The network for 'negative regulation of cellular protein metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of cellular protein metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
BCK1 Bck1p 0.663
PIL1 Pil1p 0.472
CDC55 Cdc55p 0.443
PPH21 Pph21p 0.387
BRE5 Bre5p 0.358
CDC28 Cdc28p 0.350
CDC20 Cdc20p 0.304
STI1 Sti1p 0.289
SUI3 Sui3p 0.283
PPH22 Pph22p 0.269
MAD2 Mad2p 0.243
SIS1 Sis1p 0.226
MYO5 Myo5p 0.199
SPT16 Spt16p 0.187
KSP1 Ksp1p 0.184
HTA1 Hta1p 0.172
CTF13 Ctf13p 0.172
DHH1 Dhh1p 0.168
BOI1 Boi1p 0.155
STE20 Ste20p 0.154
REG1 Reg1p 0.150
RTS1 Rts1p 0.144
PLC1 Plc1p 0.143
CKB1 Ckb1p 0.141
MAD3 Mad3p 0.123
SIC1 Sic1p 0.120
DEF1 Def1p 0.116
IPL1 Ipl1p 0.113
SSA1 Ssa1p 0.112
SUS1 Sus1p 0.110
PAN1 Pan1p 0.104
SDS22 Sds22p 0.098
NPL3 Npl3p 0.094
FAB1 Fab1p 0.091
KEM1 Kem1p 0.090
CAK1 Cak1p 0.089
CSE4 Cse4p 0.088
SLI15 Sli15p 0.087
SGV1 Sgv1p 0.086
CDC37 Cdc37p 0.086
MLP2 Mlp2p 0.086
CPR6 Cpr6p 0.084
CDC6 Cdc6p 0.084
CTI6 Cti6p 0.082
ADR1 Adr1p 0.080
HHF2 Hhf2p 0.078
TIF1 Tif1p 0.078
SSC1 Ssc1p 0.078
INP53 Inp53p 0.076
TCP1 Tcp1p 0.076
DED1 Ded1p 0.075
SNF1 Snf1p 0.074
CLB3 Clb3p 0.073
TPD3 Tpd3p 0.073
MPT5 Mpt5p 0.072
TIF4632 Tif4632p 0.071
SRO9 Sro9p 0.070
UBR2 Ubr2p 0.069
GLC7 Glc7p 0.068
SWE1 Swe1p 0.068
ESS1 Ess1p 0.066
RPS9B Rps9bp 0.066
BUB1 Bub1p 0.066
SPT15 Spt15p 0.064
KIP1 Kip1p 0.064
BUB3 Bub3p 0.064
NBL1 Nbl1p 0.063
DAM1 Dam1p 0.063
RIF1 Rif1p 0.062
ROM2 Rom2p 0.062
YBP2 Ybp2p 0.062
DCP2 Dcp2p 0.062
VHS3 Vhs3p 0.061
URN1 Urn1p 0.060
SLT2 Slt2p 0.060
SGT1 Sgt1p 0.059
MDH1 Mdh1p 0.059
MTW1 Mtw1p 0.059
PSY4 Psy4p 0.059
SPT6 Spt6p 0.057
SOK1 Sok1p 0.057
STE4 Ste4p 0.057
PBS2 Pbs2p 0.057
RRP1 Rrp1p 0.057
SLK19 Slk19p 0.057
PAM1 Pam1p 0.056
HTB1 Htb1p 0.056
SMC2 Smc2p 0.056
CHL4 Chl4p 0.056
YME1 Yme1p 0.055
SFI1 Sfi1p 0.055
DRS1 Drs1p 0.055
GLG2 Glg2p 0.054
CYC8 Cyc8p 0.054
TSR1 Tsr1p 0.054
BRX1 Brx1p 0.054
GBP2 Gbp2p 0.054
MKS1 Mks1p 0.053
PXA1 Pxa1p 0.053
IMP2' Imp2'p 0.052
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
unc-9 Protein UNC-9 0.165
par-5 Protein PAR-5 0.151
mec-2 Protein MEC-2 0.141
F26B1.2 Protein F26B1.2 0.141
egl-44 Protein EGL-44 0.137
imb-2 Protein IMB-2 0.137
mex-5 Protein MEX-5 0.135
ztf-7 Protein ZTF-7 0.132
ntl-4 Protein NTL-4 0.126
brp-1 Protein BRP-1 0.121
unc-53 Protein UNC-53 0.106
tps-1 Protein TPS-1 0.104
sax-3 Protein SAX-3 0.103
F21A10.2 Protein F21A10.2 0.090
gld-1 Protein GLD-1 0.088
CELE_K08F4.2 Protein K08F4.2 0.087
chd-7 Protein CHD-7 0.086
spc-1 Protein SPC-1 0.084
tba-2 Protein TBA-2 0.080
inx-3 Protein INX-3 0.080
C37H5.6 Protein C37H5.6 0.078
vab-3 Protein VAB-3 0.075
tbb-2 Protein TBB-2 0.074
sma-3 Protein SMA-3 0.072
vps-33.2 Protein VPS-33.2 0.068
dgk-2 Protein DGK-2 0.068
hlh-30 Protein HLH-30 0.065
inx-13 Protein INX-13 0.063
dmd-6 Protein DMD-6 0.063
eps-8 Protein EPS-8 0.062
ntl-2 Protein NTL-2 0.061
hum-6 Protein HUM-6 0.060
egl-27 Protein EGL-27 0.059
ubq-1 Protein UBQ-1 0.059
nap-1 Protein NAP-1 0.057
daf-21 Protein DAF-21 0.055
lin-7 Protein LIN-7 0.053
smp-1 Protein SMP-1 0.053
pry-1 Protein PRY-1 0.053
CELE_Y61A9LA.3 Protein Y61A9LA.3 0.051
sma-6 Protein SMA-6 0.050
hpo-32 Protein HPO-32 0.049
rhi-1 Protein RHI-1 0.049
dsh-2 Protein DSH-2 0.047
dnc-1 Protein DNC-1 0.046
ZK512.2 Protein ZK512.2 0.045
alx-1 Protein ALX-1 0.045
egl-8 Protein EGL-8 0.045
F25B3.6 Protein F25B3.6 0.043
his-45 Protein HIS-45 0.042
ajm-1 Protein AJM-1 0.041
skn-1 Protein SKN-1 0.041
dli-1 Protein DLI-1 0.041
atg-2 Protein ATG-2 0.040
nhr-10 Protein NHR-10 0.040
wago-1 Protein WAGO-1 0.040
plk-1 Protein PLK-1 0.040
snr-2 Protein SNR-2 0.040
ptp-3 Protein PTP-3 0.040
gld-2 Protein GLD-2 0.039
ztf-17 Protein ZTF-17 0.039
eif-3.B Protein EIF-3.B 0.038
lmn-1 Protein LMN-1 0.037
gpr-1 Protein GPR-1 0.037
C35D10.1 Protein C35D10.1 0.037
ptr-2 Protein PTR-2 0.037
ZK507.6 Protein ZK507.6 0.035
gyg-2 Protein GYG-2 0.035
ify-1 Protein IFY-1 0.035
sym-4 Protein SYM-4 0.034
mex-3 Protein MEX-3 0.034
afd-1 Protein AFD-1 0.034
cpg-2 Protein CPG-2 0.034
F55F8.9 Protein F55F8.9 0.033
cye-1 Protein CYE-1 0.033
stau-1 Protein STAU-1 0.033
B0336.3 Protein B0336.3 0.033
daf-3 Protein DAF-3 0.033
lbp-3 Protein LBP-3 0.032
lars-1 Protein LARS-1 0.032
pat-3 Protein PAT-3 0.032
ife-3 Protein IFE-3 0.032
dlk-1 Protein DLK-1 0.032
atg-9 Protein ATG-9 0.032
cyk-4 Protein CYK-4 0.032
cgh-1 Protein CGH-1 0.031
Y87G2A.1 Protein Y87G2A.1 0.031
B0035.1 Protein B0035.1 0.031
daf-1 Protein DAF-1 0.031
puf-6 Protein PUF-6 0.031
tiar-1 Protein TIAR-1 0.031
zoo-1 Protein ZOO-1 0.031
rrbs-1 Protein RRBS-1 0.030
C13F10.4 Protein C13F10.4 0.030
cpg-1 Protein CPG-1 0.030
CELE_B0334.5 Protein B0334.5 0.030
D1081.9 Protein D1081.9 0.030
nhr-143 Protein NHR-143 0.029
pde-4 Protein PDE-4 0.029
F49C12.9 Protein F49C12.9 0.029
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
ef1a elongation factor 1-alpha 0.144
sox9b SRY-box containing gene 9b 0.123
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.101
tp53 tumor protein p53 0.099
sema3aa semaphorin 3aa 0.097
bcl2l1 bcl2-like 1 0.073
spry4 sprouty (Drosophila) homolog 4 0.059
shha sonic hedgehog a 0.059
nf1a neurofibromin 1a 0.056
ywhaqb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b 0.050
sox11a SRY-box containing gene 11a 0.050
bmp2b bone morphogenetic protein 2b 0.048
cdk8 cyclin-dependent kinase 8 0.047
bactin1 bactin1 0.045
pcsk5b proprotein convertase subtilisin/kexin type 5b 0.045
ywhabb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b 0.045
tcf12 transcription factor 12 0.044
ywhae1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 0.041
fxr2 fragile X mental retardation, autosomal homolog 2 0.040
hspa4b heat shock protein 4b 0.040
furina furin (paired basic amino acid cleaving enzyme) a 0.039
hspa4a heat shock protein 4a 0.039
sall1a sal-like 1a (Drosophila) 0.039
bactin2 bactin2 0.037
usp5 ubiquitin specific protease 5 0.036
pcna proliferating cell nuclear antigen 0.034
cdc20 cell division cycle 20 homolog 0.033
eif3s10 eukaryotic translation initiation factor 3, subunit 10 (theta) 0.033
ccna2 cyclin A2 0.032
gadd45ba growth arrest and DNA-damage-inducible, beta a 0.032
tgif1 TGFB-induced factor homeobox 1 0.032
lims1 LIM and senescent cell antigen-like domains 1 0.032
pak2a p21 (CDKN1A)-activated kinase 2a 0.031
ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform 0.030
ccnb1 cyclin B1 0.030
stac3 SH3 and cysteine rich domain 3 0.030
ptgs1 prostaglandin-endoperoxide synthase 1 0.030
zgc:56304 zgc:56304 0.029
dusp6 dual specificity phosphatase 6 0.028
per2 period homolog 2 (Drosophila) 0.028
fgfr2 fibroblast growth factor receptor 2 0.028
naa15a N(alpha)-acetyltransferase 15, NatA auxiliary subunit a 0.027
baxa bcl2-associated X protein, a 0.027
jun jun proto-oncogene 0.026
hnrnpk heterogeneous nuclear ribonucleoprotein K 0.026
dnmt3 DNA (cytosine-5-)-methyltransferase 3 0.026
stc1l stanniocalcin 1, like 0.026
flh floating head 0.025
dag1 dystroglycan 1 0.025
nrg2a neuregulin 2a 0.025
lama4 laminin, alpha 4 0.025
zgc:111944 zgc:111944 0.025
bcl2l10 BCL2-like 10 (apoptosis facilitator) 0.024
rarab retinoic acid receptor, alpha b 0.024
dmd dystrophin 0.024
rbfox2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.024
nfkbiab nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b 0.024
rhoub ras homolog gene family, member Ub 0.024
elk4 ELK4, ETS-domain protein 0.023
caprin1a cell cycle associated protein 1a 0.023
nr3c1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.022
hs6st1b heparan sulfate 6-O-sulfotransferase 1b 0.022
pafah1b1b platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b 0.022
ncl nucleolin 0.022
junb jun B proto-oncogene 0.022
s1pr1 sphingosine-1-phosphate receptor 1 0.022
trim71 tripartite motif-containing 71 0.022
sox2 SRY-box containing gene 2 0.022
egr1 early growth response 1 0.021
fabp10a fatty acid binding protein 10a, liver basic 0.021
hsp90a.2 heat shock protein 90-alpha 2 0.021
ppp1r12a protein phosphatase 1, regulatory (inhibitor) subunit 12A 0.021
neurod4 neurogenic differentiation 4 0.021
tnpo3 transportin 3 0.021
ube2i2 ubiquitin-conjugating enzyme E2I2 0.021
usp10 ubiquitin specific peptidase 10 0.020
yes1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 0.020
dzip1 DAZ interacting protein 1 0.020
cebpd CCAAT/enhancer binding protein (C/EBP), delta 0.020
wu:fi25h02 wu:fi25h02 0.020
tm4sf4 transmembrane 4 L six family member 4 0.020
polr2d polymerase (RNA) II (DNA directed) polypeptide D 0.019
strap serine/threonine kinase receptor associated protein 0.019
lcp1 lymphocyte cytosolic plastin 1 0.019
evx1 even-skipped homeobox 1 0.019
prkci protein kinase C, iota 0.019
mstnb myostatin b 0.019
hhip hedgehog interacting protein 0.019
sepw1 selenoprotein W, 1 0.019
ntn2 netrin 2 0.019
junbl jun B proto-oncogene, like 0.019
smad1 MAD homolog 1 (Drosophila) 0.019
lass2 LAG1 homolog, ceramide synthase 2 (S. cerevisiae) 0.018
ahsa1l AHA1, activator of heat shock protein ATPase homolog 1, like 0.018
gadd45ab growth arrest and DNA-damage-inducible, alpha, b 0.018
kif23 kinesin family member 23 0.018
plp1a proteolipid protein 1a 0.018
mbnl2 muscleblind-like 2 (Drosophila) 0.018
foxi1 forkhead box I1 0.018
axin2 axin 2 (conductin, axil) 0.018
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Akt1 CG4006 gene product from transcript CG4006-RA 0.612
drk downstream of receptor kinase 0.573
osk oskar 0.570
Src64B Src oncogene at 64B 0.531
Egfr Epidermal growth factor receptor 0.523
spi spitz 0.471
Mad Mothers against dpp 0.451
Su(var)205 Suppressor of variegation 205 0.413
Tak1 TGF-beta activated kinase 1 0.395
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.390
Ras85D Ras oncogene at 85D 0.334
dnc dunce 0.321
Ubx Ultrabithorax 0.318
G-oalpha47A G protein oalpha 47A 0.298
rl rolled 0.263
rin rasputin 0.253
shg shotgun 0.250
SF2 CG6987 gene product from transcript CG6987-RA 0.232
Abl Abl tyrosine kinase 0.226
sxc super sex combs 0.225
Iswi Imitation SWI 0.224
rap retina aberrant in pattern 0.217
smt3 CG4494 gene product from transcript CG4494-RA 0.215
egh egghead 0.215
bchs blue cheese 0.192
tws twins 0.190
brm brahma 0.190
Hsp83 Heat shock protein 83 0.190
Adf1 Adh transcription factor 1 0.184
rho rhomboid 0.180
Dad Daughters against dpp 0.180
ena enabled 0.178
dpp decapentaplegic 0.170
thr three rows 0.169
scny scrawny 0.165
Socs36E Suppressor of cytokine signaling at 36E 0.163
tai taiman 0.163
gish gilgamesh 0.163
Hsc70-4 Heat shock protein cognate 4 0.161
hts hu li tai shao 0.160
lgs legless 0.158
simj simjang 0.158
so sine oculis 0.155
Smox Smad on X 0.152
Pen Pendulin 0.151
krz kurtz 0.151
eya eyes absent 0.149
Uba2 Smt3 activating enzyme 2 0.149
Pten CG5671 gene product from transcript CG5671-RB 0.148
rictor rapamycin-insensitive companion of Tor 0.138
mts microtubule star 0.136
Tao-1 CG14217 gene product from transcript CG14217-RF 0.134
Nrx-IV Neurexin IV 0.132
Tsp Thrombospondin 0.131
mirr mirror 0.130
Ptp69D Protein tyrosine phosphatase 69D 0.126
dap dacapo 0.126
msn misshapen 0.125
EndoGI Endonuclease G inhibitor 0.125
Hrb27C Heterogeneous nuclear ribonucleoprotein at 27C 0.124
tsh teashirt 0.124
rut rutabaga 0.123
bam bag of marbles 0.122
Thor CG8846 gene product from transcript CG8846-RA 0.122
sog short gastrulation 0.122
Galpha49B G protein alpha49B 0.120
th thread 0.119
14-3-3epsilon CG31196 gene product from transcript CG31196-RA 0.119
RanBPM Ran-binding protein M 0.114
gw gawky 0.113
Nmt N-myristoyl transferase 0.112
NFAT NFAT homolog 0.112
Top1 Topoisomerase 1 0.111
stck steamer duck 0.111
Cdc42 CG12530 gene product from transcript CG12530-RA 0.110
CycA Cyclin A 0.110
loqs loquacious 0.109
KP78b CG17216 gene product from transcript CG17216-RB 0.109
sty sprouty 0.109
Cam Calmodulin 0.108
Psf2 CG18013 gene product from transcript CG18013-RA 0.105
Shc SHC-adaptor protein 0.104
tkv thickveins 0.103
scb scab 0.103
kek1 kekkon-1 0.101
swm second mitotic wave missing 0.099
drpr draper 0.098
jing CG9397 gene product from transcript CG9397-RI 0.097
CycB Cyclin B 0.097
Fmr1 CG6203 gene product from transcript CG6203-RC 0.095
foxo forkhead box, sub-group O 0.093
Utx CG5640 gene product from transcript CG5640-RD 0.093
amn amnesiac 0.092
gammaTub23C gamma-Tubulin at 23C 0.092
Six4 CG3871 gene product from transcript CG3871-RA 0.092
eEF1delta CG4912 gene product from transcript CG4912-RB 0.091
CG1553 CG1553 gene product from transcript CG1553-RA 0.090
smo smoothened 0.090
rpr reaper 0.089
polo CG12306 gene product from transcript CG12306-RA 0.088
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 1.000
RB1 retinoblastoma 1 0.999
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.997
GSK3B glycogen synthase kinase 3 beta 0.997
MAPK14 mitogen-activated protein kinase 14 0.995
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.991
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.990
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.989
MAPK1 mitogen-activated protein kinase 1 0.986
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.986
UBC ubiquitin C 0.976
EGFR epidermal growth factor receptor 0.973
PRKCZ protein kinase C, zeta 0.965
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.950
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.919
MET met proto-oncogene (hepatocyte growth factor receptor) 0.910
TP53 tumor protein p53 0.906
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.902
SFN stratifin 0.898
PLCG1 phospholipase C, gamma 1 0.875
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.873
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.864
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.856
JUN jun proto-oncogene 0.847
BCL2 B-cell CLL/lymphoma 2 0.846
PRKCA protein kinase C, alpha 0.845
BCAR1 breast cancer anti-estrogen resistance 1 0.829
DAXX death-domain associated protein 0.824
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.821
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.815
CDK4 cyclin-dependent kinase 4 0.815
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.812
APP amyloid beta (A4) precursor protein 0.803
BUB1B budding uninhibited by benzimidazoles 1 homolog beta (yeast) 0.798
ELAVL1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.795
BCL2L1 BCL2-like 1 0.794
VIM vimentin 0.781
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.779
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.779
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.773
CUL3 cullin 3 0.769
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.768
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.768
ZNF43 zinc finger protein 43 0.744
CREBBP CREB binding protein 0.741
EGR1 early growth response 1 0.736
SMAD3 SMAD family member 3 0.736
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.729
HSPA1B heat shock 70kDa protein 1B 0.727
CDC27 cell division cycle 27 homolog (S. cerevisiae) 0.724
SMAD7 SMAD family member 7 0.723
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.723
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.721
DUSP1 dual specificity phosphatase 1 0.720
RICTOR RPTOR independent companion of MTOR, complex 2 0.716
QKI quaking homolog, KH domain RNA binding (mouse) 0.712
GHR growth hormone receptor 0.711
E2F1 E2F transcription factor 1 0.708
TOB1 transducer of ERBB2, 1 0.691
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.681
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.676
CTSB cathepsin B 0.659
GRB2 growth factor receptor-bound protein 2 0.656
CCND1 cyclin D1 0.655
LCK lymphocyte-specific protein tyrosine kinase 0.653
ACTB actin, beta 0.644
ZNF273 zinc finger protein 273 0.640
GABARAP GABA(A) receptor-associated protein 0.639
HDAC1 histone deacetylase 1 0.634
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.633
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.630
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.627
FYN FYN oncogene related to SRC, FGR, YES 0.620
TRIM28 tripartite motif containing 28 0.610
FOS FBJ murine osteosarcoma viral oncogene homolog 0.590
ADAM15 ADAM metallopeptidase domain 15 0.590
ARRB1 arrestin, beta 1 0.588
CDC5L CDC5 cell division cycle 5-like (S. pombe) 0.586
RPTOR regulatory associated protein of MTOR, complex 1 0.584
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.581
HUWE1 HECT, UBA and WWE domain containing 1 0.581
PARP1 poly (ADP-ribose) polymerase 1 0.578
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.574
HSPA4 heat shock 70kDa protein 4 0.574
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.565
A2M alpha-2-macroglobulin 0.564
GRB10 growth factor receptor-bound protein 10 0.564
RARA retinoic acid receptor, alpha 0.563
ATF2 activating transcription factor 2 0.555
BIRC2 baculoviral IAP repeat containing 2 0.550
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.548
MED28 mediator complex subunit 28 0.540
KLF6 Kruppel-like factor 6 0.539
SMAD4 SMAD family member 4 0.532
CNOT8 CCR4-NOT transcription complex, subunit 8 0.531
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.529
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.529
PABPC1 poly(A) binding protein, cytoplasmic 1 0.529
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.528
TSC2 tuberous sclerosis 2 0.525
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 1.000
Pten phosphatase and tensin homolog 1.000
Lepr leptin receptor 0.980
Ctnnb1 catenin (cadherin associated protein), beta 1 0.979
Skil SKI-like 0.972
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.970
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.960
Rb1 retinoblastoma 1 0.955
Axin1 axin 1 0.951
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.937
Gsk3b glycogen synthase kinase 3 beta 0.937
Pax8 paired box gene 8 0.932
Bcl2 B-cell leukemia/lymphoma 2 0.918
Suz12 suppressor of zeste 12 homolog (Drosophila) 0.914
Clock circadian locomotor output cycles kaput 0.913
Lyz2 lysozyme 2 0.905
Per2 period homolog 2 (Drosophila) 0.901
Fas Fas (TNF receptor superfamily member 6) 0.899
Mdm2 transformed mouse 3T3 cell double minute 2 0.893
Ret ret proto-oncogene 0.892
Dusp1 dual specificity phosphatase 1 0.872
Nos1 nitric oxide synthase 1, neuronal 0.866
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.863
Ppp2ca protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform 0.853
Grb2 growth factor receptor bound protein 2 0.848
Apc adenomatosis polyposis coli 0.842
Jun Jun oncogene 0.840
Cbl Casitas B-lineage lymphoma 0.825
Stat3 signal transducer and activator of transcription 3 0.821
Fos FBJ osteosarcoma oncogene 0.794
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.792
Hr hairless 0.789
Ptgs2 prostaglandin-endoperoxide synthase 2 0.784
Casp1 caspase 1 0.782
Cry2 cryptochrome 2 (photolyase-like) 0.778
Cdk4 cyclin-dependent kinase 4 0.776
Elavl1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.776
Nr4a1 nuclear receptor subfamily 4, group A, member 1 0.771
Shh sonic hedgehog 0.764
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.764
Gli2 GLI-Kruppel family member GLI2 0.760
Smad3 MAD homolog 3 (Drosophila) 0.755
Nf2 neurofibromatosis 2 0.750
Egfr epidermal growth factor receptor 0.750
Brca1 breast cancer 1 0.747
Kdm2b lysine (K)-specific demethylase 2B 0.746
Blnk B-cell linker 0.744
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.742
Ncoa3 nuclear receptor coactivator 3 0.727
Onecut1 one cut domain, family member 1 0.718
Il1r1 interleukin 1 receptor, type I 0.708
Myd88 myeloid differentiation primary response gene 88 0.698
Crk v-crk sarcoma virus CT10 oncogene homolog (avian) 0.686
Junb Jun-B oncogene 0.680
Mdm4 transformed mouse 3T3 cell double minute 4 0.679
Iigp1 interferon inducible GTPase 1 0.677
Rara retinoic acid receptor, alpha 0.677
Tcf7l1 transcription factor 7-like 1 (T-cell specific, HMG box) 0.673
Smad7 MAD homolog 7 (Drosophila) 0.663
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.642
Tsc1 tuberous sclerosis 1 0.638
Fyn Fyn proto-oncogene 0.635
Ghr growth hormone receptor 0.632
Plcg2 phospholipase C, gamma 2 0.626
Prpf40a PRP40 pre-mRNA processing factor 40 homolog A (yeast) 0.620
Nf1 neurofibromatosis 1 0.620
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.616
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.613
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.605
Foxp1 forkhead box P1 0.603
Jak2 Janus kinase 2 0.596
Eif2c2 eukaryotic translation initiation factor 2C, 2 0.595
Nos3 nitric oxide synthase 3, endothelial cell 0.595
Ctla2b cytotoxic T lymphocyte-associated protein 2 beta 0.592
Aim2 absent in melanoma 2 0.586
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.585
Vegfa vascular endothelial growth factor A 0.584
Tek endothelial-specific receptor tyrosine kinase 0.576
Mapk8 mitogen-activated protein kinase 8 0.574
Rxra retinoid X receptor alpha 0.566
Psen1 presenilin 1 0.562
Cdkn2c cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.558
Mndal myeloid nuclear differentiation antigen like 0.555
Atm ataxia telangiectasia mutated homolog (human) 0.555
Braf Braf transforming gene 0.552
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.552
Drd2 dopamine receptor D2 0.541
Cd28 CD28 antigen 0.540
Rarb retinoic acid receptor, beta 0.538
Tsc2 tuberous sclerosis 2 0.536
Bax BCL2-associated X protein 0.535
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.532
Grb10 growth factor receptor bound protein 10 0.527
Smad1 MAD homolog 1 (Drosophila) 0.518
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.511
Nlrp3 NLR family, pyrin domain containing 3 0.511
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.509
Btg2 B-cell translocation gene 2, anti-proliferative 0.507
Neurod4 neurogenic differentiation 4 0.506
Fgfr1 fibroblast growth factor receptor 1 0.493
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Fos FBJ osteosarcoma oncogene 0.513
Junb jun B proto-oncogene 0.424
Dusp1 dual specificity phosphatase 1 0.370
Egr1 early growth response 1 0.347
Zfp36 zinc finger protein 36 0.313
Jun Jun oncogene 0.216
Nr4a3 nuclear receptor subfamily 4, group A, member 3 0.202
Btg2 BTG family, member 2 0.174
Lgals3 lectin, galactoside-binding, soluble, 3 0.172
Calcrl calcitonin receptor-like 0.144
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.138
Errfi1 ERBB receptor feedback inhibitor 1 0.136
Ppp1r15a protein phosphatase 1, regulatory (inhibitor) subunit 15A 0.133
Anxa2 annexin A2 0.129
Myo1b myosin Ib 0.117
Dnajb1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.116
Klf9 Kruppel-like factor 9 0.115
Metap2 methionyl aminopeptidase 2 0.109
Nr2f6 nuclear receptor subfamily 2, group F, member 6 0.108
Proc protein C 0.108
C9 complement component 9 0.107
Egr2 early growth response 2 0.107
Atf3 activating transcription factor 3 0.106
Jak2 Janus kinase 2 0.104
Hspa1a heat shock 70kD protein 1A 0.103
Gpam glycerol-3-phosphate acyltransferase, mitochondrial 0.102
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.101
Fgfr2 fibroblast growth factor receptor 2 0.100
Apba3 amyloid beta (A4) precursor protein-binding, family A, member 3 0.096
Tcfe2a transcription factor E2a 0.096
Gja1 gap junction protein, alpha 1 0.096
Adam10 ADAM metallopeptidase domain 10 0.093
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.093
Mllt4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.086
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.082
Ptgs2 prostaglandin-endoperoxide synthase 2 0.081
Klf4 Kruppel-like factor 4 (gut) 0.080
Cfb complement factor B 0.080
Hspa9 heat shock protein 9 0.080
Stip1 stress-induced phosphoprotein 1 0.077
Homer3 homer homolog 3 (Drosophila) 0.077
Ptch1 patched homolog 1 (Drosophila) 0.076
Marcks myristoylated alanine rich protein kinase C substrate 0.076
Irs1 insulin receptor substrate 1 0.074
Apoh apolipoprotein H (beta-2-glycoprotein I) 0.074
Klf12 Kruppel-like factor 12 0.073
Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 0.072
Apoa5 apolipoprotein A-V 0.072
Ahsg alpha-2-HS-glycoprotein 0.071
Apoa2 apolipoprotein A-II 0.071
Hspb1 heat shock protein 1 0.070
Taok1 TAO kinase 1 0.070
Bmpr1a bone morphogenetic protein receptor, type IA 0.069
Ptms parathymosin 0.068
Tgoln1 trans-golgi network protein 0.068
Spp2 secreted phosphoprotein 2 0.068
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.067
Rhob ras homolog gene family, member B 0.067
Socs3 suppressor of cytokine signaling 3 0.067
Tdo2 tryptophan 2,3-dioxygenase 0.066
Utrn utrophin 0.066
Anxa4 annexin A4 0.066
Gjb3 gap junction protein, beta 3 0.065
LOC299282 Serine protease inhibitor 0.065
Casp2 caspase 2 0.063
Fga fibrinogen alpha chain 0.062
Usf2 upstream transcription factor 2, c-fos interacting 0.062
Apoe apolipoprotein E 0.062
Dnaja4 DnaJ (Hsp40) homolog, subfamily A, member 4 0.061
Lyve1 lymphatic vessel endothelial hyaluronan receptor 1 0.061
Cdx1 caudal type homeo box 1 0.061
Ptger3 prostaglandin E receptor 3 (subtype EP3) 0.061
Cd63 Cd63 molecule 0.059
Stat5b signal transducer and activator of transcription 5B 0.059
Gja5 gap junction protein, alpha 5 0.059
Apoa1 apolipoprotein A-I 0.058
Cckar cholecystokinin A receptor 0.058
Rgs14 regulator of G-protein signaling 14 0.057
Dctn1 dynactin 1 0.057
Kng2 kininogen 2 0.057
Klf6 Kruppel-like factor 6 0.057
Nos1 nitric oxide synthase 1, neuronal 0.057
Cdca3 cell division cycle associated 3 0.056
Arnt2 aryl hydrocarbon receptor nuclear translocator 2 0.056
Tgfbr2 transforming growth factor, beta receptor II 0.056
Epn1 Epsin 1 0.056
Amh anti-Mullerian hormone 0.055
Stat6 signal transducer and activator of transcription 6 0.055
Notch3 Notch homolog 3 (Drosophila) 0.054
Cngb1 cyclic nucleotide gated channel beta 1 0.054
Klf2 Kruppel-like factor 2 (lung) 0.054
Ppp1r9b protein phosphatase 1, regulatory subunit 9B 0.054
Slc15a1 solute carrier family 15 (oligopeptide transporter), member 1 0.053
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.053
Dlg1 discs, large homolog 1 (Drosophila) 0.053
Rgs1 regulator of G-protein signaling 1 0.053
Obp2b odorant binding protein 2B 0.052
Sgk1 serum/glucocorticoid regulated kinase 1 0.052
Nr4a1 nuclear receptor subfamily 4, group A, member 1 0.052
Slfn2 schlafen 2 0.052