The network for 'modification dependent macromolecule catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

modification dependent macromolecule catabolic process

The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
CDC48 Cdc48p 1.000
RPT1 Rpt1p 0.999
KAR2 Kar2p 0.999
RAD23 Rad23p 0.999
SKP1 Skp1p 0.998
NPL4 Npl4p 0.992
CSL4 Csl4p 0.988
RPN10 Rpn10p 0.982
RPT6 Rpt6p 0.980
RPT2 Rpt2p 0.978
RPT4 Rpt4p 0.974
RPT3 Rpt3p 0.972
PRE1 Pre1p 0.971
RPN12 Rpn12p 0.965
OTU1 Otu1p 0.957
RPN11 Rpn11p 0.956
MND2 Mnd2p 0.947
PMT1 Pmt1p 0.944
UBP6 Ubp6p 0.938
UFD2 Ufd2p 0.931
UBR1 Ubr1p 0.925
APC5 Apc5p 0.914
RRP6 Rrp6p 0.912
RPT5 Rpt5p 0.909
FYV10 Fyv10p 0.908
PRE5 Pre5p 0.901
MAD2 Mad2p 0.901
RPN6 Rpn6p 0.901
VPS36 Vps36p 0.883
DOC1 Doc1p 0.882
UFD1 Ufd1p 0.882
DER1 Der1p 0.863
PRE9 Pre9p 0.860
CDC27 Cdc27p 0.860
DSK2 Dsk2p 0.850
RRP46 Rrp46p 0.846
PRE2 Pre2p 0.843
RPN9 Rpn9p 0.838
CDC16 Cdc16p 0.838
SWM1 Swm1p 0.832
PUP2 Pup2p 0.828
PRE10 Pre10p 0.819
UFD4 Ufd4p 0.811
PPH22 Pph22p 0.810
PRE6 Pre6p 0.809
DFM1 Dfm1p 0.809
RPN3 Rpn3p 0.808
APC2 Apc2p 0.802
NOP6 Nop6p 0.790
RPN7 Rpn7p 0.782
MUB1 Mub1p 0.780
RPN13 Rpn13p 0.770
CDC23 Cdc23p 0.762
UMP1 Ump1p 0.753
UBX2 Ubx2p 0.750
SKI6 Ski6p 0.749
RRP40 Rrp40p 0.746
CTF13 Ctf13p 0.729
PRE4 Pre4p 0.726
VPS27 Vps27p 0.720
SSM4 Ssm4p 0.712
CDC26 Cdc26p 0.702
SCJ1 Scj1p 0.701
RPN8 Rpn8p 0.688
RKR1 Rkr1p 0.684
RRP43 Rrp43p 0.683
MTR3 Mtr3p 0.666
PRE7 Pre7p 0.657
CDC4 Cdc4p 0.654
RRP4 Rrp4p 0.643
SCL1 Scl1p 0.640
HRD3 Hrd3p 0.635
PUP1 Pup1p 0.632
PPH21 Pph21p 0.631
VID24 Vid24p 0.621
RPN1 Rpn1p 0.614
CDC53 Cdc53p 0.611
SKI7 Ski7p 0.604
DIS3 Dis3p 0.601
HRD1 Hrd1p 0.599
UBC4 Ubc4p 0.584
VPS60 Vps60p 0.574
FPK1 Fpk1p 0.564
APC9 Apc9p 0.554
ELC1 Elc1p 0.554
CUE1 Cue1p 0.546
RMD5 Rmd5p 0.535
TID3 Tid3p 0.533
RAD6 Rad6p 0.527
SLK19 Slk19p 0.526
GID7 Gid7p 0.524
APC1 Apc1p 0.522
YPT1 Ypt1p 0.506
LAG2 Lag2p 0.481
VID28 Vid28p 0.478
YMR258C hypothetical protein 0.477
VID30 Vid30p 0.477
BRE5 Bre5p 0.477
YLR352W hypothetical protein 0.476
CBF2 Cbf2p 0.468
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
pas-4 Protein PAS-4 0.846
rpt-2 Protein RPT-2 0.724
rpt-3 Protein RPT-3 0.712
pbs-6 Protein PBS-6 0.638
rpn-12 Protein RPN-12 0.566
rpt-5 Protein RPT-5 0.496
rpn-3 Protein RPN-3 0.446
rpn-7 Protein RPN-7 0.415
npl-4.2 Protein NPL-4.2 0.374
pas-6 Protein PAS-6 0.341
cul-1 Protein CUL-1 0.307
rpn-10 Protein RPN-10 0.306
rpn-6.1 Protein RPN-6.1 0.268
pbs-5 Protein PBS-5 0.250
rpn-5 Protein RPN-5 0.233
hgrs-1 Protein HGRS-1 0.231
pbs-7 Protein PBS-7 0.226
pbs-3 Protein PBS-3 0.224
K08E3.5 Protein K08E3.5 0.203
pbs-2 Protein PBS-2 0.191
mig-5 Protein MIG-5 0.189
bub-1 Protein BUB-1 0.180
mdf-2 Protein MDF-2 0.169
rpn-9 Protein RPN-9 0.153
taf-5 Protein TAF-5 0.152
imb-2 Protein IMB-2 0.148
rnr-1 Protein RNR-1 0.144
atx-3 Protein ATX-3 0.142
pas-2 Protein PAS-2 0.139
dpy-30 Protein DPY-30 0.136
pbs-4 Protein PBS-4 0.136
tba-2 Protein TBA-2 0.129
pas-1 Protein PAS-1 0.124
cdc-48.2 Protein CDC-48.2 0.122
rpn-1 Protein RPN-1 0.121
egl-18 Protein EGL-18 0.117
E04D5.1 Protein E04D5.1 0.114
rpt-4 Protein RPT-4 0.108
T20B12.7 Protein T20B12.7 0.107
rpn-2 Protein RPN-2 0.103
app-1 Protein APP-1 0.101
F53B7.3 Protein F53B7.3 0.101
pbs-1 Protein PBS-1 0.096
hda-1 Protein HDA-1 0.094
npl-4.1 Protein NPL-4.1 0.094
T22F3.2 Protein T22F3.2 0.084
his-42 Protein HIS-42 0.082
asb-1 Protein ASB-1 0.081
klp-16 Protein KLP-16 0.080
T07F10.3 Protein T07F10.3 0.075
CELE_C24H12.5 Protein C24H12.5 0.072
zen-4 Protein ZEN-4 0.066
gei-11 Protein GEI-11 0.066
pup-2 Protein PUP-2 0.064
F25B3.6 Protein F25B3.6 0.063
klp-19 Protein KLP-19 0.061
puf-7 Protein PUF-7 0.060
syx-17 Protein SYX-17 0.057
ubxn-1 Protein UBXN-1 0.056
hcp-1 Protein HCP-1 0.056
pgl-1 Protein PGL-1 0.055
rod-1 Protein ROD-1 0.055
ima-2 Protein IMA-2 0.052
C31E10.6 Protein C31E10.6 0.051
rpn-8 Protein RPN-8 0.051
nduf-2.2 Protein NDUF-2.2 0.050
taf-9 Protein TAF-9 0.050
B0454.9 Protein B0454.9 0.050
D1081.8 Protein D1081.8 0.049
spas-1 Protein SPAS-1 0.049
rpl-11.1 Protein RPL-11.1 0.049
R11A8.7 Protein R11A8.7 0.048
F46F11.6 Protein F46F11.6 0.048
CELE_K08F4.1 Protein K08F4.1 0.048
F37A4.1 Protein F37A4.1 0.045
M106.3 Protein M106.3 0.045
rsd-2 Protein RSD-2 0.045
tbb-2 Protein TBB-2 0.044
mcm-2 Protein MCM-2 0.044
spn-4 Protein SPN-4 0.044
rpt-6 Protein RPT-6 0.043
rpn-11 Protein RPN-11 0.043
syx-5 Protein SYX-5 0.043
tba-1 Protein TBA-1 0.043
C13F10.5 Protein C13F10.5 0.042
atg-3 Protein ATG-3 0.042
cpg-8 Protein CPG-8 0.041
rha-1 Protein RHA-1 0.041
CELE_B0334.5 Protein B0334.5 0.041
ZK1010.2 Protein ZK1010.2 0.040
mex-3 Protein MEX-3 0.039
asd-1 Protein ASD-1 0.039
rfc-2 Protein RFC-2 0.039
spk-1 Protein SPK-1 0.039
gyg-2 Protein GYG-2 0.039
sas-5 Protein SAS-5 0.039
pas-5 Protein PAS-5 0.038
sel-9 Protein SEL-9 0.038
pap-1 Protein PAP-1 0.038
mcm-6 Protein MCM-6 0.038
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
psmd6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.967
psmb1 proteasome (prosome, macropain) subunit, beta type, 1 0.957
psmd4b proteasome (prosome, macropain) 26S subunit, non-ATPase, 4b 0.853
psma6a proteasome (prosome, macropain) subunit, alpha type, 6a 0.823
psmb7 proteasome (prosome, macropain) subunit, beta type, 7 0.805
psma8 proteasome (prosome, macropain) subunit, alpha type, 8 0.797
psmb4 proteasome (prosome, macropain) subunit, beta type, 4 0.789
psmd12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.766
psmb3 proteasome (prosome, macropain) subunit, beta type, 3 0.764
zgc:92775 zgc:92775 0.735
psmc6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.732
adrm1b adhesion regulating molecule 1b 0.676
psmd1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.641
ube2d1 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) 0.613
psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.610
psmd13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 0.580
ccnb1 cyclin B1 0.574
psmc1b proteasome (prosome, macropain) 26S subunit, ATPase, 1b 0.566
tia1l cytotoxic granule-associated RNA binding protein 1, like 0.498
wnt4a wingless-type MMTV integration site family, member 4a 0.489
psma4 proteasome (prosome, macropain) subunit, alpha type, 4 0.477
chuk conserved helix-loop-helix ubiquitous kinase 0.474
vcp valosin containing protein 0.455
rab1a RAB1A, member RAS oncogene family 0.441
hspa5 heat shock protein 5 0.436
bc2 putative breast adenocarcinoma marker 0.434
ywhabb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b 0.418
psma2 proteasome (prosome, macropain) subunit, alpha type, 2 0.408
cdt1 chromatin licensing and DNA replication factor 1 0.399
psmc4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.399
mcts1 malignant T cell amplified sequence 1 0.399
psmb2 proteasome (prosome, macropain) subunit, beta type, 2 0.384
ck2b casein kinase 2 beta 0.378
eif1b eukaryotic translation initiation factor 1B 0.363
psmc5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.357
psma1 proteasome (prosome, macropain) subunit, alpha type, 1 0.356
kif23 kinesin family member 23 0.351
tsc22d2 TSC22 domain family 2 and TSC22 domain family, member 2 0.351
aurkb aurora kinase B 0.345
si:ch73-9j13.1 si:ch73-9j13.1 0.330
pdlim4 PDZ and LIM domain 4 0.322
lancl1 LanC antibiotic synthetase component C-like 1 (bacterial) 0.321
ihha Indian hedgehog homolog a 0.307
si:ch211-239j15.4 si:ch211-239j15.4 0.305
hspa4b heat shock protein 4b 0.301
zgc:111944 zgc:111944 0.299
plk1 polo-like kinase 1 (Drosophila) 0.297
ccnb2 cyclin B2 0.295
chmp4b chromatin modifying protein 4B 0.293
baxa bcl2-associated X protein, a 0.285
zgc:123326 zgc:123326 0.285
dnm1l dynamin 1-like 0.274
gps1 G protein pathway suppressor 1 0.272
arpp19a cAMP-regulated phosphoprotein 19a 0.267
sumo1 SMT3 suppressor of mif two 3 homolog 1 (yeast) 0.264
psmd11b proteasome (prosome, macropain) 216S subunit, non-ATPase, 11b 0.263
psmb5 proteasome (prosome, macropain) subunit, beta type, 5 0.254
psma5 proteasome (prosome, macropain) subunit, alpha type,5 0.252
pdia4 protein disulfide isomerase associated 4 0.251
sirt1 sirtuin (silent mating type information regulation 2 homolog) 1 0.250
smarcb1a SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1a 0.247
psmd11a proteasome (prosome, macropain) 216S subunit, non-ATPase, 11a 0.246
cnot6 CCR4-NOT transcription complex, subunit 6 0.242
dnajc3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.240
tmem93 transmembrane protein 93 0.240
flii flightless I homolog (Drosophila) 0.239
ddx42 DEAD (Asp-Glu-Ala-Asp) box polypeptide 42 0.236
bsdc1 BSD domain containing 1 0.231
tacc3 transforming, acidic coiled-coil containing protein 3 0.229
zgc:85866 zgc:85866 0.229
zgc:55448 zgc:55448 0.223
dusp1 dual specificity phosphatase 1 0.222
zgc:110116 zgc:110116 0.220
syap1 synapse associated protein 1 0.220
syvn1 synovial apoptosis inhibitor 1, synoviolin 0.218
psmc1a proteasome (prosome, macropain) 26S subunit, ATPase, 1a 0.217
crkl v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.216
ube2q2 ubiquitin-conjugating enzyme E2Q family member 2 0.214
max myc-associated factor X 0.213
rae1 RAE1 RNA export 1 homolog (S. pombe) 0.213
tnpo3 transportin 3 0.212
usp5 ubiquitin specific protease 5 0.212
srsf11 serine/arginine-rich splicing factor 11 0.210
faf2 Fas associated factor family member 2 0.208
dirc2 disrupted in renal carcinoma 2 0.207
zgc:86903 zgc:86903 0.206
fbxw2 F-box and WD repeat domain containing 2 0.206
exoc3 exocyst complex component 3 0.205
si:ch211-51m24.3 si:ch211-51m24.3 0.203
arf2 ADP-ribosylation factor 2 0.202
ccne cyclin E 0.200
capn2b calpain 2, (m/II) large subunit b 0.197
psmb11 proteasome (prosome, macropain) subunit, beta type, 11 0.196
kdm5c lysine (K)-specific demethylase 5C 0.192
psmd2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.185
hirip5 HIRA interacting protein 5 0.184
zfand5b zinc finger, AN1-type domain 5b 0.183
ube2g2 ubiquitin-conjugating enzyme E2G 2 0.182
pxn paxillin 0.180
orc1 origin recognition complex, subunit 1 0.180
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Rpt3 CG16916 gene product from transcript CG16916-RA 0.980
Prosbeta2 Proteasome beta2 subunit 0.969
Pros29 Proteasome 29kD subunit 0.958
Mov34 CG3416 gene product from transcript CG3416-RA 0.950
Rpn9 CG10230 gene product from transcript CG10230-RB 0.947
Rpt1 CG1341 gene product from transcript CG1341-RA 0.942
Prosbeta1 Proteasome beta1 subunit 0.933
Rpn1 CG7762 gene product from transcript CG7762-RA 0.931
tefu telomere fusion 0.923
CG13349 CG13349 gene product from transcript CG13349-RA 0.922
Rpn11 CG18174 gene product from transcript CG18174-RA 0.915
Pros25 Proteasome 25kD subunit 0.907
Rpn2 CG11888 gene product from transcript CG11888-RA 0.903
Prosalpha5 Proteasome alpha5 subunit 0.893
Pp1-87B Protein phosphatase 1 at 87B 0.890
Pros26.4 Proteasome 26S subunit subunit 4 ATPase 0.889
CG12321 CG12321 gene product from transcript CG12321-RA 0.846
Rpn6 Proteasome p44.5 subunit 0.845
Prosalpha7 Proteasome alpha7 subunit 0.837
Uba1 Ubiquitin activating enzyme 1 0.825
brm brahma 0.815
CG8979 CG8979 gene product from transcript CG8979-RC 0.748
CycB Cyclin B 0.745
Pros26 Proteasome 26kD subunit 0.739
Pros28.1 Proteasome 28kD subunit 1 0.705
Prosbeta3 Proteasome beta3 subunit 0.693
TER94 CG2331 gene product from transcript CG2331-RA 0.686
CG17331 CG17331 gene product from transcript CG17331-RA 0.686
Rpn3 Regulatory particle non-ATPase 3 0.615
Rpt4 CG3455 gene product from transcript CG3455-RA 0.603
Rpn5 CG1100 gene product from transcript CG1100-RA 0.590
Rpn12 CG4157 gene product from transcript CG4157-RA 0.563
hyd hyperplastic discs 0.561
dco discs overgrown 0.555
Rpn7 CG5378 gene product from transcript CG5378-RA 0.540
Pros35 Proteasome 35kD subunit 0.532
Prosbeta7 Proteasome beta7 subunit 0.527
Prosbeta5 Proteasome beta5 subunit 0.527
Fcp1 CG12252 gene product from transcript CG12252-RA 0.502
Pros54 Proteasome 54kD subunit 0.474
Tbp-1 Tat-binding protein-1 0.459
Pros45 CG1489 gene product from transcript CG1489-RA 0.447
wdb widerborst 0.428
ncd non-claret disjunctional 0.392
lqf liquid facets 0.382
Incenp Inner centromere protein 0.378
UbcD2 Ubiquitin conjugating enzyme 2 0.372
CG2046 CG2046 gene product from transcript CG2046-RA 0.369
cpa capping protein alpha 0.368
CycE Cyclin E 0.365
cav caravaggio 0.354
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.348
bel belle 0.340
Uch-L3 Ubiquitin C-terminal hydrolase 0.330
borr borealin-related 0.323
cdc23 CG2508 gene product from transcript CG2508-RA 0.320
Mgat1 UDP-GlcNAc:a-3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I 0.318
Cap-G CG34438 gene product from transcript CG34438-RF 0.313
yki yorkie 0.309
CG11347 CG11347 gene product from transcript CG11347-RE 0.309
polo CG12306 gene product from transcript CG12306-RA 0.305
Tak1 TGF-beta activated kinase 1 0.303
CG7375 CG7375 gene product from transcript CG7375-RA 0.295
smo smoothened 0.294
CSN5 COP9 complex homolog subunit 5 0.290
CycD Cyclin D 0.289
Top1 Topoisomerase 1 0.287
Cul-5 Cullin-5 0.286
CSN7 COP9 complex homolog subunit 7 0.280
CG32581 CG32581 gene product from transcript CG32581-RB 0.274
Sara Smad anchor for receptor activation 0.268
skpA CG16983 gene product from transcript CG16983-RD 0.262
smt3 CG4494 gene product from transcript CG4494-RA 0.260
p47 CG11139 gene product from transcript CG11139-RA 0.255
Ras85D Ras oncogene at 85D 0.253
sgg shaggy 0.252
lin19 lin-19-like 0.250
krz kurtz 0.249
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.245
jub Ajuba LIM protein 0.241
tsh teashirt 0.241
CG5384 CG5384 gene product from transcript CG5384-RA 0.235
Ufd1-like Ubiquitin fusion-degradation 1-like 0.235
CG4673 CG4673 gene product from transcript CG4673-RB 0.229
msps mini spindles 0.229
CG8974 CG8974 gene product from transcript CG8974-RD 0.228
fzy fizzy 0.227
Nipped-A CG33554 gene product from transcript CG33554-RE 0.222
RYBP Ring and YY1 Binding Protein 0.221
Atg6 Autophagy-specific gene 6 0.216
Rab1 Rab-protein 1 0.216
tum tumbleweed 0.214
Akt1 CG4006 gene product from transcript CG4006-RA 0.211
CycG Cyclin G 0.211
Tip60 CG6121 gene product from transcript CG6121-RA 0.208
Rcd1 Reduction in Cnn dots 1 0.204
Prp8 pre-mRNA processing factor 8 0.202
pie pineapple eye 0.199
dup double parked 0.189
TSG101 tumor suppressor protein 101 0.188
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
UBC ubiquitin C 1.000
UBE2D3 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) 1.000
RNF11 ring finger protein 11 1.000
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 1.000
VCP valosin containing protein 1.000
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 1.000
SMAD2 SMAD family member 2 1.000
CUL3 cullin 3 1.000
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 1.000
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 1.000
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 1.000
TP53 tumor protein p53 1.000
UBE2D2 ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) 1.000
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 0.999
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.999
SKP1 S-phase kinase-associated protein 1 0.999
UBE2N ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) 0.999
COPS5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) 0.998
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.998
CDC20 cell division cycle 20 homolog (S. cerevisiae) 0.998
RB1 retinoblastoma 1 0.998
CUL1 cullin 1 0.998
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.997
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 0.997
BTRC beta-transducin repeat containing 0.997
FBXW11 F-box and WD repeat domain containing 11 0.996
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 0.995
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.994
CDC27 cell division cycle 27 homolog (S. cerevisiae) 0.992
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 0.991
SYVN1 synovial apoptosis inhibitor 1, synoviolin 0.991
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.991
RNF111 ring finger protein 111 0.991
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.990
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) 0.990
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 0.990
XIAP X-linked inhibitor of apoptosis 0.990
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.990
UBQLN1 ubiquilin 1 0.989
RNF5 ring finger protein 5 0.989
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.988
UBE2D1 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) 0.986
PLK1 polo-like kinase 1 0.986
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.982
SMAD4 SMAD family member 4 0.978
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.978
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.975
CUL2 cullin 2 0.973
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 0.973
ARIH2 ariadne homolog 2 (Drosophila) 0.970
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.968
SKP2 S-phase kinase-associated protein 2 (p45) 0.967
UBE2B ubiquitin-conjugating enzyme E2B (RAD6 homolog) 0.966
BRCA1 breast cancer 1, early onset 0.966
EXOSC3 exosome component 3 0.965
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.965
TRAF6 TNF receptor-associated factor 6 0.963
BUB1B budding uninhibited by benzimidazoles 1 homolog beta (yeast) 0.961
PTK2 PTK2 protein tyrosine kinase 2 0.961
POMP proteasome maturation protein 0.959
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 0.955
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.953
CCNB1 cyclin B1 0.952
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 0.948
ZNRF1 zinc and ring finger 1 0.945
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 0.942
UFD1L ubiquitin fusion degradation 1 like (yeast) 0.939
SMAD7 SMAD family member 7 0.938
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.935
TRIM39 tripartite motif containing 39 0.930
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.928
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.926
MARCH7 membrane-associated ring finger (C3HC4) 7 0.925
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2 0.921
MDM4 Mdm4 p53 binding protein homolog (mouse) 0.914
CKS1B CDC28 protein kinase regulatory subunit 1B 0.913
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 0.912
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.909
ANAPC11 anaphase promoting complex subunit 11 0.902
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.893
SMAD5 SMAD family member 5 0.890
HDAC1 histone deacetylase 1 0.889
GSK3B glycogen synthase kinase 3 beta 0.884
CCNA2 cyclin A2 0.883
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.883
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.876
AMFR autocrine motility factor receptor 0.875
YY1 YY1 transcription factor 0.866
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae) 0.866
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.864
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 0.859
CDK2 cyclin-dependent kinase 2 0.849
TRIM43 tripartite motif containing 43 0.834
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.832
OTUB1 OTU domain, ubiquitin aldehyde binding 1 0.832
FAF2 Fas associated factor family member 2 0.832
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.830
ANAPC4 anaphase promoting complex subunit 4 0.830
HSPA8 heat shock 70kDa protein 8 0.829
FBXW7 F-box and WD repeat domain containing 7 0.820
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 1.000
Ctnnb1 catenin (cadherin associated protein), beta 1 1.000
Mdm2 transformed mouse 3T3 cell double minute 2 0.999
Psma7 proteasome (prosome, macropain) subunit, alpha type 7 0.997
Vcp valosin containing protein 0.997
Axin1 axin 1 0.996
Per2 period homolog 2 (Drosophila) 0.996
Psen1 presenilin 1 0.991
Psma1 proteasome (prosome, macropain) subunit, alpha type 1 0.991
Psma2 proteasome (prosome, macropain) subunit, alpha type 2 0.989
Psma5 proteasome (prosome, macropain) subunit, alpha type 5 0.988
Gsk3b glycogen synthase kinase 3 beta 0.987
Psmb6 proteasome (prosome, macropain) subunit, beta type 6 0.986
Psmd4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.979
Clock circadian locomotor output cycles kaput 0.976
Per1 period homolog 1 (Drosophila) 0.975
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.971
Ranbp9 RAN binding protein 9 0.959
Ncstn nicastrin 0.948
Cry2 cryptochrome 2 (photolyase-like) 0.943
Ncoa3 nuclear receptor coactivator 3 0.915
Mdm4 transformed mouse 3T3 cell double minute 4 0.910
Psma3 proteasome (prosome, macropain) subunit, alpha type 3 0.907
Rnf111 ring finger 111 0.899
Psmc3 proteasome (prosome, macropain) 26S subunit, ATPase 3 0.899
Apc adenomatosis polyposis coli 0.886
Psmb7 proteasome (prosome, macropain) subunit, beta type 7 0.885
Ccnb1 cyclin B1 0.882
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.875
Psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.872
Cdk1 cyclin-dependent kinase 1 0.859
Pten phosphatase and tensin homolog 0.856
Usp9x ubiquitin specific peptidase 9, X chromosome 0.852
Psma6 proteasome (prosome, macropain) subunit, alpha type 6 0.836
Gli3 GLI-Kruppel family member GLI3 0.830
Skil SKI-like 0.827
Sirt1 sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae) 0.826
App amyloid beta (A4) precursor protein 0.801
Mbd3 methyl-CpG binding domain protein 3 0.797
Zfand5 zinc finger, AN1-type domain 5 0.782
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.782
Hdac6 histone deacetylase 6 0.775
Tax1bp1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.747
Cul3 cullin 3 0.734
Arid1b AT rich interactive domain 1B (SWI-like) 0.727
Pax2 paired box gene 2 0.721
Psmd14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.711
Arrb1 arrestin, beta 1 0.694
Cops5 COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana) 0.693
Cul4a cullin 4A 0.692
Smad7 MAD homolog 7 (Drosophila) 0.689
Csnk1e casein kinase 1, epsilon 0.683
Rnf2 ring finger protein 2 0.683
Yap1 yes-associated protein 1 0.674
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.666
Arhgef7 Rho guanine nucleotide exchange factor (GEF7) 0.644
Cry1 cryptochrome 1 (photolyase-like) 0.631
Pias2 protein inhibitor of activated STAT 2 0.630
Pomp proteasome maturation protein 0.625
Ube2v1 ubiquitin-conjugating enzyme E2 variant 1 0.624
Fzr1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.624
Fgfr1 fibroblast growth factor receptor 1 0.619
Trp73 transformation related protein 73 0.617
Ccne1 cyclin E1 0.615
Birc5 baculoviral IAP repeat-containing 5 0.614
Dvl1 dishevelled, dsh homolog 1 (Drosophila) 0.601
Banf1 barrier to autointegration factor 1 0.591
Dyrk1a dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a 0.585
Psmb3 proteasome (prosome, macropain) subunit, beta type 3 0.581
Rnf19a ring finger protein 19A 0.579
Psmb5 proteasome (prosome, macropain) subunit, beta type 5 0.578
Htt huntingtin 0.574
Psmd3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 0.572
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.571
Traf6 TNF receptor-associated factor 6 0.566
Psmd6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.565
Aamp angio-associated migratory protein 0.547
Rbl2 retinoblastoma-like 2 0.545
Setdb1 SET domain, bifurcated 1 0.544
Gnb2 guanine nucleotide binding protein (G protein), beta 2 0.542
Cdk4 cyclin-dependent kinase 4 0.538
Socs1 suppressor of cytokine signaling 1 0.538
Cul1 cullin 1 0.536
Pcna proliferating cell nuclear antigen 0.527
Psma4 proteasome (prosome, macropain) subunit, alpha type 4 0.514
Mgea5 meningioma expressed antigen 5 (hyaluronidase) 0.505
Ppp1ca protein phosphatase 1, catalytic subunit, alpha isoform 0.503
Cdk2 cyclin-dependent kinase 2 0.501
Bcl2 B-cell leukemia/lymphoma 2 0.498
Smurf2 SMAD specific E3 ubiquitin protein ligase 2 0.489
Arrb2 arrestin, beta 2 0.486
Agap3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 0.485
Asf1b ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.477
Glrx3 glutaredoxin 3 0.471
Skp1a S-phase kinase-associated protein 1A 0.459
Anapc2 anaphase promoting complex subunit 2 0.459
Iqcb1 IQ calmodulin-binding motif containing 1 0.455
Phf1 PHD finger protein 1 0.454
Add1 adducin 1 (alpha) 0.454
Tab3 TGF-beta activated kinase 1/MAP3K7 binding protein 3 0.447
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Psma3 proteasome (prosome, macropain) subunit, alpha type 3 0.990
Psma5 proteasome (prosome, macropain) subunit, alpha type 5 0.986
Dnaja2 DnaJ (Hsp40) homolog, subfamily A, member 2 0.981
Psmb3 proteasome (prosome, macropain) subunit, beta type 3 0.956
Psma7 proteasome (prosome, macropain) subunit, alpha type 7 0.887
Psma4 proteasome (prosome, macropain) subunit, alpha type 4 0.882
Psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.839
Psmb2 proteasome (prosome, macropain) subunit, beta type 2 0.808
Psmc1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.731
Psmb6 proteasome (prosome, macropain) subunit, beta type 6 0.602
Psma2 proteasome (prosome, macropain) subunit, alpha type 2 0.491
Psmd13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 0.460
Psmd6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.387
Psmc3 proteasome (prosome, macropain) 26S subunit, ATPase 3 0.377
Psme2 proteasome (prosome, macropain) activator subunit 2 0.368
Nsfl1c NSFL1 (p97) cofactor (p47) 0.322
Cnbp CCHC-type zinc finger, nucleic acid binding protein 0.298
Psmb7 proteasome (prosome, macropain) subunit, beta type 7 0.279
Ppp1cb protein phosphatase 1, catalytic subunit, beta isoform 0.271
Eef2 eukaryotic translation elongation factor 2 0.270
Psmb1 proteasome (prosome, macropain) subunit, beta type 1 0.262
Psmb10 proteasome (prosome, macropain) subunit, beta type 10 0.202
Psmb4 proteasome (prosome, macropain) subunit, beta type 4 0.182
Golph3 golgi phosphoprotein 3 (coat-protein) 0.178
Psmc4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.174
Psmc5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.173
Ptges3 prostaglandin E synthase 3 (cytosolic) 0.147
Ndfip2 Nedd4 family interacting protein 2 0.142
Cwc15 CWC15 spliceosome-associated protein homolog (S. cerevisiae) 0.124
Zfand5 zinc finger, AN1-type domain 5 0.120
Psmb5 proteasome (prosome, macropain) subunit, beta type 5 0.120
Psma1 proteasome (prosome, macropain) subunit, alpha type 1 0.119
Phax phosphorylated adaptor for RNA export 0.115
Rab21 RAB21, member RAS oncogene family 0.107
Dnajb9 DnaJ (Hsp40) homolog, subfamily B, member 9 0.103
Txnrd1 thioredoxin reductase 1 0.102
Psma6 proteasome (prosome, macropain) subunit, alpha type 6 0.101
Rad23b RAD23 homolog B (S. cerevisiae) 0.098
Csnk1d casein kinase 1, delta 0.095
Hsph1 heat shock 105/110 protein 1 0.091
Psmd4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.089
Psmd7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 0.087
Nploc4 nuclear protein localization 4 homolog (S. cerevisiae) 0.082
Dnajb11 DnaJ (Hsp40) homolog, subfamily B, member 11 0.082
Manf mesencephalic astrocyte-derived neurotrophic factor 0.080
Rnf146 ring finger protein 146 0.076
Gorasp2 golgi reassembly stacking protein 2 0.076
Psmd2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.072
Pdia4 protein disulfide isomerase family A, member 4 0.068
Canx calnexin 0.067
Psmd3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 0.065
Vcp valosin-containing protein 0.062
Mapre1 microtubule-associated protein, RP/EB family, member 1 0.060
Cdc37 cell division cycle 37 homolog (S. cerevisiae) 0.057
Syngr2 synaptogyrin 2 0.052
Calr calreticulin 0.049
Usp47 ubiquitin specific peptidase 47 0.049
Ubc ubiquitin C 0.048
LOC100366237 prefoldin subunit 4-like 0.047
Ppp1r2 protein phosphatase 1, regulatory (inhibitor) subunit 2 0.046
Psmd1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.045
Pomp proteasome maturation protein 0.044
LOC362855 P55 0.043
Ufd1l ubiquitin fusion degradation 1 like (yeast) 0.043
Ptp4a1 protein tyrosine phosphatase type IVA, member 1 0.042
Ppm1b protein phosphatase 1B, magnesium dependent, beta isoform 0.041
Cmtm6 CKLF-like MARVEL transmembrane domain containing 6 0.041
Hprt1 hypoxanthine phosphoribosyltransferase 1 0.040
Cops5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) 0.040
Hk1 hexokinase 1 0.039
Cdk7 cyclin-dependent kinase 7 0.039
Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) 0.039
Cand1 cullin-associated and neddylation-dissociated 1 0.039
Dnaja1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.039
Txnl1 thioredoxin-like 1 0.038
Psmd14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.037
Rbbp7 retinoblastoma binding protein 7 0.034
Oaz1 ornithine decarboxylase antizyme 1 0.034
Irf1 interferon regulatory factor 1 0.033
Lgals3bp lectin, galactoside-binding, soluble, 3 binding protein 0.033
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.032
Higd1a HIG1 hypoxia inducible domain family, member 1A 0.032
Acyp2 acylphosphatase 2, muscle type 0.032
Ube2d2 ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) 0.031
Eif5a eukaryotic translation initiation factor 5A 0.031
Ube2i ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.030
Rgs19 regulator of G-protein signaling 19 0.029
Rab11a RAB11a, member RAS oncogene family 0.028
Pctk2 PCTAIRE protein kinase 2 0.028
Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.028
Creld2 cysteine-rich with EGF-like domains 2 0.027
Dlg1 discs, large homolog 1 (Drosophila) 0.027
Usp14 ubiquitin specific peptidase 14 0.026
St13 suppression of tumorigenicity 13 0.026
Mgat2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase 0.026
Clns1a chloride channel, nucleotide-sensitive, 1A 0.025
LOC100364212 heterogeneous nuclear ribonucleoprotein K-like 0.024
Csnk2b casein kinase 2, beta polypeptide 0.024
Rnf2 ring finger protein 2 0.024
Rnf19a ring finger protein 19A 0.023