The network for 'negative regulation of protein catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of protein catabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
CDC55 Cdc55p 0.670
CDC20 Cdc20p 0.661
PPH22 Pph22p 0.616
PPH21 Pph21p 0.586
MAD2 Mad2p 0.526
HHF2 Hhf2p 0.511
CSE4 Cse4p 0.446
RTS1 Rts1p 0.312
CTF13 Ctf13p 0.257
PPZ1 Ppz1p 0.254
SLK19 Slk19p 0.237
MAD3 Mad3p 0.215
CHL4 Chl4p 0.214
MAD1 Mad1p 0.200
MTW1 Mtw1p 0.150
KIP1 Kip1p 0.149
ZDS1 Zds1p 0.125
MLC1 Mlc1p 0.120
NBL1 Nbl1p 0.119
YPI1 Ypi1p 0.116
IML3 Iml3p 0.110
BUB3 Bub3p 0.108
SLI15 Sli15p 0.098
CTF3 Ctf3p 0.094
BUB1 Bub1p 0.093
SDS22 Sds22p 0.083
NSL1 Nsl1p 0.079
MCM21 Mcm21p 0.077
HTA1 Hta1p 0.050
EAF1 Eaf1p 0.050
TIP41 Tip41p 0.045
STE4 Ste4p 0.045
HTB1 Htb1p 0.042
DAM1 Dam1p 0.042
SPC24 Spc24p 0.041
VIK1 Vik1p 0.040
PIG2 Pig2p 0.039
UFD2 Ufd2p 0.039
RFA1 Rfa1p 0.038
YIL151C hypothetical protein 0.038
IPL1 Ipl1p 0.037
SPO12 Spo12p 0.035
ASE1 Ase1p 0.034
FMP48 Fmp48p 0.034
KIN1 Kin1p 0.034
NTO1 Nto1p 0.033
YBP2 Ybp2p 0.033
YKL075C hypothetical protein 0.032
CTF8 Ctf8p 0.031
SLG1 Slg1p 0.030
CDC28 Cdc28p 0.030
GLG1 Glg1p 0.029
PCL10 Pcl10p 0.029
SPC110 Spc110p 0.029
CIN1 Cin1p 0.029
PKC1 Pkc1p 0.029
PTI1 Pti1p 0.028
SET2 Set2p 0.027
YML053C hypothetical protein 0.027
GIP2 Gip2p 0.027
BET5 Bet5p 0.027
SPC105 Spc105p 0.026
SRD1 Srd1p 0.026
YGL010W hypothetical protein 0.026
HHT1 Hht1p 0.025
YNL144C hypothetical protein 0.025
JLP2 Jlp2p 0.025
ATG27 Atg27p 0.024
PDR15 Pdr15p 0.024
STD1 Std1p 0.024
DSN1 Dsn1p 0.024
SMC5 Smc5p 0.024
TRA1 Tra1p 0.024
YOL038C-A hypothetical protein 0.024
PLC1 Plc1p 0.024
YLR162W hypothetical protein 0.024
RMD5 Rmd5p 0.023
LEU2 Leu2p 0.023
SWC4 Swc4p 0.023
SAP4 Sap4p 0.023
YLR264C-A hypothetical protein 0.023
SMC4 Smc4p 0.023
VHS2 Vhs2p 0.023
CBF1 Cbf1p 0.022
CAB3 Cab3p 0.022
STU1 Stu1p 0.022
CAR1 Car1p 0.022
MER1 Mer1p 0.022
HST3 Hst3p 0.022
ARG8 Arg8p 0.021
HIT1 Hit1p 0.021
MEC1 Mec1p 0.021
YDL206W hypothetical protein 0.021
SWC7 Swc7p 0.021
GLC7 Glc7p 0.021
TAF11 Taf11p 0.021
FRA2 Fra2p 0.021
SFI1 Sfi1p 0.021
YNR014W hypothetical protein 0.021
CIN8 Cin8p 0.021
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
gpr-2 Protein GPR-2 0.013
abl-1 Protein ABL-1 0.012
his-42 Protein HIS-42 0.012
imb-2 Protein IMB-2 0.011
his-45 Protein HIS-45 0.011
pri-2 Protein PRI-2 0.011
rsd-6 Protein RSD-6 0.011
asd-1 Protein ASD-1 0.011
goa-1 Protein GOA-1 0.010
sma-6 Protein SMA-6 0.010
bli-1 Protein BLI-1 0.010
C49H3.9 Protein C49H3.9 0.010
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
CycB Cyclin B 0.083
CSN5 COP9 complex homolog subunit 5 0.064
Pp1-87B Protein phosphatase 1 at 87B 0.038
Su(var)205 Suppressor of variegation 205 0.036
MEP-1 CG1244 gene product from transcript CG1244-RG 0.034
Iswi Imitation SWI 0.033
ncd non-claret disjunctional 0.033
alphaTub67C alpha-Tubulin at 67C 0.030
fzy fizzy 0.029
Bap55 Brahma associated protein 55kD 0.027
Nup153 Nucleoporin 153 0.026
brm brahma 0.024
rin rasputin 0.024
Abl Abl tyrosine kinase 0.023
pr-set7 CG3307 gene product from transcript CG3307-RC 0.021
Incenp Inner centromere protein 0.020
KP78b CG17216 gene product from transcript CG17216-RB 0.020
CycB3 Cyclin B3 0.019
cdc2 CG5363 gene product from transcript CG5363-RA 0.019
asl asterless 0.019
Ras85D Ras oncogene at 85D 0.019
nct nicastrin 0.018
Mmp1 Matrix metalloproteinase 1 0.018
tefu telomere fusion 0.018
hh hedgehog 0.018
Egfr Epidermal growth factor receptor 0.017
CycT Cyclin T 0.017
rux roughex 0.016
vas vasa 0.016
borr borealin-related 0.016
Sep2 Septin-2 0.015
RpS20 Ribosomal protein S20 0.015
hts hu li tai shao 0.015
hyd hyperplastic discs 0.014
rtet tetracycline resistance 0.014
Taf2 TBP-associated factor 2 0.014
Psf2 CG18013 gene product from transcript CG18013-RA 0.014
capt capulet 0.014
B52 CG10851 gene product from transcript CG10851-RB 0.014
fwd four wheel drive 0.013
sgl sugarless 0.013
CG2926 CG2926 gene product from transcript CG2926-RA 0.013
CSN6 COP9 complex homolog subunit 6 0.013
imd immune deficiency 0.012
Syx13 Syntaxin 13 0.012
spn-D spindle D 0.012
CG4771 CG4771 gene product from transcript CG4771-RA 0.012
cdc16 CG6759 gene product from transcript CG6759-RA 0.012
loco locomotion defects 0.012
Gef26 CG9491 gene product from transcript CG9491-RB 0.012
NELF-B CG32721 gene product from transcript CG32721-RA 0.012
FBX011 FBX011 ortholog 0.012
DNApol-alpha60 DNA polymerase alpha 60kD 0.012
Cdc37 CG12019 gene product from transcript CG12019-RA 0.011
Cap-G CG34438 gene product from transcript CG34438-RF 0.011
Cks30A Cyclin-dependent kinase subunit 30A 0.011
Spn77Ba Serpin 77Ba 0.011
mus301 mutagen-sensitive 301 0.011
thr three rows 0.011
Syt4 Synaptotagmin 4 0.010
CG2224 CG2224 gene product from transcript CG2224-RA 0.010
Cenp-C CG31258 gene product from transcript CG31258-RA 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
SMAD3 SMAD family member 3 0.984
TRAF6 TNF receptor-associated factor 6 0.869
BUB1B budding uninhibited by benzimidazoles 1 homolog beta (yeast) 0.813
BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) 0.539
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.532
SQSTM1 sequestosome 1 0.520
DLG4 discs, large homolog 4 (Drosophila) 0.462
PRKCZ protein kinase C, zeta 0.446
TP53 tumor protein p53 0.383
PML promyelocytic leukemia 0.382
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.363
IRAK2 interleukin-1 receptor-associated kinase 2 0.354
SMAD2 SMAD family member 2 0.343
TRIM39 tripartite motif containing 39 0.301
SMAD1 SMAD family member 1 0.294
DAXX death-domain associated protein 0.285
CCT4 chaperonin containing TCP1, subunit 4 (delta) 0.262
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.241
MYD88 myeloid differentiation primary response gene (88) 0.213
BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast) 0.205
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.169
TRIM43 tripartite motif containing 43 0.168
AGAP5 ArfGAP with GTPase domain, ankyrin repeat and PH domain 5 0.160
CCT8 chaperonin containing TCP1, subunit 8 (theta) 0.153
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.141
AGAP7 ArfGAP with GTPase domain, ankyrin repeat and PH domain 7 0.141
GABARAPL2 GABA(A) receptor-associated protein-like 2 0.140
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.135
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.131
FLNB filamin B, beta 0.131
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.110
LMNA lamin A/C 0.110
PXN paxillin 0.102
GABARAPL1 GABA(A) receptor-associated protein like 1 0.094
FAS Fas (TNF receptor superfamily, member 6) 0.093
GABARAP GABA(A) receptor-associated protein 0.092
ARIH2 ariadne homolog 2 (Drosophila) 0.091
VCP valosin containing protein 0.082
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.081
PLK1 polo-like kinase 1 0.078
KPNA3 karyopherin alpha 3 (importin alpha 4) 0.078
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 0.076
FLNA filamin A, alpha 0.073
CCNA2 cyclin A2 0.072
IL22RA2 interleukin 22 receptor, alpha 2 0.071
RB1 retinoblastoma 1 0.071
FBXW7 F-box and WD repeat domain containing 7 0.070
APP amyloid beta (A4) precursor protein 0.070
NOXA1 NADPH oxidase activator 1 0.069
ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.068
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 0.067
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.066
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.066
VHL von Hippel-Lindau tumor suppressor 0.065
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.065
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.064
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.063
COPS2 COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) 0.063
ADRBK1 adrenergic, beta, receptor kinase 1 0.063
TPBG trophoblast glycoprotein 0.061
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.061
ATM ataxia telangiectasia mutated 0.061
GHR growth hormone receptor 0.061
PARD3 par-3 partitioning defective 3 homolog (C. elegans) 0.060
DOT1L DOT1-like, histone H3 methyltransferase (S. cerevisiae) 0.059
HDAC6 histone deacetylase 6 0.059
ZNF263 zinc finger protein 263 0.058
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative) 0.058
TRIM32 tripartite motif containing 32 0.057
ASF1A ASF1 anti-silencing function 1 homolog A (S. cerevisiae) 0.056
NBR1 neighbor of BRCA1 gene 1 0.056
CDC27 cell division cycle 27 homolog (S. cerevisiae) 0.056
KAT5 K(lysine) acetyltransferase 5 0.054
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.054
S100A4 S100 calcium binding protein A4 0.052
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.051
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 0.050
CDCP1 CUB domain containing protein 1 0.050
MBIP MAP3K12 binding inhibitory protein 1 0.049
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.048
COPS8 COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis) 0.047
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.047
MED15 mediator complex subunit 15 0.046
CCND1 cyclin D1 0.046
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.046
DLG1 discs, large homolog 1 (Drosophila) 0.046
CD81 CD81 molecule 0.045
FOXM1 forkhead box M1 0.045
IRAK3 interleukin-1 receptor-associated kinase 3 0.044
SPRR2A small proline-rich protein 2A 0.044
SKA2 spindle and kinetochore associated complex subunit 2 0.044
CUL3 cullin 3 0.044
CBX5 chromobox homolog 5 0.044
CASC5 cancer susceptibility candidate 5 0.043
SKP2 S-phase kinase-associated protein 2 (p45) 0.043
ITGB1BP3 integrin beta 1 binding protein 3 0.043
TERF2IP telomeric repeat binding factor 2, interacting protein 0.042
SKA3 spindle and kinetochore associated complex subunit 3 0.042
CIB1 calcium and integrin binding 1 (calmyrin) 0.042
COPS6 COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis) 0.042
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Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 0.996
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.986
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.831
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.809
Mdm2 transformed mouse 3T3 cell double minute 2 0.651
Traf6 TNF receptor-associated factor 6 0.524
Pten phosphatase and tensin homolog 0.430
Dlg4 discs, large homolog 4 (Drosophila) 0.357
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.336
Ctnnb1 catenin (cadherin associated protein), beta 1 0.332
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.330
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.299
Igh immunoglobulin heavy chain complex 0.249
App amyloid beta (A4) precursor protein 0.184
Tnf tumor necrosis factor 0.176
Il2rg interleukin 2 receptor, gamma chain 0.157
Cd19 CD19 antigen 0.151
Thbs1 thrombospondin 1 0.142
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.130
Notch2 Notch gene homolog 2 (Drosophila) 0.127
Esr1 estrogen receptor 1 (alpha) 0.126
Apc adenomatosis polyposis coli 0.125
Amhr2 anti-Mullerian hormone type 2 receptor 0.119
Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) 0.117
Sap18 Sin3-associated polypeptide 18 0.115
Lhx1 LIM homeobox protein 1 0.113
Notch1 Notch gene homolog 1 (Drosophila) 0.112
Myd88 myeloid differentiation primary response gene 88 0.106
Socs1 suppressor of cytokine signaling 1 0.105
Skil SKI-like 0.100
Cbl Casitas B-lineage lymphoma 0.094
Cd40 CD40 antigen 0.090
Emx1 empty spiracles homolog 1 (Drosophila) 0.089
Lin9 lin-9 homolog (C. elegans) 0.087
Fas Fas (TNF receptor superfamily member 6) 0.086
Stat3 signal transducer and activator of transcription 3 0.085
Pax2 paired box gene 2 0.082
Vdr vitamin D receptor 0.081
Daxx Fas death domain-associated protein 0.081
Cit citron 0.078
Sgol2 shugoshin-like 2 (S. pombe) 0.077
Aire autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) 0.076
Wnt10b wingless related MMTV integration site 10b 0.073
Bcl3 B-cell leukemia/lymphoma 3 0.073
Pgr progesterone receptor 0.071
Pcsk5 proprotein convertase subtilisin/kexin type 5 0.071
Ikzf1 IKAROS family zinc finger 1 0.068
Ptk2b PTK2 protein tyrosine kinase 2 beta 0.066
Psen1 presenilin 1 0.065
Hmmr hyaluronan mediated motility receptor (RHAMM) 0.065
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.065
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.063
Dlgap1 discs, large (Drosophila) homolog-associated protein 1 0.062
Plcg2 phospholipase C, gamma 2 0.060
Shank2 SH3/ankyrin domain gene 2 0.060
Nos1 nitric oxide synthase 1, neuronal 0.059
Sgol1 shugoshin-like 1 (S. pombe) 0.058
Brca1 breast cancer 1 0.057
Axin1 axin 1 0.054
Psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.053
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.052
Ncoa3 nuclear receptor coactivator 3 0.051
Ooep oocyte expressed protein homolog (dog) 0.050
Spag5 sperm associated antigen 5 0.050
Dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.050
Trp73 transformation related protein 73 0.050
Dlg2 discs, large homolog 2 (Drosophila) 0.049
Ret ret proto-oncogene 0.049
Brca2 breast cancer 2 0.048
Foxn1 forkhead box N1 0.048
Cdk1 cyclin-dependent kinase 1 0.048
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.047
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.046
Arid1a AT rich interactive domain 1A (SWI-like) 0.045
Ptk2 PTK2 protein tyrosine kinase 2 0.045
T brachyury 0.045
Ccna2 cyclin A2 0.043
Cdca8 cell division cycle associated 8 0.043
Wnt7a wingless-related MMTV integration site 7A 0.042
Plcg1 phospholipase C, gamma 1 0.042
Cbx1 chromobox homolog 1 (Drosophila HP1 beta) 0.042
Cdkn2c cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.042
Prkce protein kinase C, epsilon 0.041
Was Wiskott-Aldrich syndrome homolog (human) 0.041
Nbn nibrin 0.041
Ccnb1 cyclin B1 0.041
Bdnf brain derived neurotrophic factor 0.041
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.041
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.040
Gdnf glial cell line derived neurotrophic factor 0.040
Cops4 COP9 (constitutive photomorphogenic) homolog, subunit 4 (Arabidopsis thaliana) 0.040
Scube1 signal peptide, CUB domain, EGF-like 1 0.040
Cep55 centrosomal protein 55 0.039
Mdm4 transformed mouse 3T3 cell double minute 4 0.039
Ncapg2 non-SMC condensin II complex, subunit G2 0.039
Ncstn nicastrin 0.039
Glrx3 glutaredoxin 3 0.037
Axl AXL receptor tyrosine kinase 0.037
Csf1 colony stimulating factor 1 (macrophage) 0.036
Pax8 paired box gene 8 0.035
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Rattus norvegicus
Name Description Probability Func Analog Organism