The network for 'negative regulation of dna replication' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of dna replication

Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
RAD53 Rad53p 0.330
MRC1 Mrc1p 0.242
NOP10 Nop10p 0.217
CDC34 Cdc34p 0.132
EST1 Est1p 0.127
HRK1 Hrk1p 0.115
PTK2 Ptk2p 0.102
POL1 Pol1p 0.082
DUN1 Dun1p 0.072
RIO1 Rio1p 0.072
PDS1 Pds1p 0.068
CSM3 Csm3p 0.066
TEN1 Ten1p 0.065
PDS5 Pds5p 0.062
DIA2 Dia2p 0.060
RAD5 Rad5p 0.054
MMS1 Mms1p 0.049
PSY2 Psy2p 0.049
POL12 Pol12p 0.046
TOF2 Tof2p 0.046
YPL260W hypothetical protein 0.046
HSL1 Hsl1p 0.044
ESF1 Esf1p 0.042
TOR1 Tor1p 0.042
NOP7 Nop7p 0.040
RRM3 Rrm3p 0.039
PRI1 Pri1p 0.037
NET1 Net1p 0.036
GAR1 Gar1p 0.036
CMK2 Cmk2p 0.035
PAM1 Pam1p 0.035
IRC8 Irc8p 0.034
HOP1 Hop1p 0.034
YLR177W hypothetical protein 0.033
SAE2 Sae2p 0.032
TOF1 Tof1p 0.031
DDC1 Ddc1p 0.028
CDC14 Cdc14p 0.028
MDS3 Mds3p 0.028
TEL1 Tel1p 0.027
EST2 Est2p 0.026
VID22 Vid22p 0.026
CDH1 Cdh1p 0.025
HAL5 Hal5p 0.025
UTR1 Utr1p 0.024
TCO89 Tco89p 0.024
CTF18 Ctf18p 0.024
POP2 Pop2p 0.024
YPS1 Yps1p 0.023
RAD9 Rad9p 0.023
MEC1 Mec1p 0.022
CDC13 Cdc13p 0.022
CDC4 Cdc4p 0.022
SEF1 Sef1p 0.022
CDC20 Cdc20p 0.022
YNL234W hypothetical protein 0.022
RGC1 Rgc1p 0.022
NAF1 Naf1p 0.022
ADE16 Ade16p 0.022
YPK1 Ypk1p 0.021
YLR162W hypothetical protein 0.021
RMI1 Rmi1p 0.021
MCM4 Mcm4p 0.021
RED1 Red1p 0.021
NUP157 Nup157p 0.020
RAD24 Rad24p 0.020
RRP36 Rrp36p 0.020
AKL1 Akl1p 0.019
CDC9 Cdc9p 0.019
CDC23 Cdc23p 0.019
MCM10 Mcm10p 0.019
RTS1 Rts1p 0.019
YIL151C hypothetical protein 0.019
SCH9 Sch9p 0.019
SCC2 Scc2p 0.019
OSH2 Osh2p 0.019
ROD1 Rod1p 0.018
VHS1 Vhs1p 0.018
SIA1 Sia1p 0.018
PRI2 Pri2p 0.018
MBF1 Mbf1p 0.018
MSI1 Msi1p 0.017
NUR1 Nur1p 0.017
YGR071C hypothetical protein 0.016
RCK2 Rck2p 0.016
RIF1 Rif1p 0.016
YLR257W hypothetical protein 0.016
KOG1 Kog1p 0.016
AZF1 Azf1p 0.016
YBL081W hypothetical protein 0.015
HOG1 Hog1p 0.015
YTM1 Ytm1p 0.015
DIN7 Din7p 0.015
YOR385W hypothetical protein 0.015
SRD1 Srd1p 0.015
SMC6 Smc6p 0.015
SAK1 Sak1p 0.015
ZPS1 Zps1p 0.015
TOP1 Top1p 0.015
YLR264C-A hypothetical protein 0.014
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
tbx1 T-box 1 0.144
pds5b PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) 0.123
gpia glucose phosphate isomerase a 0.119
zgc:64114 zgc:64114 0.098
zgc:171553 zgc:171553 0.097
mapk14a mitogen-activated protein kinase 14a 0.095
sox11b SRY-box containing gene 11b 0.090
paf1 paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.081
eif3c eukaryotic translation initiation factor 3, subunit C 0.076
mef2a myocyte enhancer factor 2a 0.070
nsa2 NSA2 ribosome biogenesis homolog (S. cerevisiae) 0.068
zff9 zinc finger protein 9 0.068
smad5 MAD homolog 5 (Drosophila) 0.062
mbnl2 muscleblind-like 2 (Drosophila) 0.061
ddx21 DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 0.058
ca15b carbonic anhydrase XV b 0.058
hcfc1a host cell factor C1a 0.056
nap1l1 nucleosome assembly protein 1, like 1 0.052
smc1al structural maintenance of chromosomes 1A, like 0.051
mapk1 mitogen-activated protein kinase 1 0.051
nr3c1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.051
mapk6 mitogen-activated protein kinase 6 0.050
mapk3 mitogen-activated protein kinase 3 0.050
slc2a10 solute carrier family 2 (facilitated glucose transporter), member 10 0.049
col5a1 procollagen, type V, alpha 1 0.048
cacnb2b calcium channel, voltage-dependent, beta 2b 0.048
cx43.4 connexin 43.4 0.046
zgc:73273 zgc:73273 0.045
frem3 Fras1 related extracellular matrix 3 0.045
crh corticotropin releasing hormone 0.044
sparc secreted acidic cysteine rich glycoprotein 0.043
stmn4 stathmin-like 4 0.043
fabp11a fatty acid binding protein 11a 0.042
zgc:123178 zgc:123178 0.042
smc3 structural maintenance of chromosomes 3 0.042
gro2 groucho 2 0.041
lepr leptin receptor 0.041
si:ch211-57k11.10 si:ch211-57k11.10 0.041
slc12a3 solute carrier family 12 (sodium/chloride transporters), member 3 0.041
tnfa tumor necrosis factor a (TNF superfamily, member 2) 0.041
pinx1 pin2/trf1-interacting protein 1 0.040
sh3gl1b SH3-domain GRB2-like 1b 0.040
ctgf connective tissue growth factor 0.039
dnmt5 DNA (cytosine-5-)-methyltransferase 5 0.039
lzts2a leucine zipper, putative tumor suppressor 2a 0.039
chrna6 cholinergic receptor, nicotinic, alpha 6 0.039
stmn2b stathmin-like 2b 0.038
bactin1 bactin1 0.038
rorca RAR-related orphan receptor C a 0.038
satb2 SATB homeobox 2 0.038
naca nascent polypeptide-associated complex alpha polypeptide 0.038
nr0b1 nuclear receptor subfamily 0, group B, member 1 0.037
morc2 MORC family CW-type zinc finger 2 0.037
col10a1 collagen, type X, alpha 1 0.036
LOC100000687 signal peptide, CUB and EGF-like domain-containing protein 3-like 0.036
dnmt1 DNA (cytosine-5-)-methyltransferase 1 0.036
igf2b insulin-like growth factor 2b 0.034
rad21 RAD21 homolog (S. pombe) 0.033
si:dkey-228g21.4 si:dkey-228g21.4 0.033
srrm2 serine/arginine repetitive matrix 2 0.033
twist1a twist1a 0.033
ripply1 ripply1 0.032
sid4 secreted immunoglobulin domain 4 0.032
valopb vertebrate ancient long opsin b 0.032
ccne cyclin E 0.031
vsx2 visual system homeobox 2 0.031
pck1 phosphoenolpyruvate carboxykinase 1 (soluble) 0.031
srsf4 serine/arginine-rich splicing factor 4 0.031
fgf8a fibroblast growth factor 8 a 0.031
palb2 partner and localizer of BRCA2 0.031
igfbp3 insulin-like growth factor binding protein 3 0.030
p2rx8 purinergic receptor P2X, ligand-gated ion channel, 8 0.030
spry4 sprouty (Drosophila) homolog 4 0.030
im:7153552 im:7153552 0.030
ephb4b eph receptor B4b 0.030
si:dkey-67c22.2 si:dkey-67c22.2 0.030
zgc:154063 zgc:154063 0.030
zgc:112986 zgc:112986 0.029
th2 tyrosine hydroxylase 2 0.029
matr3l matrin 3-like 0.029
cp ceruloplasmin 0.029
pdlim1 PDZ and LIM domain 1 (elfin) 0.028
sox9b SRY-box containing gene 9b 0.028
kiss1rb KISS1 receptor b 0.028
celf1 cugbp, Elav-like family member 1 0.028
zgc:63947 zgc:63947 0.028
prpf4b PRP4 pre-mRNA processing factor 4 homolog B 0.028
ryk receptor-like tyrosine kinase 0.027
myod1 myogenic differentiation 1 0.027
junb jun B proto-oncogene 0.027
gpib glucose phosphate isomerase b 0.027
trpm6 transient receptor potential cation channel, subfamily M, member 6 0.027
gng8 guanine nucleotide binding protein (G protein), gamma 8 0.027
irf2bp2b interferon regulatory factor 2 binding protein 2b 0.027
stat1b signal transducer and activator of transcription 1b 0.027
dhfr dihydrofolate reductase 0.026
lmna lamin A 0.026
eif4ebp3l eukaryotic translation initiation factor 4E binding protein 3, like 0.026
eif3s10 eukaryotic translation initiation factor 3, subunit 10 (theta) 0.026
sass6 spindle assembly 6 homolog (C. elegans) 0.026
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Rbf Retinoblastoma-family protein 0.114
debcl death executioner Bcl-2 homologue 0.066
png pan gu 0.049
Dp DP transcription factor 0.033
tefu telomere fusion 0.029
CG9772 CG9772 gene product from transcript CG9772-RB 0.020
dap dacapo 0.016
CG10414 CG10414 gene product from transcript CG10414-RA 0.015
Cdk4 Cyclin-dependent kinase 4 0.013
luna CG33473 gene product from transcript CG33473-RB 0.013
mus304 mutagen-sensitive 304 0.012
rad50 CG6339 gene product from transcript CG6339-RD 0.011
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
SMC1A structural maintenance of chromosomes 1A 0.985
STAG2 stromal antigen 2 0.982
STAG1 stromal antigen 1 0.980
WAPAL wings apart-like homolog (Drosophila) 0.976
RAD21 RAD21 homolog (S. pombe) 0.952
SMC3 structural maintenance of chromosomes 3 0.952
NBN nibrin 0.892
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.863
RBL2 retinoblastoma-like 2 (p130) 0.861
RAD50 RAD50 homolog (S. cerevisiae) 0.719
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 0.702
PDS5A PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae) 0.680
PDS5B PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) 0.655
BRCA1 breast cancer 1, early onset 0.594
RB1 retinoblastoma 1 0.554
TERF2 telomeric repeat binding factor 2 0.532
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 0.474
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.431
ATM ataxia telangiectasia mutated 0.347
CDK2 cyclin-dependent kinase 2 0.345
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 0.334
RFC1 replication factor C (activator 1) 1, 145kDa 0.306
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.296
NR2E3 nuclear receptor subfamily 2, group E, member 3 0.246
TERF2IP telomeric repeat binding factor 2, interacting protein 0.235
ENG endoglin 0.190
RBBP8 retinoblastoma binding protein 8 0.176
RBL1 retinoblastoma-like 1 (p107) 0.161
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.147
CNOT2 CCR4-NOT transcription complex, subunit 2 0.126
CCNE1 cyclin E1 0.122
MDM4 Mdm4 p53 binding protein homolog (mouse) 0.116
CDC26 cell division cycle 26 homolog (S. cerevisiae) 0.115
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.115
EZR ezrin 0.112
C17orf28 chromosome 17 open reading frame 28 0.110
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.099
MMS22L MMS22-like, DNA repair protein 0.094
INSR insulin receptor 0.093
SCHIP1 schwannomin interacting protein 1 0.092
TBC1D10A TBC1 domain family, member 10A 0.079
E2F5 E2F transcription factor 5, p130-binding 0.079
WRN Werner syndrome, RecQ helicase-like 0.075
CNOT7 CCR4-NOT transcription complex, subunit 7 0.074
INO80B INO80 complex subunit B 0.074
LIN9 lin-9 homolog (C. elegans) 0.068
ACD adrenocortical dysplasia homolog (mouse) 0.068
SKP2 S-phase kinase-associated protein 2 (p45) 0.064
ORC2 origin recognition complex, subunit 2 0.061
CCDC6 coiled-coil domain containing 6 0.060
CNOT1 CCR4-NOT transcription complex, subunit 1 0.059
FSTL1 follistatin-like 1 0.057
LARP7 La ribonucleoprotein domain family, member 7 0.056
LIN54 lin-54 homolog (C. elegans) 0.055
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.054
SSU72 SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae) 0.053
RAD9A RAD9 homolog A (S. pombe) 0.053
EP300 E1A binding protein p300 0.052
TGFB1 transforming growth factor, beta 1 0.049
JUB jub, ajuba homolog (Xenopus laevis) 0.048
SORBS1 sorbin and SH3 domain containing 1 0.048
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.043
BLM Bloom syndrome, RecQ helicase-like 0.042
FANCD2 Fanconi anemia, complementation group D2 0.040
NUP153 nucleoporin 153kDa 0.039
HIPK2 homeodomain interacting protein kinase 2 0.038
DEK DEK oncogene 0.036
BTRC beta-transducin repeat containing 0.036
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit 0.034
E2F1 E2F transcription factor 1 0.034
TGFB3 transforming growth factor, beta 3 0.034
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.034
RIF1 RAP1 interacting factor homolog (yeast) 0.033
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.033
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.033
MYH9 myosin, heavy chain 9, non-muscle 0.032
CUL1 cullin 1 0.031
RAD1 RAD1 homolog (S. pombe) 0.030
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.030
AFF1 AF4/FMR2 family, member 1 0.030
AFF4 AF4/FMR2 family, member 4 0.030
NRP1 neuropilin 1 0.029
RAD17 RAD17 homolog (S. pombe) 0.029
SLX4 SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) 0.029
CNOT8 CCR4-NOT transcription complex, subunit 8 0.028
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.027
DMC1 DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast) 0.026
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.026
DAXX death-domain associated protein 0.025
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.025
RHOA ras homolog gene family, member A 0.025
MSN moesin 0.025
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.024
CCNT1 cyclin T1 0.024
CKS2 CDC28 protein kinase regulatory subunit 2 0.023
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa 0.023
BANP BTG3 associated nuclear protein 0.023
E2F4 E2F transcription factor 4, p107/p130-binding 0.023
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.022
ANAPC4 anaphase promoting complex subunit 4 0.022
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 1.000
Brca1 breast cancer 1 0.975
Smc1a structural maintenance of chromosomes 1A 0.975
Nbn nibrin 0.949
Atm ataxia telangiectasia mutated homolog (human) 0.941
Trp73 transformation related protein 73 0.898
Smc3 structural maintenace of chromosomes 3 0.896
Pten phosphatase and tensin homolog 0.864
Terf1 telomeric repeat binding factor 1 0.845
Rbl1 retinoblastoma-like 1 (p107) 0.786
Mdm4 transformed mouse 3T3 cell double minute 4 0.765
Skil SKI-like 0.758
Mdm2 transformed mouse 3T3 cell double minute 2 0.738
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.727
Rb1 retinoblastoma 1 0.649
Msh2 mutS homolog 2 (E. coli) 0.591
Mybl2 myeloblastosis oncogene-like 2 0.579
Apc adenomatosis polyposis coli 0.469
Rara retinoic acid receptor, alpha 0.449
Kitl kit ligand 0.439
Chuk conserved helix-loop-helix ubiquitous kinase 0.432
Sirt1 sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae) 0.383
Dicer1 Dicer1, Dcr-1 homolog (Drosophila) 0.376
Daxx Fas death domain-associated protein 0.362
E2f1 E2F transcription factor 1 0.356
Atrx alpha thalassemia/mental retardation syndrome X-linked homolog (human) 0.342
Mecp2 methyl CpG binding protein 2 0.329
Brca2 breast cancer 2 0.323
Rad21 RAD21 homolog (S. pombe) 0.307
Tsc2 tuberous sclerosis 2 0.299
Col1a1 collagen, type I, alpha 1 0.269
Acd adrenocortical dysplasia 0.259
Elavl1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.252
Smad3 MAD homolog 3 (Drosophila) 0.239
Pds5a PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae) 0.224
Lepr leptin receptor 0.224
Trp63 transformation related protein 63 0.218
Mlh1 mutL homolog 1 (E. coli) 0.200
Fgfr2 fibroblast growth factor receptor 2 0.199
Nf1 neurofibromatosis 1 0.189
Tsc1 tuberous sclerosis 1 0.188
Suz12 suppressor of zeste 12 homolog (Drosophila) 0.180
Myc myelocytomatosis oncogene 0.133
Parp1 poly (ADP-ribose) polymerase family, member 1 0.126
Wdr43 WD repeat domain 43 0.118
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.117
Wrn Werner syndrome homolog (human) 0.116
Huwe1 HECT, UBA and WWE domain containing 1 0.113
Cav1 caveolin 1, caveolae protein 0.111
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.111
Stk11 serine/threonine kinase 11 0.110
Pkdcc protein kinase domain containing, cytoplasmic 0.109
Ctnnb1 catenin (cadherin associated protein), beta 1 0.105
Hells helicase, lymphoid specific 0.104
Men1 multiple endocrine neoplasia 1 0.103
Mapk14 mitogen-activated protein kinase 14 0.103
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.100
Tfdp2 transcription factor Dp 2 0.098
Shh sonic hedgehog 0.098
Prkdc protein kinase, DNA activated, catalytic polypeptide 0.094
Stat1 signal transducer and activator of transcription 1 0.093
Stat6 signal transducer and activator of transcription 6 0.090
Braf Braf transforming gene 0.090
Cxcr4 chemokine (C-X-C motif) receptor 4 0.086
Nup54 nucleoporin 54 0.086
Sox2 SRY-box containing gene 2 0.086
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.086
Rbl2 retinoblastoma-like 2 0.085
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.081
Rrs1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 0.081
Gli3 GLI-Kruppel family member GLI3 0.080
Smarcd1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 0.079
Yap1 yes-associated protein 1 0.078
Ep300 E1A binding protein p300 0.076
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.076
Cdkn2c cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.076
Copz2 coatomer protein complex, subunit zeta 2 0.076
Ltv1 LTV1 homolog (S. cerevisiae) 0.075
Stk4 serine/threonine kinase 4 0.072
Wls wntless homolog (Drosophila) 0.071
En1 engrailed 1 0.069
Dna2 DNA replication helicase 2 homolog (yeast) 0.068
Smn1 survival motor neuron 1 0.067
Pms2 postmeiotic segregation increased 2 (S. cerevisiae) 0.067
Rint1 RAD50 interactor 1 0.067
Dok1 docking protein 1 0.065
Actr6 ARP6 actin-related protein 6 homolog (yeast) 0.064
Arid1b AT rich interactive domain 1B (SWI-like) 0.064
Sox9 SRY-box containing gene 9 0.064
Rad50 RAD50 homolog (S. cerevisiae) 0.063
Ints9 integrator complex subunit 9 0.063
Hcfc1 host cell factor C1 0.059
Atad5 ATPase family, AAA domain containing 5 0.059
Smad2 MAD homolog 2 (Drosophila) 0.059
Pds5b PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) 0.058
Twist1 twist homolog 1 (Drosophila) 0.058
Cebpz CCAAT/enhancer binding protein zeta 0.056
Esr1 estrogen receptor 1 (alpha) 0.056
Bmpr1a bone morphogenetic protein receptor, type 1A 0.056
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.055
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism