The network for 'histone deubiquitination' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

histone deubiquitination

The modification of histones by removal of ubiquitin groups.

Name Description Probability Func Analog Organism
TRA1 Tra1p 0.988
ADA2 Ada2p 0.903
SGF73 Sgf73p 0.780
SPT7 Spt7p 0.743
TAF6 Taf6p 0.709
NGG1 Ngg1p 0.684
UBP8 Ubp8p 0.553
SUS1 Sus1p 0.549
TAF12 Taf12p 0.472
TAF5 Taf5p 0.463
SGF29 Sgf29p 0.444
SPT20 Spt20p 0.426
SPT8 Spt8p 0.323
HFI1 Hfi1p 0.135
TAF9 Taf9p 0.116
SGF11 Sgf11p 0.080
SPT3 Spt3p 0.069
TAF10 Taf10p 0.057
RPN2 Rpn2p 0.021
GYL1 Gyl1p 0.012
CHZ1 Chz1p 0.011
GCN5 Gcn5p 0.010
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
not non-stop 0.707
Ptp69D Protein tyrosine phosphatase 69D 0.366
lid little imaginal discs 0.335
heph hephaestus 0.210
Pcaf CG4107 gene product from transcript CG4107-RA 0.124
Taf1 TBP-associated factor 1 0.093
tan tantalus 0.087
CG5986 CG5986 gene product from transcript CG5986-RA 0.073
Taf4 TBP-associated factor 4 0.072
lolal lola like 0.061
Hcf Host cell factor 0.053
Nup153 Nucleoporin 153 0.040
ash1 absent, small, or homeotic discs 1 0.040
dik diskette 0.039
Dcp2 Decapping protein 2 0.038
tsr twinstar 0.036
calypso CG8445 gene product from transcript CG8445-RB 0.033
rnh1 ribonuclease H1 0.032
Hrb27C Heterogeneous nuclear ribonucleoprotein at 27C 0.030
bur burgundy 0.027
brm brahma 0.025
Sgf11 CG13379 gene product from transcript CG13379-RB 0.024
MED26 Mediator complex subunit 26 0.019
flfl falafel 0.017
sxc super sex combs 0.015
Map205 Microtubule-associated protein 205 0.015
ash2 absent, small, or homeotic discs 2 0.014
vimar visceral mesodermal armadillo-repeats 0.014
CG8830 CG8830 gene product from transcript CG8830-RB 0.014
Mlf Myelodysplasia/myeloid leukemia factor 0.014
Saf6 SAGA factor-like TAF6 0.014
wds will die slowly 0.013
Sam-S S-adenosylmethionine Synthetase 0.013
CSN6 COP9 complex homolog subunit 6 0.012
RpII215 RNA polymerase II 215kD subunit 0.011
Rox8 CG5422 gene product from transcript CG5422-RD 0.011
milt milton 0.011
HIP-R Hsc/Hsp70-interacting protein related 0.011
Gug Grunge 0.011
CG4699 CG4699 gene product from transcript CG4699-RJ 0.011
kek5 kekkon5 0.011
CtBP C-terminal Binding Protein 0.011
CG5720 CG5720 gene product from transcript CG5720-RA 0.010
Hr39 Hormone receptor-like in 39 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
TRRAP transformation/transcription domain-associated protein 1.000
KAT2A K(lysine) acetyltransferase 2A 1.000
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa 0.992
USP22 ubiquitin specific peptidase 22 0.983
FAM175A family with sequence similarity 175, member A 0.983
TADA3 transcriptional adaptor 3 0.849
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) 0.836
ATXN7 ataxin 7 0.734
TAF6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa 0.707
HERC2 hect domain and RLD 2 0.548
MDM4 Mdm4 p53 binding protein homolog (mouse) 0.443
BRE brain and reproductive organ-expressed (TNFRSF1A modulator) 0.245
PICK1 protein interacting with PRKCA 1 0.163
EP300 E1A binding protein p300 0.158
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa 0.157
SETD7 SET domain containing (lysine methyltransferase) 7 0.141
TADA2A transcriptional adaptor 2A 0.135
ASXL1 additional sex combs like 1 (Drosophila) 0.129
FUBP1 far upstream element (FUSE) binding protein 1 0.107
MED12 mediator complex subunit 12 0.099
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.087
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa 0.075
SECISBP2 SECIS binding protein 2 0.071
HEXA hexosaminidase A (alpha polypeptide) 0.064
KPNA3 karyopherin alpha 3 (importin alpha 4) 0.058
ATXN7L3 ataxin 7-like 3 0.056
RNF220 ring finger protein 220 0.047
YLPM1 YLP motif containing 1 0.044
INO80 INO80 homolog (S. cerevisiae) 0.042
EP400 E1A binding protein p400 0.039
FAM175B family with sequence similarity 175, member B 0.039
MED24 mediator complex subunit 24 0.038
USP6 ubiquitin specific peptidase 6 (Tre-2 oncogene) 0.038
USP44 ubiquitin specific peptidase 44 0.037
HIST2H2AC histone cluster 2, H2ac 0.036
FAM193A family with sequence similarity 193, member A 0.034
TADA1 transcriptional adaptor 1 0.033
YY1 YY1 transcription factor 0.032
HUWE1 HECT, UBA and WWE domain containing 1 0.032
MRPL10 mitochondrial ribosomal protein L10 0.031
USP49 ubiquitin specific peptidase 49 0.029
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 0.028
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa 0.027
CCDC101 coiled-coil domain containing 101 0.026
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.026
TBP TATA box binding protein 0.025
BRD1 bromodomain containing 1 0.023
ANKRD52 ankyrin repeat domain 52 0.022
GTF2I general transcription factor IIi 0.022
FOXK2 forkhead box K2 0.022
PAPD7 PAP associated domain containing 7 0.021
ACACA acetyl-CoA carboxylase alpha 0.021
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa 0.020
HCFC1 host cell factor C1 (VP16-accessory protein) 0.020
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.019
BRAP BRCA1 associated protein 0.017
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.017
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 0.017
RBBP8 retinoblastoma binding protein 8 0.016
RAD23B RAD23 homolog B (S. cerevisiae) 0.016
UBE2O ubiquitin-conjugating enzyme E2O 0.016
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.015
SCAF4 SR-related CTD-associated factor 4 0.015
MCM3AP minichromosome maintenance complex component 3 associated protein 0.014
RINT1 RAD50 interactor 1 0.014
KDM1B lysine (K)-specific demethylase 1B 0.013
UIMC1 ubiquitin interaction motif containing 1 0.013
UTP18 UTP18, small subunit (SSU) processome component, homolog (yeast) 0.013
NCOA6 nuclear receptor coactivator 6 0.013
TADA2B transcriptional adaptor 2B 0.012
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.012
USP11 ubiquitin specific peptidase 11 0.011
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa 0.011
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 0.011
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.011
C20orf20 chromosome 20 open reading frame 20 0.010
ACTR5 ARP5 actin-related protein 5 homolog (yeast) 0.010
NFRKB nuclear factor related to kappaB binding protein 0.010
ZNF692 zinc finger protein 692 0.010
TXNL1 thioredoxin-like 1 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Arid1a AT rich interactive domain 1A (SWI-like) 0.971
Csrp2bp cysteine and glycine-rich protein 2 binding protein 0.793
Trrap transformation/transcription domain-associated protein 0.730
Atxn7l3 ataxin 7-like 3 0.702
Wdr5 WD repeat domain 5 0.677
Tada3 transcriptional adaptor 3 0.673
Yeats2 YEATS domain containing 2 0.633
Tada2a transcriptional adaptor 2A 0.622
Brd4 bromodomain containing 4 0.605
Trim28 tripartite motif-containing 28 0.580
Stam2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 0.546
Kat2a K(lysine) acetyltransferase 2A 0.519
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.445
Rnf41 ring finger protein 41 0.427
Taf6l TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor 0.412
Taf5l TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor 0.397
Ubap2 ubiquitin-associated protein 2 0.342
Ep400 E1A binding protein p400 0.338
Xpo6 exportin 6 0.324
Hcfc1 host cell factor C1 0.310
Brd2 bromodomain containing 2 0.212
Cry2 cryptochrome 2 (photolyase-like) 0.193
Pygo2 pygopus 2 0.163
Acin1 apoptotic chromatin condensation inducer 1 0.152
Asxl1 additional sex combs like 1 (Drosophila) 0.146
Srsf4 serine/arginine-rich splicing factor 4 0.129
Bap1 Brca1 associated protein 1 0.127
Per1 period homolog 1 (Drosophila) 0.126
Bag6 BCL2-associated athanogene 6 0.113
Ehmt2 euchromatic histone lysine N-methyltransferase 2 0.102
Srrt serrate RNA effector molecule homolog (Arabidopsis) 0.092
Atxn7 ataxin 7 0.092
Pabpn1 poly(A) binding protein, nuclear 1 0.084
Kat5 K(lysine) acetyltransferase 5 0.079
Pcbp2 poly(rC) binding protein 2 0.078
Hdac6 histone deacetylase 6 0.074
Wbp7 WW domain binding protein 7 0.072
Ubqln4 ubiquilin 4 0.070
Zfp574 zinc finger protein 574 0.068
Numa1 nuclear mitotic apparatus protein 1 0.067
Csnk1d casein kinase 1, delta 0.067
Prpf8 pre-mRNA processing factor 8 0.067
Bptf bromodomain PHD finger transcription factor 0.066
Men1 multiple endocrine neoplasia 1 0.065
Pum1 pumilio 1 (Drosophila) 0.059
Morc2a microrchidia 2A 0.056
Edc4 enhancer of mRNA decapping 4 0.055
Pcnxl3 pecanex-like 3 (Drosophila) 0.052
Ddx39b DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.052
Mdm2 transformed mouse 3T3 cell double minute 2 0.049
Neurl4 neuralized homolog 4 (Drosophila) 0.049
Per2 period homolog 2 (Drosophila) 0.047
Sltm SAFB-like, transcription modulator 0.047
Ap1m1 adaptor-related protein complex AP-1, mu subunit 1 0.047
H2afy H2A histone family, member Y 0.046
Safb scaffold attachment factor B 0.046
Hsf1 heat shock factor 1 0.046
Phc1 polyhomeotic-like 1 (Drosophila) 0.045
Cpsf1 cleavage and polyadenylation specific factor 1 0.045
Atp13a1 ATPase type 13A1 0.044
Ptov1 prostate tumor over expressed gene 1 0.044
Ncoa5 nuclear receptor coactivator 5 0.041
Npepps aminopeptidase puromycin sensitive 0.041
Axin1 axin 1 0.041
Zfp740 zinc finger protein 740 0.039
Rae1 RAE1 RNA export 1 homolog (S. pombe) 0.039
Spata20 spermatogenesis associated 20 0.037
Qrich1 glutamine-rich 1 0.037
Scrib scribbled homolog (Drosophila) 0.036
Agap3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 0.036
Deaf1 deformed epidermal autoregulatory factor 1 (Drosophila) 0.036
Pom121 nuclear pore membrane protein 121 0.035
Crebbp CREB binding protein 0.035
Fiz1 Flt3 interacting zinc finger protein 1 0.035
Rnf2 ring finger protein 2 0.034
Sf3b3 splicing factor 3b, subunit 3 0.034
Safb2 scaffold attachment factor B2 0.034
Ncoa6 nuclear receptor coactivator 6 0.034
Odf2 outer dense fiber of sperm tails 2 0.034
Smg7 Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans) 0.033
Dgcr2 DiGeorge syndrome critical region gene 2 0.031
Hdgf hepatoma-derived growth factor 0.031
Vps16 vacuolar protein sorting 16 (yeast) 0.030
Reps1 RalBP1 associated Eps domain containing protein 0.030
Rnf8 ring finger protein 8 0.030
Sbno1 sno, strawberry notch homolog 1 (Drosophila) 0.029
Msl1 male-specific lethal 1 homolog (Drosophila) 0.029
Ubr4 ubiquitin protein ligase E3 component n-recognin 4 0.028
Btbd2 BTB (POZ) domain containing 2 0.027
Smarcc1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.026
Med16 mediator complex subunit 16 0.026
Csnk1g2 casein kinase 1, gamma 2 0.025
Cdk9 cyclin-dependent kinase 9 (CDC2-related kinase) 0.025
Mllt1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 0.025
Xab2 XPA binding protein 2 0.024
Zfp746 zinc finger protein 746 0.024
Csnk1e casein kinase 1, epsilon 0.023
Mdm4 transformed mouse 3T3 cell double minute 4 0.023
Prrc2b proline-rich coiled-coil 2B 0.023
Mta1 metastasis associated 1 0.023
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Rattus norvegicus
Name Description Probability Func Analog Organism