The network for 'negative regulation of sister chromatid segregation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of sister chromatid segregation

Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
MAD2 Mad2p 0.908
IML3 Iml3p 0.891
CDC20 Cdc20p 0.846
DSN1 Dsn1p 0.791
AME1 Ame1p 0.757
NSL1 Nsl1p 0.751
BUB3 Bub3p 0.731
MTW1 Mtw1p 0.704
BUB1 Bub1p 0.481
GLC7 Glc7p 0.478
CSE4 Cse4p 0.471
MCM21 Mcm21p 0.432
TID3 Tid3p 0.407
PPH22 Pph22p 0.396
RTS1 Rts1p 0.391
PPZ1 Ppz1p 0.351
MAD1 Mad1p 0.339
SPC24 Spc24p 0.324
SLK19 Slk19p 0.317
CHL4 Chl4p 0.282
HHF2 Hhf2p 0.268
GIP2 Gip2p 0.267
HHT1 Hht1p 0.265
MAD3 Mad3p 0.257
CDC55 Cdc55p 0.247
MCM22 Mcm22p 0.246
YBP2 Ybp2p 0.245
PPH21 Pph21p 0.228
HTA1 Hta1p 0.200
TIP41 Tip41p 0.176
KIP1 Kip1p 0.171
SLI15 Sli15p 0.158
SPC105 Spc105p 0.151
FMP48 Fmp48p 0.149
KIC1 Kic1p 0.146
YPI1 Ypi1p 0.145
SDS22 Sds22p 0.124
OKP1 Okp1p 0.123
CTF3 Ctf3p 0.120
MIF2 Mif2p 0.105
SPC25 Spc25p 0.103
RAD53 Rad53p 0.099
IPL1 Ipl1p 0.096
NUF2 Nuf2p 0.095
SMC4 Smc4p 0.081
GLG1 Glg1p 0.071
MPS1 Mps1p 0.067
HHT2 Hht2p 0.066
DAM1 Dam1p 0.062
ECO1 Eco1p 0.061
NNF1 Nnf1p 0.060
NBL1 Nbl1p 0.060
CTF13 Ctf13p 0.052
BFA1 Bfa1p 0.051
PSP1 Psp1p 0.050
YKL075C hypothetical protein 0.049
SMC5 Smc5p 0.048
PTI1 Pti1p 0.046
NTO1 Nto1p 0.044
CIN1 Cin1p 0.042
SCC2 Scc2p 0.042
SPO14 Spo14p 0.039
PKC1 Pkc1p 0.039
CTF19 Ctf19p 0.038
EAF1 Eaf1p 0.038
SPC110 Spc110p 0.038
HYM1 Hym1p 0.037
SRD1 Srd1p 0.037
VIK1 Vik1p 0.037
PSY4 Psy4p 0.036
YGL010W hypothetical protein 0.034
SPO12 Spo12p 0.034
PCL10 Pcl10p 0.033
KAR3 Kar3p 0.033
RAD61 Rad61p 0.033
YOL038C-A hypothetical protein 0.032
MER1 Mer1p 0.031
ZDS2 Zds2p 0.031
CBF1 Cbf1p 0.031
LEU2 Leu2p 0.031
PCT1 Pct1p 0.030
YLR162W hypothetical protein 0.030
ASE1 Ase1p 0.030
HST3 Hst3p 0.029
HAL1 Hal1p 0.029
YLR264C-A hypothetical protein 0.029
PSK1 Psk1p 0.029
YIL151C hypothetical protein 0.029
IML1 Iml1p 0.028
CRP1 Crp1p 0.028
IRC15 Irc15p 0.028
ARG8 Arg8p 0.026
YHR033W hypothetical protein 0.026
PRP28 Prp28p 0.026
YML053C hypothetical protein 0.025
URA3 Ura3p 0.025
ZPS1 Zps1p 0.025
RCO1 Rco1p 0.025
THP3 Thp3p 0.025
SGE1 Sge1p 0.024
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
bmk-1 Protein BMK-1 0.018
ZK507.6 Protein ZK507.6 0.014
bub-1 Protein BUB-1 0.012
rnr-1 Protein RNR-1 0.012
cdl-1 Protein CDL-1 0.012
his-6 Protein HIS-6 0.011
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Iswi Imitation SWI 0.293
Bap55 Brahma associated protein 55kD 0.145
Nup153 Nucleoporin 153 0.126
spn-D spindle D 0.119
msb1l CG10364 gene product from transcript CG10364-RA 0.113
cav caravaggio 0.090
CycB Cyclin B 0.081
flfl falafel 0.068
ncd non-claret disjunctional 0.064
CycB3 Cyclin B3 0.056
mus209 mutagen-sensitive 209 0.056
nbs CG6754 gene product from transcript CG6754-RC 0.055
gek genghis khan 0.052
PPP4R2r Protein phosphatase 4 regulatory subunit 2-related protein 0.049
alphaTub67C alpha-Tubulin at 67C 0.047
rux roughex 0.045
prod proliferation disrupter 0.042
Pp1-87B Protein phosphatase 1 at 87B 0.042
BubR1 Bub1-related kinase 0.041
RanGap Ran GTPase activating protein 0.040
mus301 mutagen-sensitive 301 0.039
Sep2 Septin-2 0.036
CycA Cyclin A 0.035
pav pavarotti 0.034
Mcm10 Sensitized chromosome inheritance modifier 19 0.033
cnn centrosomin 0.032
Bj1 Bj1 protein 0.032
Mcm7 Minichromosome maintenance 7 0.032
mad2 CG17498 gene product from transcript CG17498-RA 0.025
Cap-G CG34438 gene product from transcript CG34438-RF 0.023
Cks30A Cyclin-dependent kinase subunit 30A 0.022
CG14213 CG14213 gene product from transcript CG14213-RB 0.021
SMC2 CG10212 gene product from transcript CG10212-RA 0.021
Mi-2 CG8103 gene product from transcript CG8103-RA 0.021
hay haywire 0.020
bam bag of marbles 0.020
asl asterless 0.020
crp cropped 0.019
fzy fizzy 0.019
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.019
CycJ Cyclin J 0.019
enok enoki mushroom 0.019
Cdc37 CG12019 gene product from transcript CG12019-RA 0.018
mus312 mutagen-sensitive 312 0.017
dup double parked 0.017
atms antimeros 0.017
CG8223 CG8223 gene product from transcript CG8223-RA 0.017
NiPp1 Nuclear inhibitor of Protein phosphatase 1 0.016
MEP-1 CG1244 gene product from transcript CG1244-RG 0.016
Pms2 CG8169 gene product from transcript CG8169-RA 0.016
CG2617 CG2617 gene product from transcript CG2617-RA 0.016
mus308 mutagen-sensitive 308 0.016
RecQ4 CG7487 gene product from transcript CG7487-RA 0.016
pim pimples 0.015
CycE Cyclin E 0.015
Axud1 CG4272 gene product from transcript CG4272-RA 0.015
CSN6 COP9 complex homolog subunit 6 0.014
CG32685 CG32685 gene product from transcript CG32685-RC 0.014
CG6418 CG6418 gene product from transcript CG6418-RB 0.014
CSN4 COP9 complex homolog subunit 4 0.013
Mcm5 Minichromosome maintenance 5 0.013
CycC Cyclin C 0.013
gwl greatwall 0.013
DNApol-alpha60 DNA polymerase alpha 60kD 0.013
CG10694 CG10694 gene product from transcript CG10694-RA 0.013
dre4 CG1828 gene product from transcript CG1828-RB 0.013
CG4973 CG4973 gene product from transcript CG4973-RA 0.012
CTCF CG8591 gene product from transcript CG8591-RA 0.012
gsb gooseberry 0.011
HP1e CG8120 gene product from transcript CG8120-RA 0.011
pont pontin 0.011
Grip75 CG6176 gene product from transcript CG6176-RA 0.011
nod no distributive disjunction 0.011
NELF-B CG32721 gene product from transcript CG32721-RA 0.011
I-2 Inhibitor-2 0.011
PTP-ER Protein tyrosine phosphatase-ERK/Enhancer of Ras1 0.010
tld tolloid 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
CDK2 cyclin-dependent kinase 2 0.801
BUB1B budding uninhibited by benzimidazoles 1 homolog beta (yeast) 0.797
CDC27 cell division cycle 27 homolog (S. cerevisiae) 0.756
CCT4 chaperonin containing TCP1, subunit 4 (delta) 0.549
CCNA2 cyclin A2 0.507
CDC20 cell division cycle 20 homolog (S. cerevisiae) 0.341
BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast) 0.338
CCNB1 cyclin B1 0.309
BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) 0.300
CCT8 chaperonin containing TCP1, subunit 8 (theta) 0.180
RAD51 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) 0.158
ANAPC4 anaphase promoting complex subunit 4 0.121
CASC5 cancer susceptibility candidate 5 0.116
NDC80 NDC80 homolog, kinetochore complex component (S. cerevisiae) 0.109
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 0.098
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.095
BRCA2 breast cancer 2, early onset 0.092
ANAPC7 anaphase promoting complex subunit 7 0.088
CBX5 chromobox homolog 5 0.084
CCNE1 cyclin E1 0.081
SKA1 spindle and kinetochore associated complex subunit 1 0.072
MDC1 mediator of DNA-damage checkpoint 1 0.064
SKP2 S-phase kinase-associated protein 2 (p45) 0.064
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.063
TP53BP1 tumor protein p53 binding protein 1 0.053
ORC2 origin recognition complex, subunit 2 0.049
SKA2 spindle and kinetochore associated complex subunit 2 0.049
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 0.047
FANCD2 Fanconi anemia, complementation group D2 0.046
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.045
ANAPC5 anaphase promoting complex subunit 5 0.045
CKS1B CDC28 protein kinase regulatory subunit 1B 0.043
CHAF1A chromatin assembly factor 1, subunit A (p150) 0.042
CDC23 cell division cycle 23 homolog (S. cerevisiae) 0.042
ANAPC11 anaphase promoting complex subunit 11 0.035
SKA3 spindle and kinetochore associated complex subunit 3 0.035
AURKB aurora kinase B 0.033
H2AFX H2A histone family, member X 0.033
C13orf34 chromosome 13 open reading frame 34 0.030
KIF11 kinesin family member 11 0.030
DOT1L DOT1-like, histone H3 methyltransferase (S. cerevisiae) 0.028
CENPE centromere protein E, 312kDa 0.028
PRNP prion protein 0.026
INCENP inner centromere protein antigens 135/155kDa 0.026
FBXO5 F-box protein 5 0.026
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 0.026
UBE2C ubiquitin-conjugating enzyme E2C 0.026
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.026
ANAPC1 anaphase promoting complex subunit 1 0.025
CDKN3 cyclin-dependent kinase inhibitor 3 0.024
ANKRD52 ankyrin repeat domain 52 0.024
HERC2 hect domain and RLD 2 0.024
PTTG1 pituitary tumor-transforming 1 0.023
KIF18A kinesin family member 18A 0.023
PLK4 polo-like kinase 4 0.023
CDC6 cell division cycle 6 homolog (S. cerevisiae) 0.022
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.021
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.021
CDT1 chromatin licensing and DNA replication factor 1 0.020
MYST1 MYST histone acetyltransferase 1 0.020
SMC3 structural maintenance of chromosomes 3 0.020
NBN nibrin 0.019
C19orf39 chromosome 19 open reading frame 39 0.018
PPME1 protein phosphatase methylesterase 1 0.018
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.018
ZNF828 zinc finger protein 828 0.018
OTUB1 OTU domain, ubiquitin aldehyde binding 1 0.017
FXR2 fragile X mental retardation, autosomal homolog 2 0.017
HIST1H4F histone cluster 1, H4f 0.017
NUF2 NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae) 0.016
SPC25 SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) 0.016
PPP4C protein phosphatase 4, catalytic subunit 0.016
ZNF207 zinc finger protein 207 0.016
CHAF1B chromatin assembly factor 1, subunit B (p60) 0.015
CDC16 cell division cycle 16 homolog (S. cerevisiae) 0.015
CHEK2 CHK2 checkpoint homolog (S. pombe) 0.015
CCNB2 cyclin B2 0.015
HIST1H4A histone cluster 1, H4a 0.015
ZWINT ZW10 interactor 0.015
SMC1A structural maintenance of chromosomes 1A 0.015
NASP nuclear autoantigenic sperm protein (histone-binding) 0.014
PPP2R1B protein phosphatase 2, regulatory subunit A, beta 0.014
CCNE2 cyclin E2 0.014
PARP3 poly (ADP-ribose) polymerase family, member 3 0.014
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.014
HIST1H3D histone cluster 1, H3d 0.014
NEK2 NIMA (never in mitosis gene a)-related kinase 2 0.013
BRCA1 breast cancer 1, early onset 0.013
CKS2 CDC28 protein kinase regulatory subunit 2 0.013
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.012
NSL1 NSL1, MIND kinetochore complex component, homolog (S. cerevisiae) 0.012
KAT5 K(lysine) acetyltransferase 5 0.012
HUWE1 HECT, UBA and WWE domain containing 1 0.012
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 0.012
CBX1 chromobox homolog 1 0.012
CEP55 centrosomal protein 55kDa 0.011
CCDC99 coiled-coil domain containing 99 0.011
MAPRE1 microtubule-associated protein, RP/EB family, member 1 0.011
MKRN1 makorin ring finger protein 1 0.011
SMC4 structural maintenance of chromosomes 4 0.011
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Mus musculus
Name Description Probability Func Analog Organism
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.681
Ccnb1 cyclin B1 0.649
Cdk1 cyclin-dependent kinase 1 0.636
Ccnb2 cyclin B2 0.395
Ccna2 cyclin A2 0.373
Kif20a kinesin family member 20A 0.274
Birc5 baculoviral IAP repeat-containing 5 0.267
Bub1b budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) 0.258
Kif22 kinesin family member 22 0.245
Prc1 protein regulator of cytokinesis 1 0.212
Asf1b ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.152
Aurkb aurora kinase B 0.109
Cenpe centromere protein E 0.094
Kif11 kinesin family member 11 0.081
Ccnf cyclin F 0.080
Trp53 transformation related protein 53 0.079
Brca1 breast cancer 1 0.076
Hmmr hyaluronan mediated motility receptor (RHAMM) 0.075
Spag5 sperm associated antigen 5 0.074
C330027C09Rik RIKEN cDNA C330027C09 gene 0.072
Cdca8 cell division cycle associated 8 0.069
Kif23 kinesin family member 23 0.054
Kif2c kinesin family member 2C 0.050
Kif4 kinesin family member 4 0.049
Aurka aurora kinase A 0.048
Cdc25c cell division cycle 25 homolog C (S. pombe) 0.048
Ube2c ubiquitin-conjugating enzyme E2C 0.043
Nek2 NIMA (never in mitosis gene a)-related expressed kinase 2 0.042
Mki67 antigen identified by monoclonal antibody Ki 67 0.042
Cdk2 cyclin-dependent kinase 2 0.041
Ckap2 cytoskeleton associated protein 2 0.039
Ect2 ect2 oncogene 0.035
Smc2 structural maintenance of chromosomes 2 0.031
Ube2t ubiquitin-conjugating enzyme E2T (putative) 0.031
Gsg2 germ cell-specific gene 2 0.031
Brca2 breast cancer 2 0.031
Melk maternal embryonic leucine zipper kinase 0.029
Top2a topoisomerase (DNA) II alpha 0.028
Sgol1 shugoshin-like 1 (S. pombe) 0.028
Dlgap5 discs, large (Drosophila) homolog-associated protein 5 0.028
Hmgb2 high mobility group box 2 0.025
Trim59 tripartite motif-containing 59 0.024
H2afz H2A histone family, member Z 0.024
Ttk Ttk protein kinase 0.023
Uhrf1 ubiquitin-like, containing PHD and RING finger domains, 1 0.023
Bub1 budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) 0.023
Ncapg non-SMC condensin I complex, subunit G 0.022
Ooep oocyte expressed protein homolog (dog) 0.021
Dna2 DNA replication helicase 2 homolog (yeast) 0.021
Racgap1 Rac GTPase-activating protein 1 0.021
Smc4 structural maintenance of chromosomes 4 0.020
Plk4 polo-like kinase 4 (Drosophila) 0.020
Cdca5 cell division cycle associated 5 0.020
Stil Scl/Tal1 interrupting locus 0.020
Wdhd1 WD repeat and HMG-box DNA binding protein 1 0.018
Cep55 centrosomal protein 55 0.018
Ccdc99 coiled-coil domain containing 99 0.018
Rad51ap1 RAD51 associated protein 1 0.017
Chek1 checkpoint kinase 1 homolog (S. pombe) 0.017
Nuf2 NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae) 0.016
Mis18bp1 MIS18 binding protein 1 0.016
Cdc6 cell division cycle 6 homolog (S. cerevisiae) 0.015
Tacc3 transforming, acidic coiled-coil containing protein 3 0.015
Cdkn3 cyclin-dependent kinase inhibitor 3 0.015
Chaf1b chromatin assembly factor 1, subunit B (p60) 0.014
Cenpk centromere protein K 0.013
Cks2 CDC28 protein kinase regulatory subunit 2 0.013
Ndc80 NDC80 homolog, kinetochore complex component (S. cerevisiae) 0.013
2810417H13Rik RIKEN cDNA 2810417H13 gene 0.013
Cenpa centromere protein A 0.012
Cenpf centromere protein F 0.012
Ncapd2 non-SMC condensin I complex, subunit D2 0.012
Msh2 mutS homolog 2 (E. coli) 0.012
D2Ertd750e DNA segment, Chr 2, ERATO Doi 750, expressed 0.012
Ccne1 cyclin E1 0.012
Anln anillin, actin binding protein 0.012
Trip13 thyroid hormone receptor interactor 13 0.012
Suv39h2 suppressor of variegation 3-9 homolog 2 (Drosophila) 0.012
Blm Bloom syndrome, RecQ helicase-like 0.012
Cenpn centromere protein N 0.011
Ncaph non-SMC condensin I complex, subunit H 0.011
Lin9 lin-9 homolog (C. elegans) 0.011
Gtse1 G two S phase expressed protein 1 0.011
Aspm asp (abnormal spindle)-like, microcephaly associated (Drosophila) 0.011
Plk1 polo-like kinase 1 (Drosophila) 0.010
Depdc1a DEP domain containing 1a 0.010
Hells helicase, lymphoid specific 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism