The network for 'iron ion homeostasis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

iron ion homeostasis

Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
ARN1 Arn1p 0.990
TIS11 Tis11p 0.832
FIT2 Fit2p 0.561
GRX3 Grx3p 0.493
FTR1 Ftr1p 0.445
PHO86 Pho86p 0.418
ISU1 Isu1p 0.321
AFT1 Aft1p 0.275
CCC2 Ccc2p 0.251
SIT1 Sit1p 0.229
FRE6 Fre6p 0.192
GRX4 Grx4p 0.171
SKS1 Sks1p 0.155
ENB1 Enb1p 0.155
PEX11 Pex11p 0.151
CFD1 Cfd1p 0.142
FRE1 Fre1p 0.137
YPL088W hypothetical protein 0.129
ISA1 Isa1p 0.128
ZRT3 Zrt3p 0.122
YFH1 Yfh1p 0.105
PEX25 Pex25p 0.105
FET3 Fet3p 0.095
NTG1 Ntg1p 0.093
PHO89 Pho89p 0.090
NFS1 Nfs1p 0.089
HTD2 Htd2p 0.088
ODC2 Odc2p 0.087
ERG8 Erg8p 0.081
IRC21 Irc21p 0.080
PET8 Pet8p 0.076
FIT3 Fit3p 0.075
VMA16 Vma16p 0.075
UTR1 Utr1p 0.073
LYS9 Lys9p 0.073
CYM1 Cym1p 0.070
SPC2 Spc2p 0.070
SAL1 Sal1p 0.067
JAC1 Jac1p 0.062
ERS1 Ers1p 0.062
YHB1 Yhb1p 0.060
MRL1 Mrl1p 0.060
NHX1 Nhx1p 0.057
SFA1 Sfa1p 0.057
FRA1 Fra1p 0.055
SHE3 She3p 0.055
GLG2 Glg2p 0.054
POS5 Pos5p 0.053
PMP2 Pmp2p 0.053
MCX1 Mcx1p 0.052
NTA1 Nta1p 0.052
CNB1 Cnb1p 0.052
GRX5 Grx5p 0.051
TGL4 Tgl4p 0.051
PRK1 Prk1p 0.050
YPR011C hypothetical protein 0.049
CUE4 Cue4p 0.048
GDE1 Gde1p 0.048
ISD11 Isd11p 0.048
YLR137W hypothetical protein 0.045
GDH2 Gdh2p 0.044
RIB3 Rib3p 0.044
UGA3 Uga3p 0.043
CTR2 Ctr2p 0.041
YDL012C hypothetical protein 0.041
AAT2 Aat2p 0.041
ROX1 Rox1p 0.040
PET111 Pet111p 0.039
DSD1 Dsd1p 0.039
KTR5 Ktr5p 0.039
REX3 Rex3p 0.038
YPL216W hypothetical protein 0.038
APD1 Apd1p 0.037
MST1 Mst1p 0.037
SDT1 Sdt1p 0.036
PNG1 Png1p 0.036
DRE2 Dre2p 0.036
UBA1 Uba1p 0.035
AGP1 Agp1p 0.035
YSP3 Ysp3p 0.035
PGA2 Pga2p 0.034
SSQ1 Ssq1p 0.034
RIB1 Rib1p 0.033
RPL41A Rpl41ap 0.033
YPL199C hypothetical protein 0.033
GAS5 Gas5p 0.033
UPS3 Ups3p 0.032
OST4 Ost4p 0.032
CEM1 Cem1p 0.031
YLR264C-A hypothetical protein 0.031
TIM44 Tim44p 0.031
SRD1 Srd1p 0.031
TUB4 Tub4p 0.031
ICS2 Ics2p 0.031
TIM8 Tim8p 0.031
YGL010W hypothetical protein 0.030
HSP60 Hsp60p 0.030
TOK1 Tok1p 0.030
MBF1 Mbf1p 0.029
PPQ1 Ppq1p 0.029
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
R12C12.7 Protein R12C12.7 0.036
T22C1.5 Protein T22C1.5 0.018
CELE_T26A8.1 Protein T26A8.1 0.015
CELE_C29F7.3 Protein C29F7.3 0.014
ced-5 Protein CED-5 0.013
cdd-2 Protein CDD-2 0.010
R07E5.1 Protein R07E5.1 0.010
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Danio rerio
Name Description Probability Func Analog Organism
slc4a1a solute carrier family 4, anion exchanger, member 1a 0.576
hbaa1 hemoglobin alpha adult-1 0.491
hbae3 hemoglobin alpha embryonic-3 0.375
tal1 T-cell acute lymphocytic leukemia 1 0.348
urod uroporphyrinogen decarboxylase 0.328
slc11a2 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 0.208
polr2d polymerase (RNA) II (DNA directed) polypeptide D 0.207
sod1 superoxide dismutase 1, soluble 0.136
zgc:64115 zgc:64115 0.133
slc25a37 solute carrier family 25, member 37 0.118
robo1 roundabout homolog 1 0.093
epas1b endothelial PAS domain protein 1b 0.091
tfr1a transferrin receptor 1a 0.085
prdx2 peroxiredoxin 2 0.081
hmbsb hydroxymethylbilane synthase, b 0.080
cpox coproporphyrinogen oxidase 0.080
grna granulin a 0.077
blvrb biliverdin reductase B (flavin reductase (NADPH)) 0.076
sptb spectrin, beta, erythrocytic 0.063
uros uroporphyrinogen III synthase 0.060
junb jun B proto-oncogene 0.059
ins preproinsulin 0.054
trim33 tripartite motif-containing 33 0.053
fev FEV (ETS oncogene family) 0.051
epb41 erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) 0.047
vmhc ventricular myosin heavy chain 0.046
tlr3 toll-like receptor 3 0.045
hif1ab hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b 0.042
zgc:152984 zgc:152984 0.041
adipor2 adiponectin receptor 2 0.041
gstp1 glutathione S-transferase pi 0.040
gdf6a growth differentiation factor 6a 0.038
acadm acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain 0.038
trpv6 transient receptor potential cation channel, subfamily V, member 6 0.037
pnrc2 proline-rich nuclear receptor coactivator 2 0.037
gng13a guanine nucleotide binding protein (G protein), gamma 13a 0.036
si:ch211-9d9.3 si:ch211-9d9.3 0.034
cyp3c1 cytochrome P450, family 3, subfamily c, polypeptide 1 0.034
mych myelocytomatosis oncogene homolog 0.034
g6pd glucose-6-phosphate dehydrogenase 0.033
notch2 notch homolog 2 0.033
rhcgl1 Rhesus blood group, C glycoprotein, like 1 0.033
klfd Kruppel-like factor d 0.033
zgc:110775 zgc:110775 0.032
pacsin3 protein kinase C and casein kinase substrate in neurons 3 0.032
b2m beta-2-microglobulin 0.031
zgc:92745 zgc:92745 0.031
atp2b1a ATPase, Ca++ transporting, plasma membrane 1a 0.030
sod2 superoxide dismutase 2, mitochondrial 0.029
slc4a4b solute carrier family 4, sodium bicarbonate cotransporter, member 4b 0.029
zgc:73311 zgc:73311 0.029
itgb1a integrin, beta 1a 0.029
cltca clathrin, heavy polypeptide a (Hc) 0.028
adrb2a adrenergic receptor, beta 2a 0.028
mdh1a malate dehydrogenase 1a, NAD (soluble) 0.028
cldng claudin g 0.028
ahr2 aryl hydrocarbon receptor 2 0.028
hdr hematopoietic death receptor 0.028
kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.027
zgc:66484 zgc:66484 0.026
zgc:101847 zgc:101847 0.026
tecrb trans-2,3-enoyl-CoA reductase b 0.025
gng8 guanine nucleotide binding protein (G protein), gamma 8 0.025
eaf1 ELL associated factor 1 0.025
tbp TATA box binding protein 0.025
map1lc3b microtubule-associated protein 1 light chain 3 beta 0.025
gata1a GATA binding protein 1a 0.025
hsd17b12b hydroxysteroid (17-beta) dehydrogenase 12b 0.025
stat1a signal transduction and activation of transcription 1a 0.025
cyp1a cytochrome P450, family 1, subfamily A 0.025
cap1 Cap1 CAP, adenylate cyclase-associated protein 1 0.025
psap prosaposin 0.024
sdcbp syndecan binding protein (syntenin) 0.024
sdha succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.024
gfi1.1 growth factor independent 1.1 0.024
alg3 asparagine-linked glycosylation 3 homolog (S. cerevisiae, alpha-1,3-mannosyltransferase) 0.024
mbnl2 muscleblind-like 2 (Drosophila) 0.023
cops4 COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis) 0.023
dab2 disabled homolog 2 (Drosophila) 0.023
park7 parkinson disease (autosomal recessive, early onset) 7 0.023
gnb1a guanine nucleotide binding protein (G protein), beta polypeptide 1a 0.022
alas2 aminolevulinate, delta-, synthetase 2 0.022
mpeg1 macrophage expressed 1 0.022
glulb glutamate-ammonia ligase (glutamine synthase) b 0.022
bckdhb branched chain ketoacid dehydrogenase E1, beta polypeptide 0.022
gabarapa GABA(A) receptor-associated protein a 0.021
ptprb protein tyrosine phosphatase, receptor type, b 0.021
actn3a actinin alpha 3a 0.021
mt2 metallothionein 2 0.021
tm9sf2 transmembrane 9 superfamily member 2 0.021
cat catalase 0.021
mstna myostatin a 0.020
casrl calcium-sensing receptor, like 0.020
psme2 proteasome activator subunit 2 0.020
smyd1a SET and MYND domain containing 1a 0.020
pou3f3a POU class 3 homeobox 3a 0.020
irf11 interferon regulatory factor 11 0.020
gna13b guanine nucleotide binding protein (G protein), alpha 13b 0.020
ppox protoporphyrinogen oxidase 0.020
abcc4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 0.020
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Drosophila melanogaster
Name Description Probability Func Analog Organism
CG4858 CG4858 gene product from transcript CG4858-RA 0.747
Fer2LCH Ferritin 2 light chain homologue 0.235
Fer1HCH Ferritin 1 heavy chain homologue 0.180
Cat Catalase 0.136
CG32549 CG32549 gene product from transcript CG32549-RD 0.049
CG15741 CG15741 gene product from transcript CG15741-RA 0.045
Sap-r Saposin-related 0.043
Thiolase CG4581 gene product from transcript CG4581-RA 0.035
CG8132 CG8132 gene product from transcript CG8132-RA 0.029
tld tolloid 0.024
CG33156 CG33156 gene product from transcript CG33156-RE 0.017
CG12140 CG12140 gene product from transcript CG12140-RA 0.016
myoglianin CG1838 gene product from transcript CG1838-RD 0.015
cathD CG1548 gene product from transcript CG1548-RA 0.013
rab3-GAP CG7061 gene product from transcript CG7061-RA 0.012
scaf6 CG33522 gene product from transcript CG33522-RA 0.011
CG14985 CG14985 gene product from transcript CG14985-RB 0.011
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
SLC4A1 solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) 0.616
PDZD11 PDZ domain containing 11 0.441
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.383
NAMPT nicotinamide phosphoribosyltransferase 0.254
MAX MYC associated factor X 0.218
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 0.202
SH3BP4 SH3-domain binding protein 4 0.183
SPTB spectrin, beta, erythrocytic 0.183
SDCBP syndecan binding protein (syntenin) 0.160
SPINT1 serine peptidase inhibitor, Kunitz type 1 0.146
SGSM2 small G protein signaling modulator 2 0.097
HFE hemochromatosis 0.080
PPP1R16A protein phosphatase 1, regulatory (inhibitor) subunit 16A 0.064
GYPB glycophorin B (MNS blood group) 0.057
ARNT aryl hydrocarbon receptor nuclear translocator 0.056
RHD Rh blood group, D antigen 0.053
RHCE Rh blood group, CcEe antigens 0.046
HLA-C major histocompatibility complex, class I, C 0.043
CIAPIN1 cytokine induced apoptosis inhibitor 1 0.042
EGLN1 egl nine homolog 1 (C. elegans) 0.042
SKP1 S-phase kinase-associated protein 1 0.038
EPAS1 endothelial PAS domain protein 1 0.031
EGLN3 egl nine homolog 3 (C. elegans) 0.030
SPTA1 spectrin, alpha, erythrocytic 1 (elliptocytosis 2) 0.028
RANBP9 RAN binding protein 9 0.028
VHL von Hippel-Lindau tumor suppressor 0.028
KLF1 Kruppel-like factor 1 (erythroid) 0.026
SQSTM1 sequestosome 1 0.024
NTN1 netrin 1 0.023
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like 0.022
FTH1 ferritin, heavy polypeptide 1 0.021
CHD3 chromodomain helicase DNA binding protein 3 0.020
GSTO1 glutathione S-transferase omega 1 0.018
CLTC clathrin, heavy chain (Hc) 0.018
GOLM1 golgi membrane protein 1 0.018
MYO10 myosin X 0.017
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.017
ACSL1 acyl-CoA synthetase long-chain family member 1 0.016
RAB8A RAB8A, member RAS oncogene family 0.016
FTL ferritin, light polypeptide 0.015
C3 complement component 3 0.015
CORO1C coronin, actin binding protein, 1C 0.015
VAMP3 vesicle-associated membrane protein 3 (cellubrevin) 0.015
SREBF2 sterol regulatory element binding transcription factor 2 0.014
POU2F1 POU class 2 homeobox 1 0.014
MYL4 myosin, light chain 4, alkali; atrial, embryonic 0.014
NBR1 neighbor of BRCA1 gene 1 0.013
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa 0.013
SMAD3 SMAD family member 3 0.013
SNAP23 synaptosomal-associated protein, 23kDa 0.013
ADD2 adducin 2 (beta) 0.013
ANK1 ankyrin 1, erythrocytic 0.013
OCRL oculocerebrorenal syndrome of Lowe 0.012
BIN1 bridging integrator 1 0.012
FN1 fibronectin 1 0.012
PLSCR1 phospholipid scramblase 1 0.012
CAMP cathelicidin antimicrobial peptide 0.012
MAP3K12 mitogen-activated protein kinase kinase kinase 12 0.011
TREM2 triggering receptor expressed on myeloid cells 2 0.011
MYO1G myosin IG 0.011
CSF3R colony stimulating factor 3 receptor (granulocyte) 0.011
HEXDC hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing 0.010
HIP1 huntingtin interacting protein 1 0.010
FBXW2 F-box and WD repeat domain containing 2 0.010
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 0.010
ITM2B integral membrane protein 2B 0.010
IK IK cytokine, down-regulator of HLA II 0.010
STX12 syntaxin 12 0.010
RIPK2 receptor-interacting serine-threonine kinase 2 0.010
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Slc40a1 solute carrier family 40 (iron-regulated transporter), member 1 0.997
Spna1 spectrin alpha 1 0.994
H2-D1 histocompatibility 2, D region locus 1 0.943
B2m beta-2 microglobulin 0.925
Cp ceruloplasmin 0.912
H2-K1 histocompatibility 2, K1, K region 0.887
Hbb-b1 hemoglobin, beta adult major chain 0.806
Slc4a1 solute carrier family 4 (anion exchanger), member 1 0.567
H2-Q7 histocompatibility 2, Q region locus 7 0.515
Klf1 Kruppel-like factor 1 (erythroid) 0.466
Slc11a2 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 0.438
Ftl1 ferritin light chain 1 0.416
Ank1 ankyrin 1, erythroid 0.407
Hfe hemochromatosis 0.373
Hand2 heart and neural crest derivatives expressed transcript 2 0.311
Spnb1 spectrin beta 1 0.301
Gdf3 growth differentiation factor 3 0.283
Egln1 EGL nine homolog 1 (C. elegans) 0.275
Ntn1 netrin 1 0.274
Uros uroporphyrinogen III synthase 0.255
Exoc6 exocyst complex component 6 0.222
Stat1 signal transducer and activator of transcription 1 0.191
Steap3 STEAP family member 3 0.176
Ostm1 osteopetrosis associated transmembrane protein 1 0.166
Hbb-b2 hemoglobin, beta adult minor chain 0.165
Gdf5 growth differentiation factor 5 0.157
Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) 0.152
Bmp7 bone morphogenetic protein 7 0.152
Tbx15 T-box 15 0.152
Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.144
Tapbp TAP binding protein 0.143
Hmox1 heme oxygenase (decycling) 1 0.130
Tspo2 translocator protein 2 0.128
Gypa glycophorin A 0.121
Fcna ficolin A 0.118
Itm2b integral membrane protein 2B 0.116
Elane elastase, neutrophil expressed 0.113
Slc26a9 solute carrier family 26, member 9 0.104
Msx2 homeobox, msh-like 2 0.103
Otx2 orthodenticle homolog 2 (Drosophila) 0.100
H2-Q6 histocompatibility 2, Q region locus 6 0.100
Hba-a2 hemoglobin alpha, adult chain 2 0.095
Rdh10 retinol dehydrogenase 10 (all-trans) 0.095
Arnt2 aryl hydrocarbon receptor nuclear translocator 2 0.091
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.091
Tfrc transferrin receptor 0.089
Nr1h4 nuclear receptor subfamily 1, group H, member 4 0.088
Abcb7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 0.088
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.088
Nfatc2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.085
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.082
Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.081
Clcnka chloride channel Ka 0.079
Atp4a ATPase, H+/K+ exchanging, gastric, alpha polypeptide 0.077
Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) 0.071
Gdf6 growth differentiation factor 6 0.071
Msx1 homeobox, msh-like 1 0.070
Cd5l CD5 antigen-like 0.069
Hoxd13 homeobox D13 0.069
Fech ferrochelatase 0.067
Hoxa13 homeobox A13 0.067
Shbg sex hormone binding globulin 0.066
Lhx1 LIM homeobox protein 1 0.066
Txnip thioredoxin interacting protein 0.065
Cdon cell adhesion molecule-related/down-regulated by oncogenes 0.065
Epor erythropoietin receptor 0.064
Gla galactosidase, alpha 0.063
Fgf15 fibroblast growth factor 15 0.058
Trim10 tripartite motif-containing 10 0.056
Add2 adducin 2 (beta) 0.055
Ftl2 ferritin light chain 2 0.055
Vhl von Hippel-Lindau tumor suppressor 0.054
Alx4 aristaless-like homeobox 4 0.054
Slc22a6 solute carrier family 22 (organic anion transporter), member 6 0.051
Hand1 heart and neural crest derivatives expressed transcript 1 0.050
Hpx hemopexin 0.049
Myo10 myosin X 0.048
Neurog1 neurogenin 1 0.048
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.047
Col4a3 collagen, type IV, alpha 3 0.047
Pklr pyruvate kinase liver and red blood cell 0.047
Cckbr cholecystokinin B receptor 0.046
Bmp4 bone morphogenetic protein 4 0.046
Ccr5 chemokine (C-C motif) receptor 5 0.045
Slc31a1 solute carrier family 31, member 1 0.045
Max Max protein 0.045
Lrp2 low density lipoprotein receptor-related protein 2 0.044
Pnpla6 patatin-like phospholipase domain containing 6 0.044
Cat catalase 0.044
Ppp4c protein phosphatase 4, catalytic subunit 0.043
Tgfbr3 transforming growth factor, beta receptor III 0.043
Ahr aryl-hydrocarbon receptor 0.042
Pah phenylalanine hydroxylase 0.042
Ctsl cathepsin L 0.042
Beta-s hemoglobin subunit beta-1-like 0.040
Hbb-bh1 hemoglobin Z, beta-like embryonic chain 0.040
Mpo myeloperoxidase 0.040
Gbp2 guanylate binding protein 2 0.040
Slc39a4 solute carrier family 39 (zinc transporter), member 4 0.039
Btg4 B-cell translocation gene 4 0.038
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Rattus norvegicus
Name Description Probability Func Analog Organism
RT1-EC2 RT1 class Ib, locus EC2 0.022
LOC100364500 RT1 class I, locus CE11-like 0.011