The network for 'sterol biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

sterol biosynthetic process

The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
ERG25 Erg25p 0.999
ERG28 Erg28p 0.999
ERG26 Erg26p 0.998
ERG3 Erg3p 0.998
ERG27 Erg27p 0.997
ERG5 Erg5p 0.991
ERG11 Erg11p 0.986
ERG6 Erg6p 0.981
ERG2 Erg2p 0.944
ERG24 Erg24p 0.835
MVD1 Mvd1p 0.812
ERG7 Erg7p 0.808
HMG1 Hmg1p 0.804
ERG4 Erg4p 0.666
ERG1 Erg1p 0.661
ERG8 Erg8p 0.659
ERG13 Erg13p 0.625
ERG9 Erg9p 0.558
ERG10 Erg10p 0.469
ERG12 Erg12p 0.368
BUL2 Bul2p 0.227
YJU3 Yju3p 0.174
PHO86 Pho86p 0.152
SCM4 Scm4p 0.145
MET4 Met4p 0.132
ECM22 Ecm22p 0.103
FRA1 Fra1p 0.097
ACS2 Acs2p 0.095
YPL014W hypothetical protein 0.094
HMG2 Hmg2p 0.086
CYB5 Cyb5p 0.080
HXT3 Hxt3p 0.079
SAM2 Sam2p 0.073
HSF1 Hsf1p 0.073
UPC2 Upc2p 0.072
ARE2 Are2p 0.071
HXK2 Hxk2p 0.068
MOT3 Mot3p 0.066
CSN9 Csn9p 0.065
PCD1 Pcd1p 0.062
ATF2 Atf2p 0.060
SSK2 Ssk2p 0.059
RPI1 Rpi1p 0.058
CYC7 Cyc7p 0.058
SCS7 Scs7p 0.057
GIS1 Gis1p 0.053
ROX1 Rox1p 0.052
YLR257W hypothetical protein 0.051
PHM8 Phm8p 0.050
PSD2 Psd2p 0.048
HAP1 Hap1p 0.048
CSI1 Csi1p 0.048
ZAP1 Zap1p 0.045
YJR116W hypothetical protein 0.045
YPR157W hypothetical protein 0.044
VPS60 Vps60p 0.043
TRA1 Tra1p 0.042
NUP157 Nup157p 0.042
YOR385W hypothetical protein 0.041
BSD2 Bsd2p 0.041
YLR297W hypothetical protein 0.041
YEH1 Yeh1p 0.040
YKL187C hypothetical protein 0.039
NRG1 Nrg1p 0.038
KIC1 Kic1p 0.037
DIA1 Dia1p 0.036
OLE1 Ole1p 0.034
TYE7 Tye7p 0.034
DAL81 Dal81p 0.033
AGP1 Agp1p 0.033
OPY2 Opy2p 0.033
PDR16 Pdr16p 0.032
POG1 Pog1p 0.032
HHO1 Hho1p 0.032
STF1 Stf1p 0.032
FAA2 Faa2p 0.032
PET10 Pet10p 0.030
WSC4 Wsc4p 0.029
LCB1 Lcb1p 0.029
IOC4 Ioc4p 0.028
EAF3 Eaf3p 0.028
MSC7 Msc7p 0.028
PLB2 Plb2p 0.028
COX13 Cox13p 0.028
RMA1 Rma1p 0.027
GLN3 Gln3p 0.027
MGA2 Mga2p 0.027
PUT4 Put4p 0.027
VAC7 Vac7p 0.026
ODC1 Odc1p 0.026
GPI11 Gpi11p 0.026
SMP1 Smp1p 0.026
NDD1 Ndd1p 0.026
MNN1 Mnn1p 0.025
CHA1 Cha1p 0.025
YIR035C hypothetical protein 0.025
GUF1 Guf1p 0.024
ISC1 Isc1p 0.024
PIN4 Pin4p 0.024
SWI1 Swi1p 0.024
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Cyp12a4 CG6042 gene product from transcript CG6042-RA 0.577
Ugt35a UDP-glycosyltransferase 35a 0.285
Cyp12d1-p CG30489 gene product from transcript CG30489-RA 0.200
Cyp4ac1 CG14032 gene product from transcript CG14032-RA 0.147
sad shadow 0.125
Cyp6a21 CG10247 gene product from transcript CG10247-RA 0.117
Cyp28d1 CG10833 gene product from transcript CG10833-RA 0.104
Cyp6a23 CG10242 gene product from transcript CG10242-RA 0.097
dib disembodied 0.095
alpha-Est7 alpha-Esterase-7 0.081
Cyp12d1-d CG33503 gene product from transcript CG33503-RA 0.078
CG6834 CG6834 gene product from transcript CG6834-RA 0.070
Rpb4 CG33520 gene product from transcript CG33520-RF 0.063
Cyp12a5 CG11821 gene product from transcript CG11821-RA 0.062
shd shade 0.062
JhI-26 Juvenile hormone-inducible protein 26 0.061
Cyp9b2 Cytochrome P450-9b2 0.051
Cyp6d5 CG3050 gene product from transcript CG3050-RA 0.047
spo spook 0.038
sro shroud 0.035
Npc1b Niemann-Pick type C-1b 0.033
Cyp6a13 CG2397 gene product from transcript CG2397-RA 0.032
Cyp6a2 Cytochrome P450-6a2 0.031
CG12672 CG12672 gene product from transcript CG12672-RA 0.031
Cyp4p1 Cytochrome P450-4p1 0.030
Cyp4e2 Cytochrome P450-4e2 0.029
Cyp12e1 CG14680 gene product from transcript CG14680-RC 0.029
Cyp6a9 Cytochrome P450-6a9 0.028
Cyp6g1 CG8453 gene product from transcript CG8453-RA 0.026
CG6830 CG6830 gene product from transcript CG6830-RA 0.025
Est-Q Esterase Q 0.024
CG33120 CG33120 gene product from transcript CG33120-RA 0.024
Ilp5 Insulin-like peptide 5 0.021
mol moladietz 0.019
Osi6 Osiris 6 0.017
CG6908 CG6908 gene product from transcript CG6908-RA 0.017
CDC45L CG3658 gene product from transcript CG3658-RA 0.016
CG10562 CG10562 gene product from transcript CG10562-RA 0.015
Cyp28a5 CG8864 gene product from transcript CG8864-RA 0.014
nvd neverland 0.014
pex16 peroxin 16 0.013
CG9396 CG9396 gene product from transcript CG9396-RA 0.013
TotA Turandot A 0.013
Cyp6w1 CG8345 gene product from transcript CG8345-RA 0.013
CG10824 CG10824 gene product from transcript CG10824-RA 0.012
CG33307 CG33307 gene product from transcript CG33307-RA 0.012
CG10550 CG10550 gene product from transcript CG10550-RB 0.012
CG8029 CG8029 gene product from transcript CG8029-RB 0.012
zen zerknullt 0.012
CG5819 CG5819 gene product from transcript CG5819-RA 0.012
CG3759 CG3759 gene product from transcript CG3759-RB 0.011
CG4630 CG4630 gene product from transcript CG4630-RA 0.011
CG9360 CG9360 gene product from transcript CG9360-RA 0.011
CG3091 CG3091 gene product from transcript CG3091-RA 0.011
Trc8 CG2304 gene product from transcript CG2304-RB 0.010
CG16799 CG16799 gene product from transcript CG16799-RA 0.010
lab labial 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.919
FGFR2 fibroblast growth factor receptor 2 0.913
SC4MOL sterol-C4-methyl oxidase-like 0.903
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.894
INSIG1 insulin induced gene 1 0.885
DHCR7 7-dehydrocholesterol reductase 0.880
NSDHL NAD(P) dependent steroid dehydrogenase-like 0.879
C14orf1 chromosome 14 open reading frame 1 0.863
SQLE squalene epoxidase 0.769
FDPS farnesyl diphosphate synthase 0.753
ACAT2 acetyl-CoA acetyltransferase 2 0.712
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.688
SREBF2 sterol regulatory element binding transcription factor 2 0.619
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.584
IDI1 isopentenyl-diphosphate delta isomerase 1 0.559
DHCR24 24-dehydrocholesterol reductase 0.516
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.403
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.232
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.192
FGFR1 fibroblast growth factor receptor 1 0.167
FGF1 fibroblast growth factor 1 (acidic) 0.150
FGF10 fibroblast growth factor 10 0.125
HP haptoglobin 0.116
LDLR low density lipoprotein receptor 0.113
MVD mevalonate (diphospho) decarboxylase 0.085
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 0.076
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 0.068
A2M alpha-2-macroglobulin 0.047
WWP1 WW domain containing E3 ubiquitin protein ligase 1 0.042
SC5DL sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like 0.040
ZFYVE9 zinc finger, FYVE domain containing 9 0.030
FADS1 fatty acid desaturase 1 0.026
SMAD3 SMAD family member 3 0.025
PRDX1 peroxiredoxin 1 0.024
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.022
MED15 mediator complex subunit 15 0.022
APOC1 apolipoprotein C-I 0.021
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like 0.019
ANKRD13A ankyrin repeat domain 13A 0.016
STARD4 StAR-related lipid transfer (START) domain containing 4 0.015
ACLY ATP citrate lyase 0.015
MVK mevalonate kinase 0.013
FBXL15 F-box and leucine-rich repeat protein 15 0.012
UBE2D3 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) 0.012
FGF7 fibroblast growth factor 7 0.011
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Mus musculus
Name Description Probability Func Analog Organism
Cyp51 cytochrome P450, family 51 1.000
Dhcr7 7-dehydrocholesterol reductase 0.987
Mvd mevalonate (diphospho) decarboxylase 0.984
Lss lanosterol synthase 0.984
Idi1 isopentenyl-diphosphate delta isomerase 0.971
Sqle squalene epoxidase 0.971
Ldlr low density lipoprotein receptor 0.968
Hmgcs1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 0.945
Apoa1 apolipoprotein A-I 0.676
Dhcr24 24-dehydrocholesterol reductase 0.658
Sc4mol sterol-C4-methyl oxidase-like 0.560
0610007P14Rik RIKEN cDNA 0610007P14 gene 0.502
Abca1 ATP-binding cassette, sub-family A (ABC1), member 1 0.450
Fdps farnesyl diphosphate synthetase 0.436
Nsdhl NAD(P) dependent steroid dehydrogenase-like 0.395
Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 0.371
Fasn fatty acid synthase 0.369
Acat2 acetyl-Coenzyme A acetyltransferase 2 0.358
Aacs acetoacetyl-CoA synthetase 0.255
Tm7sf2 transmembrane 7 superfamily member 2 0.249
Slc25a1 solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1 0.213
Pcyt2 phosphate cytidylyltransferase 2, ethanolamine 0.179
Stard4 StAR-related lipid transfer (START) domain containing 4 0.165
Acly ATP citrate lyase 0.164
Sc5d sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae) 0.155
Apoe apolipoprotein E 0.135
Npc1 Niemann Pick type C1 0.131
Mvk mevalonate kinase 0.123
Rdh11 retinol dehydrogenase 11 0.111
Scd2 stearoyl-Coenzyme A desaturase 2 0.111
Scd1 stearoyl-Coenzyme A desaturase 1 0.101
Apob apolipoprotein B 0.082
Srebf2 sterol regulatory element binding factor 2 0.081
Cyb5b cytochrome b5 type B 0.063
Elovl6 ELOVL family member 6, elongation of long chain fatty acids (yeast) 0.056
Pmvk phosphomevalonate kinase 0.049
Fads2 fatty acid desaturase 2 0.047
Cyld cylindromatosis (turban tumor syndrome) 0.044
Slc9a3r1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.043
Tmem97 transmembrane protein 97 0.043
Cyp26c1 cytochrome P450, family 26, subfamily c, polypeptide 1 0.039
Hsd17b12 hydroxysteroid (17-beta) dehydrogenase 12 0.034
Aldob aldolase B, fructose-bisphosphate 0.033
Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase 0.033
Insig1 insulin induced gene 1 0.026
Tmem64 transmembrane protein 64 0.024
Fdft1 farnesyl diphosphate farnesyl transferase 1 0.024
Srebf1 sterol regulatory element binding transcription factor 1 0.023
Fads1 fatty acid desaturase 1 0.023
Ebag9 estrogen receptor-binding fragment-associated gene 9 0.023
Tax1bp1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.022
Reep6 receptor accessory protein 6 0.021
Rnf11 ring finger protein 11 0.019
Sigmar1 sigma non-opioid intracellular receptor 1 0.018
Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 0.017
Slc4a4 solute carrier family 4 (anion exchanger), member 4 0.017
Lyz2 lysozyme 2 0.016
Srf serum response factor 0.016
Apoa2 apolipoprotein A-II 0.015
Pex3 peroxisomal biogenesis factor 3 0.015
Pgd phosphogluconate dehydrogenase 0.014
Apoc3 apolipoprotein C-III 0.014
Slc31a1 solute carrier family 31, member 1 0.014
F2 coagulation factor II 0.014
Tmem135 transmembrane protein 135 0.013
Cflar CASP8 and FADD-like apoptosis regulator 0.013
Traf6 TNF receptor-associated factor 6 0.012
Grb10 growth factor receptor bound protein 10 0.012
Hnf4a hepatic nuclear factor 4, alpha 0.012
Tkt transketolase 0.012
Scarb1 scavenger receptor class B, member 1 0.012
Rnf103 ring finger protein 103 0.011
Lcat lecithin cholesterol acyltransferase 0.011
Ppara peroxisome proliferator activated receptor alpha 0.011
Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 0.011
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.011
Fga fibrinogen alpha chain 0.011
Ambp alpha 1 microglobulin/bikunin 0.011
Ndfip1 Nedd4 family interacting protein 1 0.011
Foxa2 forkhead box A2 0.011
Pank3 pantothenate kinase 3 0.010
Tecr trans-2,3-enoyl-CoA reductase 0.010
Apoa4 apolipoprotein A-IV 0.010
Apom apolipoprotein M 0.010
Fgg fibrinogen gamma chain 0.010
Sec14l2 SEC14-like 2 (S. cerevisiae) 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Hmgcs1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) 0.779
Fasn fatty acid synthase 0.748
Sc4mol sterol-C4-methyl oxidase-like 0.663
Cyp51 cytochrome P450, family 51 0.656
Sqle squalene epoxidase 0.530
Fdps farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) 0.434
Insig1 insulin induced gene 1 0.210
Acat3 acetyl-Coenzyme A acetyltransferase 3 0.167
Idi1 isopentenyl-diphosphate delta isomerase 1 0.113
Fdft1 farnesyl diphosphate farnesyl transferase 1 0.109
Dhcr24 24-dehydrocholesterol reductase 0.047
Lss lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 0.036
Tm7sf2 transmembrane 7 superfamily member 2 0.032
Sc5dl sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like 0.022
Tmem97 transmembrane protein 97 0.021
Nsdhl NAD(P) dependent steroid dehydrogenase-like 0.021
Acss2 acyl-CoA synthetase short-chain family member 2 0.011