The network for 'negative regulation of binding' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of binding

Any process that stops or reduces the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
RIM11 Rim11p 0.026
DCS1 Dcs1p 0.024
TPS1 Tps1p 0.020
TPK2 Tpk2p 0.018
SSE2 Sse2p 0.017
FMP21 Fmp21p 0.016
UBI4 Ubi4p 0.016
SSD1 Ssd1p 0.015
TPK1 Tpk1p 0.014
OM45 Om45p 0.014
YET1 Yet1p 0.013
YBR139W hypothetical protein 0.013
RCN2 Rcn2p 0.013
YHR138C hypothetical protein 0.013
PDE1 Pde1p 0.013
RTC3 Rtc3p 0.013
YAK1 Yak1p 0.013
YFL042C hypothetical protein 0.012
AMS1 Ams1p 0.012
MCR1 Mcr1p 0.012
YNL305C hypothetical protein 0.012
AIM17 Aim17p 0.012
RCR2 Rcr2p 0.012
YJL163C hypothetical protein 0.012
ATG1 Atg1p 0.012
YJL132W hypothetical protein 0.011
AFR1 Afr1p 0.011
COQ4 Coq4p 0.011
GID8 Gid8p 0.010
ATG20 Atg20p 0.010
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
ush u-shaped 0.164
Gug Grunge 0.110
numb CG3779 gene product from transcript CG3779-RB 0.095
18w 18 wheeler 0.080
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.059
hth homothorax 0.047
Dad Daughters against dpp 0.046
kay kayak 0.031
fas faint sausage 0.030
ci cubitus interruptus 0.029
shn schnurri 0.026
pnr pannier 0.026
scb scab 0.026
osa CG7467 gene product from transcript CG7467-RD 0.019
tim timeless 0.017
per period 0.017
cora coracle 0.014
Droj2 DnaJ-like-2 0.012
CG6744 CG6744 gene product from transcript CG6744-RA 0.012
spas spastin 0.011
NFAT NFAT homolog 0.011
wb wing blister 0.010
Mes2 CG11100 gene product from transcript CG11100-RB 0.010
Jarid2 CG3654 gene product from transcript CG3654-RD 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1.000
FHL2 four and a half LIM domains 2 0.995
ZNF43 zinc finger protein 43 0.990
BCL2L1 BCL2-like 1 0.964
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.854
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.825
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.774
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.772
ZNF253 zinc finger protein 253 0.716
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.713
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.705
ARRB1 arrestin, beta 1 0.700
ZNF675 zinc finger protein 675 0.666
MAPK14 mitogen-activated protein kinase 14 0.652
JUN jun proto-oncogene 0.631
TAL1 T-cell acute lymphocytic leukemia 1 0.627
SKIL SKI-like oncogene 0.601
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.540
JUP junction plakoglobin 0.524
BCL2 B-cell CLL/lymphoma 2 0.519
FN1 fibronectin 1 0.516
C1QA complement component 1, q subcomponent, A chain 0.500
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 0.464
CCL5 chemokine (C-C motif) ligand 5 0.462
CCR5 chemokine (C-C motif) receptor 5 0.405
SUMO2 SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) 0.375
ESR1 estrogen receptor 1 0.367
ZNF273 zinc finger protein 273 0.344
SOCS3 suppressor of cytokine signaling 3 0.324
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 0.312
ENG endoglin 0.311
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor 0.310
SMAD4 SMAD family member 4 0.305
BAK1 BCL2-antagonist/killer 1 0.299
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.296
ABI2 abl-interactor 2 0.285
HEXIM1 hexamethylene bis-acetamide inducible 1 0.278
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 0.277
DDX21 DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 0.268
SMAD3 SMAD family member 3 0.263
CCL4 chemokine (C-C motif) ligand 4 0.258
AR androgen receptor 0.256
ZNF430 zinc finger protein 430 0.251
ATF3 activating transcription factor 3 0.248
RBBP4 retinoblastoma binding protein 4 0.238
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.223
PEX13 peroxisomal biogenesis factor 13 0.223
MPDZ multiple PDZ domain protein 0.208
ZNF91 zinc finger protein 91 0.201
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.200
HDAC2 histone deacetylase 2 0.198
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 0.198
BAX BCL2-associated X protein 0.195
GSK3B glycogen synthase kinase 3 beta 0.192
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 0.189
AXIN1 axin 1 0.189
PTEN phosphatase and tensin homolog 0.186
FAF1 Fas (TNFRSF6) associated factor 1 0.184
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.183
ZNF117 zinc finger protein 117 0.182
GNLY granulysin 0.180
PXN paxillin 0.176
HDAC1 histone deacetylase 1 0.176
SP100 SP100 nuclear antigen 0.172
DVL1 dishevelled, dsh homolog 1 (Drosophila) 0.167
LRP6 low density lipoprotein receptor-related protein 6 0.162
STAG1 stromal antigen 1 0.161
MAPK1 mitogen-activated protein kinase 1 0.160
ICAM1 intercellular adhesion molecule 1 0.158
FOS FBJ murine osteosarcoma viral oncogene homolog 0.156
CD63 CD63 molecule 0.151
CXCL9 chemokine (C-X-C motif) ligand 9 0.149
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.138
SUMO1 SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) 0.135
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 0.127
CDK9 cyclin-dependent kinase 9 0.125
CCL13 chemokine (C-C motif) ligand 13 0.124
C1QC complement component 1, q subcomponent, C chain 0.124
IDE insulin-degrading enzyme 0.123
CAV1 caveolin 1, caveolae protein, 22kDa 0.122
PDIA3 protein disulfide isomerase family A, member 3 0.121
ZNF93 zinc finger protein 93 0.120
PSEN2 presenilin 2 (Alzheimer disease 4) 0.120
IL8 interleukin 8 0.120
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.117
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.116
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.112
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.111
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.109
TCF4 transcription factor 4 0.104
ZNF254 zinc finger protein 254 0.104
CCL8 chemokine (C-C motif) ligand 8 0.103
ATF2 activating transcription factor 2 0.101
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.099
ZNF708 zinc finger protein 708 0.097
PRF1 perforin 1 (pore forming protein) 0.096
YBX1 Y box binding protein 1 0.094
NR2E3 nuclear receptor subfamily 2, group E, member 3 0.094
ZNF680 zinc finger protein 680 0.093
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.093
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Mus musculus
Name Description Probability Func Analog Organism
Otx2 orthodenticle homolog 2 (Drosophila) 0.976
Pax2 paired box gene 2 0.941
Pitx2 paired-like homeodomain transcription factor 2 0.762
Gata4 GATA binding protein 4 0.677
Isl1 ISL1 transcription factor, LIM/homeodomain 0.652
Pax3 paired box gene 3 0.606
Pax6 paired box gene 6 0.590
Sox2 SRY-box containing gene 2 0.469
Id1 inhibitor of DNA binding 1 0.430
Tgfb2 transforming growth factor, beta 2 0.429
Lhx3 LIM homeobox protein 3 0.400
Foxg1 forkhead box G1 0.398
Fgf8 fibroblast growth factor 8 0.393
Emx1 empty spiracles homolog 1 (Drosophila) 0.362
Ptf1a pancreas specific transcription factor, 1a 0.359
Msx1 homeobox, msh-like 1 0.327
Hand2 heart and neural crest derivatives expressed transcript 2 0.321
Tcf4 transcription factor 4 0.304
Pten phosphatase and tensin homolog 0.303
Emx2 empty spiracles homolog 2 (Drosophila) 0.288
Neurod1 neurogenic differentiation 1 0.277
Klc1 kinesin light chain 1 0.258
Axin1 axin 1 0.251
Foxc1 forkhead box C1 0.248
Mstn myostatin 0.248
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.245
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.241
Ctnnb1 catenin (cadherin associated protein), beta 1 0.241
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.240
Bmp4 bone morphogenetic protein 4 0.233
Id3 inhibitor of DNA binding 3 0.230
Mapk8 mitogen-activated protein kinase 8 0.230
Foxc2 forkhead box C2 0.221
Hey1 hairy/enhancer-of-split related with YRPW motif 1 0.211
Gja1 gap junction protein, alpha 1 0.204
Notch1 Notch gene homolog 1 (Drosophila) 0.200
Tal1 T-cell acute lymphocytic leukemia 1 0.195
Hes5 hairy and enhancer of split 5 (Drosophila) 0.186
Tcfcp2l1 transcription factor CP2-like 1 0.181
Tcf3 transcription factor 3 0.181
Shh sonic hedgehog 0.177
Cry2 cryptochrome 2 (photolyase-like) 0.161
Zic2 zinc finger protein of the cerebellum 2 0.149
Ncoa3 nuclear receptor coactivator 3 0.148
Ednra endothelin receptor type A 0.142
Hes1 hairy and enhancer of split 1 (Drosophila) 0.140
Csnk1e casein kinase 1, epsilon 0.137
Fst follistatin 0.124
Sox11 SRY-box containing gene 11 0.121
Efnb2 ephrin B2 0.120
Nhlh1 nescient helix loop helix 1 0.119
Lhx9 LIM homeobox protein 9 0.114
Gata6 GATA binding protein 6 0.114
Ntf3 neurotrophin 3 0.109
Meox2 mesenchyme homeobox 2 0.108
Hoxd13 homeobox D13 0.106
Arrb1 arrestin, beta 1 0.106
Jag1 jagged 1 0.105
Neurog2 neurogenin 2 0.105
Lmx1b LIM homeobox transcription factor 1 beta 0.103
Mndal myeloid nuclear differentiation antigen like 0.103
Mapk3 mitogen-activated protein kinase 3 0.098
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.094
Rxra retinoid X receptor alpha 0.092
Gsc goosecoid homeobox 0.090
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.086
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.084
Lhx5 LIM homeobox protein 5 0.084
Trp53 transformation related protein 53 0.084
Insm1 insulinoma-associated 1 0.083
Tcfap2a transcription factor AP-2, alpha 0.082
Mesp1 mesoderm posterior 1 0.081
Gli3 GLI-Kruppel family member GLI3 0.081
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.081
Gbp7 guanylate binding protein 7 0.078
Ifit3 interferon-induced protein with tetratricopeptide repeats 3 0.078
En1 engrailed 1 0.077
Atoh7 atonal homolog 7 (Drosophila) 0.076
Thra thyroid hormone receptor alpha 0.074
Foxa2 forkhead box A2 0.072
Kiss1 KiSS-1 metastasis-suppressor 0.072
Mdm2 transformed mouse 3T3 cell double minute 2 0.071
Gata1 GATA binding protein 1 0.071
Tbx1 T-box 1 0.068
Hoxa13 homeobox A13 0.066
Lep leptin 0.065
Runx1t1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.064
Gli2 GLI-Kruppel family member GLI2 0.063
Bmpr1a bone morphogenetic protein receptor, type 1A 0.063
Vangl2 vang-like 2 (van gogh, Drosophila) 0.062
Ifi203 interferon activated gene 203 0.059
Mecom MDS1 and EVI1 complex locus 0.059
Hmx1 H6 homeobox 1 0.057
Neurod4 neurogenic differentiation 4 0.057
Lrp2 low density lipoprotein receptor-related protein 2 0.054
Cbfa2t3 core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human) 0.053
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.053
Gas1 growth arrest specific 1 0.052
Neurog3 neurogenin 3 0.050
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.050
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Rattus norvegicus
Name Description Probability Func Analog Organism