The network for 'mitotic cell cycle checkpoint' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

mitotic cell cycle checkpoint

A cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.

Name Description Probability Func Analog Organism
GLC7 Glc7p 0.979
MAD2 Mad2p 0.831
GIC1 Gic1p 0.742
SLK19 Slk19p 0.725
KEL1 Kel1p 0.694
RAD53 Rad53p 0.657
CDC55 Cdc55p 0.651
BUB3 Bub3p 0.553
PPH22 Pph22p 0.485
PPH21 Pph21p 0.467
BCK1 Bck1p 0.460
DBF4 Dbf4p 0.455
RAD52 Rad52p 0.415
CDC6 Cdc6p 0.367
CTF18 Ctf18p 0.333
SIC1 Sic1p 0.333
CDC28 Cdc28p 0.319
BUB1 Bub1p 0.314
SPT5 Spt5p 0.306
ZDS2 Zds2p 0.303
CKA1 Cka1p 0.299
CDC20 Cdc20p 0.291
MCM21 Mcm21p 0.283
CDC14 Cdc14p 0.276
BMH2 Bmh2p 0.269
RTS1 Rts1p 0.261
DIA2 Dia2p 0.234
TFG1 Tfg1p 0.230
MCD1 Mcd1p 0.211
BFA1 Bfa1p 0.210
DPB2 Dpb2p 0.191
CHL1 Chl1p 0.191
PPZ1 Ppz1p 0.186
CTF4 Ctf4p 0.185
CTF13 Ctf13p 0.184
NUD1 Nud1p 0.177
BMH1 Bmh1p 0.174
IML3 Iml3p 0.174
FMP48 Fmp48p 0.174
SMC4 Smc4p 0.170
CSE4 Cse4p 0.167
DUN1 Dun1p 0.166
SDS22 Sds22p 0.163
ELG1 Elg1p 0.161
RPO26 Rpo26p 0.160
POL30 Pol30p 0.157
CLB6 Clb6p 0.155
KIN3 Kin3p 0.152
SLI15 Sli15p 0.144
BIM1 Bim1p 0.141
NOP6 Nop6p 0.138
FAR1 Far1p 0.133
GBP2 Gbp2p 0.132
RPB3 Rpb3p 0.126
LCD1 Lcd1p 0.123
RCO1 Rco1p 0.119
MAD3 Mad3p 0.118
SCC2 Scc2p 0.115
SET1 Set1p 0.112
MCM10 Mcm10p 0.111
PDS1 Pds1p 0.111
CIN1 Cin1p 0.110
KIC1 Kic1p 0.109
CKS1 Cks1p 0.109
MRC1 Mrc1p 0.106
REG1 Reg1p 0.106
CLA4 Cla4p 0.105
PEX22 Pex22p 0.103
DSN1 Dsn1p 0.099
CLB1 Clb1p 0.098
GSY2 Gsy2p 0.098
DMA2 Dma2p 0.098
PLC1 Plc1p 0.097
POL1 Pol1p 0.094
SGO1 Sgo1p 0.094
RAD9 Rad9p 0.093
MAD1 Mad1p 0.090
SRS2 Srs2p 0.090
PCL10 Pcl10p 0.089
MCM6 Mcm6p 0.088
PDS5 Pds5p 0.086
IST1 Ist1p 0.086
RRM3 Rrm3p 0.084
STU1 Stu1p 0.084
TID3 Tid3p 0.081
CDC12 Cdc12p 0.080
EAF1 Eaf1p 0.079
CDC15 Cdc15p 0.079
RNH202 Rnh202p 0.078
MOB2 Mob2p 0.078
HSL1 Hsl1p 0.076
CTF3 Ctf3p 0.076
MPT5 Mpt5p 0.076
KIN1 Kin1p 0.074
MCM2 Mcm2p 0.074
SKM1 Skm1p 0.074
POL2 Pol2p 0.073
GPH1 Gph1p 0.073
DEF1 Def1p 0.072
ZDS1 Zds1p 0.071
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
rnr-1 Protein RNR-1 0.145
imb-2 Protein IMB-2 0.071
csn-3 Protein CSN-3 0.069
brc-1 Protein BRC-1 0.065
his-45 Protein HIS-45 0.051
hcf-1 Protein HCF-1 0.051
T28D9.4 Protein T28D9.4 0.048
egl-18 Protein EGL-18 0.048
bub-1 Protein BUB-1 0.041
lmn-1 Protein LMN-1 0.039
B0205.9 Protein B0205.9 0.036
cep-1 Protein CEP-1 0.036
D1081.8 Protein D1081.8 0.034
cin-4 Protein CIN-4 0.033
lex-1 Protein LEX-1 0.032
his-6 Protein HIS-6 0.028
mat-3 Protein MAT-3 0.026
CELE_C24H12.5 Protein C24H12.5 0.026
sas-6 Protein SAS-6 0.026
Y59E9AL.4 Protein Y59E9AL.4 0.025
rod-1 Protein ROD-1 0.024
pcn-1 Protein PCN-1 0.022
nra-1 Protein NRA-1 0.021
npp-16 Protein NPP-16 0.021
npp-21 Protein NPP-21 0.020
cyb-2.1 Protein CYB-2.1 0.020
htz-1 Protein HTZ-1 0.020
wht-7 Protein WHT-7 0.019
csn-1 Protein CSN-1 0.019
rps-15 Protein RPS-15 0.018
sas-5 Protein SAS-5 0.018
hsr-9 Protein HSR-9 0.018
tba-2 Protein TBA-2 0.017
set-1 Protein SET-1 0.017
isw-1 Protein ISW-1 0.016
cul-1 Protein CUL-1 0.016
F20A1.9 Protein F20A1.9 0.016
his-42 Protein HIS-42 0.015
hpo-10 Protein HPO-10 0.015
npp-11 Protein NPP-11 0.015
uaf-1 Protein UAF-1 0.015
rpa-1 Protein RPA-1 0.014
hpo-9 Protein HPO-9 0.014
mcm-5 Protein MCM-5 0.014
emb-5 Protein EMB-5 0.014
T22C1.1 Protein T22C1.1 0.014
him-10 Protein HIM-10 0.014
dpl-1 Protein DPL-1 0.014
lin-9 Protein LIN-9 0.014
C30A5.3 Protein C30A5.3 0.013
dsh-2 Protein DSH-2 0.013
hcp-1 Protein HCP-1 0.012
fic-1 Protein FIC-1 0.012
T05E8.3 Protein T05E8.3 0.012
mex-5 Protein MEX-5 0.012
pri-2 Protein PRI-2 0.011
F25B3.6 Protein F25B3.6 0.011
klp-19 Protein KLP-19 0.011
cul-2 Protein CUL-2 0.011
spt-5 Protein SPT-5 0.011
ZK507.6 Protein ZK507.6 0.010
rev-1 Protein REV-1 0.010
csn-2 Protein CSN-2 0.010
panl-2 Protein PANL-2 0.010
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
pcna proliferating cell nuclear antigen 0.235
ccnd1 cyclin D1 0.214
ywhaqb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b 0.205
ywhae1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 0.139
mcm5 MCM5 minichromosome maintenance deficient 5 (S. cerevisiae) 0.136
stil TAL1 (SCL) interrupting locus 0.130
aurkb aurora kinase B 0.123
ccnb1 cyclin B1 0.112
myca myelocytomatosis oncogene a 0.100
brd2a bromodomain-containing 2a 0.092
ywhabb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b 0.080
cand1 cullin-associated and neddylation-dissociated 1 0.072
mobkl3 MOB1, Mps One Binder kinase activator-like 3 (yeast) 0.067
plk1 polo-like kinase 1 (Drosophila) 0.063
tgif1 TGFB-induced factor homeobox 1 0.059
kpna2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 0.051
ccnb2 cyclin B2 0.047
fen1 flap structure-specific endonuclease 1 0.046
ywhaqa tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a 0.044
pafah1b1b platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b 0.042
chaf1b chromatin assembly factor 1, subunit B 0.041
zff9 zinc finger protein 9 0.038
tfam transcription factor A, mitochondrial 0.038
sumo3a SMT3 suppressor of mif two 3 homolog 3a 0.037
aurka aurora kinase A 0.036
ywhabl tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like 0.036
cdk8 cyclin-dependent kinase 8 0.036
rhoab ras homolog gene family, member Ab 0.035
si:ch211-59d15.5 si:ch211-59d15.5 0.034
rad21 RAD21 homolog (S. pombe) 0.033
ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform 0.033
ncapg non-SMC condensin I complex, subunit G 0.029
ywhaba tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a 0.028
ube2g2 ubiquitin-conjugating enzyme E2G 2 0.028
atrx alpha thalassemia/mental retardation syndrome X-linked homolog (human) 0.028
ccna2 cyclin A2 0.028
g2e3 G2/M-phase specific E3 ubiquitin ligase 0.027
smc3 structural maintenance of chromosomes 3 0.025
chek1 CHK1 checkpoint homolog (S. pombe) 0.024
hug HuG 0.023
esco2 establishment of cohesion 1 homolog 2 0.023
rrm1 ribonucleotide reductase M1 polypeptide 0.023
ybx1 Y box binding protein 1 0.023
ppp2r5eb protein phosphatase 2, regulatory subunit B', epsilon isoform b 0.022
tbc1d23 TBC1 domain family, member 23 0.022
pak2b p21 (CDKN1A)-activated kinase 2b 0.022
pafah1b1a platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit a 0.022
rpl7a ribosomal protein L7a 0.022
gnb2l1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 0.022
fabp7a fatty acid binding protein 7, brain, a 0.022
naa15b N(alpha)-acetyltransferase 15, NatA auxiliary subunit b 0.021
snrpd1 small nuclear ribonucleoprotein D1 polypeptide 0.021
sass6 spindle assembly 6 homolog (C. elegans) 0.020
mdm2 transformed 3T3 cell double minute 2 homolog (mouse) 0.020
cstf1 cleavage stimulation factor, 3' pre-RNA, subunit 1 0.020
ing5b inhibitor of growth family, member 5b 0.020
tia1 cytotoxic granule-associated RNA binding protein 1 0.020
gdf6a growth differentiation factor 6a 0.019
id2a inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a 0.019
kif23 kinesin family member 23 0.018
ck2b casein kinase 2 beta 0.018
ube2i2 ubiquitin-conjugating enzyme E2I2 0.017
wu:fq41a10 wu:fq41a10 0.016
rqcd1 RCD1 required for cell differentiation1 homolog (S. pombe) 0.016
orc6 origin recognition complex, subunit 6 0.016
caprin1a cell cycle associated protein 1a 0.016
srsf1a serine/arginine-rich splicing factor 1a 0.015
lsm8 LSM8 homolog, U6 small nuclear RNA associated 0.015
smc1al structural maintenance of chromosomes 1A, like 0.015
cul3a cullin 3a 0.015
crip2 cysteine-rich protein 2 0.015
dtl denticleless homolog (Drosophila) 0.014
rasl11b RAS-like, family 11, member B 0.014
dnmt5 DNA (cytosine-5-)-methyltransferase 5 0.014
usp4 ubiquitin specific protease 4 (proto-oncogene) 0.014
csnk1g2b casein kinase 1, gamma 2b 0.014
smc4 structural maintenance of chromosomes 4 0.014
eif2d eukaryotic translation initiation factor 2D 0.014
nasp nuclear autoantigenic sperm protein (histone-binding) 0.014
skp2 S-phase kinase-associated protein 2 (p45) 0.013
prkrir protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) 0.013
cdt1 chromatin licensing and DNA replication factor 1 0.013
dct dopachrome tautomerase 0.013
kif14 kinesin family member 14 0.013
ncapd2 non-SMC condensin I complex, subunit D2 0.013
lrwd1 leucine-rich repeats and WD repeat domain containing 1 0.013
acp5a acid phosphatase 5a, tartrate resistant 0.012
msh6 mutS homolog 6 (E. coli) 0.012
tmem167a transmembrane protein 167A 0.012
cdc20 cell division cycle 20 homolog 0.012
ccnt2b cyclin T2b 0.012
zgc:101598 zgc:101598 0.012
prim1 primase polypeptide 1 0.012
ccne cyclin E 0.012
mab21l1 mab-21-like 1 0.012
crkl v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.012
celsr3 cadherin, EGF LAG seven-pass G-type receptor 3 0.011
wdr82 WD repeat domain containing 82 0.011
mapk3 mitogen-activated protein kinase 3 0.011
zgc:113183 zgc:113183 0.011
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
p53 CG33336 gene product from transcript CG33336-RB 0.923
Pp1-87B Protein phosphatase 1 at 87B 0.881
lok loki 0.875
Pp2A-29B Protein phosphatase 2A at 29B 0.872
Dref DNA replication-related element factor 0.858
skpA CG16983 gene product from transcript CG16983-RD 0.855
MED6 Mediator complex subunit 6 0.847
rad50 CG6339 gene product from transcript CG6339-RD 0.839
RanGap Ran GTPase activating protein 0.811
CSN5 COP9 complex homolog subunit 5 0.805
mus205 mutagen-sensitive 205 0.793
polo CG12306 gene product from transcript CG12306-RA 0.784
asp abnormal spindle 0.762
Iswi Imitation SWI 0.723
DNApol-eta CG7143 gene product from transcript CG7143-RA 0.695
cdc2 CG5363 gene product from transcript CG5363-RA 0.683
Rcd1 Reduction in Cnn dots 1 0.676
Brca2 Breast cancer 2, early onset homolog 0.655
CSN3 COP9 complex homolog subunit 3 0.654
cdc2c CG10498 gene product from transcript CG10498-RC 0.642
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.608
pic piccolo 0.607
BRWD3 CG31132 gene product from transcript CG31132-RA 0.602
CG13298 CG13298 gene product from transcript CG13298-RA 0.589
imd immune deficiency 0.588
Lnk CG17367 gene product from transcript CG17367-RC 0.587
scny scrawny 0.585
hay haywire 0.575
Bap55 Brahma associated protein 55kD 0.571
tefu telomere fusion 0.553
Nup50 Nucleoporin 50 0.549
poly CG9829 gene product from transcript CG9829-RB 0.520
Cdc37 CG12019 gene product from transcript CG12019-RA 0.464
Tip60 CG6121 gene product from transcript CG6121-RA 0.439
CG15141 CG15141 gene product from transcript CG15141-RA 0.436
CG4699 CG4699 gene product from transcript CG4699-RJ 0.425
CSN7 COP9 complex homolog subunit 7 0.425
cdm cadmus 0.405
chico CG5686 gene product from transcript CG5686-RB 0.385
CG5524 CG5524 gene product from transcript CG5524-RA 0.372
borr borealin-related 0.372
CSN4 COP9 complex homolog subunit 4 0.361
Spc105R Spc105-related 0.360
okr okra 0.351
CkIIbeta Casein kinase II beta subunit 0.344
mus304 mutagen-sensitive 304 0.341
ncd non-claret disjunctional 0.328
fzy fizzy 0.325
Hdac3 Histone deacetylase 3 0.319
Cap-G CG34438 gene product from transcript CG34438-RF 0.312
Mcm7 Minichromosome maintenance 7 0.311
dre4 CG1828 gene product from transcript CG1828-RB 0.310
Nup153 Nucleoporin 153 0.301
wapl wings apart-like 0.297
Klp3A Kinesin-like protein at 3A 0.292
glu gluon 0.284
CDC45L CG3658 gene product from transcript CG3658-RA 0.274
cnn centrosomin 0.274
Akt1 CG4006 gene product from transcript CG4006-RA 0.269
eIF4AIII CG7483 gene product from transcript CG7483-RA 0.258
Mcm10 Sensitized chromosome inheritance modifier 19 0.255
alphaTub67C alpha-Tubulin at 67C 0.255
CG9772 CG9772 gene product from transcript CG9772-RB 0.254
Trn Transportin 0.243
His2Av Histone H2A variant 0.239
Cat Catalase 0.232
CycB3 Cyclin B3 0.230
l(2)NC136 lethal (2) NC136 0.225
trol terribly reduced optic lobes 0.225
B52 CG10851 gene product from transcript CG10851-RB 0.223
CG34415 CG34415 gene product from transcript CG34415-RC 0.222
Sas-4 CG10061 gene product from transcript CG10061-RA 0.218
CSN8 COP9 complex homolog subunit 8 0.213
gwl greatwall 0.213
pie pineapple eye 0.209
MED31 Mediator complex subunit 31 0.209
flfl falafel 0.205
RpII140 RNA polymerase II 140kD subunit 0.202
CHORD CG6198 gene product from transcript CG6198-RA 0.201
mago mago nashi 0.198
KP78b CG17216 gene product from transcript CG17216-RB 0.195
CG9797 CG9797 gene product from transcript CG9797-RA 0.194
SAK Sak kinase 0.194
SMC1 CG6057 gene product from transcript CG6057-RA 0.193
CG10754 CG10754 gene product from transcript CG10754-RA 0.192
CG10267 CG10267 gene product from transcript CG10267-RB 0.190
Srp54 CG4602 gene product from transcript CG4602-RA 0.188
mus308 mutagen-sensitive 308 0.188
tos tosca 0.188
alph alphabet 0.185
mus301 mutagen-sensitive 301 0.184
Spt5 CG7626 gene product from transcript CG7626-RA 0.182
Cdk4 Cyclin-dependent kinase 4 0.180
Liprin-alpha CG11199 gene product from transcript CG11199-RB 0.179
Fcp1 CG12252 gene product from transcript CG12252-RA 0.177
CG9576 CG9576 gene product from transcript CG9576-RA 0.176
Caf1 Chromatin assembly factor 1 subunit 0.175
Uch-L3 Ubiquitin C-terminal hydrolase 0.174
mats mob as tumor suppressor 0.173
plu plutonium 0.167
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
TP53 tumor protein p53 1.000
RB1 retinoblastoma 1 1.000
MDM2 Mdm2 p53 binding protein homolog (mouse) 1.000
BRCA1 breast cancer 1, early onset 0.998
RAD51 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) 0.992
MDC1 mediator of DNA-damage checkpoint 1 0.989
CDK2 cyclin-dependent kinase 2 0.981
COPS5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) 0.981
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.932
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.916
PLK1 polo-like kinase 1 0.886
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.847
BRCA2 breast cancer 2, early onset 0.798
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.761
H2AFX H2A histone family, member X 0.756
E2F1 E2F transcription factor 1 0.751
RBL1 retinoblastoma-like 1 (p107) 0.749
RAD50 RAD50 homolog (S. cerevisiae) 0.717
CDC25A cell division cycle 25 homolog A (S. pombe) 0.717
COPS4 COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis) 0.688
BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) 0.676
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.670
BCL2 B-cell CLL/lymphoma 2 0.616
CHEK1 CHK1 checkpoint homolog (S. pombe) 0.612
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.611
SKP2 S-phase kinase-associated protein 2 (p45) 0.605
HDAC1 histone deacetylase 1 0.601
CUL1 cullin 1 0.593
BCL2L1 BCL2-like 1 0.590
XIAP X-linked inhibitor of apoptosis 0.573
CLSPN claspin 0.568
CCNE1 cyclin E1 0.567
CUL2 cullin 2 0.544
EME1 essential meiotic endonuclease 1 homolog 1 (S. pombe) 0.506
CCNA2 cyclin A2 0.503
CUL4A cullin 4A 0.500
CDC45 cell division cycle 45 homolog (S. cerevisiae) 0.480
MCM7 minichromosome maintenance complex component 7 0.469
MSH6 mutS homolog 6 (E. coli) 0.468
CCNB1 cyclin B1 0.464
BUB1B budding uninhibited by benzimidazoles 1 homolog beta (yeast) 0.464
TOPBP1 topoisomerase (DNA) II binding protein 1 0.458
UBE2D1 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) 0.454
CHEK2 CHK2 checkpoint homolog (S. pombe) 0.447
PARP1 poly (ADP-ribose) polymerase 1 0.441
PPP2R1B protein phosphatase 2, regulatory subunit A, beta 0.437
COPS3 COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis) 0.435
RFWD2 ring finger and WD repeat domain 2 0.424
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.406
UBA1 ubiquitin-like modifier activating enzyme 1 0.387
DDB1 damage-specific DNA binding protein 1, 127kDa 0.368
RAD1 RAD1 homolog (S. pombe) 0.363
CCND1 cyclin D1 0.363
ATM ataxia telangiectasia mutated 0.361
RBBP8 retinoblastoma binding protein 8 0.360
CDC27 cell division cycle 27 homolog (S. cerevisiae) 0.360
CCND3 cyclin D3 0.358
CDK8 cyclin-dependent kinase 8 0.350
MED1 mediator complex subunit 1 0.346
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.334
ZWINT ZW10 interactor 0.325
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.317
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.304
JUN jun proto-oncogene 0.292
WRN Werner syndrome, RecQ helicase-like 0.289
MCM2 minichromosome maintenance complex component 2 0.289
RBL2 retinoblastoma-like 2 (p130) 0.286
CSNK2B casein kinase 2, beta polypeptide 0.285
PKM2 pyruvate kinase, muscle 0.279
CDC25C cell division cycle 25 homolog C (S. pombe) 0.271
CDK6 cyclin-dependent kinase 6 0.270
BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast) 0.267
APAF1 apoptotic peptidase activating factor 1 0.266
FADD Fas (TNFRSF6)-associated via death domain 0.264
FAS Fas (TNF receptor superfamily, member 6) 0.256
TRIP13 thyroid hormone receptor interactor 13 0.250
DDB2 damage-specific DNA binding protein 2, 48kDa 0.249
CNOT3 CCR4-NOT transcription complex, subunit 3 0.248
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.248
CCNE2 cyclin E2 0.245
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.243
COPS8 COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis) 0.230
ORC1 origin recognition complex, subunit 1 0.226
CASP2 caspase 2, apoptosis-related cysteine peptidase 0.224
IER3 immediate early response 3 0.222
NBN nibrin 0.222
PPP2R5B protein phosphatase 2, regulatory subunit B', beta 0.215
CHAF1A chromatin assembly factor 1, subunit A (p150) 0.203
UBE2M ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast) 0.200
OTUB1 OTU domain, ubiquitin aldehyde binding 1 0.199
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.197
ATF3 activating transcription factor 3 0.197
CDK1 cyclin-dependent kinase 1 0.195
TP53BP1 tumor protein p53 binding protein 1 0.194
CDC20 cell division cycle 20 homolog (S. cerevisiae) 0.193
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.188
RAD9A RAD9 homolog A (S. pombe) 0.183
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3 0.178
FOXM1 forkhead box M1 0.177
DTL denticleless homolog (Drosophila) 0.177
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 1.000
Brca2 breast cancer 2 0.912
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.847
Cdk4 cyclin-dependent kinase 4 0.738
Brca1 breast cancer 1 0.713
Pten phosphatase and tensin homolog 0.640
Rb1 retinoblastoma 1 0.637
E2f1 E2F transcription factor 1 0.634
Cdk1 cyclin-dependent kinase 1 0.631
Mdm2 transformed mouse 3T3 cell double minute 2 0.587
Mdm4 transformed mouse 3T3 cell double minute 4 0.493
Rbl1 retinoblastoma-like 1 (p107) 0.415
Prc1 protein regulator of cytokinesis 1 0.382
Cenpk centromere protein K 0.371
Cdk2 cyclin-dependent kinase 2 0.357
Ccna2 cyclin A2 0.264
Kif20a kinesin family member 20A 0.248
Rpgrip1l Rpgrip1-like 0.242
Suz12 suppressor of zeste 12 homolog (Drosophila) 0.225
Mis18bp1 MIS18 binding protein 1 0.220
Aurkb aurora kinase B 0.206
Gps1 G protein pathway suppressor 1 0.205
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.198
Skil SKI-like 0.198
Mcm2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae) 0.187
Nde1 nuclear distribution gene E homolog 1 (A nidulans) 0.187
Cdkn2c cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.182
Kif22 kinesin family member 22 0.175
Crk v-crk sarcoma virus CT10 oncogene homolog (avian) 0.174
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.172
Tcf3 transcription factor 3 0.164
Kif23 kinesin family member 23 0.161
Top2a topoisomerase (DNA) II alpha 0.158
Gtse1 G two S phase expressed protein 1 0.141
Ccnf cyclin F 0.135
Eif2c2 eukaryotic translation initiation factor 2C, 2 0.133
Ctnnb1 catenin (cadherin associated protein), beta 1 0.129
Nf1 neurofibromatosis 1 0.125
Sirt1 sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae) 0.120
Ndel1 nuclear distribution gene E-like homolog 1 (A. nidulans) 0.116
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.113
Dlgap5 discs, large (Drosophila) homolog-associated protein 5 0.106
Ccnb2 cyclin B2 0.103
Bub1b budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) 0.101
Aurka aurora kinase A 0.100
Apc adenomatosis polyposis coli 0.100
Nasp nuclear autoantigenic sperm protein (histone-binding) 0.100
Smc2 structural maintenance of chromosomes 2 0.099
Ccdc99 coiled-coil domain containing 99 0.099
Kif11 kinesin family member 11 0.097
Kif2c kinesin family member 2C 0.097
C330027C09Rik RIKEN cDNA C330027C09 gene 0.096
Mybl2 myeloblastosis oncogene-like 2 0.095
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.094
Smc3 structural maintenace of chromosomes 3 0.090
Egr2 early growth response 2 0.088
Rara retinoic acid receptor, alpha 0.088
Cdc45 cell division cycle 45 homolog (S. cerevisiae) 0.088
Smad4 MAD homolog 4 (Drosophila) 0.086
Gapdh glyceraldehyde-3-phosphate dehydrogenase 0.085
Rnf2 ring finger protein 2 0.084
Acd adrenocortical dysplasia 0.083
Trp73 transformation related protein 73 0.083
Lig1 ligase I, DNA, ATP-dependent 0.082
Dicer1 Dicer1, Dcr-1 homolog (Drosophila) 0.080
Birc5 baculoviral IAP repeat-containing 5 0.079
Elavl1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.077
Kat2a K(lysine) acetyltransferase 2A 0.077
Dtl denticleless homolog (Drosophila) 0.077
Gpi1 glucose phosphate isomerase 1 0.077
Ccnb1 cyclin B1 0.075
Ruvbl2 RuvB-like protein 2 0.073
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.072
Msh2 mutS homolog 2 (E. coli) 0.070
Ckap2 cytoskeleton associated protein 2 0.070
Hmgb1 high mobility group box 1 0.069
Crebbp CREB binding protein 0.068
Nup107 nucleoporin 107 0.067
Ptch1 patched homolog 1 0.067
Topbp1 topoisomerase (DNA) II binding protein 1 0.066
Tmpo thymopoietin 0.066
Pou5f1 POU domain, class 5, transcription factor 1 0.066
Kif4 kinesin family member 4 0.066
Sae1 SUMO1 activating enzyme subunit 1 0.063
Pkm2 pyruvate kinase, muscle 0.061
Nbn nibrin 0.059
Sp1 trans-acting transcription factor 1 0.059
Trp63 transformation related protein 63 0.059
Ccnd1 cyclin D1 0.059
Lin9 lin-9 homolog (C. elegans) 0.058
Tcf19 transcription factor 19 0.057
Mlh1 mutL homolog 1 (E. coli) 0.056
Spag5 sperm associated antigen 5 0.056
Tpi1 triosephosphate isomerase 1 0.056
Ccne1 cyclin E1 0.055
Rad51ap1 RAD51 associated protein 1 0.055
Asf1b ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.055
Mcm3 minichromosome maintenance deficient 3 (S. cerevisiae) 0.054
Xpa xeroderma pigmentosum, complementation group A 0.054
Mitf microphthalmia-associated transcription factor 0.054
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Pkm2 pyruvate kinase, muscle 0.051
Racgap1 Rac GTPase-activating protein 1 0.051
Spc25 SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) 0.040
Hmmr hyaluronan mediated motility receptor (RHAMM) 0.039
Tnks2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 0.034
Pcyox1 prenylcysteine oxidase 1 0.031
Top2a topoisomerase (DNA) II alpha 0.030
Tcp11l2 t-complex 11 (mouse) like 2 0.029
Kif2c kinesin family member 2C 0.028
Zfand5 zinc finger, AN1-type domain 5 0.026
Ptbp1 polypyrimidine tract binding protein 1 0.025
Ppp1ca protein phosphatase 1, catalytic subunit, alpha isoform 0.025
Bub1b budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) 0.024
Ppp1cb protein phosphatase 1, catalytic subunit, beta isoform 0.024
Mdm2 Mdm2 p53 binding protein homolog (mouse) 0.023
Ect2 epithelial cell transforming sequence 2 oncogene 0.023
Sesn1 sestrin 1 0.023
Pdp1 pyruvate dehyrogenase phosphatase catalytic subunit 1 0.022
Traf4af1 TRAF4 associated factor 1 0.022
Zfand6 zinc finger, AN1-type domain 6 0.021
Cdca3 cell division cycle associated 3 0.021
Serinc1 serine incorporator 1 0.021
Cdk4 cyclin-dependent kinase 4 0.021
Scamp2 secretory carrier membrane protein 2 0.020
Cdc42bpb CDC42 binding protein kinase beta (DMPK-like) 0.020
Bcl2l2 Bcl2-like 2 0.020
Mak10 MAK10 homolog, amino-acid N-acetyltransferase subunit, (S. cerevisiae) 0.019
Tcf12 transcription factor 12 0.019
Cdca4 cell division cycle associated 4 0.019
Rpa2 replication protein A2 0.019
Rbbp7 retinoblastoma binding protein 7 0.019
Dnaja2 DnaJ (Hsp40) homolog, subfamily A, member 2 0.019
Ccnb2 cyclin B2 0.018
Ril reversion induced LIM gene 0.018
Prkacb protein kinase, cAMP dependent, catalytic, beta 0.018
Bnip3l BCL2/adenovirus E1B interacting protein 3-like 0.018
LOC100364212 heterogeneous nuclear ribonucleoprotein K-like 0.018
Gapdh glyceraldehyde-3-phosphate dehydrogenase 0.018
Cdca7 cell division cycle associated 7 0.017
Fundc1 FUN14 domain containing 1 0.017
Necap2 NECAP endocytosis associated 2 0.017
Aurkb aurora kinase B 0.017
Gnb2 guanine nucleotide binding protein (G protein), beta polypeptide 2 0.017
Ccnd3 cyclin D3 0.017
Sepw1 selenoprotein W, 1 0.017
Dlg3 discs, large homolog 3 (Drosophila) 0.016
Usp9x ubiquitin specific peptidase 9, X-linked 0.016
Tob1 transducer of ErbB-2.1 0.016
Txndc15 thioredoxin domain containing 15 0.016
Hbp1 HMG-box transcription factor 1 0.016
Pctk2 PCTAIRE protein kinase 2 0.016
Rrm2 ribonucleotide reductase M2 0.016
Nos3 nitric oxide synthase 3, endothelial cell 0.016
Bak1 BCL2-antagonist/killer 1 0.016
Ube2t ubiquitin-conjugating enzyme E2T (putative) 0.016
Stx7 syntaxin 7 0.015
Zyx zyxin 0.015
Ccng2 cyclin G2 0.015
Ccni cyclin I 0.015
Prim2 primase, DNA, polypeptide 2 0.015
Vegfa vascular endothelial growth factor A 0.015
Acyp2 acylphosphatase 2, muscle type 0.015
Ube2c ubiquitin-conjugating enzyme E2C 0.015
Ccdc99 coiled-coil domain containing 99 0.015
Troap trophinin associated protein 0.015
Cdca8 cell division cycle associated 8 0.015
Zhx1 zinc fingers and homeoboxes 1 0.015
Cdkn3 cyclin-dependent kinase inhibitor 3 0.015
Stxbp3 syntaxin binding protein 3 0.015
Zbtb6 zinc finger and BTB domain containing 6 0.015
Ogt O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) 0.015
Tm2d2 TM2 domain containing 2 0.015
Asna1 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) 0.015
Cul3 cullin 3 0.014
Ubl3 ubiquitin-like 3 0.014
Daxx death-domain associated protein 0.014
Prkd3 protein kinase D3 0.014
Pola1 polymerase (DNA directed), alpha 1 0.014
Gpi glucose phosphate isomerase 0.014
Atp5b ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide 0.014
Ccnb1 cyclin B1 0.014
Ythdf3 YTH domain family, member 3 0.014
Top2b topoisomerase (DNA) II beta 0.014
Fam116a family with sequence similarity 116, member A 0.014
Ndrg2 N-myc downstream regulated gene 2 0.014
Mrpl38 mitochondrial ribosomal protein L38 0.014
Dctn4 dynactin 4 0.014
Nudt3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 0.014
Pcmtd2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 0.014
Cdc34 cell division cycle 34 homolog (S. cerevisiae) 0.014
Tln1 talin 1 0.014
Tmpo thymopoietin 0.014
Znf467 zinc finger protein 467 0.014
Sh3yl1 SH3 domain containing, Ysc84-like 1 (S. cerevisiae) 0.014
Gcs1 glucosidase 1 0.014
Pctk1 PCTAIRE protein kinase 1 0.014
Tmco3 transmembrane and coiled-coil domains 3 0.014
Brms1l breast cancer metastasis-suppressor 1-like 0.014
Dhfr dihydrofolate reductase 0.013
Prdm4 PR domain containing 4 0.013