The network for 'regulation of cell aging' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of cell aging

Any process that modulates the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan.

Name Description Probability Func Analog Organism
GLN3 Gln3p 0.050
YPL014W hypothetical protein 0.037
HXT3 Hxt3p 0.037
LYS5 Lys5p 0.033
MIG1 Mig1p 0.033
HAL5 Hal5p 0.031
CSR2 Csr2p 0.030
HST3 Hst3p 0.028
DBF2 Dbf2p 0.027
ROX1 Rox1p 0.026
MOB1 Mob1p 0.026
IRC8 Irc8p 0.024
CRZ1 Crz1p 0.022
SSK2 Ssk2p 0.022
NUP157 Nup157p 0.022
FAA2 Faa2p 0.022
CDC23 Cdc23p 0.022
TRA1 Tra1p 0.021
SWI1 Swi1p 0.021
WAR1 War1p 0.021
GAT2 Gat2p 0.020
TYE7 Tye7p 0.020
YER130C hypothetical protein 0.020
YPR157W hypothetical protein 0.019
ROG3 Rog3p 0.019
HSF1 Hsf1p 0.019
DAL81 Dal81p 0.019
ZAP1 Zap1p 0.019
CHA1 Cha1p 0.019
TPO2 Tpo2p 0.019
RTG3 Rtg3p 0.019
SRD1 Srd1p 0.019
CAT8 Cat8p 0.019
AGP2 Agp2p 0.018
RMA1 Rma1p 0.018
YGR035C hypothetical protein 0.018
SBE22 Sbe22p 0.018
YKR075C hypothetical protein 0.018
YLR297W hypothetical protein 0.018
TAO3 Tao3p 0.018
YNL234W hypothetical protein 0.018
PHO80 Pho80p 0.018
YLR264C-A hypothetical protein 0.017
LEU2 Leu2p 0.017
HOR2 Hor2p 0.017
MIG2 Mig2p 0.017
NTO1 Nto1p 0.017
RMD8 Rmd8p 0.017
PHO12 Pho12p 0.017
YOL038C-A hypothetical protein 0.017
RIM13 Rim13p 0.017
PUT4 Put4p 0.017
RPI1 Rpi1p 0.017
ARP10 Arp10p 0.017
RGS2 Rgs2p 0.017
YLR162W hypothetical protein 0.017
AFT1 Aft1p 0.017
ATG29 Atg29p 0.017
MOT3 Mot3p 0.017
GIP2 Gip2p 0.017
VHS1 Vhs1p 0.016
KRE29 Kre29p 0.016
HRQ1 Hrq1p 0.016
PHM8 Phm8p 0.016
SOG2 Sog2p 0.016
SFL1 Sfl1p 0.016
YIR035C hypothetical protein 0.016
PSK2 Psk2p 0.016
SMP1 Smp1p 0.016
ICY1 Icy1p 0.016
YIR042C hypothetical protein 0.016
CUP1-1 Cup1-1p 0.016
RIB2 Rib2p 0.016
YAR066W hypothetical protein 0.016
BSC1 Bsc1p 0.016
SPL2 Spl2p 0.016
STL1 Stl1p 0.016
FIT1 Fit1p 0.016
HDA2 Hda2p 0.016
YPR013C hypothetical protein 0.016
MKS1 Mks1p 0.016
TIP1 Tip1p 0.016
ICS2 Ics2p 0.016
RPN4 Rpn4p 0.016
ATP6 Atp6p 0.016
TOS3 Tos3p 0.016
ECM22 Ecm22p 0.016
YER034W hypothetical protein 0.015
YHR035W hypothetical protein 0.015
HPF1 Hpf1p 0.015
SAK1 Sak1p 0.015
YAR068W hypothetical protein 0.015
YAP5 Yap5p 0.015
GIS4 Gis4p 0.015
MDJ2 Mdj2p 0.015
FMT1 Fmt1p 0.015
FMP48 Fmp48p 0.015
YDR186C hypothetical protein 0.015
ARP8 Arp8p 0.015
AUA1 Aua1p 0.015
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
hnf1ba HNF1 homeobox Ba 0.094
acvr1b activin A receptor, type IB 0.064
mapk14a mitogen-activated protein kinase 14a 0.045
med12 mediator of RNA polymerase II transcription, subunit 12 homolog 0.039
ikzf5 IKAROS family zinc finger 5 0.037
egr2b early growth response 2b 0.036
smad5 MAD homolog 5 (Drosophila) 0.031
zbtb22b zinc finger and BTB domain containing 22b 0.030
hspb1 heat shock protein, alpha-crystallin-related, 1 0.027
krt4 keratin 4 0.025
rag1 recombination activating gene 1 0.024
morc2 MORC family CW-type zinc finger 2 0.024
max myc-associated factor X 0.022
top2a topoisomerase (DNA) II alpha 0.020
tp73 tumor protein p73 0.020
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.020
cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 0.019
lama5 laminin, alpha 5 0.019
si:ch211-173o4.2 si:ch211-173o4.2 0.019
yes1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 0.017
prkci protein kinase C, iota 0.017
rspo3 R-spondin 3 homolog (Xenopus laevis) 0.017
dazl daz-like gene 0.017
pwp2h PWP2 periodic tryptophan protein homolog (yeast) 0.017
ptpra protein tyrosine phosphatase, receptor type, A 0.016
pcbp2 poly(rC) binding protein 2 0.016
zgc:103564 zgc:103564 0.016
tbx1 T-box 1 0.015
smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.015
cdh1 cadherin 1, epithelial 0.015
myst2 MYST histone acetyltransferase 2 0.015
tfap2c transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.015
her5 hairy-related 5 0.015
npas2 neuronal PAS domain protein 2 0.014
acvr1l activin A receptor, type I like 0.014
irf6 interferon regulatory factor 6 0.014
pbx4 pre-B-cell leukemia transcription factor 4 0.014
dag1 dystroglycan 1 0.014
sf3b1 splicing factor 3b, subunit 1 0.014
boc brother of CDO 0.014
grem1a gremlin 1 homolog a, cysteine knot superfamily (Xenopus laevis) 0.014
fzd7b frizzled homolog 7b 0.013
zgc:152986 zgc:152986 0.013
gpr19 G protein-coupled receptor 19 0.013
nr3c1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.013
zgc:112083 zgc:112083 0.013
mapk3 mitogen-activated protein kinase 3 0.013
pcdh2ac protocadherin 2 alpha c 0.012
igf1 insulin-like growth factor 1 0.012
nrg2a neuregulin 2a 0.012
eif3s10 eukaryotic translation initiation factor 3, subunit 10 (theta) 0.012
rlf rearranged L-myc fusion 0.012
runx1 runt-related transcription factor 1 0.012
ca15b carbonic anhydrase XV b 0.012
alg1 asparagine-linked glycosylation 1 homolog (yeast, beta-1,4-mannosyltransferase) 0.012
zgc:66488 zgc:66488 0.012
efnb1 ephrin B1 0.012
mecp2 methyl CpG binding protein 2 0.012
rpl28 ribosomal protein L28 0.012
sfrp5 secreted frizzled-related protein 5 0.012
trim33 tripartite motif-containing 33 0.012
cxcl12a chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) 0.012
rpl19 ribosomal protein L19 0.012
dlx3b distal-less homeobox gene 3b 0.012
zgc:113293 zgc:113293 0.012
tnfsf10l4 tumor necrosis factor (ligand) superfamily, member 10 like 4 0.012
cmyb transcription factor cmyb 0.012
si:dkeyp-34c12.1 si:dkeyp-34c12.1 0.012
LOC100332351 hypothetical protein LOC100332351 0.012
fmr1 fragile X mental retardation 1 0.012
cfl2l cofilin 2, like 0.012
styxl1 serine/threonine/tyrosine interacting-like 1 0.012
smarce1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 0.012
vdra vitamin D receptor a 0.012
fn1 fibronectin 1 0.011
ciz1 CDKN1A interacting zinc finger protein 1 0.011
ctnnb1 catenin (cadherin-associated protein), beta 1 0.011
gdf6a growth differentiation factor 6a 0.011
apc adenomatosis polyposis coli 0.011
cirbp cold inducible RNA binding protein 0.011
gdf11 growth differentiation factor 11 0.011
piga phosphatidylinositol glycan anchor biosynthesis, class A 0.011
pde6h phosphodiesterase 6H, cGMP-specific, cone, gamma 0.011
hmgcrb 3-hydroxy-3-methylglutaryl-Coenzyme A reductase b 0.011
zgc:162485 zgc:162485 0.011
bactin2 bactin2 0.011
rxrbb retinoid x receptor, beta b 0.011
tsc1 tuberous sclerosis 1 0.011
brd2b bromodomain containing 2b 0.010
zgc:113143 zgc:113143 0.010
rbpja recombination signal binding protein for immunoglobulin kappa J region a 0.010
si:ch211-239j15.4 si:ch211-239j15.4 0.010
mc2r melanocortin 2 receptor 0.010
sap130a Sin3A-associated protein a 0.010
tp53 tumor protein p53 0.010
ef1a elongation factor 1-alpha 0.010
sart3 squamous cell carcinoma antigen recognised by T cells 3 0.010
LOC572344 hypothetical protein LOC572344 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.247
CCND1 cyclin D1 0.115
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.100
RB1 retinoblastoma 1 0.099
CCNE1 cyclin E1 0.075
RUNX1 runt-related transcription factor 1 0.073
CDK4 cyclin-dependent kinase 4 0.054
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.053
CDK6 cyclin-dependent kinase 6 0.049
SETD8 SET domain containing (lysine methyltransferase) 8 0.048
CDK2 cyclin-dependent kinase 2 0.046
NEK6 NIMA (never in mitosis gene a)-related kinase 6 0.045
CCND3 cyclin D3 0.044
PTBP1 polypyrimidine tract binding protein 1 0.038
MFN2 mitofusin 2 0.037
CLOCK clock homolog (mouse) 0.037
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.035
UBE2S ubiquitin-conjugating enzyme E2S 0.031
SIRT2 sirtuin 2 0.030
PLK1 polo-like kinase 1 0.028
TAL1 T-cell acute lymphocytic leukemia 1 0.024
MYCN v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.024
KRT5 keratin 5 0.024
JUN jun proto-oncogene 0.022
CLSPN claspin 0.021
SSRP1 structure specific recognition protein 1 0.020
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.020
GATA2 GATA binding protein 2 0.019
MCM10 minichromosome maintenance complex component 10 0.019
FZD1 frizzled homolog 1 (Drosophila) 0.019
NCOR2 nuclear receptor corepressor 2 0.019
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.018
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 0.018
CDC20 cell division cycle 20 homolog (S. cerevisiae) 0.016
MAK male germ cell-associated kinase 0.015
SATB2 SATB homeobox 2 0.015
HCFC1 host cell factor C1 (VP16-accessory protein) 0.014
TP73 tumor protein p73 0.014
H2AFX H2A histone family, member X 0.014
EP300 E1A binding protein p300 0.014
WWOX WW domain containing oxidoreductase 0.014
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.014
HIPK2 homeodomain interacting protein kinase 2 0.014
YAP1 Yes-associated protein 1 0.013
CABLES1 Cdk5 and Abl enzyme substrate 1 0.013
PCDH9 protocadherin 9 0.013
HDGF hepatoma-derived growth factor 0.013
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 0.013
MCM3 minichromosome maintenance complex component 3 0.012
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.012
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) 0.011
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.011
HIST2H3C histone cluster 2, H3c 0.010
FGF3 fibroblast growth factor 3 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Pten phosphatase and tensin homolog 0.977
Trp53 transformation related protein 53 0.946
Acvr1 activin A receptor, type 1 0.905
Ahr aryl-hydrocarbon receptor 0.564
Fbn1 fibrillin 1 0.511
Apc adenomatosis polyposis coli 0.487
Smad4 MAD homolog 4 (Drosophila) 0.328
Clock circadian locomotor output cycles kaput 0.239
Tgfbr2 transforming growth factor, beta receptor II 0.218
Eng endoglin 0.197
Ptk2 PTK2 protein tyrosine kinase 2 0.167
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.153
Smad3 MAD homolog 3 (Drosophila) 0.107
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.106
Ctnnb1 catenin (cadherin associated protein), beta 1 0.102
Abl1 c-abl oncogene 1, non-receptor tyrosine kinase 0.086
Atp7a ATPase, Cu++ transporting, alpha polypeptide 0.073
Nf1 neurofibromatosis 1 0.070
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.063
Tgfbr3 transforming growth factor, beta receptor III 0.061
Ric8 resistance to inhibitors of cholinesterase 8 homolog (C. elegans) 0.061
Vegfa vascular endothelial growth factor A 0.056
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.055
Ccnd2 cyclin D2 0.055
Trp73 transformation related protein 73 0.052
Cdh5 cadherin 5 0.051
Sox9 SRY-box containing gene 9 0.046
Bmpr1a bone morphogenetic protein receptor, type 1A 0.045
Fgfr1 fibroblast growth factor receptor 1 0.043
En1 engrailed 1 0.041
Ccnd1 cyclin D1 0.039
Nos3 nitric oxide synthase 3, endothelial cell 0.039
Smo smoothened homolog (Drosophila) 0.037
Notch1 Notch gene homolog 1 (Drosophila) 0.037
Shc1 src homology 2 domain-containing transforming protein C1 0.033
Yap1 yes-associated protein 1 0.032
Dok1 docking protein 1 0.029
Foxc1 forkhead box C1 0.029
Braf Braf transforming gene 0.028
Pparg peroxisome proliferator activated receptor gamma 0.028
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.028
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.027
Per2 period homolog 2 (Drosophila) 0.027
Npas2 neuronal PAS domain protein 2 0.025
Hoxa3 homeobox A3 0.025
Tgfbr1 transforming growth factor, beta receptor I 0.025
Ece1 endothelin converting enzyme 1 0.023
Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.023
Gata4 GATA binding protein 4 0.022
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.021
Tgfb2 transforming growth factor, beta 2 0.021
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.020
Smn1 survival motor neuron 1 0.020
Prkg1 protein kinase, cGMP-dependent, type I 0.019
Pcmtd2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 0.018
Fgf8 fibroblast growth factor 8 0.018
Dicer1 Dicer1, Dcr-1 homolog (Drosophila) 0.018
Igh immunoglobulin heavy chain complex 0.017
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.016
Vcl vinculin 0.016
Xiap X-linked inhibitor of apoptosis 0.016
Rxra retinoid X receptor alpha 0.016
Pdgfb platelet derived growth factor, B polypeptide 0.016
Emx1 empty spiracles homolog 1 (Drosophila) 0.015
Ank progressive ankylosis 0.015
Rara retinoic acid receptor, alpha 0.014
Smad2 MAD homolog 2 (Drosophila) 0.014
Hprt hypoxanthine guanine phosphoribosyl transferase 0.014
Skil SKI-like 0.013
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.013
Abl2 v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene) 0.013
Aplnr apelin receptor 0.013
Hif1a hypoxia inducible factor 1, alpha subunit 0.013
Meox2 mesenchyme homeobox 2 0.013
Mapk8 mitogen-activated protein kinase 8 0.012
Prdm1 PR domain containing 1, with ZNF domain 0.012
Cry2 cryptochrome 2 (photolyase-like) 0.012
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.012
Rc3h1 RING CCCH (C3H) domains 1 0.012
Bmpr2 bone morphogenic protein receptor, type II (serine/threonine kinase) 0.012
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.011
Bmp2 bone morphogenetic protein 2 0.011
Hipk3 homeodomain interacting protein kinase 3 0.011
Esr1 estrogen receptor 1 (alpha) 0.011
Smad6 MAD homolog 6 (Drosophila) 0.011
Rarg retinoic acid receptor, gamma 0.011
Wnt3a wingless-related MMTV integration site 3A 0.011
Ghr growth hormone receptor 0.011
Mapk14 mitogen-activated protein kinase 14 0.010
Pno1 partner of NOB1 homolog (S. cerevisiae) 0.010
Vhl von Hippel-Lindau tumor suppressor 0.010
Otx2 orthodenticle homolog 2 (Drosophila) 0.010
Klhl7 kelch-like 7 (Drosophila) 0.010
Prrx2 paired related homeobox 2 0.010
Polr2a polymerase (RNA) II (DNA directed) polypeptide A 0.010
Hes1 hairy and enhancer of split 1 (Drosophila) 0.010
Gli3 GLI-Kruppel family member GLI3 0.010
Sh3pxd2b SH3 and PX domains 2B 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
LOC301124 hypothetical LOC301124 0.033
Mrps16 mitochondrial ribosomal protein S16 0.030
Ifitm2 interferon induced transmembrane protein 2 0.029
Robld3 roadblock domain containing 3 0.018
Ndufb2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2 0.017
Dpm3 dolichyl-phosphate mannosyltransferase polypeptide 3 0.015
Rpl27 ribosomal protein L27 0.014
Psmb3 proteasome (prosome, macropain) subunit, beta type 3 0.014
Vkorc1 vitamin K epoxide reductase complex, subunit 1 0.014
Ostc oligosaccharyltransferase complex subunit 0.014
Ccdc80 coiled-coil domain containing 80 0.014
Eif3i eukaryotic translation initiation factor 3, subunit I 0.014
Ifitm1 interferon induced transmembrane protein 1 0.013
Rps19 ribosomal protein S19 0.013
Psmb1 proteasome (prosome, macropain) subunit, beta type 1 0.013
Laptm5 lysosomal protein transmembrane 5 0.011
Rps17 ribosomal protein S17 0.011
Ehd2 EH-domain containing 2 0.011
Taf10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor 0.011
mrpl11 mitochondrial ribosomal protein L11 0.011
Mrp63 mitochondrial ribosomal protein 63 0.010
Cd53 Cd53 molecule 0.010
Ccna2 cyclin A2 0.010