The network for 'aerobic respiration' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

aerobic respiration

The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
COR1 Cor1p 0.782
ACB1 Acb1p 0.735
COX13 Cox13p 0.723
IDH2 Idh2p 0.603
COX2 Cox2p 0.536
CYT1 Cyt1p 0.534
QCR7 Qcr7p 0.439
MDH1 Mdh1p 0.421
PET9 Pet9p 0.389
COX6 Cox6p 0.385
PET309 Pet309p 0.368
SDH2 Sdh2p 0.342
YFH1 Yfh1p 0.299
RPM2 Rpm2p 0.276
QCR6 Qcr6p 0.267
COB Cobp 0.244
EMI5 Emi5p 0.239
SDH1 Sdh1p 0.236
SDH3 Sdh3p 0.234
RIP1 Rip1p 0.224
COX14 Cox14p 0.202
CYC1 Cyc1p 0.198
MSS116 Mss116p 0.191
SCO1 Sco1p 0.188
QCR10 Qcr10p 0.187
COX1 Cox1p 0.176
TIM9 Tim9p 0.172
PDH1 Pdh1p 0.169
IFM1 Ifm1p 0.165
PET100 Pet100p 0.154
MTO1 Mto1p 0.149
IDH1 Idh1p 0.149
LEU2 Leu2p 0.143
TCM62 Tcm62p 0.136
COX5A Cox5ap 0.136
CYB2 Cyb2p 0.136
PET111 Pet111p 0.134
COA1 Coa1p 0.129
NAM2 Nam2p 0.129
CIR2 Cir2p 0.129
AAC1 Aac1p 0.126
HAP4 Hap4p 0.123
SDH4 Sdh4p 0.116
MDL2 Mdl2p 0.114
HUG1 Hug1p 0.113
ATP6 Atp6p 0.113
DED1 Ded1p 0.112
CUP9 Cup9p 0.111
YMR31 Ymr31p 0.109
FMP10 Fmp10p 0.106
OXA1 Oxa1p 0.106
ACH1 Ach1p 0.103
ERG10 Erg10p 0.101
HEM3 Hem3p 0.099
COX4 Cox4p 0.099
PET494 Pet494p 0.096
DIE2 Die2p 0.094
COX18 Cox18p 0.093
REG2 Reg2p 0.093
YLR125W hypothetical protein 0.092
COA4 Coa4p 0.091
YTP1 Ytp1p 0.090
POR1 Por1p 0.087
HEM15 Hem15p 0.086
FAA1 Faa1p 0.084
ADH5 Adh5p 0.084
EAP1 Eap1p 0.083
COX10 Cox10p 0.083
QCR8 Qcr8p 0.082
MIC17 Mic17p 0.081
RPO41 Rpo41p 0.081
PPM2 Ppm2p 0.080
HOM2 Hom2p 0.078
YPR098C hypothetical protein 0.075
COX12 Cox12p 0.075
UBA3 Uba3p 0.074
FUM1 Fum1p 0.073
INO1 Ino1p 0.072
CAF40 Caf40p 0.070
CLU1 Clu1p 0.070
AIM31 Aim31p 0.068
ISU1 Isu1p 0.067
FMP52 Fmp52p 0.067
MIC14 Mic14p 0.067
ODC1 Odc1p 0.066
RSM28 Rsm28p 0.066
RGT1 Rgt1p 0.066
BI4 Bi4p 0.066
ECL1 Ecl1p 0.065
PTM1 Ptm1p 0.063
HTD2 Htd2p 0.063
OLI1 F0-ATP synthase subunit c (ATPase-associated proteolipid), encoded on the mitochondrial genome; mutation confers oligomycin resistance; expression is specifically dependent on the nuclear genes AEP1 and AEP2 0.062
QCR9 Qcr9p 0.061
MRS3 Mrs3p 0.060
COQ9 Coq9p 0.060
ILV6 Ilv6p 0.059
CAR1 Car1p 0.059
YEL073C hypothetical protein 0.058
NDE1 Nde1p 0.058
ICY1 Icy1p 0.058
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Acon Aconitase 0.032
l(1)G0156 lethal (1) G0156 0.022
blw bellwether 0.021
Eno Enolase 0.016
ND75 NADH:ubiquinone reductase 75kD subunit precursor 0.015
CG3731 CG3731 gene product from transcript CG3731-RA 0.011
CG6439 CG6439 gene product from transcript CG6439-RA 0.011
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Homo sapiens
Name Description Probability Func Analog Organism
HDAC1 histone deacetylase 1 0.995
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide 0.937
UQCRC2 ubiquinol-cytochrome c reductase core protein II 0.672
HDAC2 histone deacetylase 2 0.557
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma 0.454
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 0.377
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.351
UQCRC1 ubiquinol-cytochrome c reductase core protein I 0.328
OXA1L oxidase (cytochrome c) assembly 1-like 0.263
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.228
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 0.217
PDHX pyruvate dehydrogenase complex, component X 0.120
PDHB pyruvate dehydrogenase (lipoamide) beta 0.116
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 0.109
HIGD2A HIG1 hypoxia inducible domain family, member 2A 0.095
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 0.087
NCAPD2 non-SMC condensin I complex, subunit D2 0.068
GOT1 glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) 0.059
ECH1 enoyl CoA hydratase 1, peroxisomal 0.058
SUCLG1 succinate-CoA ligase, alpha subunit 0.053
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.050
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha 0.046
ACO2 aconitase 2, mitochondrial 0.044
SNAPIN SNAP-associated protein 0.041
DLAT dihydrolipoamide S-acetyltransferase 0.037
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 0.037
MDH2 malate dehydrogenase 2, NAD (mitochondrial) 0.029
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 0.028
PLDN pallidin homolog (mouse) 0.028
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.027
COX5A cytochrome c oxidase subunit Va 0.024
USPL1 ubiquitin specific peptidase like 1 0.021
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) 0.018
C3orf15 chromosome 3 open reading frame 15 0.018
HADH hydroxyacyl-CoA dehydrogenase 0.018
GPI glucose-6-phosphate isomerase 0.018
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 0.017
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.017
BLOC1S3 biogenesis of lysosomal organelles complex-1, subunit 3 0.016
FH fumarate hydratase 0.016
C21orf33 chromosome 21 open reading frame 33 0.014
GRHPR glyoxylate reductase/hydroxypyruvate reductase 0.012
PFDN1 prefoldin subunit 1 0.012
ADRBK1 adrenergic, beta, receptor kinase 1 0.012
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial 0.012
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 0.012
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa 0.011
PHB2 prohibitin 2 0.010
ACAT1 acetyl-CoA acetyltransferase 1 0.010
VDAC2 voltage-dependent anion channel 2 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Cyc1 cytochrome c-1 0.626
Atp5a1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1 0.582
Aco2 aconitase 2, mitochondrial 0.389
Uqcrfs1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 0.273
Atp5b ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit 0.144
Cs citrate synthase 0.111
Ndufa9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9 0.100
Ndufs1 NADH dehydrogenase (ubiquinone) Fe-S protein 1 0.096
Ndufs2 NADH dehydrogenase (ubiquinone) Fe-S protein 2 0.086
Ndufv1 NADH dehydrogenase (ubiquinone) flavoprotein 1 0.063
Mdh2 malate dehydrogenase 2, NAD (mitochondrial) 0.054
Idh3g isocitrate dehydrogenase 3 (NAD+), gamma 0.053
Uqcrc2 ubiquinol cytochrome c reductase core protein 2 0.039
Uqcrc1 ubiquinol-cytochrome c reductase core protein 1 0.033
Mup10 major urinary protein 10 0.030
LOC100048884 novel member of the major urinary protein (Mup) gene family 0.030
Suclg1 succinate-CoA ligase, GDP-forming, alpha subunit 0.029
Mup19 major urinary protein 19 0.021
Ndufb5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5 0.020
Mup9 major urinary protein 9 0.020
Fh1 fumarate hydratase 1 0.018
Idh3a isocitrate dehydrogenase 3 (NAD+) alpha 0.016
Mup1 major urinary protein 1 0.015
Dlat dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) 0.012
Mup7 major urinary protein 7 0.012
Sdhd succinate dehydrogenase complex, subunit D, integral membrane protein 0.012
Ndufs3 NADH dehydrogenase (ubiquinone) Fe-S protein 3 0.011
Mup12 major urinary protein 12 0.011
Sdha succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.011
Mup2 major urinary protein 2 0.011
Atp5f1 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1 0.010
Mup13 major urinary protein 13 0.010
Mup11 major urinary protein 11 0.010
Mup17 major urinary protein 17 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Atp5a1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 0.997
Mdh1 malate dehydrogenase 1, NAD (soluble) 0.689
Uqcrfs1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 0.545
Atp5c1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 0.538
Slc25a3 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 0.441
Fh1 fumarate hydratase 1 0.437
Mdh2 malate dehydrogenase 2, NAD (mitochondrial) 0.428
Sdha succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.293
Sdhd succinate dehydrogenase complex, subunit D, integral membrane protein 0.240
Idh3B isocitrate dehydrogenase 3 (NAD+) beta 0.226
Cyc1 cytochrome c-1 0.197
Ndufv1 NADH dehydrogenase (ubiquinone) flavoprotein 1 0.134
Ndufs1 NADH dehydrogenase (ubiquinone) Fe-S protein 1 0.119
Atp5g3 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9) 0.102
Ghitm growth hormone inducible transmembrane protein 0.100
Vdac2 voltage-dependent anion channel 2 0.063
Atp5f1 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1 0.055
Ndufs2 NADH dehydrogenase (ubiquinone) Fe-S protein 2 0.046
Pdhb pyruvate dehydrogenase (lipoamide) beta 0.044
Sdhc succinate dehydrogenase complex, subunit C, integral membrane protein 0.042
Acat1 acetyl-coenzyme A acetyltransferase 1 0.039
Uqcrc2 ubiquinol cytochrome c reductase core protein 2 0.039
Hspd1 heat shock protein 1 (chaperonin) 0.031
Cycs cytochrome c, somatic 0.029
Hadhb hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit 0.029
Atp5b ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide 0.029
Aco2 aconitase 2, mitochondrial 0.027
Got1 glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) 0.027
Auh AU RNA binding protein/enoyl-coenzyme A hydratase 0.025
Etfdh electron-transferring-flavoprotein dehydrogenase 0.022
Pdha1 pyruvate dehydrogenase (lipoamide) alpha 1 0.022
Atp6v1e1 ATPase, H+ transporting, lysosomal V1 subunit E1 0.020
Trap1 TNF receptor-associated protein 1 0.018
Slc25a12 solute carrier family 25 (mitochondrial carrier, Aralar), member 12 0.017
Prdx3 peroxiredoxin 3 0.017
Idh3g isocitrate dehydrogenase 3 (NAD), gamma 0.016
Slc25a4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 0.016
Vdac1 voltage-dependent anion channel 1 0.016
Dlat dihydrolipoamide S-acetyltransferase 0.014
LOC259246 alpha-2u globulin PGCL1 0.014
Mccc2 methylcrotonoyl-Coenzyme A carboxylase 2 (beta) 0.012
Ldhb lactate dehydrogenase B 0.012
Mup5 major urinary protein 5 0.012
Chchd10 coiled-coil-helix-coiled-coil-helix domain containing 10 0.011
Ndufa10l1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10-like 1 0.011
Pgk1 phosphoglycerate kinase 1 0.010
Cox7b cytochrome c oxidase subunit VIIb 0.010