The network for 'response to chemical' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to chemical

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
STE11 Ste11p 0.985
ATG1 Atg1p 0.928
STE4 Ste4p 0.909
PPH21 Pph21p 0.891
STE5 Ste5p 0.863
FUS3 Fus3p 0.829
SWE1 Swe1p 0.814
SSA1 Ssa1p 0.775
STE2 Ste2p 0.767
HOG1 Hog1p 0.766
HSP82 Hsp82p 0.765
BMH1 Bmh1p 0.745
RPN4 Rpn4p 0.742
STE20 Ste20p 0.738
FAR1 Far1p 0.735
TPK1 Tpk1p 0.731
CLA4 Cla4p 0.716
SLT2 Slt2p 0.716
GFA1 Gfa1p 0.675
AGA1 Aga1p 0.672
HSP104 Hsp104p 0.669
FAR11 Far11p 0.635
SNF2 Snf2p 0.630
UIP3 Uip3p 0.618
TSA2 Tsa2p 0.613
YAP1 Yap1p 0.610
AGA2 Aga2p 0.606
HSP42 Hsp42p 0.592
RIM101 Rim101p 0.588
CDC42 Cdc42p 0.579
CPR7 Cpr7p 0.558
RHO1 Rho1p 0.555
SOK2 Sok2p 0.543
BEM1 Bem1p 0.536
CLN3 Cln3p 0.535
SST2 Sst2p 0.534
FUS1 Fus1p 0.531
PFK26 Pfk26p 0.530
GLN3 Gln3p 0.522
MKS1 Mks1p 0.517
FIG2 Fig2p 0.512
RAV1 Rav1p 0.510
GRX4 Grx4p 0.502
MSG5 Msg5p 0.500
STE7 Ste7p 0.496
MFA1 Mfa1p 0.480
DOT6 Dot6p 0.478
SKS1 Sks1p 0.476
PTC1 Ptc1p 0.473
BCY1 Bcy1p 0.468
XBP1 Xbp1p 0.466
RPG1 Rpg1p 0.464
ARP8 Arp8p 0.462
AFT1 Aft1p 0.457
AHC1 Ahc1p 0.456
ROM2 Rom2p 0.456
SET1 Set1p 0.449
STE18 Ste18p 0.448
SSK1 Ssk1p 0.446
SNT1 Snt1p 0.444
URE2 Ure2p 0.442
MIG1 Mig1p 0.437
SAM1 Sam1p 0.435
ULP2 Ulp2p 0.430
TOR1 Tor1p 0.430
LSM1 Lsm1p 0.427
TFS1 Tfs1p 0.426
RRI1 Rri1p 0.422
YAK1 Yak1p 0.421
PDR12 Pdr12p 0.417
MSN4 Msn4p 0.415
CRZ1 Crz1p 0.409
MGA2 Mga2p 0.403
CNB1 Cnb1p 0.401
UGA1 Uga1p 0.396
GRR1 Grr1p 0.395
RTG3 Rtg3p 0.394
UBA1 Uba1p 0.393
GIS1 Gis1p 0.393
SCH9 Sch9p 0.390
GCD7 Gcd7p 0.390
VPS20 Vps20p 0.386
USA1 Usa1p 0.383
FAR3 Far3p 0.382
VPS62 Vps62p 0.379
BDH1 Bdh1p 0.378
GPA1 Gpa1p 0.375
ADR1 Adr1p 0.372
SEC66 Sec66p 0.371
KSS1 Kss1p 0.368
GLR1 Glr1p 0.367
TPK2 Tpk2p 0.365
STE50 Ste50p 0.364
HXT2 Hxt2p 0.362
CUP9 Cup9p 0.361
ISW2 Isw2p 0.356
OTU1 Otu1p 0.356
SHP1 Shp1p 0.354
VAC7 Vac7p 0.352
FIG4 Fig4p 0.351
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
vab-3 Protein VAB-3 0.994
unc-9 Protein UNC-9 0.914
egl-18 Protein EGL-18 0.799
tag-320 Protein TAG-320 0.754
acs-4 Protein ACS-4 0.736
par-5 Protein PAR-5 0.735
egg-6 Protein EGG-6 0.723
nhr-67 Protein NHR-67 0.708
ida-1 Protein IDA-1 0.705
fln-2 Protein FLN-2 0.687
unc-42 Protein UNC-42 0.675
pkg-1 Protein PKG-1 0.652
pry-1 Protein PRY-1 0.651
unc-70 Protein UNC-70 0.649
che-2 Protein CHE-2 0.648
lin-25 Protein LIN-25 0.631
fkh-2 Protein FKH-2 0.630
hlh-2 Protein HLH-2 0.621
osm-5 Protein OSM-5 0.581
unc-104 Protein UNC-104 0.580
CELE_T05E11.3 Protein T05E11.3 0.577
hsp-3 Protein HSP-3 0.576
vab-10 Protein VAB-10 0.569
unc-57 Protein UNC-57 0.561
bar-1 Protein BAR-1 0.559
let-418 Protein LET-418 0.555
unc-73 Protein UNC-73 0.545
egl-8 Protein EGL-8 0.537
sax-3 Protein SAX-3 0.516
cki-2 Protein CKI-2 0.516
egl-46 Protein EGL-46 0.513
jnk-1 Protein JNK-1 0.502
pde-4 Protein PDE-4 0.499
let-2 Protein LET-2 0.493
CELE_Y57A10A.13 Protein Y57A10A.13 0.486
hum-5 Protein HUM-5 0.481
cam-1 Protein CAM-1 0.480
unc-86 Protein UNC-86 0.474
fan-1 Protein FAN-1 0.466
soc-2 Protein SOC-2 0.462
deb-1 Protein DEB-1 0.461
abl-1 Protein ABL-1 0.460
hlh-1 Protein HLH-1 0.458
lin-5 Protein LIN-5 0.457
odr-3 Protein ODR-3 0.453
rfp-1 Protein RFP-1 0.453
ZK686.3 Protein ZK686.3 0.449
mls-2 Protein MLS-2 0.446
eps-8 Protein EPS-8 0.442
daf-11 Protein DAF-11 0.434
mbk-2 Protein MBK-2 0.431
sdz-28 Protein SDZ-28 0.430
sgt-1 Protein SGT-1 0.430
let-60 Protein LET-60 0.426
itr-1 Protein ITR-1 0.425
K10D6.4 Protein K10D6.4 0.424
zip-7 Protein ZIP-7 0.422
egl-5 Protein EGL-5 0.421
mat-3 Protein MAT-3 0.416
cdc-37 Protein CDC-37 0.415
rig-6 Protein RIG-6 0.415
hsp-4 Protein HSP-4 0.412
vab-8 Protein VAB-8 0.412
che-3 Protein CHE-3 0.411
somi-1 Protein SOMI-1 0.410
sym-4 Protein SYM-4 0.409
atg-2 Protein ATG-2 0.407
T28F4.1 Protein T28F4.1 0.403
unc-7 Protein UNC-7 0.397
ldb-1 Protein LDB-1 0.397
hsp-16.1 Protein HSP-16.1 0.393
apr-1 Protein APR-1 0.390
egl-13 Protein EGL-13 0.389
fln-1 Protein FLN-1 0.388
gpb-2 Protein GPB-2 0.386
T10B11.2 Protein T10B11.2 0.386
tbb-4 Protein TBB-4 0.382
unc-62 Protein UNC-62 0.380
sng-1 Protein SNG-1 0.380
npr-1 Protein NPR-1 0.375
unc-32 Protein UNC-32 0.372
lin-17 Protein LIN-17 0.371
shn-1 Protein SHN-1 0.369
ceh-20 Protein CEH-20 0.366
cid-1 Protein CID-1 0.362
clh-5 Protein CLH-5 0.360
syg-1 Protein SYG-1 0.359
mig-2 Protein MIG-2 0.358
unc-98 Protein UNC-98 0.357
vit-6 Protein VIT-6 0.357
hsp-16.41 Protein HSP-16.41 0.355
wrk-1 Protein WRK-1 0.355
pha-4 Protein PHA-4 0.354
unc-83 Protein UNC-83 0.351
ung-1 Protein UNG-1 0.347
egl-15 Protein EGL-15 0.347
F33H2.3 Protein F33H2.3 0.346
cdf-1 Protein CDF-1 0.343
mab-5 Protein MAB-5 0.343
zen-4 Protein ZEN-4 0.341
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Danio rerio
Name Description Probability Func Analog Organism
fgf3 fibroblast growth factor 3 1.000
pitx3 paired-like homeodomain transcription factor 3 0.996
ndr2 nodal-related 2 0.996
wnt8b wingless-type MMTV integration site family, member 8b 0.980
pax6a paired box gene 6a 0.976
fgfr1a fibroblast growth factor receptor 1a 0.973
pax2a paired box gene 2a 0.966
shha sonic hedgehog a 0.965
lef1 lymphocyte enhancer binding factor 1 0.938
gli2a GLI-Kruppel family member GLI2a 0.936
dzip1 DAZ interacting protein 1 0.933
chd chordin 0.928
otpa orthopedia homolog a 0.925
prnprs3 prion protein, related sequence 3 0.920
wnt1 wingless-type MMTV integration site family, member 1 0.913
osr1 odd-skipped related 1 (Drosophila) 0.911
gcm2 glial cells missing homolog 2 (Drosophila) 0.911
egr1 early growth response 1 0.907
cyp11a1 cytochrome P450, subfamily XIA, polypeptide 1 0.905
dag1 dystroglycan 1 0.895
vasa vasa homolog 0.892
boc brother of CDO 0.891
shhb sonic hedgehog b 0.886
sox9a SRY-box containing gene 9a 0.883
ptgs2a prostaglandin-endoperoxide synthase 2a 0.883
tbx20 T-box 20 0.883
efnb2a ephrin B2a 0.879
dlx5a distal-less homeobox gene 5a 0.875
robo3 roundabout homolog 3 0.873
dharma dharma 0.862
col1a1a collagen, type I, alpha 1a 0.856
fabp11a fatty acid binding protein 11a 0.845
lft1 lefty1 0.842
foxn4 forkhead box N4 0.835
piwil1 piwi-like 1 (Drosophila) 0.832
mmp14a matrix metalloproteinase 14a (membrane-inserted) 0.831
igf1ra insulin-like growth factor 1a receptor 0.831
cyp19a1b cytochrome P450, family 19, subfamily A, polypeptide 1b 0.824
etv5b ets variant 5b 0.822
fgfr2 fibroblast growth factor receptor 2 0.822
axin1 axin 1 0.822
bmper BMP binding endothelial regulator 0.817
pomca proopiomelanocortin a 0.808
foxp2 forkhead box P2 0.807
tal1 T-cell acute lymphocytic leukemia 1 0.805
cxcr4a chemokine (C-X-C motif) receptor 4a 0.803
olfm2 olfactomedin 2 0.792
pax8 paired box gene 8 0.791
trpv6 transient receptor potential cation channel, subfamily V, member 6 0.791
dab1a disabled homolog 1a (Drosophila) 0.781
mstnb myostatin b 0.776
gli1 GLI-Kruppel family member 1 0.773
wnt11 wingless-type MMTV integration site family, member 11 0.765
prmt1 protein arginine methyltransferase 1 0.764
dmd dystrophin 0.762
robo2 roundabout homolog 2 0.760
arx aristaless related homeobox 0.756
cdx4 caudal type homeo box transcription factor 4 0.754
sox32 SRY-box containing gene 32 0.753
il17rd interleukin 17 receptor D 0.737
dab1b disabled homolog 1b (Drosophila) 0.737
col4a5 collagen, type IV, alpha 5 (Alport syndrome) 0.718
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.717
arnt2 aryl hydrocarbon receptor nuclear translocator 2 0.714
tp73 tumor protein p73 0.714
tram1 translocating chain-associating membrane protein 1 0.710
hspa5 heat shock protein 5 0.709
fgf8a fibroblast growth factor 8 a 0.708
spry4 sprouty (Drosophila) homolog 4 0.706
spi1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 0.702
chrna1 cholinergic receptor, nicotinic, alpha polypeptide 1 0.692
nrp2b neuropilin 2b 0.686
dlx2a distal-less homeobox gene 2a 0.686
jag2 jagged 2 0.685
foxi3a forkhead box I3a 0.683
lamc1 laminin, gamma 1 0.679
mll myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.678
sulf1 sulfatase 1 0.676
nkx3.2 NK3 homeobox 2 0.673
cdh1 cadherin 1, epithelial 0.662
sox4a SRY-box containing gene 4a 0.661
alcamb activated leukocyte cell adhesion molecule b 0.660
gng3 guanine nucleotide binding protein (G protein), gamma 3 0.657
nf1a neurofibromin 1a 0.656
gro2 groucho 2 0.656
hoxc1a homeo box C1a 0.656
mycbp2 MYC binding protein 2 0.652
gpia glucose phosphate isomerase a 0.647
phox2a paired-like homeobox 2a 0.638
st8sia2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.638
ets1a v-ets erythroblastosis virus E26 oncogene homolog 1a 0.637
ascl1a achaete-scute complex-like 1a (Drosophila) 0.629
pou4f2 POU domain, class 4, transcription factor 2 0.627
tgfb1a transforming growth factor, beta 1a 0.627
atp1b1a ATPase, Na+/K+ transporting, beta 1a polypeptide 0.626
nadl1.2 neural adhesion molecule L1.2 0.624
prdm1a PR domain containing 1a, with ZNF domain 0.623
rx3 retinal homeobox gene 3 0.623
esrrga estrogen-related receptor gamma a 0.623
ptmaa prothymosin, alpha a 0.622
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism