The network for 'response to organic substance' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to organic substance

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
STE4 Ste4p 0.990
STE11 Ste11p 0.972
BEM1 Bem1p 0.964
HSP82 Hsp82p 0.959
SST2 Sst2p 0.955
FAR1 Far1p 0.938
SLT2 Slt2p 0.884
FUS3 Fus3p 0.877
AGA2 Aga2p 0.852
RHO1 Rho1p 0.845
STE5 Ste5p 0.825
HOG1 Hog1p 0.825
STE2 Ste2p 0.815
PPH21 Pph21p 0.815
CLA4 Cla4p 0.794
RTG3 Rtg3p 0.784
CDC48 Cdc48p 0.784
AGA1 Aga1p 0.751
CDC24 Cdc24p 0.740
STE7 Ste7p 0.689
RPN4 Rpn4p 0.681
MIG1 Mig1p 0.678
STE20 Ste20p 0.671
SHO1 Sho1p 0.670
CRZ1 Crz1p 0.663
TPK1 Tpk1p 0.659
HSP104 Hsp104p 0.650
GLN3 Gln3p 0.625
TOR1 Tor1p 0.614
SLG1 Slg1p 0.605
HXT7 Hxt7p 0.582
RAS2 Ras2p 0.581
GPA1 Gpa1p 0.571
FAR10 Far10p 0.552
PMT1 Pmt1p 0.533
KDX1 Kdx1p 0.526
SSK2 Ssk2p 0.522
KSS1 Kss1p 0.519
SSA1 Ssa1p 0.517
UBP15 Ubp15p 0.515
BMH1 Bmh1p 0.513
SGT2 Sgt2p 0.512
MFA1 Mfa1p 0.507
PTC1 Ptc1p 0.499
SGV1 Sgv1p 0.491
KSP1 Ksp1p 0.489
NPR1 Npr1p 0.481
FAR11 Far11p 0.481
FUS1 Fus1p 0.469
PPZ1 Ppz1p 0.467
HSP60 Hsp60p 0.462
STE18 Ste18p 0.449
STE50 Ste50p 0.428
LCB4 Lcb4p 0.426
PRC1 Prc1p 0.411
CLB6 Clb6p 0.390
TPO4 Tpo4p 0.385
CLB3 Clb3p 0.380
SWE1 Swe1p 0.380
LDB19 Ldb19p 0.379
AHA1 Aha1p 0.378
MKK1 Mkk1p 0.374
MSG5 Msg5p 0.373
RRI2 Rri2p 0.366
USA1 Usa1p 0.365
YPL150W hypothetical protein 0.364
PST2 Pst2p 0.364
MKS1 Mks1p 0.358
RRI1 Rri1p 0.358
SUP35 Sup35p 0.354
FIG2 Fig2p 0.352
KCC4 Kcc4p 0.339
BAR1 Bar1p 0.336
AKR1 Akr1p 0.331
CMP2 Cmp2p 0.326
RHO5 Rho5p 0.324
PMT2 Pmt2p 0.318
ASG1 Asg1p 0.314
DIA2 Dia2p 0.314
FAR3 Far3p 0.312
FUS2 Fus2p 0.306
HSL7 Hsl7p 0.301
LYS5 Lys5p 0.299
PRK1 Prk1p 0.295
CSG2 Csg2p 0.295
ROG3 Rog3p 0.293
ATG32 Atg32p 0.293
BDF1 Bdf1p 0.292
YJL163C hypothetical protein 0.289
SAP185 Sap185p 0.288
SSE2 Sse2p 0.284
PTR3 Ptr3p 0.283
HRK1 Hrk1p 0.282
GPR1 Gpr1p 0.282
AQY2 Aqy2p 0.277
HXT6 Hxt6p 0.277
CSN9 Csn9p 0.277
ESP1 Esp1p 0.275
MF(ALPHA)1 Mf(alpha)1p 0.270
MIG2 Mig2p 0.262
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
vab-3 Protein VAB-3 0.821
hsp-16.2 Protein HSP-16.2 0.647
nhr-67 Protein NHR-67 0.606
F13H6.1 Protein F13H6.1 0.596
mig-15 Protein MIG-15 0.581
hsp-16.1 Protein HSP-16.1 0.545
hsp-3 Protein HSP-3 0.543
pmk-1 Protein PMK-1 0.523
hsp-16.41 Protein HSP-16.41 0.493
egg-6 Protein EGG-6 0.468
let-60 Protein LET-60 0.458
egl-18 Protein EGL-18 0.450
mat-3 Protein MAT-3 0.444
glp-1 Protein GLP-1 0.435
par-5 Protein PAR-5 0.429
acs-4 Protein ACS-4 0.423
tag-320 Protein TAG-320 0.417
hsp-70 Protein HSP-70 0.410
egl-44 Protein EGL-44 0.407
sma-6 Protein SMA-6 0.398
hsp-4 Protein HSP-4 0.394
cgh-1 Protein CGH-1 0.391
pkg-1 Protein PKG-1 0.367
unc-9 Protein UNC-9 0.366
daf-14 Protein DAF-14 0.355
gpb-2 Protein GPB-2 0.354
egl-13 Protein EGL-13 0.352
osm-3 Protein OSM-3 0.347
osm-5 Protein OSM-5 0.335
ifg-1 Protein IFG-1 0.330
Y47D3B.6 Protein Y47D3B.6 0.325
abl-1 Protein ABL-1 0.321
abu-15 Protein ABU-15 0.318
hsp-17 Protein HSP-17 0.312
pdfr-1 Protein PDFR-1 0.300
apc-2 Protein APC-2 0.298
hnd-1 Protein HND-1 0.298
pqn-54 Protein PQN-54 0.291
hmr-1 Protein HMR-1 0.291
F44E5.4 Protein F44E5.4 0.285
abu-1 Protein ABU-1 0.285
pkn-1 Protein PKN-1 0.283
aak-2 Protein AAK-2 0.280
ccch-1 Protein CCCH-1 0.277
bar-1 Protein BAR-1 0.276
wrn-1 Protein WRN-1 0.276
W02B8.1 Protein W02B8.1 0.273
lmn-1 Protein LMN-1 0.271
mig-5 Protein MIG-5 0.269
kin-3 Protein KIN-3 0.265
pmt-1 Protein PMT-1 0.257
sas-5 Protein SAS-5 0.251
ahcy-1 Protein AHCY-1 0.251
F53F10.2 Protein F53F10.2 0.249
unc-86 Protein UNC-86 0.249
che-2 Protein CHE-2 0.245
unc-62 Protein UNC-62 0.243
unc-104 Protein UNC-104 0.241
lin-25 Protein LIN-25 0.239
C35C5.3 Protein C35C5.3 0.238
daf-11 Protein DAF-11 0.238
osm-6 Protein OSM-6 0.234
sos-1 Protein SOS-1 0.233
hum-5 Protein HUM-5 0.229
unc-7 Protein UNC-7 0.228
elt-6 Protein ELT-6 0.227
itr-1 Protein ITR-1 0.212
nhr-25 Protein NHR-25 0.208
CELE_T05E11.3 Protein T05E11.3 0.204
egl-15 Protein EGL-15 0.204
ptr-14 Protein PTR-14 0.203
sid-1 Protein SID-1 0.198
vit-2 Protein VIT-2 0.197
egl-8 Protein EGL-8 0.197
unc-40 Protein UNC-40 0.196
tax-6 Protein TAX-6 0.193
gld-1 Protein GLD-1 0.192
abu-14 Protein ABU-14 0.189
oac-46 Protein OAC-46 0.189
inx-1 Protein INX-1 0.188
odr-3 Protein ODR-3 0.188
sur-2 Protein SUR-2 0.188
unc-32 Protein UNC-32 0.186
dlk-1 Protein DLK-1 0.184
cam-1 Protein CAM-1 0.181
sel-7 Protein SEL-7 0.179
jmjd-3.1 Protein JMJD-3.1 0.178
cyp-35C1 Protein CYP-35C1 0.177
daf-7 Protein DAF-7 0.177
nhr-34 Protein NHR-34 0.175
apr-1 Protein APR-1 0.175
abu-11 Protein ABU-11 0.174
chd-7 Protein CHD-7 0.174
cat-2 Protein CAT-2 0.167
CELE_C01G6.5 Protein C01G6.5 0.166
inx-4 Protein INX-4 0.165
lact-3 Protein LACT-3 0.165
dsc-4 Protein DSC-4 0.165
daf-2 Protein DAF-2 0.164
atg-2 Protein ATG-2 0.161
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Danio rerio
Name Description Probability Func Analog Organism
fgf3 fibroblast growth factor 3 0.994
apoeb apolipoprotein Eb 0.993
spry4 sprouty (Drosophila) homolog 4 0.964
myod1 myogenic differentiation 1 0.954
robo3 roundabout homolog 3 0.953
notch1a notch homolog 1a 0.944
shha sonic hedgehog a 0.939
pax6a paired box gene 6a 0.910
atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.904
foxa2 forkhead box A2 0.884
runx2b runt-related transcription factor 2b 0.869
cdh2 cadherin 2, neuronal 0.863
flh floating head 0.807
dusp6 dual specificity phosphatase 6 0.798
bmp4 bone morphogenetic protein 4 0.792
gata5 GATA-binding protein 5 0.788
otpa orthopedia homolog a 0.787
fgf8a fibroblast growth factor 8 a 0.760
sox17 SRY-box containing gene 17 0.747
cdh1 cadherin 1, epithelial 0.745
th tyrosine hydroxylase 0.742
ptch2 patched 2 0.734
gata3 GATA-binding protein 3 0.731
cyp11a1 cytochrome P450, subfamily XIA, polypeptide 1 0.730
efnb2a ephrin B2a 0.728
rarab retinoic acid receptor, alpha b 0.721
wnt5b wingless-type MMTV integration site family, member 5b 0.693
vasa vasa homolog 0.688
ef1a elongation factor 1-alpha 0.658
ntla no tail a 0.657
ndr2 nodal-related 2 0.657
pax7a paired box gene 7a 0.654
wnt11 wingless-type MMTV integration site family, member 11 0.628
xbp1 X-box binding protein 1 0.623
sox32 SRY-box containing gene 32 0.612
gata1a GATA binding protein 1a 0.608
hspa5 heat shock protein 5 0.604
bactin2 bactin2 0.603
cdx4 caudal type homeo box transcription factor 4 0.595
oep one-eyed pinhead 0.581
dlx2a distal-less homeobox gene 2a 0.570
flncb filamin C, gamma b (actin binding protein 280) 0.569
gpia glucose phosphate isomerase a 0.567
pitx3 paired-like homeodomain transcription factor 3 0.557
flt4 fms-related tyrosine kinase 4 0.557
foxa3 forkhead box A3 0.551
snai1a snail homolog 1a (Drosophila) 0.549
esr2a estrogen receptor 2a 0.546
fabp11a fatty acid binding protein 11a 0.544
hnf1ba HNF1 homeobox Ba 0.540
pdgfaa platelet-derived growth factor alpha a 0.534
atp1b1a ATPase, Na+/K+ transporting, beta 1a polypeptide 0.525
notch3 notch homolog 3 0.525
nanos3 nanos homolog 3 0.524
nrp2b neuropilin 2b 0.524
nkx2.5 NK2 transcription factor related 5 0.519
lhcgr luteinizing hormone/choriogonadotropin receptor 0.514
smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.509
ptprk protein tyrosine phosphatase, receptor type, K 0.506
pea3 ETS-domain transcription factor pea3 0.501
dlc deltaC 0.496
fgf4 fibroblast growth factor 4 0.489
chd chordin 0.487
esr1 estrogen receptor 1 0.485
sox11a SRY-box containing gene 11a 0.480
cx27.5 connexin 27.5 0.466
krt18 keratin 18 0.463
barhl1.1 BarH-like 1.1 0.461
jun jun proto-oncogene 0.460
bbc3 BCL2 binding component 3 0.459
pcna proliferating cell nuclear antigen 0.459
barhl2 BarH-like 2 0.451
mao monoamine oxidase 0.449
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.443
ptena phosphatase and tensin homolog A 0.443
mt2 metallothionein 2 0.439
lef1 lymphocyte enhancer binding factor 1 0.433
wnt1 wingless-type MMTV integration site family, member 1 0.425
ncf1 neutrophil cytosolic factor 1 0.421
sall1a sal-like 1a (Drosophila) 0.411
zgc:64114 zgc:64114 0.404
nr3c1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.400
plagl2 pleiomorphic adenoma gene-like 2 0.398
foxp2 forkhead box P2 0.397
anxa1a annexin A1a 0.397
igf1ra insulin-like growth factor 1a receptor 0.396
il17rd interleukin 17 receptor D 0.396
dmbx1a diencephalon/mesencephalon homeobox 1a 0.395
jag2 jagged 2 0.395
cyp1a cytochrome P450, family 1, subfamily A 0.393
paqr8 progestin and adipoQ receptor family member VIII 0.392
hsp90b1 heat shock protein 90, beta (grp94), member 1 0.385
fzd7b frizzled homolog 7b 0.384
ptgs2a prostaglandin-endoperoxide synthase 2a 0.383
arnt2 aryl hydrocarbon receptor nuclear translocator 2 0.381
nfkbiab nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b 0.381
per2 period homolog 2 (Drosophila) 0.381
mcl1a myeloid cell leukemia sequence 1a 0.381
nfe2l2 nuclear factor (erythroid-derived 2)-like 2 0.375
cxcl12a chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) 0.373
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Drosophila melanogaster
Name Description Probability Func Analog Organism
EcR Ecdysone receptor 0.997
S6k RPS6-p70-protein kinase 0.995
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.995
Egfr Epidermal growth factor receptor 0.994
Ras85D Ras oncogene at 85D 0.980
InR Insulin-like receptor 0.974
Sir2 CG5216 gene product from transcript CG5216-RA 0.968
foxo forkhead box, sub-group O 0.965
phl pole hole 0.964
p53 CG33336 gene product from transcript CG33336-RB 0.950
rl rolled 0.940
sina seven in absentia 0.937
ci cubitus interruptus 0.926
rut rutabaga 0.903
Stat92E Signal-transducer and activator of transcription protein at 92E 0.888
eve even skipped 0.886
Rel Relish 0.881
bowl brother of odd with entrails limited 0.879
chico CG5686 gene product from transcript CG5686-RB 0.874
hep hemipterous 0.872
milt milton 0.848
drk downstream of receptor kinase 0.847
Akt1 CG4006 gene product from transcript CG4006-RA 0.834
Pink1 PTEN-induced putative kinase 1 0.832
G-salpha60A G protein salpha 60A 0.823
Hsc70-4 Heat shock protein cognate 4 0.819
bsk basket 0.813
Fmr1 CG6203 gene product from transcript CG6203-RC 0.812
Mad Mothers against dpp 0.812
Smox Smad on X 0.806
Mer Merlin 0.805
arr arrow 0.801
Cat Catalase 0.801
dm diminutive 0.799
Lis-1 Lissencephaly-1 0.794
Hsp68 Heat shock protein 68 0.788
fru fruitless 0.780
emc extra macrochaetae 0.776
loqs loquacious 0.768
Jra Jun-related antigen 0.753
Pka-C1 cAMP-dependent protein kinase 1 0.753
pan pangolin 0.751
put punt 0.747
NFAT NFAT homolog 0.745
Tpi Triose phosphate isomerase 0.740
shn schnurri 0.739
shi shibire 0.738
N Notch 0.704
Hsp70Ab Heat-shock-protein-70Ab 0.698
dsx doublesex 0.686
Ubqn Ubiquilin 0.682
Spn27A Serpin 27A 0.675
CG7998 CG7998 gene product from transcript CG7998-RA 0.675
hth homothorax 0.668
neb nebbish 0.661
nkd naked cuticle 0.660
csw corkscrew 0.660
sfl sulfateless 0.650
Adh Alcohol dehydrogenase 0.631
Kr-h1 Kruppel homolog 1 0.624
drl derailed 0.620
scny scrawny 0.619
ttv tout-velu 0.617
gcm glial cells missing 0.615
ss spineless 0.613
pnt pointed 0.609
RpII215 RNA polymerase II 215kD subunit 0.607
Sod Superoxide dismutase 0.603
ap apterous 0.602
Nmdar1 NMDA receptor 1 0.595
sev sevenless 0.593
ex expanded 0.588
disco disconnected 0.587
amos absent MD neurons and olfactory sensilla 0.572
rap retina aberrant in pattern 0.571
argos CG4531 gene product from transcript CG4531-RA 0.564
Ubx Ultrabithorax 0.560
Trh Tryptophan hydroxylase 0.553
dsh dishevelled 0.544
fu fused 0.543
E(spl) Enhancer of split 0.537
Dad Daughters against dpp 0.531
CycG Cyclin G 0.513
ben bendless 0.511
CG8155 CG8155 gene product from transcript CG8155-RA 0.510
hh hedgehog 0.508
Galpha49B G protein alpha49B 0.503
Ugt35a UDP-glycosyltransferase 35a 0.502
egr eiger 0.500
pum pumilio 0.500
par-1 CG8201 gene product from transcript CG8201-RA 0.499
Cdc42 CG12530 gene product from transcript CG12530-RA 0.494
tara taranis 0.492
sd scalloped 0.491
lin19 lin-19-like 0.484
wts warts 0.482
mof males absent on the first 0.474
Lnk CG17367 gene product from transcript CG17367-RC 0.473
Caps Calcium activated protein for secretion 0.471
CG17734 CG17734 gene product from transcript CG17734-RA 0.468
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism