The network for 'vacuole organization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

vacuole organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
VTI1 Vti1p 0.968
PEP12 Pep12p 0.934
YKT6 Ykt6p 0.930
VPS45 Vps45p 0.899
VPS21 Vps21p 0.885
VAM6 Vam6p 0.807
VAM7 Vam7p 0.753
VPS41 Vps41p 0.742
VTC1 Vtc1p 0.714
PEP3 Pep3p 0.714
VPS16 Vps16p 0.614
VPS33 Vps33p 0.604
VPS15 Vps15p 0.593
SEC4 Sec4p 0.519
VAM3 Vam3p 0.358
SEC17 Sec17p 0.347
SYS1 Sys1p 0.316
VTC4 Vtc4p 0.309
PEP5 Pep5p 0.308
ATG20 Atg20p 0.298
VTC3 Vtc3p 0.291
CDC42 Cdc42p 0.279
TLG2 Tlg2p 0.255
CNB1 Cnb1p 0.255
ATG9 Atg9p 0.250
VPS60 Vps60p 0.247
ATG8 Atg8p 0.243
CTR9 Ctr9p 0.238
SSO1 Sso1p 0.229
ATG3 Atg3p 0.228
TOM1 Tom1p 0.228
FAB1 Fab1p 0.215
VPS8 Vps8p 0.186
SCP1 Scp1p 0.175
ATG4 Atg4p 0.168
MLC1 Mlc1p 0.167
AHP1 Ahp1p 0.166
ATG14 Atg14p 0.165
RCY1 Rcy1p 0.160
PAF1 Paf1p 0.158
ERR3 Err3p 0.157
YPT1 Ypt1p 0.150
GPA2 Gpa2p 0.148
YPT52 Ypt52p 0.146
VTC2 Vtc2p 0.143
DRS2 Drs2p 0.139
PHO81 Pho81p 0.138
ATG29 Atg29p 0.136
HSV2 Hsv2p 0.135
RHO4 Rho4p 0.135
ATG18 Atg18p 0.130
RHO1 Rho1p 0.125
KEX1 Kex1p 0.125
YPT7 Ypt7p 0.121
CIS1 Cis1p 0.121
VPS51 Vps51p 0.118
TLG1 Tlg1p 0.115
LRG1 Lrg1p 0.111
NBP2 Nbp2p 0.108
LCB2 Lcb2p 0.106
ATG13 Atg13p 0.106
VPS3 Vps3p 0.105
ATG11 Atg11p 0.103
ATG23 Atg23p 0.101
STF1 Stf1p 0.100
TPI1 Tpi1p 0.100
LEM3 Lem3p 0.098
CDC55 Cdc55p 0.091
PHO84 Pho84p 0.091
DOP1 Dop1p 0.091
COX13 Cox13p 0.090
MUK1 Muk1p 0.090
SYN8 Syn8p 0.088
PTC1 Ptc1p 0.086
SHE2 She2p 0.086
ARP2 Arp2p 0.086
SPO7 Spo7p 0.086
GDI1 Gdi1p 0.086
VPS17 Vps17p 0.080
GPI1 Gpi1p 0.078
ATG16 Atg16p 0.078
PHM6 Phm6p 0.077
BEM4 Bem4p 0.076
VMA6 Vma6p 0.075
ARV1 Arv1p 0.074
ATG7 Atg7p 0.073
CAP1 Cap1p 0.072
ARE2 Are2p 0.071
SHE3 She3p 0.071
ARC18 Arc18p 0.071
GCS1 Gcs1p 0.070
MSB3 Msb3p 0.070
COT1 Cot1p 0.070
NPR2 Npr2p 0.070
ATG1 Atg1p 0.070
AKR1 Akr1p 0.069
NYV1 Nyv1p 0.069
PHO11 Pho11p 0.068
SRL1 Srl1p 0.068
GPR1 Gpr1p 0.068
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
skn-1 Protein SKN-1 0.014
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Danio rerio
Name Description Probability Func Analog Organism
tbx1 T-box 1 0.143
atp6v1h ATPase, H+ transporting, lysosomal, V1 subunit H 0.118
atp6ap1 ATPase, H+ transporting, lysosomal accessory protein 1 0.103
cltca clathrin, heavy polypeptide a (Hc) 0.080
arf2 ADP-ribosylation factor 2 0.062
zgc:110239 zgc:110239 0.061
arf5 ADP-ribosylation factor 5 0.061
rab13 RAB13, member RAS oncogene family 0.059
gapdhs glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 0.059
vps39 vacuolar protein sorting 39 homolog (S. cerevisiae) 0.058
atp6v1f ATPase, H+ transporting, V1 subunit F 0.058
ctsd cathepsin D 0.050
cnn2 calponin 2 0.047
snx4 sorting nexin 4 0.043
ctsz cathepsin Z 0.038
slc45a2 solute carrier family 45, member 2 0.035
elovl1b elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1b 0.035
apg3l APG3 autophagy 3-like 0.035
zgc:77849 zgc:77849 0.033
mxd4 MAX dimerization protein 4 0.033
atp6v1ba ATPase, H+ transporting, lysosomal, V1 subunit B, member a 0.033
pfn2 profilin 2 0.033
ppp1cb protein phosphatase 1, catalytic subunit, beta isoform 0.031
sept2 septin 2 0.030
zgc:110815 zgc:110815 0.030
atp6v1e1b ATPase, H+ transporting, lysosomal, V1 subunit E isoform 1b 0.030
bc2 putative breast adenocarcinoma marker 0.029
atp6ap2 ATPase, H+ transporting, lysosomal accessory protein 2 0.028
cpvl carboxypeptidase, vitellogenic-like 0.027
atp6v0ca ATPase, H+ transporting, lysosomal, V0 subunit c, a 0.027
atp6v1d ATPase, H+ transporting, V1 subunit D and ATPase, H+ transporting, V1 subunit D 0.024
rab5aa RAB5A, member RAS oncogene family, a 0.024
smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.022
vps18 vacuolar protein sorting protein 18 0.022
ctsf cathepsin F 0.022
ccm2 cerebral cavernous malformation 2 0.021
stxbp2 syntaxin binding protein 2 0.021
map1lc3a microtubule-associated protein 1 light chain 3 alpha 0.021
zgc:152830 zgc:152830 0.020
zgc:92765 zgc:92765 0.019
clcn7 chloride channel 7 0.018
gabarapa GABA(A) receptor-associated protein a 0.018
msna moesin a 0.018
rab5c RAB5C, member RAS oncogene family 0.018
zgc:55813 zgc:55813 0.017
ck2b casein kinase 2 beta 0.017
erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog 0.016
si:dkey-222f8.3 si:dkey-222f8.3 0.016
ctbs chitobiase, di-N-acetyl- 0.015
cd63 Cd63 antigen 0.015
nr3c1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.015
eno1 enolase 1, (alpha) 0.014
gle1 GLE1 RNA export mediator homolog (yeast) 0.014
tax1bp1b Tax1 (human T-cell leukemia virus type I) binding protein 1b 0.014
wdr45 WD repeat domain 45 0.014
dnaja2l DnaJ (Hsp40) homolog, subfamily A, member 2, like 0.014
zgc:123177 zgc:123177 0.014
grina glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 0.014
zgc:91910 zgc:91910 0.013
mxi1 max interacting protein 0.013
pkm2a pyruvate kinase, muscle, a 0.013
neb nebulin 0.012
atp6v1a ATPase, H+ transporting, lysosomal V1 subunit A 0.012
med7 mediator complex subunit 7 0.012
pgk1 phosphoglycerate kinase 1 0.012
atp6v1g1 ATPase, H+ transporting, V1 subunit G isoform 1 0.012
rer1 RER1 retention in endoplasmic reticulum 1 homolog (S. cerevisiae) 0.012
zgc:100919 zgc:100919 0.012
hn1l hematological and neurological expressed 1-like 0.012
map1lc3b microtubule-associated protein 1 light chain 3 beta 0.011
zgc:63831 zgc:63831 0.011
tm9sf2 transmembrane 9 superfamily member 2 0.011
sypl2b synaptophysin-like 2b 0.011
si:ch211-146l10.2 si:ch211-146l10.2 0.011
tp53 tumor protein p53 0.011
midn midnolin 0.010
zgc:77517 zgc:77517 0.010
zgc:56530 zgc:56530 0.010
map2k7 mitogen-activated protein kinase kinase 7 0.010
npc2 Niemann-Pick disease, type C2 0.010
psenen presenilin enhancer 2 homolog 0.010
mobkl3 MOB1, Mps One Binder kinase activator-like 3 (yeast) 0.010
tmem50a transmembrane protein 50A 0.010
wipi2 WD repeat domain, phosphoinositide interacting 2 0.010
tmem9b TMEM9 domain family, member B 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Rab7 Rab-protein 7 0.379
Rheb CG1081 gene product from transcript CG1081-RA 0.204
Akt1 CG4006 gene product from transcript CG4006-RA 0.135
Atg1 Autophagy-specific gene 1 0.120
Pi3K59F Phosphotidylinositol 3 kinase 59F 0.070
Rab2 Rab-protein 2 0.057
Atg18 Autophagy-specific gene 18 0.042
CG1599 CG1599 gene product from transcript CG1599-RA 0.034
Atg8a Autophagy-specific gene 8a 0.030
Rab6 Rab-protein 6 0.026
Atg2 Autophagy-specific gene 2 0.026
Syx7 Syntaxin 7 0.025
Syx17 Syntaxin 17 0.024
Snap Soluble NSF attachment protein 0.024
Gos28 CG7700 gene product from transcript CG7700-RA 0.023
CG7220 CG7220 gene product from transcript CG7220-RD 0.023
gammaSnap gamma-soluble NSF attachment protein 0.022
ClC-b Chloride channel-b 0.022
key kenny 0.021
drpr draper 0.019
Stam Signal transducing adaptor molecule 0.019
Syb Synaptobrevin 0.018
Atg9 Autophagy-specific gene 9 0.017
Atg6 Autophagy-specific gene 6 0.016
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.015
Rala Ras-related protein 0.012
CG10904 CG10904 gene product from transcript CG10904-RA 0.012
Vti1 CG3279 gene product from transcript CG3279-RA 0.012
S6k RPS6-p70-protein kinase 0.011
Rac2 CG8556 gene product from transcript CG8556-RA 0.011
CG12004 CG12004 gene product from transcript CG12004-RC 0.011
prel preli-like 0.011
mts microtubule star 0.011
CG11975 CG11975 gene product from transcript CG11975-RA 0.010
CG7611 CG7611 gene product from transcript CG7611-RJ 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
GABARAP GABA(A) receptor-associated protein 1.000
GABARAPL2 GABA(A) receptor-associated protein-like 2 0.998
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.996
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.995
ATG13 ATG13 autophagy related 13 homolog (S. cerevisiae) 0.992
CTSA cathepsin A 0.976
ULK1 unc-51-like kinase 1 (C. elegans) 0.973
BECN1 beclin 1, autophagy related 0.972
NBR1 neighbor of BRCA1 gene 1 0.935
ATG3 ATG3 autophagy related 3 homolog (S. cerevisiae) 0.920
ATG7 ATG7 autophagy related 7 homolog (S. cerevisiae) 0.897
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 0.876
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c 0.875
AKTIP AKT interacting protein 0.859
CFL1 cofilin 1 (non-muscle) 0.858
SNX6 sorting nexin 6 0.854
GRN granulin 0.835
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b 0.795
PIK3C3 phosphoinositide-3-kinase, class 3 0.795
VPS33B vacuolar protein sorting 33 homolog B (yeast) 0.765
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.761
PSAP prosaposin 0.761
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 0.751
RAB5A RAB5A, member RAS oncogene family 0.746
OCRL oculocerebrorenal syndrome of Lowe 0.741
LRRK2 leucine-rich repeat kinase 2 0.698
MON1B MON1 homolog B (yeast) 0.663
VTI1B vesicle transport through interaction with t-SNAREs homolog 1B (yeast) 0.652
PLD3 phospholipase D family, member 3 0.640
ATG5 ATG5 autophagy related 5 homolog (S. cerevisiae) 0.621
NEU1 sialidase 1 (lysosomal sialidase) 0.582
GOLGA2 golgin A2 0.578
ACTB actin, beta 0.573
ATG12 ATG12 autophagy related 12 homolog (S. cerevisiae) 0.566
ITSN1 intersectin 1 (SH3 domain protein) 0.522
AMBRA1 autophagy/beclin-1 regulator 1 0.491
INSR insulin receptor 0.490
CTSD cathepsin D 0.484
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.478
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae) 0.471
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.468
ARHGAP1 Rho GTPase activating protein 1 0.456
GABARAPL1 GABA(A) receptor-associated protein like 1 0.448
PTPN23 protein tyrosine phosphatase, non-receptor type 23 0.438
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 0.422
GDI2 GDP dissociation inhibitor 2 0.414
BCL2 B-cell CLL/lymphoma 2 0.412
MTMR12 myotubularin related protein 12 0.390
SQSTM1 sequestosome 1 0.380
STX12 syntaxin 12 0.370
MTM1 myotubularin 1 0.366
RHOA ras homolog gene family, member A 0.366
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D 0.344
WBP2 WW domain binding protein 2 0.341
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.329
EEA1 early endosome antigen 1 0.326
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.325
LAMP1 lysosomal-associated membrane protein 1 0.318
TPP1 tripeptidyl peptidase I 0.316
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha 0.309
BCL2L1 BCL2-like 1 0.307
UVRAG UV radiation resistance associated gene 0.299
TPM4 tropomyosin 4 0.269
ATG16L1 ATG16 autophagy related 16-like 1 (S. cerevisiae) 0.267
GRB2 growth factor receptor-bound protein 2 0.249
NCSTN nicastrin 0.233
RAB1B RAB1B, member RAS oncogene family 0.210
C12orf44 chromosome 12 open reading frame 44 0.203
RAB2A RAB2A, member RAS oncogene family 0.185
ATG14 ATG14 autophagy related 14 homolog (S. cerevisiae) 0.183
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) 0.177
CREB3 cAMP responsive element binding protein 3 0.174
GLB1 galactosidase, beta 1 0.170
CLTB clathrin, light chain B 0.149
MAPK8 mitogen-activated protein kinase 8 0.149
FAM134A family with sequence similarity 134, member A 0.149
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) 0.149
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 0.147
CHMP2B chromatin modifying protein 2B 0.142
RRAGA Ras-related GTP binding A 0.128
BAK1 BCL2-antagonist/killer 1 0.127
MTMR6 myotubularin related protein 6 0.126
ZFYVE1 zinc finger, FYVE domain containing 1 0.124
MAP3K11 mitogen-activated protein kinase kinase kinase 11 0.124
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.123
PINK1 PTEN induced putative kinase 1 0.122
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F 0.121
COASY CoA synthase 0.117
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) 0.113
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 0.110
KIAA1377 KIAA1377 0.109
KBTBD7 kelch repeat and BTB (POZ) domain containing 7 0.107
SESN2 sestrin 2 0.101
ARRB2 arrestin, beta 2 0.101
CFL2 cofilin 2 (muscle) 0.101
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.100
SPTLC1 serine palmitoyltransferase, long chain base subunit 1 0.100
C5orf54 chromosome 5 open reading frame 54 0.099
NSF N-ethylmaleimide-sensitive factor 0.095
TUBA1C tubulin, alpha 1c 0.094
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Mus musculus
Name Description Probability Func Analog Organism
Atg12 autophagy-related 12 (yeast) 0.996
Rac1 RAS-related C3 botulinum substrate 1 0.995
Cdc42 cell division cycle 42 homolog (S. cerevisiae) 0.987
Dpp7 dipeptidylpeptidase 7 0.958
Hexa hexosaminidase A 0.914
Hexb hexosaminidase B 0.819
Psap prosaposin 0.745
Lamp1 lysosomal-associated membrane protein 1 0.711
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.707
Hps1 Hermansky-Pudlak syndrome 1 homolog (human) 0.697
0610031J06Rik RIKEN cDNA 0610031J06 gene 0.650
Ulk1 Unc-51 like kinase 1 (C. elegans) 0.631
Ctsb cathepsin B 0.606
Mitf microphthalmia-associated transcription factor 0.600
Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 0.540
Rab11a RAB11a, member RAS oncogene family 0.532
Atg13 ATG13 autophagy related 13 homolog (S. cerevisiae) 0.525
Lrrk2 leucine-rich repeat kinase 2 0.513
Mtor mechanistic target of rapamycin (serine/threonine kinase) 0.499
Mfsd1 major facilitator superfamily domain containing 1 0.492
Actr3 ARP3 actin-related protein 3 homolog (yeast) 0.485
Atp6v1a ATPase, H+ transporting, lysosomal V1 subunit A 0.481
Gns glucosamine (N-acetyl)-6-sulfatase 0.447
Ncstn nicastrin 0.441
Rragc Ras-related GTP binding C 0.438
Lrp1 low density lipoprotein receptor-related protein 1 0.430
Atg3 autophagy-related 3 (yeast) 0.427
Npc1 Niemann Pick type C1 0.416
Igf2r insulin-like growth factor 2 receptor 0.415
Sgpl1 sphingosine phosphate lyase 1 0.415
Sqstm1 sequestosome 1 0.383
Aph1a anterior pharynx defective 1a homolog (C. elegans) 0.374
Grb10 growth factor receptor bound protein 10 0.355
Stx7 syntaxin 7 0.352
Wdr81 WD repeat domain 81 0.345
Gaa glucosidase, alpha, acid 0.331
Lpin1 lipin 1 0.331
Eef1a1 eukaryotic translation elongation factor 1 alpha 1 0.316
Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.315
Ndfip1 Nedd4 family interacting protein 1 0.315
Ctsa cathepsin A 0.312
Renbp renin binding protein 0.304
Snx2 sorting nexin 2 0.303
Grn granulin 0.300
Actg1 actin, gamma, cytoplasmic 1 0.287
Atp6v0b ATPase, H+ transporting, lysosomal V0 subunit B 0.277
Apoe apolipoprotein E 0.268
Atg5 autophagy-related 5 (yeast) 0.268
Snap23 synaptosomal-associated protein 23 0.253
Rab1 RAB1, member RAS oncogene family 0.250
Sept7 septin 7 0.248
Ctsd cathepsin D 0.241
Atp6v0e ATPase, H+ transporting, lysosomal V0 subunit E 0.237
Cltc clathrin, heavy polypeptide (Hc) 0.222
Naga N-acetyl galactosaminidase, alpha 0.212
Ctsz cathepsin Z 0.211
Rab27a RAB27A, member RAS oncogene family 0.207
Notch2 Notch gene homolog 2 (Drosophila) 0.205
Mapk9 mitogen-activated protein kinase 9 0.197
Tpp1 tripeptidyl peptidase I 0.196
Itgb5 integrin beta 5 0.192
Mapre3 microtubule-associated protein, RP/EB family, member 3 0.192
Rap1b RAS related protein 1b 0.188
Asah1 N-acylsphingosine amidohydrolase 1 0.181
Man2b1 mannosidase 2, alpha B1 0.179
Pld3 phospholipase D family, member 3 0.177
Plbd2 phospholipase B domain containing 2 0.173
Lamtor3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 0.170
Mobkl1b MOB1, Mps One Binder kinase activator-like 1B (yeast) 0.170
Clcn7 chloride channel 7 0.169
Arl1 ADP-ribosylation factor-like 1 0.161
Capza2 capping protein (actin filament) muscle Z-line, alpha 2 0.161
Idua iduronidase, alpha-L- 0.156
Trp53inp2 transformation related protein 53 inducible nuclear protein 2 0.153
Sdcbp syndecan binding protein 0.152
Arf1 ADP-ribosylation factor 1 0.151
Copb1 coatomer protein complex, subunit beta 1 0.150
Gdi2 guanosine diphosphate (GDP) dissociation inhibitor 2 0.147
a nonagouti 0.147
Calm1 calmodulin 1 0.146
Gopc golgi associated PDZ and coiled-coil motif containing 0.143
Rab18 RAB18, member RAS oncogene family 0.141
Vps35 vacuolar protein sorting 35 0.141
Npc2 Niemann Pick type C2 0.139
Ssr3 signal sequence receptor, gamma 0.138
Gusb glucuronidase, beta 0.137
Lgmn legumain 0.136
Arl8b ADP-ribosylation factor-like 8B 0.134
Atg2a ATG2 autophagy related 2 homolog A (S. cerevisiae) 0.134
Igf2 insulin-like growth factor 2 0.133
Twf1 twinfilin, actin-binding protein, homolog 1 (Drosophila) 0.131
Atp6ap2 ATPase, H+ transporting, lysosomal accessory protein 2 0.130
Tcn2 transcobalamin 2 0.130
Naglu alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB) 0.128
Pi4kb phosphatidylinositol 4-kinase, catalytic, beta polypeptide 0.123
Ikbkb inhibitor of kappaB kinase beta 0.120
Lipa lysosomal acid lipase A 0.119
Tbc1d17 TBC1 domain family, member 17 0.117
Pik3c3 phosphoinositide-3-kinase, class 3 0.116
Pldn pallidin 0.116
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Rattus norvegicus
Name Description Probability Func Analog Organism
Arf1 ADP-ribosylation factor 1 0.015