The network for 'regulation of protein kinase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of protein kinase activity

Any process that modulates the frequency, rate or extent of protein kinase activity.

Name Description Probability Func Analog Organism
PBS2 Pbs2p 0.993
PIL1 Pil1p 0.977
BCK1 Bck1p 0.958
SSK2 Ssk2p 0.956
CLB3 Clb3p 0.926
CKS1 Cks1p 0.924
CLN1 Cln1p 0.921
BOI1 Boi1p 0.900
SHO1 Sho1p 0.887
NBP2 Nbp2p 0.883
ROM2 Rom2p 0.876
CDC28 Cdc28p 0.841
HSL1 Hsl1p 0.826
CDC12 Cdc12p 0.771
CLN2 Cln2p 0.766
SLT2 Slt2p 0.717
SWE1 Swe1p 0.693
DBF2 Dbf2p 0.668
HOG1 Hog1p 0.656
NAP1 Nap1p 0.646
PHO85 Pho85p 0.635
GIN4 Gin4p 0.560
BMH1 Bmh1p 0.544
CLB6 Clb6p 0.543
MSG5 Msg5p 0.529
CLB2 Clb2p 0.522
SIC1 Sic1p 0.513
SSK1 Ssk1p 0.504
STE20 Ste20p 0.481
STE7 Ste7p 0.467
PAM1 Pam1p 0.444
CAK1 Cak1p 0.443
FAR1 Far1p 0.411
SNF1 Snf1p 0.384
SIP1 Sip1p 0.340
GAL83 Gal83p 0.335
TOR1 Tor1p 0.328
BCK2 Bck2p 0.291
PPH21 Pph21p 0.289
FUS3 Fus3p 0.283
MKK1 Mkk1p 0.281
PTC1 Ptc1p 0.276
RAD53 Rad53p 0.273
PHO81 Pho81p 0.256
CLA4 Cla4p 0.256
CDC37 Cdc37p 0.243
SNF4 Snf4p 0.243
RPP1B Rpp1bp 0.236
EDE1 Ede1p 0.230
PCL9 Pcl9p 0.219
PCL10 Pcl10p 0.217
SIL1 Sil1p 0.217
CDC6 Cdc6p 0.206
SAK1 Sak1p 0.203
PCL1 Pcl1p 0.195
MKK2 Mkk2p 0.189
CDC10 Cdc10p 0.185
SSK22 Ssk22p 0.183
MKS1 Mks1p 0.181
ERO1 Ero1p 0.175
DIA2 Dia2p 0.174
ELP2 Elp2p 0.165
STE4 Ste4p 0.149
BFR1 Bfr1p 0.139
ATG21 Atg21p 0.135
BEM2 Bem2p 0.130
CDC11 Cdc11p 0.129
YPD1 Ypd1p 0.129
SIP2 Sip2p 0.124
CRZ1 Crz1p 0.122
CLB5 Clb5p 0.118
YPL014W hypothetical protein 0.117
DIG1 Dig1p 0.116
GSY1 Gsy1p 0.114
LHS1 Lhs1p 0.113
ZDS1 Zds1p 0.112
HKR1 Hkr1p 0.111
CDC34 Cdc34p 0.110
CDH1 Cdh1p 0.110
HRR25 Hrr25p 0.109
CLB1 Clb1p 0.101
SLK19 Slk19p 0.100
TOR2 Tor2p 0.097
RPS29B Rps29bp 0.093
CDC55 Cdc55p 0.092
RLM1 Rlm1p 0.091
KCC4 Kcc4p 0.091
TRA1 Tra1p 0.091
ELP3 Elp3p 0.089
CLB4 Clb4p 0.088
SPC29 Spc29p 0.087
JEM1 Jem1p 0.087
CCW12 Ccw12p 0.086
HIR1 Hir1p 0.083
RRD1 Rrd1p 0.082
AXL2 Axl2p 0.081
PTK2 Ptk2p 0.079
PCL2 Pcl2p 0.079
RPN14 Rpn14p 0.079
RPP0 Rpp0p 0.078
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
plc-1 Protein PLC-1 0.100
vab-3 Protein VAB-3 0.099
sur-2 Protein SUR-2 0.076
mec-2 Protein MEC-2 0.069
bar-1 Protein BAR-1 0.059
tps-1 Protein TPS-1 0.053
eps-8 Protein EPS-8 0.053
pal-1 Protein PAL-1 0.053
inx-3 Protein INX-3 0.053
sax-7 Protein SAX-7 0.048
pig-1 Protein PIG-1 0.047
unc-7 Protein UNC-7 0.046
K10D6.4 Protein K10D6.4 0.045
egl-27 Protein EGL-27 0.045
nhr-6 Protein NHR-6 0.041
K08E3.5 Protein K08E3.5 0.041
mbk-2 Protein MBK-2 0.040
par-3 Protein PAR-3 0.040
daf-6 Protein DAF-6 0.038
apl-1 Protein APL-1 0.036
mpk-1 Protein MPK-1 0.035
sto-4 Protein STO-4 0.034
glp-1 Protein GLP-1 0.033
xpo-1 Protein XPO-1 0.033
atg-2 Protein ATG-2 0.033
plc-3 Protein PLC-3 0.033
chd-7 Protein CHD-7 0.032
inx-13 Protein INX-13 0.032
let-756 Protein LET-756 0.031
daf-1 Protein DAF-1 0.030
mek-2 Protein MEK-2 0.030
abl-1 Protein ABL-1 0.029
mef-2 Protein MEF-2 0.029
nth-1 Protein NTH-1 0.029
mes-3 Protein MES-3 0.029
C53B4.4 Protein C53B4.4 0.028
F07A11.2 Protein F07A11.2 0.028
egl-8 Protein EGL-8 0.028
arrd-25 Protein ARRD-25 0.027
unc-53 Protein UNC-53 0.027
cam-1 Protein CAM-1 0.026
exc-5 Protein EXC-5 0.026
mel-26 Protein MEL-26 0.026
CELE_Y57A10A.8 Protein Y57A10A.8 0.026
csnk-1 Protein CSNK-1 0.025
mei-1 Protein MEI-1 0.025
magi-1 Protein MAGI-1 0.025
unc-9 Protein UNC-9 0.025
ptr-2 Protein PTR-2 0.025
sma-6 Protein SMA-6 0.024
ceh-32 Protein CEH-32 0.024
inx-4 Protein INX-4 0.024
nlg-1 Protein NLG-1 0.023
hmr-1 Protein HMR-1 0.023
ida-1 Protein IDA-1 0.023
let-60 Protein LET-60 0.023
lin-36 Protein LIN-36 0.023
C35D10.1 Protein C35D10.1 0.023
dep-1 Protein DEP-1 0.022
egl-36 Protein EGL-36 0.022
R11A8.7 Protein R11A8.7 0.022
unc-73 Protein UNC-73 0.022
sek-1 Protein SEK-1 0.022
hmg-1.2 Protein HMG-1.2 0.021
pkn-1 Protein PKN-1 0.021
C13F10.4 Protein C13F10.4 0.021
sas-4 Protein SAS-4 0.021
M01A8.2 Protein M01A8.2 0.021
ZK507.6 Protein ZK507.6 0.021
smp-1 Protein SMP-1 0.021
eor-2 Protein EOR-2 0.021
rskn-1 Protein RSKN-1 0.020
T01G1.2 Protein T01G1.2 0.020
kgb-1 Protein KGB-1 0.020
pup-2 Protein PUP-2 0.020
alg-1 Protein ALG-1 0.019
mec-4 Protein MEC-4 0.019
smf-3 Protein SMF-3 0.019
sma-1 Protein SMA-1 0.019
ztf-7 Protein ZTF-7 0.019
svh-2 Protein SVH-2 0.019
pry-1 Protein PRY-1 0.019
C05D10.4 Protein C05D10.4 0.018
olrn-1 Protein OLRN-1 0.018
pat-12 Protein PAT-12 0.018
camt-1 Protein CAMT-1 0.018
lir-1 Protein LIR-1 0.018
tax-6 Protein TAX-6 0.018
F53B1.2 Protein F53B1.2 0.018
hel-1 Protein HEL-1 0.018
plk-1 Protein PLK-1 0.017
zyg-11 Protein ZYG-11 0.017
nhr-35 Protein NHR-35 0.017
K10D6.2 Protein K10D6.2 0.017
wwp-1 Protein WWP-1 0.017
flr-4 Protein FLR-4 0.017
T20D3.11 Protein T20D3.11 0.017
unc-43 Protein UNC-43 0.017
ftt-2 Protein FTT-2 0.016
gpd-4 Protein GPD-4 0.016
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Danio rerio
Name Description Probability Func Analog Organism
flh floating head 0.106
wnt1 wingless-type MMTV integration site family, member 1 0.085
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.084
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.081
spry4 sprouty (Drosophila) homolog 4 0.061
lcp1 lymphocyte cytosolic plastin 1 0.049
gadd45ba growth arrest and DNA-damage-inducible, beta a 0.046
dusp6 dual specificity phosphatase 6 0.045
rnd3a Rho family GTPase 3a 0.029
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.029
ccna2 cyclin A2 0.027
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.026
zbtb4 zinc finger and BTB domain containing 4 0.023
tlr3 toll-like receptor 3 0.023
igf1rb insulin-like growth factor 1b receptor 0.023
socs3a suppressor of cytokine signaling 3a 0.022
tert telomerase reverse transcriptase 0.022
crip2 cysteine-rich protein 2 0.022
ptprsa protein tyrosine phosphatase, receptor type, s, a 0.021
igf1ra insulin-like growth factor 1a receptor 0.021
pou5f1 POU domain, class 5, transcription factor 1 0.021
id1 inhibitor of DNA binding 1 0.021
gadd45bb growth arrest and DNA-damage-inducible, beta b 0.020
sall1a sal-like 1a (Drosophila) 0.020
sox11a SRY-box containing gene 11a 0.020
rhoub ras homolog gene family, member Ub 0.020
epor erythropoietin receptor 0.019
ighm immunoglobulin heavy constant mu and immunoglobulin heavy constant mu 0.018
igf1 insulin-like growth factor 1 0.018
nod1 nucleotide-binding oligomerization domain containing 1 0.018
psen1 presenilin 1 0.018
krt18 keratin 18 0.018
bnc2 basonuclin 2 0.018
pak2a p21 (CDKN1A)-activated kinase 2a 0.017
enc1 ectodermal-neural cortex (with BTB-like domain) 0.017
fgf3 fibroblast growth factor 3 0.017
neo1 neogenin 1 0.017
acvr2a activin receptor IIa 0.017
appa amyloid beta (A4) precursor protein a 0.016
jun jun proto-oncogene 0.016
foxa2 forkhead box A2 0.016
lama5 laminin, alpha 5 0.016
dharma dharma 0.016
rhoab ras homolog gene family, member Ab 0.016
spna2 spectrin alpha 2 0.016
ccnb1 cyclin B1 0.015
dag1 dystroglycan 1 0.015
rarab retinoic acid receptor, alpha b 0.015
ptenb phosphatase and tensin homolog B (mutated in multiple advanced cancers 1) 0.015
smad7 MAD, mothers against decapentaplegic homolog 7 (Drosophila) 0.015
sox32 SRY-box containing gene 32 0.014
dkk1b dickkopf 1b 0.014
erbb3a v-erb-b2 erythroblastic leukemia viral oncogene homolog 3a 0.014
osr1 odd-skipped related 1 (Drosophila) 0.014
erbb3b v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b 0.014
lratb lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b) 0.014
si:dkeyp-50f5.1 si:dkeyp-50f5.1 0.014
tnfsf10l tumor necrosis factor (ligand) superfamily, member 10 like 0.014
kdr kinase insert domain receptor (a type III receptor tyrosine kinase) 0.014
hspa4a heat shock protein 4a 0.013
mapk1 mitogen-activated protein kinase 1 0.013
fas Fas (TNF receptor superfamily, member 6) 0.013
tcf12 transcription factor 12 0.013
card9 caspase recruitment domain family, member 9 0.013
wnt10a wingless-type MMTV integration site family, member 10a 0.013
mbtps1 membrane-bound transcription factor protease, site 1 0.013
pcsk5b proprotein convertase subtilisin/kexin type 5b 0.013
atp2b4 ATPase, Ca++ transporting, plasma membrane 4 0.013
prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit 0.013
oep one-eyed pinhead 0.013
wu:fb58e05 wu:fb58e05 0.013
mapk14a mitogen-activated protein kinase 14a 0.013
col7a1l collagen type VII alpha 1-like 0.013
gnb1a guanine nucleotide binding protein (G protein), beta polypeptide 1a 0.013
junb jun B proto-oncogene 0.012
ptpra protein tyrosine phosphatase, receptor type, A 0.012
aox3 aldehyde oxidase 3 0.012
fzd7a frizzled homolog 7a 0.012
LOC100151531 zinc finger protein Gfi-1b-like 0.012
ntrk2b neurotrophic tyrosine kinase, receptor, type 2b 0.012
ved ventrally expressed dharma/bozozok antagonist 0.012
tagln2 transgelin 2 0.012
mycbp2 MYC binding protein 2 0.012
gli3 GLI-Kruppel family member GLI3 0.012
si:ch211-57k11.10 si:ch211-57k11.10 0.012
h3f3a H3 histone, family 3A 0.012
dip2c DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.012
sox11b SRY-box containing gene 11b 0.012
nr2e3 nuclear receptor subfamily 2, group E, member 3 0.012
ighz immunoglobulin heavy constant zeta 0.012
nfe2l2 nuclear factor (erythroid-derived 2)-like 2 0.012
arl4ab ADP-ribosylation factor-like 4ab 0.012
epas1b endothelial PAS domain protein 1b 0.012
socs1 suppressor of cytokine signaling 1 0.012
grin1a glutamate receptor, ionotropic, N-methyl D-aspartate 1a 0.012
wnt5b wingless-type MMTV integration site family, member 5b 0.012
mpped2 metallophosphoesterase domain containing 2 0.012
htra1a HtrA serine peptidase 1a 0.012
junbl jun B proto-oncogene, like 0.011
wnt10b wingless-type MMTV integration site family, member 10b 0.011
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Ras85D Ras oncogene at 85D 0.998
rl rolled 0.982
G-oalpha47A G protein oalpha 47A 0.970
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.939
drk downstream of receptor kinase 0.914
Akt1 CG4006 gene product from transcript CG4006-RA 0.908
Mad Mothers against dpp 0.866
CkIIalpha Casein kinase II alpha subunit 0.837
kay kayak 0.738
InR Insulin-like receptor 0.713
Rho1 CG8416 gene product from transcript CG8416-RB 0.670
par-1 CG8201 gene product from transcript CG8201-RA 0.662
Atg1 Autophagy-specific gene 1 0.652
chico CG5686 gene product from transcript CG5686-RB 0.586
Dab Disabled 0.579
ttk tramtrack 0.569
bsk basket 0.544
CycE Cyclin E 0.528
shn schnurri 0.512
Stat92E Signal-transducer and activator of transcription protein at 92E 0.486
ena enabled 0.483
dsh dishevelled 0.476
Sin3A CG8815 gene product from transcript CG8815-RC 0.421
puc puckered 0.415
G-salpha60A G protein salpha 60A 0.413
phl pole hole 0.411
Liprin-alpha CG11199 gene product from transcript CG11199-RB 0.405
Sara Smad anchor for receptor activation 0.398
Rab11 Rab-protein 11 0.379
Rac1 CG2248 gene product from transcript CG2248-RA 0.377
Rab5 Rab-protein 5 0.371
Pkn Protein kinase related to protein kinase N 0.352
scb scab 0.345
Dad Daughters against dpp 0.334
baz bazooka 0.331
rut rutabaga 0.331
Src42A Src oncogene at 42A 0.326
dap dacapo 0.324
caz cabeza 0.322
shi shibire 0.310
CG5794 CG5794 gene product from transcript CG5794-RB 0.305
CaMKII Calcium/calmodulin-dependent protein kinase II 0.302
cta concertina 0.302
nej nejire 0.299
jeb jelly belly 0.271
X11L CG5675 gene product from transcript CG5675-RB 0.251
aop anterior open 0.246
Jra Jun-related antigen 0.239
HLHmdelta E(spl) region transcript mdelta 0.236
babo baboon 0.232
Fmr1 CG6203 gene product from transcript CG6203-RC 0.232
p38b CG7393 gene product from transcript CG7393-RA 0.220
krz kurtz 0.218
HLHm7 E(spl) region transcript m7 0.215
Cdc42 CG12530 gene product from transcript CG12530-RA 0.214
NFAT NFAT homolog 0.210
Socs36E Suppressor of cytokine signaling at 36E 0.209
zfh1 Zn finger homeodomain 1 0.205
CG13253 CG13253 gene product from transcript CG13253-RB 0.204
Cip4 CG15015 gene product from transcript CG15015-RA 0.200
tws twins 0.200
sgg shaggy 0.180
Su(H) Suppressor of Hairless 0.176
ovo CG6824 gene product from transcript CG6824-RE 0.169
stck steamer duck 0.164
EndoGI Endonuclease G inhibitor 0.160
Ptp69D Protein tyrosine phosphatase 69D 0.157
p53 CG33336 gene product from transcript CG33336-RB 0.157
Tsp Thrombospondin 0.156
hipk homeodomain interacting protein kinase 0.154
Tl Toll 0.153
pnut peanut 0.151
Egfr Epidermal growth factor receptor 0.150
mew multiple edematous wings 0.149
numb CG3779 gene product from transcript CG3779-RB 0.148
Pk61C Protein kinase 61C 0.147
Dhc64C Dynein heavy chain 64C 0.145
HLHmgamma E(spl) region transcript mgamma 0.143
sev sevenless 0.140
Tao-1 CG14217 gene product from transcript CG14217-RF 0.132
CycA Cyclin A 0.129
Ras64B Ras oncogene at 64B 0.127
drongo CG3365 gene product from transcript CG3365-RH 0.125
Mob2 CG11711 gene product from transcript CG11711-RC 0.122
Tsc1 CG6147 gene product from transcript CG6147-RA 0.121
foxo forkhead box, sub-group O 0.121
pum pumilio 0.121
Caki Calcium/calmodulin-dependent protein kinase 0.120
trio CG18214 gene product from transcript CG18214-RA 0.120
Cdk4 Cyclin-dependent kinase 4 0.119
Stim Stromal interaction molecule 0.119
dia diaphanous 0.118
dos daughter of sevenless 0.117
dnc dunce 0.116
E(spl) Enhancer of split 0.115
Hs6st Heparan sulfate 6-O-sulfotransferase 0.112
dally division abnormally delayed 0.112
spas spastin 0.110
Mpk2 CG5475 gene product from transcript CG5475-RB 0.106
gig gigas 0.105
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
EGFR epidermal growth factor receptor 1.000
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 1.000
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 1.000
RB1 retinoblastoma 1 1.000
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.999
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.999
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.998
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.998
UBC ubiquitin C 0.998
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.997
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.995
TRAF6 TNF receptor-associated factor 6 0.995
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.995
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.994
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.993
PLCG1 phospholipase C, gamma 1 0.993
MAPK14 mitogen-activated protein kinase 14 0.993
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.993
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.993
MAPK8 mitogen-activated protein kinase 8 0.990
JUN jun proto-oncogene 0.987
MAPK1 mitogen-activated protein kinase 1 0.986
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.983
DUSP1 dual specificity phosphatase 1 0.981
MET met proto-oncogene (hepatocyte growth factor receptor) 0.979
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.973
GRB2 growth factor receptor-bound protein 2 0.971
SNX9 sorting nexin 9 0.971
IRAK2 interleukin-1 receptor-associated kinase 2 0.958
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.950
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.949
CCND1 cyclin D1 0.948
FYN FYN oncogene related to SRC, FGR, YES 0.941
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.939
ARRB1 arrestin, beta 1 0.939
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.938
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.935
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.932
SQSTM1 sequestosome 1 0.931
PRKCZ protein kinase C, zeta 0.931
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 0.931
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.930
BBS10 Bardet-Biedl syndrome 10 0.928
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.926
MAP3K3 mitogen-activated protein kinase kinase kinase 3 0.923
VAV1 vav 1 guanine nucleotide exchange factor 0.923
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.922
LCK lymphocyte-specific protein tyrosine kinase 0.920
TP53 tumor protein p53 0.917
IGF1R insulin-like growth factor 1 receptor 0.917
FGFR2 fibroblast growth factor receptor 2 0.915
LRRK2 leucine-rich repeat kinase 2 0.907
CDC37 cell division cycle 37 homolog (S. cerevisiae) 0.906
TOLLIP toll interacting protein 0.900
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.889
ADAM15 ADAM metallopeptidase domain 15 0.887
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.886
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.885
SMAD3 SMAD family member 3 0.883
SH3KBP1 SH3-domain kinase binding protein 1 0.881
FGFR1 fibroblast growth factor receptor 1 0.876
ESR1 estrogen receptor 1 0.875
SMAD2 SMAD family member 2 0.872
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.864
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.846
CSNK1E casein kinase 1, epsilon 0.825
CCND3 cyclin D3 0.822
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.816
GAB1 GRB2-associated binding protein 1 0.808
FOS FBJ murine osteosarcoma viral oncogene homolog 0.807
PTK2 PTK2 protein tyrosine kinase 2 0.806
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 0.806
CDK6 cyclin-dependent kinase 6 0.804
MAP3K11 mitogen-activated protein kinase kinase kinase 11 0.801
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.791
JUNB jun B proto-oncogene 0.786
CCNE1 cyclin E1 0.784
PTK2B PTK2B protein tyrosine kinase 2 beta 0.772
BTRC beta-transducin repeat containing 0.769
MAP2K4 mitogen-activated protein kinase kinase 4 0.763
CAV1 caveolin 1, caveolae protein, 22kDa 0.758
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.746
CDK9 cyclin-dependent kinase 9 0.742
C1QA complement component 1, q subcomponent, A chain 0.729
MAP2K7 mitogen-activated protein kinase kinase 7 0.728
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.727
FLNB filamin B, beta 0.727
DLG1 discs, large homolog 1 (Drosophila) 0.726
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.723
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.717
MAP2K1 mitogen-activated protein kinase kinase 1 0.717
TSC2 tuberous sclerosis 2 0.713
CREBBP CREB binding protein 0.711
CDK2 cyclin-dependent kinase 2 0.706
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.705
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 0.705
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.698
MUC1 mucin 1, cell surface associated 0.687
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.685
CDC27 cell division cycle 27 homolog (S. cerevisiae) 0.683
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Ctnnb1 catenin (cadherin associated protein), beta 1 1.000
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 1.000
Cbl Casitas B-lineage lymphoma 0.998
Trp53 transformation related protein 53 0.998
Lepr leptin receptor 0.998
Pten phosphatase and tensin homolog 0.997
Apc adenomatosis polyposis coli 0.997
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.997
Efnb2 ephrin B2 0.993
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.989
Socs1 suppressor of cytokine signaling 1 0.988
Grb2 growth factor receptor bound protein 2 0.988
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.986
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.985
Mapk8 mitogen-activated protein kinase 8 0.982
Gli3 GLI-Kruppel family member GLI3 0.982
Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 0.980
Dab1 disabled homolog 1 (Drosophila) 0.979
Egfr epidermal growth factor receptor 0.978
Src Rous sarcoma oncogene 0.978
Rb1 retinoblastoma 1 0.977
Ephb2 Eph receptor B2 0.975
Cd44 CD44 antigen 0.970
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.964
Tnf tumor necrosis factor 0.961
Rac1 RAS-related C3 botulinum substrate 1 0.961
Ptgs2 prostaglandin-endoperoxide synthase 2 0.959
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.956
Dok1 docking protein 1 0.956
Mdm2 transformed mouse 3T3 cell double minute 2 0.951
Smad3 MAD homolog 3 (Drosophila) 0.950
Vangl2 vang-like 2 (van gogh, Drosophila) 0.939
Fgfr2 fibroblast growth factor receptor 2 0.937
Lyz2 lysozyme 2 0.934
Fos FBJ osteosarcoma oncogene 0.934
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.932
Yap1 yes-associated protein 1 0.931
Plcg1 phospholipase C, gamma 1 0.929
Axin1 axin 1 0.925
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.920
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.914
Gsk3b glycogen synthase kinase 3 beta 0.914
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.912
Thbs1 thrombospondin 1 0.900
Flt1 FMS-like tyrosine kinase 1 0.898
Jun Jun oncogene 0.896
Inpp5d inositol polyphosphate-5-phosphatase D 0.895
Tgfb2 transforming growth factor, beta 2 0.890
App amyloid beta (A4) precursor protein 0.889
Il1r1 interleukin 1 receptor, type I 0.885
Cdkn2c cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.883
Ccnd1 cyclin D1 0.876
Esr1 estrogen receptor 1 (alpha) 0.863
Tsc1 tuberous sclerosis 1 0.858
Nos1 nitric oxide synthase 1, neuronal 0.855
Ret ret proto-oncogene 0.852
Mapk14 mitogen-activated protein kinase 14 0.833
Tgfbr1 transforming growth factor, beta receptor I 0.833
Trp63 transformation related protein 63 0.833
Axl AXL receptor tyrosine kinase 0.832
Traf6 TNF receptor-associated factor 6 0.828
Irs1 insulin receptor substrate 1 0.824
Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) 0.810
Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) 0.807
Csf1 colony stimulating factor 1 (macrophage) 0.805
Fyn Fyn proto-oncogene 0.805
Crk v-crk sarcoma virus CT10 oncogene homolog (avian) 0.803
Stat3 signal transducer and activator of transcription 3 0.802
Ednrb endothelin receptor type B 0.791
Cdc42 cell division cycle 42 homolog (S. cerevisiae) 0.788
Fzd4 frizzled homolog 4 (Drosophila) 0.785
Bmpr2 bone morphogenic protein receptor, type II (serine/threonine kinase) 0.780
Insr insulin receptor 0.770
Arrb2 arrestin, beta 2 0.763
Fbn1 fibrillin 1 0.752
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.751
Braf Braf transforming gene 0.747
Epas1 endothelial PAS domain protein 1 0.744
Lrp1 low density lipoprotein receptor-related protein 1 0.743
Stk4 serine/threonine kinase 4 0.742
Tgfa transforming growth factor alpha 0.736
Il6st interleukin 6 signal transducer 0.731
Efnb1 ephrin B1 0.727
Ptk7 PTK7 protein tyrosine kinase 7 0.722
Klf7 Kruppel-like factor 7 (ubiquitous) 0.716
Nck2 non-catalytic region of tyrosine kinase adaptor protein 2 0.712
Prkce protein kinase C, epsilon 0.710
Slc7a2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.705
C3ar1 complement component 3a receptor 1 0.705
Bmpr1a bone morphogenetic protein receptor, type 1A 0.703
Dvl3 dishevelled 3, dsh homolog (Drosophila) 0.702
Nf1 neurofibromatosis 1 0.700
Adam12 a disintegrin and metallopeptidase domain 12 (meltrin alpha) 0.699
Gab1 growth factor receptor bound protein 2-associated protein 1 0.698
Ptk2 PTK2 protein tyrosine kinase 2 0.696
Rictor RPTOR independent companion of MTOR, complex 2 0.694
Trp73 transformation related protein 73 0.687
Ccr1 chemokine (C-C motif) receptor 1 0.686
Il1b interleukin 1 beta 0.682
Tspan9 tetraspanin 9 0.680
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Dusp1 dual specificity phosphatase 1 0.598
Sirpa signal-regulatory protein alpha 0.596
Jak2 Janus kinase 2 0.575
Jun Jun oncogene 0.509
Inpp5d inositol polyphosphate-5-phosphatase D 0.366
Grb2 growth factor receptor bound protein 2 0.315
Klf6 Kruppel-like factor 6 0.301
Mr1 major histocompatibility complex, class I-related 0.288
Btg2 BTG family, member 2 0.280
Mapk9 mitogen-activated protein kinase 9 0.261
Junb jun B proto-oncogene 0.258
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.255
Vav1 vav 1 guanine nucleotide exchange factor 0.239
Nrp1 neuropilin 1 0.222
Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.220
Agtr1a angiotensin II receptor, type 1a 0.214
Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 0.210
Prkcd protein kinase C, delta 0.208
Zfp36 zinc finger protein 36 0.203
Cdh17 cadherin 17 0.201
Cdkn2b cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.200
Egfr epidermal growth factor receptor 0.197
Fosl1 fos-like antigen 1 0.196
Errfi1 ERBB receptor feedback inhibitor 1 0.191
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.180
Cd38 CD38 molecule 0.179
Mapk1 mitogen activated protein kinase 1 0.176
Bcan brevican 0.176
Prdm2 PR domain containing 2, with ZNF domain 0.175
Cmklr1 chemokine-like receptor 1 0.168
Mapk3 mitogen activated protein kinase 3 0.167
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.162
Fos FBJ osteosarcoma oncogene 0.155
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.152
Vom2r53 vomeronasal 2 receptor, 53 0.152
Grm7 glutamate receptor, metabotropic 7 0.151
Myo1e myosin IE 0.150
Drd2 dopamine receptor D2 0.149
Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit 0.148
Hpca hippocalcin 0.148
Slc7a12 solute carrier family 7 (cationic amino acid transporter, y+ system), member 12 0.148
Homer3 homer homolog 3 (Drosophila) 0.147
Slc7a2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.146
Tas2r107 taste receptor, type 2, member 107 0.145
Clstn3 calsyntenin 3 0.145
Nsf N-ethylmaleimide-sensitive factor 0.143
Met met proto-oncogene 0.137
Mpeg1 macrophage expressed 1 0.137
Gna12 guanine nucleotide binding protein (G protein) alpha 12 0.136
Adrbk1 adrenergic, beta, receptor kinase 1 0.133
Cdc42 cell division cycle 42 (GTP binding protein) 0.132
Nr4a1 nuclear receptor subfamily 4, group A, member 1 0.132
Cx3cr1 chemokine (C-X3-C motif) receptor 1 0.132
Pnlip pancreatic lipase 0.132
Slc6a6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 0.131
Trhr thyrotropin releasing hormone receptor 0.130
Unc5b unc-5 homolog B (C. elegans) 0.129
Ier2 immediate early response 2 0.128
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.128
Crk v-crk sarcoma virus CT10 oncogene homolog (avian) 0.128
Ptpn7 protein tyrosine phosphatase, non-receptor type 7 0.127
Wdr26 WD repeat domain 26 0.127
RGD1564664 similar to LOC387763 protein 0.124
Itpkb inositol 1,4,5-trisphosphate 3-kinase B 0.124
Slco2a1 solute carrier organic anion transporter family, member 2a1 0.123
Cfp complement factor properdin 0.120
Fgfr1 Fibroblast growth factor receptor 1 0.118
Akt1 v-akt murine thymoma viral oncogene homolog 1 0.118
Pctk2 PCTAIRE protein kinase 2 0.118
Stip1 stress-induced phosphoprotein 1 0.117
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.117
Map6 microtubule-associated protein 6 0.117
Smad3 SMAD family member 3 0.116
Myo1b myosin Ib 0.116
Cd4 Cd4 molecule 0.115
Irs1 insulin receptor substrate 1 0.115
Bdkrb2 bradykinin receptor B2 0.114
Hk1 hexokinase 1 0.112
Egr1 early growth response 1 0.112
Prkch protein kinase C, eta 0.111
Necab1 N-terminal EF-hand calcium binding protein 1 0.111
Atp2b1 ATPase, Ca++ transporting, plasma membrane 1 0.111
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.110
Prkacb protein kinase, cAMP dependent, catalytic, beta 0.110
Jak1 Janus kinase 1 0.109
Ptprq protein tyrosine phosphatase, receptor type, Q 0.109
Utrn utrophin 0.109
Pcnxl3 pecanex-like 3 (Drosophila) 0.109
Ptafr platelet-activating factor receptor 0.108
Hpcal4 hippocalcin-like 4 0.107
Tle4 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) 0.107
Adora2a adenosine A2a receptor 0.107
Dusp6 dual specificity phosphatase 6 0.106
Scarb1 scavenger receptor class B, member 1 0.105
Ccnd1 cyclin D1 0.105
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.104
Calcrl calcitonin receptor-like 0.103
Slc9a1 solute carrier family 9 (sodium/hydrogen exchanger), member 1 0.103
Atf3 activating transcription factor 3 0.103
Fgfr2 fibroblast growth factor receptor 2 0.102