The network for 'serine family amino acid metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

serine family amino acid metabolic process

The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
SHM2 Shm2p 0.830
GCV3 Gcv3p 0.590
SER33 Ser33p 0.338
TRP5 Trp5p 0.263
SER3 Ser3p 0.261
GND1 Gnd1p 0.203
LAT1 Lat1p 0.199
ARO2 Aro2p 0.178
SUL1 Sul1p 0.150
GCV1 Gcv1p 0.120
MET3 Met3p 0.118
MTD1 Mtd1p 0.107
ALG13 Alg13p 0.100
GCV2 Gcv2p 0.098
THR1 Thr1p 0.093
DPS1 Dps1p 0.089
ADE12 Ade12p 0.088
FMP40 Fmp40p 0.088
PHO11 Pho11p 0.085
GUS1 Gus1p 0.079
PCL10 Pcl10p 0.079
MET2 Met2p 0.077
ERG13 Erg13p 0.076
BDH1 Bdh1p 0.071
ILV6 Ilv6p 0.069
FPR1 Fpr1p 0.068
NPL3 Npl3p 0.068
NMA2 Nma2p 0.066
ADE17 Ade17p 0.066
ASR1 Asr1p 0.066
MET22 Met22p 0.065
HOM3 Hom3p 0.064
RBK1 Rbk1p 0.063
CYS3 Cys3p 0.062
ASN1 Asn1p 0.057
SUL2 Sul2p 0.054
THR4 Thr4p 0.054
GCY1 Gcy1p 0.053
YGR054W hypothetical protein 0.053
MCH4 Mch4p 0.051
PHO12 Pho12p 0.051
DLD3 Dld3p 0.049
LSC2 Lsc2p 0.049
PRM7 Prm7p 0.048
ADE3 Ade3p 0.048
GNP1 Gnp1p 0.048
ARO10 Aro10p 0.047
SER1 Ser1p 0.045
LEU2 Leu2p 0.044
BIT61 Bit61p 0.042
SAM3 Sam3p 0.042
TPN1 Tpn1p 0.041
ALT1 Alt1p 0.041
MET6 Met6p 0.041
YER163C hypothetical protein 0.040
SRD1 Srd1p 0.040
ADO1 Ado1p 0.039
GDH1 Gdh1p 0.038
ADE1 Ade1p 0.038
STF1 Stf1p 0.038
FAS2 Fas2p 0.036
YLR264C-A hypothetical protein 0.036
ARP10 Arp10p 0.035
ODC1 Odc1p 0.035
YGR205W hypothetical protein 0.035
ADP1 Adp1p 0.035
YLR281C hypothetical protein 0.035
YCT1 Yct1p 0.034
YOL038C-A hypothetical protein 0.034
YAT2 Yat2p 0.034
BSC1 Bsc1p 0.033
RPE1 Rpe1p 0.033
ARO9 Aro9p 0.033
MER1 Mer1p 0.032
ICL2 Icl2p 0.032
MET16 Met16p 0.031
MMF1 Mmf1p 0.031
YLR042C hypothetical protein 0.030
ADH6 Adh6p 0.030
ALP1 Alp1p 0.030
YLR162W hypothetical protein 0.030
ARR2 Arr2p 0.030
YPR157W hypothetical protein 0.029
YJR085C hypothetical protein 0.029
DUG1 Dug1p 0.029
YOR302W hypothetical protein 0.028
CUP1-1 Cup1-1p 0.028
CYB2 Cyb2p 0.028
MET14 Met14p 0.028
HPF1 Hpf1p 0.028
YGR016W hypothetical protein 0.027
YAR068W hypothetical protein 0.027
ZPS1 Zps1p 0.027
PCL9 Pcl9p 0.027
ATP6 Atp6p 0.027
MET8 Met8p 0.027
YIR035C hypothetical protein 0.027
SRX1 Srx1p 0.026
SMF1 Smf1p 0.026
YIR042C hypothetical protein 0.026
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 0.801
AARS alanyl-tRNA synthetase 0.691
GARS glycyl-tRNA synthetase 0.659
MARS methionyl-tRNA synthetase 0.616
PSAT1 phosphoserine aminotransferase 1 0.538
YARS tyrosyl-tRNA synthetase 0.431
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 0.309
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.296
TRIB3 tribbles homolog 3 (Drosophila) 0.123
CARS cysteinyl-tRNA synthetase 0.121
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 0.121
ALDOB aldolase B, fructose-bisphosphate 0.087
PHGDH phosphoglycerate dehydrogenase 0.083
TUBGCP4 tubulin, gamma complex associated protein 4 0.068
IARS isoleucyl-tRNA synthetase 0.054
LONP1 lon peptidase 1, mitochondrial 0.045
ATF4 activating transcription factor 4 (tax-responsive enhancer element B67) 0.041
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.039
XPOT exportin, tRNA (nuclear export receptor for tRNAs) 0.036
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 0.020
SARS seryl-tRNA synthetase 0.018
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma 0.014
ZNF277 zinc finger protein 277 0.014
SLC7A5 solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 0.012
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) 0.012
TARS threonyl-tRNA synthetase 0.012
CHAC1 ChaC, cation transport regulator homolog 1 (E. coli) 0.011
SLC3A2 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 0.011
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 0.011
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Mus musculus
Name Description Probability Func Analog Organism
Gclc glutamate-cysteine ligase, catalytic subunit 0.995
Gclm glutamate-cysteine ligase, modifier subunit 0.991
Atad3a ATPase family, AAA domain containing 3A 0.264
BC048355 cDNA sequence BC048355 0.124
Gsr glutathione reductase 0.098
Gnrh1 gonadotropin releasing hormone 1 0.089
Shmt1 serine hydroxymethyltransferase 1 (soluble) 0.082
Dazap1 DAZ associated protein 1 0.060
Fpgs folylpolyglutamyl synthetase 0.059
Slc6a13 solute carrier family 6 (neurotransmitter transporter, GABA), member 13 0.053
Umps uridine monophosphate synthetase 0.046
Slc19a1 solute carrier family 19 (sodium/hydrogen exchanger), member 1 0.039
Acy1 aminoacylase 1 0.037
Slc6a12 solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 0.031
Dok1 docking protein 1 0.029
Srxn1 sulfiredoxin 1 homolog (S. cerevisiae) 0.028
Lactb2 lactamase, beta 2 0.026
Ifrd2 interferon-related developmental regulator 2 0.025
C1qbp complement component 1, q subcomponent binding protein 0.025
Shmt2 serine hydroxymethyltransferase 2 (mitochondrial) 0.024
Phlda2 pleckstrin homology-like domain, family A, member 2 0.022
F13b coagulation factor XIII, beta subunit 0.020
Smyd5 SET and MYND domain containing 5 0.019
Tbrg4 transforming growth factor beta regulated gene 4 0.019
Pbld2 phenazine biosynthesis-like protein domain containing 2 0.018
Aldob aldolase B, fructose-bisphosphate 0.018
Usp10 ubiquitin specific peptidase 10 0.018
Hspa9 heat shock protein 9 0.017
Rrp1b ribosomal RNA processing 1 homolog B (S. cerevisiae) 0.017
Mif macrophage migration inhibitory factor 0.017
Gdf15 growth differentiation factor 15 0.016
Rrp9 RRP9, small subunit (SSU) processome component, homolog (yeast) 0.016
Sfxn1 sideroflexin 1 0.016
Agxt alanine-glyoxylate aminotransferase 0.016
Tmem183a transmembrane protein 183A 0.016
Clcnka chloride channel Ka 0.016
Hpd 4-hydroxyphenylpyruvic acid dioxygenase 0.016
Eif4a1 eukaryotic translation initiation factor 4A1 0.015
Sars2 seryl-aminoacyl-tRNA synthetase 2 0.015
Tspan12 tetraspanin 12 0.015
Sardh sarcosine dehydrogenase 0.015
Aldh18a1 aldehyde dehydrogenase 18 family, member A1 0.015
Eif4g1 eukaryotic translation initiation factor 4, gamma 1 0.014
Prodh2 proline dehydrogenase (oxidase) 2 0.014
Tpmt thiopurine methyltransferase 0.014
Lap3 leucine aminopeptidase 3 0.014
Prodh proline dehydrogenase 0.014
Hgd homogentisate 1, 2-dioxygenase 0.014
Vegfa vascular endothelial growth factor A 0.013
Mosc1 MOCO sulphurase C-terminal domain containing 1 0.013
Mthfd1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase 0.013
Plin5 perilipin 5 0.013
Aspg asparaginase homolog (S. cerevisiae) 0.013
Pzp pregnancy zone protein 0.013
Gyk glycerol kinase 0.013
Ftcd formiminotransferase cyclodeaminase 0.013
Slc25a13 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13 0.012
Mpzl2 myelin protein zero-like 2 0.012
Agmat agmatine ureohydrolase (agmatinase) 0.012
Mybl2 myeloblastosis oncogene-like 2 0.012
Hpn hepsin 0.012
Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 0.012
Gjb1 gap junction protein, beta 1 0.012
Slc26a1 solute carrier family 26 (sulfate transporter), member 1 0.012
Cwf19l1 CWF19-like 1, cell cycle control (S. pombe) 0.011
Ggnbp1 gametogenetin binding protein 1 0.011
Stc2 stanniocalcin 2 0.011
Zfp335 zinc finger protein 335 0.011
Psmg3 proteasome (prosome, macropain) assembly chaperone 3 0.011
Gnmt glycine N-methyltransferase 0.011
Sod2 superoxide dismutase 2, mitochondrial 0.011
Nadk NAD kinase 0.010
Pkp3 plakophilin 3 0.010
Dmgdh dimethylglycine dehydrogenase precursor 0.010
Slc22a6 solute carrier family 22 (organic anion transporter), member 6 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Mat1a methionine adenosyltransferase I, alpha 0.168
Dpys dihydropyrimidinase 0.114
Upb1 ureidopropionase, beta 0.065
Car5a carbonic anhydrase 5a, mitochondrial 0.062
Asgr1 asialoglycoprotein receptor 1 0.041
Pah phenylalanine hydroxylase 0.040
Ass1 argininosuccinate synthetase 1 0.039
Mro maestro 0.039
Olr59 olfactory receptor 59 0.038
Gtpbp4 GTP binding protein 4 0.031
Ube2z ubiquitin-conjugating enzyme E2Z 0.030
Fabp1 fatty acid binding protein 1, liver 0.029
Nolc1 nucleolar and coiled-body phosphoprotein 1 0.029
Gys2 glycogen synthase 2 0.028
Ung uracil-DNA glycosylase 0.028
Afm afamin 0.027
Sds serine dehydratase 0.026
Ahcy adenosylhomocysteinase 0.025
Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 0.024
Rcan1 regulator of calcineurin 1 0.024
Tbl3 transducin (beta)-like 3 0.023
Azgp1 alpha-2-glycoprotein 1, zinc-binding 0.023
Fbp1 fructose-1,6-bisphosphatase 1 0.022
Prodh2 proline dehydrogenase (oxidase) 2 0.022
Faah fatty acid amide hydrolase 0.022
Apoc4 apolipoprotein C-IV 0.021
Sardh sarcosine dehydrogenase 0.021
Tfec transcription factor EC 0.021
Abcc6 ATP-binding cassette, subfamily C (CFTR/MRP), member 6 0.021
Lipc lipase, hepatic 0.020
Gulo gulonolactone (L-) oxidase 0.020
RGD1305347 similar to RIKEN cDNA 2610528J11 0.020
Cyp2c23 cytochrome P450, family 2, subfamily c, polypeptide 23 0.020
Dhtkd1 dehydrogenase E1 and transketolase domain containing 1 0.019
Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 0.019
Dmgdh dimethylglycine dehydrogenase 0.019
Hmbs hydroxymethylbilane synthase 0.018
Xpnpep2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 0.018
Aadac arylacetamide deacetylase (esterase) 0.018
Keg1 kidney expressed gene 1 0.018
Nr1h4 nuclear receptor subfamily 1, group H, member 4 0.018
Kynu kynureninase (L-kynurenine hydrolase) 0.017
Ubqln1 ubiquilin 1 0.017
Prss2 protease, serine, 2 0.017
Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 0.016
Apom apolipoprotein M 0.016
Grhpr glyoxylate reductase/hydroxypyruvate reductase 0.016
Apob apolipoprotein B 0.016
Slc31a1 solute carrier family 31 (copper transporters), member 1 0.016
Hpd 4-hydroxyphenylpyruvate dioxygenase 0.016
Hnf1a HNF1 homeobox A 0.015
Bola3 bolA homolog 3 (E. coli) 0.015
Bhmt betaine-homocysteine methyltransferase 0.015
Hpn hepsin 0.015
Aadat aminoadipate aminotransferase 0.015
Adhfe1 alcohol dehydrogenase, iron containing, 1 0.015
Mdm2 Mdm2 p53 binding protein homolog (mouse) 0.015
Proc protein C 0.014
Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 0.014
Baat bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase) 0.014
Tp53 tumor protein p53 0.014
Afp alpha-fetoprotein 0.014
Abcc2 ATP-binding cassette, subfamily C (CFTR/MRP), member 2 0.014
Atad3a ATPase family, AAA domain containing 3A 0.014
Cela1 chymotrypsin-like elastase family, member 1 0.014
Snrpa small nuclear ribonucleoprotein polypeptide A 0.014
Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 0.013
Gjb1 gap junction protein, beta 1 0.013
RGD620382 Nucleoside 2-deoxyribosyltransferase domain containing protein RGD620382 0.013
Casp6 caspase 6 0.013
Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 0.013
Bckdhb branched chain keto acid dehydrogenase E1, beta polypeptide 0.012
Sult1c2 sulfotransferase family, cytosolic, 1C, member 2 0.012
Pdcd6ip programmed cell death 6 interacting protein 0.012
Vcp valosin-containing protein 0.012
Slc6a13 solute carrier family 6 (neurotransmitter transporter, GABA), member 13 0.012
Ces1c carboxylesterase 1C 0.012
Thop1 thimet oligopeptidase 1 0.012
Hmox1 heme oxygenase (decycling) 1 0.012
Pus1 pseudouridylate synthase 1 0.012
Amh anti-Mullerian hormone 0.011
Srxn1 sulfiredoxin 1 homolog (S. cerevisiae) 0.011
Dcxr dicarbonyl L-xylulose reductase 0.011
Gckr glucokinase (hexokinase 4) regulator 0.011
Khk ketohexokinase 0.011
Slco1b3 solute carrier organic anion transporter family, member 1b3 0.011
Dhfr dihydrofolate reductase 0.011
Hal histidine ammonia lyase 0.011
Adh1 alcohol dehydrogenase 1 (class I) 0.011
Gclc glutamate-cysteine ligase, catalytic subunit 0.010
Sult1a1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 0.010
Dpyd dihydropyrimidine dehydrogenase 0.010
RGD1564865 similar to 20-alpha-hydroxysteroid dehydrogenase 0.010
Mocs1 molybdenum cofactor synthesis 1 0.010
Haao 3-hydroxyanthranilate 3,4-dioxygenase 0.010