The network for 'negative regulation of nuclear division' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of nuclear division

Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information.

Name Description Probability Func Analog Organism
PPH22 Pph22p 0.954
HXT4 Hxt4p 0.906
GLC7 Glc7p 0.905
RED1 Red1p 0.856
PPH21 Pph21p 0.789
CDC20 Cdc20p 0.755
KIN1 Kin1p 0.751
ZDS1 Zds1p 0.680
CIN8 Cin8p 0.622
HXT2 Hxt2p 0.609
SLK19 Slk19p 0.581
CMD1 Cmd1p 0.554
STE4 Ste4p 0.539
MTH1 Mth1p 0.524
MAD1 Mad1p 0.498
HOS4 Hos4p 0.466
KEL1 Kel1p 0.435
SET1 Set1p 0.422
DMA2 Dma2p 0.413
CTF13 Ctf13p 0.411
SIF2 Sif2p 0.381
SNT1 Snt1p 0.348
TPD3 Tpd3p 0.348
GAC1 Gac1p 0.328
GIC1 Gic1p 0.316
BFA1 Bfa1p 0.312
RAD9 Rad9p 0.305
ZDS2 Zds2p 0.303
HHF2 Hhf2p 0.281
IML3 Iml3p 0.261
MEK1 Mek1p 0.254
PDS1 Pds1p 0.248
CCT2 Cct2p 0.245
GAL2 Gal2p 0.237
HSL1 Hsl1p 0.236
HOS2 Hos2p 0.230
BUB3 Bub3p 0.230
CTF19 Ctf19p 0.227
MAD2 Mad2p 0.218
SMC4 Smc4p 0.214
CHL4 Chl4p 0.213
PSY4 Psy4p 0.210
HXT1 Hxt1p 0.206
YAR028W hypothetical protein 0.203
ZIP1 Zip1p 0.201
BMH1 Bmh1p 0.189
CDC55 Cdc55p 0.186
PIG2 Pig2p 0.185
PHO81 Pho81p 0.181
HXT3 Hxt3p 0.180
GIP4 Gip4p 0.177
PCL10 Pcl10p 0.172
PPZ2 Ppz2p 0.170
NEO1 Neo1p 0.169
DBF4 Dbf4p 0.159
CHL1 Chl1p 0.158
RTS1 Rts1p 0.155
SOR1 Sor1p 0.155
FMP48 Fmp48p 0.154
NSL1 Nsl1p 0.154
MBP1 Mbp1p 0.153
BUD5 Bud5p 0.153
SMC6 Smc6p 0.149
HOP1 Hop1p 0.149
DAM1 Dam1p 0.148
SKO1 Sko1p 0.148
SET3 Set3p 0.148
CPR1 Cpr1p 0.144
KIC1 Kic1p 0.143
YPI1 Ypi1p 0.139
UBP12 Ubp12p 0.138
MAL11 Mal11p 0.138
MAD3 Mad3p 0.131
SKP2 Skp2p 0.131
HXT8 Hxt8p 0.130
SPC110 Spc110p 0.130
CIN1 Cin1p 0.128
YGL082W hypothetical protein 0.127
NDT80 Ndt80p 0.125
CDC15 Cdc15p 0.120
SKP1 Skp1p 0.118
PSD2 Psd2p 0.117
MUS81 Mus81p 0.117
CMK2 Cmk2p 0.116
RCO1 Rco1p 0.114
REG1 Reg1p 0.114
HXT15 Hxt15p 0.113
BUB1 Bub1p 0.110
SPL2 Spl2p 0.109
HST1 Hst1p 0.109
BUB2 Bub2p 0.109
DMC1 Dmc1p 0.107
ESP1 Esp1p 0.103
GIS4 Gis4p 0.103
JIP4 Jip4p 0.097
SMC3 Smc3p 0.096
MNR2 Mnr2p 0.095
KIP1 Kip1p 0.095
SCS7 Scs7p 0.093
SNF3 Snf3p 0.092
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
his-6 Protein HIS-6 0.071
gpr-2 Protein GPR-2 0.070
his-42 Protein HIS-42 0.055
cdl-1 Protein CDL-1 0.042
ani-1 Protein ANI-1 0.034
ZK507.6 Protein ZK507.6 0.033
htp-1 Protein HTP-1 0.033
CELE_C24H12.5 Protein C24H12.5 0.023
mus-101 Protein MUS-101 0.022
his-32 Protein HIS-32 0.021
fli-1 Protein FLI-1 0.019
C49H3.9 Protein C49H3.9 0.019
CELE_F52C6.3 Protein F52C6.3 0.018
lin-8 Protein LIN-8 0.018
brc-1 Protein BRC-1 0.015
rnr-1 Protein RNR-1 0.013
aipl-1 Protein AIPL-1 0.013
npp-11 Protein NPP-11 0.013
uaf-1 Protein UAF-1 0.013
pqn-51 Protein PQN-51 0.013
CELE_T02C12.3 Protein T02C12.3 0.012
mcm-5 Protein MCM-5 0.012
F12F6.1 Protein F12F6.1 0.012
let-502 Protein LET-502 0.012
spdl-1 Protein SPDL-1 0.012
hcp-1 Protein HCP-1 0.012
air-1 Protein AIR-1 0.011
ZC410.3 Protein ZC410.3 0.011
T22C1.1 Protein T22C1.1 0.010
sas-5 Protein SAS-5 0.010
dcp-66 Protein DCP-66 0.010
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Danio rerio
Name Description Probability Func Analog Organism
smc4 structural maintenance of chromosomes 4 0.941
ccnb1 cyclin B1 0.932
wnt4a wingless-type MMTV integration site family, member 4a 0.912
wnt10a wingless-type MMTV integration site family, member 10a 0.797
dbx1a developing brain homeobox 1a 0.649
hmx4 H6 family homeobox 4 0.565
plk1 polo-like kinase 1 (Drosophila) 0.555
wnt7ba wingless-type MMTV integration site family, member 7Ba 0.539
tcf21 transcription factor 21 0.536
dkk1b dickkopf 1b 0.458
mcl1b myeloid cell leukemia sequence 1b 0.450
dcc deleted in colorectal carcinoma 0.447
ccna2 cyclin A2 0.447
bcl2 B-cell leukemia/lymphoma 2 0.430
wnt7aa wingless-type MMTV integration site family, member 7Aa 0.424
wnt9b wingless-type MMTV integration site family, member 9B 0.419
nusap1 nucleolar and spindle associated protein 1 0.415
wnt8b wingless-type MMTV integration site family, member 8b 0.400
si:ch211-173o4.2 si:ch211-173o4.2 0.397
wnt3a wingless-type MMTV integration site family, member 3A 0.392
sfrp1a secreted frizzled-related protein 1a 0.391
hmx1 H6 homeo box 1 0.389
wnt3 wingless-type MMTV integration site family, member 3 0.386
wnt11r wingless-type MMTV integration site family, member 11, related 0.376
flh floating head 0.338
si:ch211-69g19.2 si:ch211-69g19.2 0.331
cdt1 chromatin licensing and DNA replication factor 1 0.320
dtl denticleless homolog (Drosophila) 0.303
g2e3 G2/M-phase specific E3 ubiquitin ligase 0.301
fgf17 fibroblast growth factor 17 0.290
suv39h1b suppressor of variegation 3-9 homolog 1b 0.282
tacc3 transforming, acidic coiled-coil containing protein 3 0.281
wdhd1 WD repeat and HMG-box DNA binding protein 1 0.270
wnt16 wingless-type MMTV integration site family, member 16 0.256
wnt2 wingless-type MMTV integration site family member 2 0.237
baxa bcl2-associated X protein, a 0.231
vcana versican a 0.207
mcl1a myeloid cell leukemia sequence 1a 0.207
cdca8 cell division cycle associated 8 0.197
orc1 origin recognition complex, subunit 1 0.197
ndc80 NDC80 homolog, kinetochore complex component (S. cerevisiae) 0.194
wnt7bb wingless-type MMTV integration site family, member 7Bb 0.185
LOC566708 FL cytokine receptor-like 0.184
ccnb2 cyclin B2 0.180
cep55l centrosomal protein 55 like 0.169
oprk1 opioid receptor, kappa 1 0.168
pcsk5b proprotein convertase subtilisin/kexin type 5b 0.166
optc opticin 0.160
csnk1da casein kinase 1, delta a 0.159
wnt5b wingless-type MMTV integration site family, member 5b 0.157
mbnl2 muscleblind-like 2 (Drosophila) 0.154
gmnn geminin, DNA replication inhibitor 0.153
ubin ataxin-1 ubiquitin-like interacting protein 0.153
sox2 SRY-box containing gene 2 0.153
dmrt3a doublesex and mab-3 related transcription factor 3a 0.150
sfrp1b secreted frizzled-related protein 1b 0.150
mapk7 mitogen-activated protein kinase 7 0.141
notch1a notch homolog 1a 0.141
bida BH3 interacting domain death agonist 0.136
zgc:113143 zgc:113143 0.134
mapk12 mitogen-activated protein kinase 12 0.134
cdc20 cell division cycle 20 homolog 0.133
e2f5 E2F transcription factor 5 0.132
cstf1 cleavage stimulation factor, 3' pre-RNA, subunit 1 0.130
smad9 MAD homolog 9 (Drosophila) 0.127
map2k7 mitogen-activated protein kinase kinase 7 0.125
LOC100536090 targeting protein for Xklp2-B-like 0.124
rad54l RAD54-like (S. cerevisiae) 0.124
zgc:56200 zgc:56200 0.123
twist1b twist1b 0.123
sass6 spindle assembly 6 homolog (C. elegans) 0.122
wnt9a wingless-type MMTV integration site family, member 9A 0.122
wnt10b wingless-type MMTV integration site family, member 10b 0.120
ncapd2 non-SMC condensin I complex, subunit D2 0.119
spry4 sprouty (Drosophila) homolog 4 0.116
ncapg non-SMC condensin I complex, subunit G 0.116
polr2b polymerase (RNA) II (DNA directed) polypeptide B 0.114
melk maternal embryonic leucine zipper kinase 0.113
gtf2h2 general transcription factor IIH, polypeptide 2 0.112
sid4 secreted immunoglobulin domain 4 0.112
si:dkey-273o13.1 si:dkey-273o13.1 0.111
map2k4b mitogen-activated protein kinase kinase 4b 0.110
map2k4a mitogen-activated protein kinase kinase 4a 0.109
sfrs3b splicing factor, arginine/serine-rich 3b 0.108
kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.107
fbxl14a F-box and leucine-rich repeat protein 14a 0.106
mecom MDS1 and EVI1 complex locus 0.104
usp5 ubiquitin specific protease 5 0.103
sephs1 selenophosphate synthetase 1 0.102
zgc:174506 zgc:174506 0.101
trip13 thyroid hormone receptor interactor 13 0.100
zgc:55521 zgc:55521 0.099
kif23 kinesin family member 23 0.099
entpd4 ectonucleoside triphosphate diphosphohydrolase 4 0.097
kpna2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 0.095
hnf1ba HNF1 homeobox Ba 0.094
egr2b early growth response 2b 0.094
tgfb3 transforming growth factor, beta 3 0.093
zgc:55671 zgc:55671 0.090
oep one-eyed pinhead 0.087
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
CycB Cyclin B 0.052
HLHm7 E(spl) region transcript m7 0.024
tld tolloid 0.023
E(spl) Enhancer of split 0.022
fzy fizzy 0.020
bam bag of marbles 0.019
polo CG12306 gene product from transcript CG12306-RA 0.016
osk oskar 0.016
Cap-G CG34438 gene product from transcript CG34438-RF 0.015
spn-D spindle D 0.014
CycB3 Cyclin B3 0.014
Krn Keren 0.011
CycA Cyclin A 0.011
DNApol-alpha60 DNA polymerase alpha 60kD 0.011
nbs CG6754 gene product from transcript CG6754-RC 0.010
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
RPL14 ribosomal protein L14 0.028
RPL15 ribosomal protein L15 0.025
RPL31 ribosomal protein L31 0.023
RPL13A ribosomal protein L13a 0.020
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.018
RPL23 ribosomal protein L23 0.018
NME1 non-metastatic cells 1, protein (NM23A) expressed in 0.015
CAND1 cullin-associated and neddylation-dissociated 1 0.014
RPS15 ribosomal protein S15 0.012
PUM2 pumilio homolog 2 (Drosophila) 0.011
FARSA phenylalanyl-tRNA synthetase, alpha subunit 0.011
RUVBL2 RuvB-like 2 (E. coli) 0.011
SEC24B SEC24 family, member B (S. cerevisiae) 0.010
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 0.987
Trp53 transformation related protein 53 0.982
Gli3 GLI-Kruppel family member GLI3 0.612
Bmp4 bone morphogenetic protein 4 0.600
Fgfr2 fibroblast growth factor receptor 2 0.564
Brca1 breast cancer 1 0.536
Sox9 SRY-box containing gene 9 0.516
Ctnnb1 catenin (cadherin associated protein), beta 1 0.451
C330027C09Rik RIKEN cDNA C330027C09 gene 0.412
Lin9 lin-9 homolog (C. elegans) 0.405
Cdk4 cyclin-dependent kinase 4 0.342
Cdk2 cyclin-dependent kinase 2 0.329
Ccnb1 cyclin B1 0.252
Cenpe centromere protein E 0.247
Atf4 activating transcription factor 4 0.230
Brca2 breast cancer 2 0.229
Hells helicase, lymphoid specific 0.221
Trim59 tripartite motif-containing 59 0.221
Sgol1 shugoshin-like 1 (S. pombe) 0.213
Ccne2 cyclin E2 0.211
Ncoa3 nuclear receptor coactivator 3 0.210
Pthlh parathyroid hormone-like peptide 0.198
Wdhd1 WD repeat and HMG-box DNA binding protein 1 0.189
Plk4 polo-like kinase 4 (Drosophila) 0.158
Rb1 retinoblastoma 1 0.151
Rpa3 replication protein A3 0.151
Trp63 transformation related protein 63 0.150
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.147
Chek1 checkpoint kinase 1 homolog (S. pombe) 0.140
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.140
Sgol2 shugoshin-like 2 (S. pombe) 0.137
Msx1 homeobox, msh-like 1 0.130
Mdm2 transformed mouse 3T3 cell double minute 2 0.126
Erg avian erythroblastosis virus E-26 (v-ets) oncogene related 0.124
Mastl microtubule associated serine/threonine kinase-like 0.121
Rara retinoic acid receptor, alpha 0.117
Pds5b PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) 0.116
Ptch1 patched homolog 1 0.116
Cenpk centromere protein K 0.112
Runx2 runt related transcription factor 2 0.111
Spag5 sperm associated antigen 5 0.109
Cbx1 chromobox homolog 1 (Drosophila HP1 beta) 0.106
Anln anillin, actin binding protein 0.106
Dtl denticleless homolog (Drosophila) 0.102
Otx2 orthodenticle homolog 2 (Drosophila) 0.098
Blm Bloom syndrome, RecQ helicase-like 0.098
Crk v-crk sarcoma virus CT10 oncogene homolog (avian) 0.096
Ppp1ca protein phosphatase 1, catalytic subunit, alpha isoform 0.094
Mdm4 transformed mouse 3T3 cell double minute 4 0.092
4632434I11Rik RIKEN cDNA 4632434I11 gene 0.092
Dbf4 DBF4 homolog (S. cerevisiae) 0.087
Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 0.086
Cenpj centromere protein J 0.082
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.082
Recql RecQ protein-like 0.079
Mis18bp1 MIS18 binding protein 1 0.079
Foxc1 forkhead box C1 0.079
Ooep oocyte expressed protein homolog (dog) 0.077
Nlrp5 NLR family, pyrin domain containing 5 0.074
Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.073
Lrrk2 leucine-rich repeat kinase 2 0.068
Sae1 SUMO1 activating enzyme subunit 1 0.067
Aspm asp (abnormal spindle)-like, microcephaly associated (Drosophila) 0.065
Prrx1 paired related homeobox 1 0.064
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.063
Hand1 heart and neural crest derivatives expressed transcript 1 0.061
Cdk1 cyclin-dependent kinase 1 0.058
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.058
Ncapg non-SMC condensin I complex, subunit G 0.057
Trip13 thyroid hormone receptor interactor 13 0.055
Haus6 HAUS augmin-like complex, subunit 6 0.055
Aurka aurora kinase A 0.053
Ncapg2 non-SMC condensin II complex, subunit G2 0.053
Rbl1 retinoblastoma-like 1 (p107) 0.049
Tsc2 tuberous sclerosis 2 0.049
Kif20a kinesin family member 20A 0.049
Kif23 kinesin family member 23 0.048
Ect2 ect2 oncogene 0.048
Fbxo5 F-box protein 5 0.048
Tsc1 tuberous sclerosis 1 0.047
Asf1b ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.047
Bmp7 bone morphogenetic protein 7 0.046
Ccna2 cyclin A2 0.044
Kif2c kinesin family member 2C 0.044
Prrx2 paired related homeobox 2 0.044
Ccne1 cyclin E1 0.043
Smc2 structural maintenance of chromosomes 2 0.043
E2f8 E2F transcription factor 8 0.042
Ccnf cyclin F 0.042
Cdca8 cell division cycle associated 8 0.041
Bub1 budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) 0.041
Rpgrip1l Rpgrip1-like 0.040
Ncapd3 non-SMC condensin II complex, subunit D3 0.040
Arl6ip6 ADP-ribosylation factor-like 6 interacting protein 6 0.039
Suv39h2 suppressor of variegation 3-9 homolog 2 (Drosophila) 0.038
Smc4 structural maintenance of chromosomes 4 0.038
Hmgb2 high mobility group box 2 0.038
Mns1 meiosis-specific nuclear structural protein 1 0.037
Fgfr1 fibroblast growth factor receptor 1 0.037
Alx1 ALX homeobox 1 0.037
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Plk1 polo-like kinase 1 (Drosophila) 0.043
Ccnb1 cyclin B1 0.034
Kifc1 kinesin family member C1 0.032
Dhfr dihydrofolate reductase 0.031
Bub1b budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) 0.029
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.028
Foxe3 forkhead box E3 0.025
Asf1b ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.025
Dlgap5 discs, large (Drosophila) homolog-associated protein 5 0.022
Arf1 ADP-ribosylation factor 1 0.022
Rad51 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) 0.021
Top2a topoisomerase (DNA) II alpha 0.019
Cenpi centromere protein I 0.018
Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha isoform 0.018
Mapre1 microtubule-associated protein, RP/EB family, member 1 0.017
Spag5 sperm associated antigen 5 0.017
Aurkb aurora kinase B 0.016
Gins4 GINS complex subunit 4 (Sld5 homolog) 0.016
Espl1 extra spindle pole bodies homolog 1 (S. cerevisiae) 0.016
Mcm5 minichromosome maintenance complex component 5 0.015
Haus4 HAUS augmin-like complex, subunit 4 0.015
Foxm1 forkhead box M1 0.015
Kif2c kinesin family member 2C 0.014
Ska1 spindle and kinetochore associated complex subunit 1 0.014
Pttg1 pituitary tumor-transforming 1 0.014
Depdc1 DEP domain containing 1 0.014
Picalm phosphatidylinositol binding clathrin assembly protein 0.013
Nsf N-ethylmaleimide-sensitive factor 0.013
Mybl2 myeloblastosis oncogene-like 2 0.013
Aspm asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.013
Brca2 breast cancer 2 0.013
Bmp7 bone morphogenetic protein 7 0.013
Birc5 baculoviral IAP repeat-containing 5 0.013
Ect2 epithelial cell transforming sequence 2 oncogene 0.012
Otub1 OTU domain, ubiquitin aldehyde binding 1 0.012
Kif18b kinesin family member 18B 0.012
Ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform 0.012
Cort cortistatin 0.012
Cdc37 cell division cycle 37 homolog (S. cerevisiae) 0.012
Ccnb2 cyclin B2 0.012
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.012
Cenpm centromere protein M 0.012
Dhodh dihydroorotate dehydrogenase 0.012
Hspbp1 HSPA binding protein, cytoplasmic cochaperone 1 0.012
Dhdpsl dihydrodipicolinate synthase-like, mitochondrial 0.012
Notch3 Notch homolog 3 (Drosophila) 0.011
MGC112830 similar to transcription factor 0.011
Cd8b CD8b molecule 0.011
Mcm7 minichromosome maintenance complex component 7 0.011
Phldb1 pleckstrin homology-like domain, family B, member 1 0.011
Tk1 thymidine kinase 1, soluble 0.011
Sssca1 Sjogren's syndrome/scleroderma autoantigen 1 homolog (human) 0.011
Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit 0.011
Cdk1 cyclin-dependent kinase 1 0.011
Nudt1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 0.011
Cdca2 cell division cycle associated 2 0.010
Hapln1 hyaluronan and proteoglycan link protein 1 0.010
Traf4af1 TRAF4 associated factor 1 0.010
Racgap1 Rac GTPase-activating protein 1 0.010
LOC100364212 heterogeneous nuclear ribonucleoprotein K-like 0.010
Galnt10 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10) 0.010
Atp2c1 ATPase, Ca++ transporting, type 2C, member 1 0.010
Troap trophinin associated protein 0.010
Slc9a1 solute carrier family 9 (sodium/hydrogen exchanger), member 1 0.010