 Rtf1p 0.178
SWD3 Swd3p 0.123
CTR9 Ctr9p 0.051
SDC1 Sdc1p 0.028
LEO1 Leo1p 0.017
SPP1 Spp1p 0.016
SUB1 Sub1p 0.011
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
prpf-4 Protein PRPF-4 0.022
unc-44 Protein UNC-44 0.020
C09E8.1 Protein C09E8.1 0.017
fbxa-170 Protein FBXA-170 0.017
K09A9.6 Protein K09A9.6 0.014
W06D11.1 Protein W06D11.1 0.014
CELE_F13E9.1 Protein F13E9.1 0.013
pat-2 Protein PAT-2 0.013
lin-3 Protein LIN-3 0.013
C09D4.3 Protein C09D4.3 0.013
rpn-2 Protein RPN-2 0.013
rskd-1 Protein RSKD-1 0.012
C14C11.1 Protein C14C11.1 0.012
suca-1 Protein SUCA-1 0.012
F56B3.6 Protein F56B3.6 0.012
retr-1 Protein RETR-1 0.012
Y71F9AR.3 Protein Y71F9AR.3 0.012
CELE_C15H7.3 Protein C15H7.3 0.012
pgrn-1 Protein PGRN-1 0.011
inx-5 Protein INX-5 0.011
F56D1.2 Protein F56D1.2 0.011
CELE_Y45F10B.13 Protein Y45F10B.13 0.011
Y71F9AL.1 Protein Y71F9AL.1 0.011
C04F5.9 Protein C04F5.9 0.011
met-2 Protein MET-2 0.010
ost-1 Protein OST-1 0.010
C50D2.9 Protein C50D2.9 0.010
dlat-1 Protein DLAT-1 0.010
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
mll4b myeloid/lymphoid or mixed-lineage leukemia 4b 0.454
whsc1l1 Wolf-Hirschhorn syndrome candidate 1-like 1 0.204
whsc1 Wolf-Hirschhorn syndrome candidate 1 0.180
prdm11 PR domain containing 11 0.149
ehmt2 euchromatic histone-lysine N-methyltransferase 2 0.140
setd2 SET domain containing 2 0.111
suv420h2 suppressor of variegation 4-20 homolog 2 (Drosophila) 0.110
ehmt1a euchromatic histone-lysine N-methyltransferase 1a 0.109
nsd1b nuclear receptor binding SET domain protein 1b 0.096
rif1 RAP1 interacting factor homolog (yeast) 0.096
setdb1a SET domain, bifurcated 1a 0.095
mll2 myeloid/lymphoid or mixed-lineage leukemia 2 0.094
si:dkey-181m9.9 si:dkey-181m9.9 0.093
prdm2b PR domain containing 2, with ZNF domain b 0.089
ehmt1b euchromatic histone-lysine N-methyltransferase 1b 0.086
lmnb1 lamin B1 0.085
smyd5 SMYD family member 5 0.077
prdm9 PR domain containing 9 0.075
cbx1a chromobox homolog 1a (HP1 beta homolog Drosophila) 0.065
smyd3 SET and MYND domain containing 3 0.060
mll4a myeloid/lymphoid or mixed-lineage leukemia 4a 0.059
ezh2 enhancer of zeste homolog 2 (Drosophila) 0.056
si:dkey-21n12.1 si:dkey-21n12.1 0.055
usp1 ubiquitin specific protease 1 0.054
setdb1b SET domain, bifurcated 1b 0.048
setd8b SET domain containing (lysine methyltransferase) 8b 0.047
fip1l1 FIP1 like 1 (S. cerevisiae) 0.041
tra2b transformer 2 beta homolog (Drosophila) 0.040
prdm8b PR domain containing 8b 0.037
setd5 SET domain containing 5 0.034
prdm1b PR domain containing 1b, with ZNF domain 0.029
si:ch211-57k11.10 si:ch211-57k11.10 0.028
setd8a SET domain containing (lysine methyltransferase) 8a 0.028
wdr18 WD repeat domain 18 0.025
nktr natural killer-tumor recognition sequence 0.024
tubg1 tubulin, gamma 1 0.023
apex1 APEX nuclease (multifunctional DNA repair enzyme) 1 0.022
ilf3a interleukin enhancer binding factor 3a 0.022
arid4a AT rich interactive domain 4A (RBP1-like) 0.022
ep300b E1A binding protein p300 b 0.021
cnn3b calponin 3, acidic b 0.020
gata1a GATA binding protein 1a 0.020
lsm14ab LSM14 homolog Ab (SCD6, S. cerevisiae) 0.020
zgc:158604 zgc:158604 0.019
nop16 NOP16 nucleolar protein homolog (yeast) 0.019
ap1s2 adaptor-related protein complex 1, sigma 2 subunit 0.019
zcchc8 zinc finger, CCHC domain containing 8 0.018
hcfc1a host cell factor C1a 0.018
LOC100331798 histone H3.3-like 0.018
suv420h1 suppressor of variegation 4-20 homolog 1 (Drosophila) 0.018
si:ch211-51m24.3 si:ch211-51m24.3 0.018
mtmr1b myotubularin related protein 1b 0.016
mycbp2 MYC binding protein 2 0.016
pcdh2ac protocadherin 2 alpha c 0.015
runx2a runt-related transcription factor 2a 0.015
zgc:65979 zgc:65979 0.014
csf3r colony stimulating factor 3 receptor (granulocyte) 0.014
acat1 acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) 0.014
smyd2a SET and MYND domain containing 2a 0.014
zgc:73269 zgc:73269 0.014
sephs1 selenophosphate synthetase 1 0.014
zgc:66100 zgc:66100 0.014
snapc1a small nuclear RNA activating complex, polypeptide 1a 0.014
rbbp6 retinoblastoma binding protein 6 0.013
gpatch8 G patch domain containing 8 0.013
hp1bp3 heterochromatin protein 1, binding protein 3 0.013
myst2 MYST histone acetyltransferase 2 0.013
LOC100333021 cohesin subunit SA-1-like 0.013
atp2b4 ATPase, Ca++ transporting, plasma membrane 4 0.013
wu:fi04c06 wu:fi04c06 0.012
pth2 parathyroid hormone 2 0.012
srrm2 serine/arginine repetitive matrix 2 0.012
tcea1 transcription elongation factor A (SII), 1 0.012
arglu1a arginine and glutamate rich 1a 0.012
zgc:73111 zgc:73111 0.012
LOC567638 hypothetical LOC567638 0.012
zc3h13 zinc finger CCCH-type containing 13 0.012
phax phosphorylated adaptor for RNA export 0.012
ptpn11b protein tyrosine phosphatase, non-receptor type 11, b 0.012
papolg poly(A) polymerase gamma 0.012
ublcp1 ubiquitin-like domain containing CTD phosphatase 1 0.012
zgc:101080 zgc:101080 0.011
si:dkey-97o5.1 si:dkey-97o5.1 0.011
akap8l A kinase (PRKA) anchor protein 8-like 0.011
tfr1a transferrin receptor 1a 0.011
mbd3a methyl-CpG binding domain protein 3a 0.011
neil3 nei endonuclease VIII-like 3 (E. coli) 0.011
asz1 ankyrin repeat, SAM and basic leucine zipper domain containing 1 0.011
cpsf6 cleavage and polyadenylation specific factor 6 0.011
LOC795535 hypothetical protein LOC795535 0.011
sept2 septin 2 0.011
rbbp9 retinoblastoma binding protein 9 0.011
msh2 mutS homolog 2 (E. coli) 0.011
LOC100151531 zinc finger protein Gfi-1b-like 0.011
serhl serine hydrolase-like 0.010
atrx alpha thalassemia/mental retardation syndrome X-linked homolog (human) 0.010
pias4a protein inhibitor of activated STAT, 4a 0.010
rap1a RAP1A, member of RAS oncogene family 0.010
ubxn7 UBX domain protein 7 0.010
zgc:112071 zgc:112071 0.010
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Snr1 Snf5-related 1 0.427
BEAF-32 Boundary element-associated factor of 32kD 0.398
Su(var)3-7 Suppressor of variegation 3-7 0.103
mor moira 0.090
pzg putzig 0.078
snf sans fille 0.066
Spt5 CG7626 gene product from transcript CG7626-RA 0.066
ash1 absent, small, or homeotic discs 1 0.054
Su(var)2-HP2 CG12864 gene product from transcript CG12864-RB 0.049
cg combgap 0.047
tsu tsunagi 0.043
CG5591 CG5591 gene product from transcript CG5591-RA 0.042
MRG15 CG6363 gene product from transcript CG6363-RA 0.040
snama something that sticks like glue 0.038
Moca-cyp CG1866 gene product from transcript CG1866-RA 0.034
Hel25E Helicase at 25E 0.032
Iswi Imitation SWI 0.031
CG2091 CG2091 gene product from transcript CG2091-RA 0.030
Cap-G CG34438 gene product from transcript CG34438-RF 0.029
Bap170 Brahma associated protein 170kD 0.028
Pc Polycomb 0.028
pds5 CG17509 gene product from transcript CG17509-RA 0.027
woc without children 0.027
hkl hook-like 0.027
Caf1 Chromatin assembly factor 1 subunit 0.026
mib1 mind bomb 1 0.025
lin lines 0.025
XNP CG4548 gene product from transcript CG4548-RA 0.025
CG3909 CG3909 gene product from transcript CG3909-RA 0.022
Atu Another transcription unit 0.021
pUf68 poly U binding factor 68kD 0.021
kis kismet 0.019
MED24 Mediator complex subunit 24 0.018
Smn survival motor neuron 0.018
gatA glutamyl-tRNA amidotransferase subunit A 0.018
gpp grappa 0.018
atms antimeros 0.016
bon bonus 0.015
D1 D1 chromosomal protein 0.015
barr barren 0.014
CG6695 CG6695 gene product from transcript CG6695-RA 0.014
capt capulet 0.014
pr-set7 CG3307 gene product from transcript CG3307-RC 0.013
Mi-2 CG8103 gene product from transcript CG8103-RA 0.012
CSN4 COP9 complex homolog subunit 4 0.012
enok enoki mushroom 0.012
polybromo CG11375 gene product from transcript CG11375-RA 0.012
His2Av Histone H2A variant 0.011
Saf-B Scaffold attachment factor B 0.011
Bap55 Brahma associated protein 55kD 0.011
eIF3-S10 CG9805 gene product from transcript CG9805-RA 0.011
CG5013 CG5013 gene product from transcript CG5013-RA 0.011
ph-p polyhomeotic proximal 0.011
CG11266 CG11266 gene product from transcript CG11266-RD 0.011
CG1646 CG1646 gene product from transcript CG1646-RH 0.011
MBD-like CG8208 gene product from transcript CG8208-RA 0.010
CG11242 CG11242 gene product from transcript CG11242-RA 0.010
msl-3 male-specific lethal 3 0.010
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila) 0.831
CBX5 chromobox homolog 5 0.713
WDR5 WD repeat domain 5 0.629
LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.409
HIST1H3B histone cluster 1, H3b 0.294
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.246
LRIF1 ligand dependent nuclear receptor interacting factor 1 0.177
NCOA6 nuclear receptor coactivator 6 0.169
RBBP5 retinoblastoma binding protein 5 0.113
TSC22D1 TSC22 domain family, member 1 0.110
CBX3 chromobox homolog 3 0.107
CDC73 cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.089
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.084
MBD1 methyl-CpG binding domain protein 1 0.061
RSBN1 round spermatid basic protein 1 0.052
MYST3 MYST histone acetyltransferase (monocytic leukemia) 3 0.046
POGZ pogo transposable element with ZNF domain 0.044
ARID4A AT rich interactive domain 4A (RBP1-like) 0.044
ADNP activity-dependent neuroprotector homeobox 0.041
MGEA5 meningioma expressed antigen 5 (hyaluronidase) 0.039
CBX1 chromobox homolog 1 0.034
RANBP2 RAN binding protein 2 0.031
MLL myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.026
CTR9 Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.023
NIPBL Nipped-B homolog (Drosophila) 0.022
CHD8 chromodomain helicase DNA binding protein 8 0.020
LBR lamin B receptor 0.019
PAN3 PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae) 0.018
ARID4B AT rich interactive domain 4B (RBP1-like) 0.018
MEN1 multiple endocrine neoplasia I 0.018
WDR61 WD repeat domain 61 0.017
HCFC1 host cell factor C1 (VP16-accessory protein) 0.016
KDM6A lysine (K)-specific demethylase 6A 0.016
CUL4A cullin 4A 0.016
NSL1 NSL1, MIND kinetochore complex component, homolog (S. cerevisiae) 0.016
PHF19 PHD finger protein 19 0.014
KDM1A lysine (K)-specific demethylase 1A 0.014
USP47 ubiquitin specific peptidase 47 0.014
SETD1A SET domain containing 1A 0.013
ANKRD12 ankyrin repeat domain 12 0.012
TOP2B topoisomerase (DNA) II beta 180kDa 0.011
MLL5 myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila) 0.011
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Arid4b AT rich interactive domain 4B (RBP1-like) 0.781
Arid1a AT rich interactive domain 1A (SWI-like) 0.608
Arid4a AT rich interactive domain 4A (RBP1-like) 0.512
Trim24 tripartite motif-containing 24 0.482
Hdac2 histone deacetylase 2 0.170
Rnf2 ring finger protein 2 0.124
Cbx5 chromobox homolog 5 (Drosophila HP1a) 0.117
Rictor RPTOR independent companion of MTOR, complex 2 0.115
Tnrc6c trinucleotide repeat containing 6C 0.112
Sin3a transcriptional regulator, SIN3A (yeast) 0.098
Sfswap splicing factor, suppressor of white-apricot homolog (Drosophila) 0.096
Trrap transformation/transcription domain-associated protein 0.087
Kdm2b lysine (K)-specific demethylase 2B 0.080
Tnrc6b trinucleotide repeat containing 6b 0.064
Rsf1 remodeling and spacing factor 1 0.059
Hcfc1 host cell factor C1 0.055
Ccnt2 cyclin T2 0.052
Bptf bromodomain PHD finger transcription factor 0.047
Crebbp CREB binding protein 0.044
Sufu suppressor of fused homolog (Drosophila) 0.043
Rbm5 RNA binding motif protein 5 0.042
Pias1 protein inhibitor of activated STAT 1 0.042
Ncoa6 nuclear receptor coactivator 6 0.041
Med13l mediator complex subunit 13-like 0.040
Fam48a family with sequence similarity 48, member A 0.037
Ankrd16 ankyrin repeat domain 16 0.037
Brd4 bromodomain containing 4 0.032
Hdac1 histone deacetylase 1 0.032
Rnf111 ring finger 111 0.031
4921513D23Rik RIKEN cDNA 4921513D23 gene 0.031
1700081L11Rik RIKEN cDNA 1700081L11 gene 0.031
Atp2b1 ATPase, Ca++ transporting, plasma membrane 1 0.029
Chd2 chromodomain helicase DNA binding protein 2 0.027
Smg1 SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans) 0.026
Brwd1 bromodomain and WD repeat domain containing 1 0.026
Rfx7 regulatory factor X, 7 0.025
Zfc3h1 zinc finger, C3H1-type containing 0.025
Zmym2 zinc finger, MYM-type 2 0.024
Nanog Nanog homeobox 0.023
Srsf1 serine/arginine-rich splicing factor 1 0.022
Wbp7 WW domain binding protein 7 0.022
Zc3h13 zinc finger CCCH type containing 13 0.022
Ncoa3 nuclear receptor coactivator 3 0.021
Sfrs18 serine/arginine-rich splicing factor 18 0.021
Trim28 tripartite motif-containing 28 0.020
2810046L04Rik RIKEN cDNA 2810046L04 gene 0.020
Nfya nuclear transcription factor-Y alpha 0.018
Atm ataxia telangiectasia mutated homolog (human) 0.018
Ncbp2 nuclear cap binding protein subunit 2 0.018
Zfp445 zinc finger protein 445 0.018
Sae1 SUMO1 activating enzyme subunit 1 0.017
Top2b topoisomerase (DNA) II beta 0.017
Safb2 scaffold attachment factor B2 0.017
Helz helicase with zinc finger domain 0.017
Arglu1 arginine and glutamate rich 1 0.017
Ddx17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 0.017
Cbx1 chromobox homolog 1 (Drosophila HP1 beta) 0.017
Rbl2 retinoblastoma-like 2 0.016
Ep300 E1A binding protein p300 0.016
Msl1 male-specific lethal 1 homolog (Drosophila) 0.016
Dgcr8 DiGeorge syndrome critical region gene 8 0.016
Rere arginine glutamic acid dipeptide (RE) repeats 0.016
Fam193b family with sequence similarity 193, member B 0.015
Ctcf CCCTC-binding factor 0.015
4933411K20Rik RIKEN cDNA 4933411K20 gene 0.015
Casc3 cancer susceptibility candidate 3 0.015
Mll5 myeloid/lymphoid or mixed-lineage leukemia 5 0.015
Ehmt1 euchromatic histone methyltransferase 1 0.015
Pogz pogo transposable element with ZNF domain 0.015
Spen SPEN homolog, transcriptional regulator (Drosophila) 0.015
Pou2f1 POU domain, class 2, transcription factor 1 0.014
Rbbp7 retinoblastoma binding protein 7 0.014
Erg avian erythroblastosis virus E-26 (v-ets) oncogene related 0.014
Nono non-POU-domain-containing, octamer binding protein 0.014
Hnrnph1 heterogeneous nuclear ribonucleoprotein H1 0.014
Mastl microtubule associated serine/threonine kinase-like 0.014
Scaf4 SR-related CTD-associated factor 4 0.013
Exo1 exonuclease 1 0.013
D030056L22Rik RIKEN cDNA D030056L22 gene 0.013
Vezf1 vascular endothelial zinc finger 1 0.013
Mgea5 meningioma expressed antigen 5 (hyaluronidase) 0.013
Rnf44 ring finger protein 44 0.013
Ino80d INO80 complex subunit D 0.013
Mga MAX gene associated 0.013
Mbtd1 mbt domain containing 1 0.012
Zfp592 zinc finger protein 592 0.012
Baz2a bromodomain adjacent to zinc finger domain, 2A 0.012
Atrx alpha thalassemia/mental retardation syndrome X-linked homolog (human) 0.012
Dync1h1 dynein cytoplasmic 1 heavy chain 1 0.012
Macf1 microtubule-actin crosslinking factor 1 0.012
Ncor1 nuclear receptor co-repressor 1 0.012
Elp2 elongation protein 2 homolog (S. cerevisiae) 0.011
Morc2a microrchidia 2A 0.011
Phf12 PHD finger protein 12 0.011
Leo1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.011
Aqr aquarius 0.011
D4Wsu53e DNA segment, Chr 4, Wayne State University 53, expressed 0.011
Ankrd12 ankyrin repeat domain 12 0.011
Chaf1a chromatin assembly factor 1, subunit A (p150) 0.011
Bcor BCL6 interacting corepressor 0.011
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism