The network for 'dna replication initiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

dna replication initiation

The process in which DNA-dependent DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action.

Name Description Probability Func Analog Organism
MCM5 Mcm5p 0.999
ORC2 Orc2p 0.998
CDC45 Cdc45p 0.996
MCM2 Mcm2p 0.996
MCM4 Mcm4p 0.996
MCM3 Mcm3p 0.993
ORC3 Orc3p 0.987
MCM7 Mcm7p 0.982
ORC1 Orc1p 0.981
MCM6 Mcm6p 0.978
CDC6 Cdc6p 0.974
CLB5 Clb5p 0.972
ORC6 Orc6p 0.961
DBF4 Dbf4p 0.949
SLD5 Sld5p 0.923
ORC5 Orc5p 0.916
SLD3 Sld3p 0.913
MCM10 Mcm10p 0.893
CHL1 Chl1p 0.867
MRC1 Mrc1p 0.857
DIA2 Dia2p 0.770
PSF1 Psf1p 0.682
SLD2 Sld2p 0.660
ORC4 Orc4p 0.649
RAD53 Rad53p 0.610
POL1 Pol1p 0.524
DPB2 Dpb2p 0.498
SIN3 Sin3p 0.453
SDS3 Sds3p 0.453
HST1 Hst1p 0.441
MDN1 Mdn1p 0.430
POL32 Pol32p 0.370
TAH11 Tah11p 0.340
DPB11 Dpb11p 0.327
POL12 Pol12p 0.300
SIR2 Sir2p 0.228
TOF1 Tof1p 0.218
SUM1 Sum1p 0.217
PHO23 Pho23p 0.215
PDS1 Pds1p 0.207
NOC3 Noc3p 0.201
SYF1 Syf1p 0.196
RAD9 Rad9p 0.182
HAT1 Hat1p 0.174
HST3 Hst3p 0.158
RLF2 Rlf2p 0.138
CTF18 Ctf18p 0.136
CDC7 Cdc7p 0.134
CDC14 Cdc14p 0.133
PDS5 Pds5p 0.114
BMH1 Bmh1p 0.112
POL2 Pol2p 0.111
SNT1 Snt1p 0.110
PSF2 Psf2p 0.107
CLB6 Clb6p 0.107
BUB1 Bub1p 0.105
UME1 Ume1p 0.101
PRI1 Pri1p 0.099
SIC1 Sic1p 0.097
CDC34 Cdc34p 0.088
YOR060C hypothetical protein 0.083
CTF4 Ctf4p 0.082
CTI6 Cti6p 0.080
SPT21 Spt21p 0.079
RCO1 Rco1p 0.079
FOB1 Fob1p 0.078
IPI3 Ipi3p 0.076
RSC4 Rsc4p 0.074
NDD1 Ndd1p 0.073
RIF1 Rif1p 0.067
MSA1 Msa1p 0.065
NOG1 Nog1p 0.057
HAL5 Hal5p 0.056
TOP1 Top1p 0.054
RSA1 Rsa1p 0.052
SCC2 Scc2p 0.052
SET3 Set3p 0.050
SET2 Set2p 0.049
TFA1 Tfa1p 0.049
FKH2 Fkh2p 0.048
MET4 Met4p 0.048
EAF3 Eaf3p 0.048
POL31 Pol31p 0.045
RPF1 Rpf1p 0.045
OPT2 Opt2p 0.044
MOT3 Mot3p 0.044
YLR257W hypothetical protein 0.044
UME6 Ume6p 0.043
SPT5 Spt5p 0.043
YNR014W hypothetical protein 0.042
HOS4 Hos4p 0.042
VMA13 Vma13p 0.042
YCG1 Ycg1p 0.041
LEU2 Leu2p 0.041
ADH2 Adh2p 0.041
MRK1 Mrk1p 0.040
HOP1 Hop1p 0.040
YLR177W hypothetical protein 0.039
RFC4 Rfc4p 0.039
MIF2 Mif2p 0.039
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Orc2 Origin recognition complex subunit 2 0.976
dpa disc proliferation abnormal 0.806
hd humpty dumpty 0.795
Mcm5 Minichromosome maintenance 5 0.640
dup double parked 0.559
Mcm2 Minichromosome maintenance 2 0.531
Orc5 Origin recognition complex subunit 5 0.409
dap dacapo 0.353
mus209 mutagen-sensitive 209 0.293
DNApol-alpha60 DNA polymerase alpha 60kD 0.260
Mcm6 Minichromosome maintenance 6 0.186
mus101 mutagen-sensitive 101 0.176
RnrS Ribonucleoside diphosphate reductase small subunit 0.115
Ndc80 CG9938 gene product from transcript CG9938-RA 0.100
Mcm10 Sensitized chromosome inheritance modifier 19 0.087
CG3430 CG3430 gene product from transcript CG3430-RA 0.076
CDC45L CG3658 gene product from transcript CG3658-RA 0.072
Mcm3 Minichromosome maintenance 3 0.061
prod proliferation disrupter 0.061
vtd verthandi 0.056
RfC4 Replication factor C subunit 4 0.046
DNApol-alpha73 DNA polymerase alpha 73kD 0.037
Caf1 Chromatin assembly factor 1 subunit 0.037
RnrL Ribonucleoside diphosphate reductase large subunit 0.034
Rbf Retinoblastoma-family protein 0.033
Slbp Stem-loop binding protein 0.032
SMC2 CG10212 gene product from transcript CG10212-RA 0.032
DNApol-alpha50 DNA polymerase alpha 50kD 0.031
neb nebbish 0.030
stg string 0.029
cdc2c CG10498 gene product from transcript CG10498-RC 0.028
BubR1 Bub1-related kinase 0.028
barr barren 0.026
Dcp-1 Death caspase-1 0.026
Cks30A Cyclin-dependent kinase subunit 30A 0.025
DNApol-delta DNA-polymerase-delta 0.024
Caf1-105 CG12892 gene product from transcript CG12892-RA 0.024
Mcm7 Minichromosome maintenance 7 0.020
rod rough deal 0.018
WRNexo WRN exonuclease 0.017
asf1 anti-silencing factor 1 0.017
RecQ4 CG7487 gene product from transcript CG7487-RA 0.016
Ets97D Ets at 97D 0.016
Orc6 Origin recognition complex subunit 6 0.015
CycJ Cyclin J 0.014
cmet CENP-meta 0.014
Klp67A Kinesin-like protein at 67A 0.013
mus301 mutagen-sensitive 301 0.013
geminin CG3183 gene product from transcript CG3183-RA 0.012
Pole2 CG10489 gene product from transcript CG10489-RA 0.011
lat latheo 0.011
CG13350 CG13350 gene product from transcript CG13350-RA 0.011
pav pavarotti 0.011
Sse Separase 0.011
ncd non-claret disjunctional 0.011
Klp61F Kinesin-like protein at 61F 0.011
spn-A spindle A 0.011
Orc4 Origin recognition complex subunit 4 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
MCM3 minichromosome maintenance complex component 3 1.000
CDK2 cyclin-dependent kinase 2 1.000
MCM2 minichromosome maintenance complex component 2 1.000
CDC6 cell division cycle 6 homolog (S. cerevisiae) 1.000
MCM4 minichromosome maintenance complex component 4 1.000
MCM6 minichromosome maintenance complex component 6 1.000
ORC2 origin recognition complex, subunit 2 1.000
ORC1 origin recognition complex, subunit 1 1.000
ORC5 origin recognition complex, subunit 5 1.000
MCM7 minichromosome maintenance complex component 7 0.999
MCM10 minichromosome maintenance complex component 10 0.998
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.998
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.996
ORC3 origin recognition complex, subunit 3 0.996
CDC45 cell division cycle 45 homolog (S. cerevisiae) 0.994
ORC6 origin recognition complex, subunit 6 0.967
CCNE1 cyclin E1 0.953
CDC7 cell division cycle 7 homolog (S. cerevisiae) 0.940
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.803
MCM5 minichromosome maintenance complex component 5 0.750
CDT1 chromatin licensing and DNA replication factor 1 0.742
CHAF1A chromatin assembly factor 1, subunit A (p150) 0.685
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.577
POLA2 polymerase (DNA directed), alpha 2 (70kD subunit) 0.567
MCMBP minichromosome maintenance complex binding protein 0.543
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.381
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 125kDa 0.333
MMS22L MMS22-like, DNA repair protein 0.253
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.229
GMNN geminin, DNA replication inhibitor 0.222
RPA1 replication protein A1, 70kDa 0.186
ORC4 origin recognition complex, subunit 4 0.184
CDC25A cell division cycle 25 homolog A (S. pombe) 0.180
ANAPC4 anaphase promoting complex subunit 4 0.164
SSRP1 structure specific recognition protein 1 0.148
DBF4 DBF4 homolog (S. cerevisiae) 0.118
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.112
ASF1B ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.107
MCM8 minichromosome maintenance complex component 8 0.094
SKP2 S-phase kinase-associated protein 2 (p45) 0.089
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.088
CCNB2 cyclin B2 0.074
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.061
ANAPC1 anaphase promoting complex subunit 1 0.055
PRIM2 primase, DNA, polypeptide 2 (58kDa) 0.050
RPA2 replication protein A2, 32kDa 0.042
E2F1 E2F transcription factor 1 0.038
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.034
CCDC6 coiled-coil domain containing 6 0.033
RBL1 retinoblastoma-like 1 (p107) 0.031
CDC25B cell division cycle 25 homolog B (S. pombe) 0.031
MORF4L1 mortality factor 4 like 1 0.029
CDC5L CDC5 cell division cycle 5-like (S. pombe) 0.021
POLD3 polymerase (DNA-directed), delta 3, accessory subunit 0.020
CHAF1B chromatin assembly factor 1, subunit B (p60) 0.018
GINS2 GINS complex subunit 2 (Psf2 homolog) 0.018
CDR2 cerebellar degeneration-related protein 2, 62kDa 0.016
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.015
HCFC1 host cell factor C1 (VP16-accessory protein) 0.014
MRFAP1 Morf4 family associated protein 1 0.014
CDC26 cell division cycle 26 homolog (S. cerevisiae) 0.013
SMC1A structural maintenance of chromosomes 1A 0.010
CLSPN claspin 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Cdt1 chromatin licensing and DNA replication factor 1 0.996
Mcm2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae) 0.978
Mcm3 minichromosome maintenance deficient 3 (S. cerevisiae) 0.871
Ccne1 cyclin E1 0.703
Mcm5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) 0.673
Mcm4 minichromosome maintenance deficient 4 homolog (S. cerevisiae) 0.558
Cdk2 cyclin-dependent kinase 2 0.455
Prim1 DNA primase, p49 subunit 0.277
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.236
Mcm7 minichromosome maintenance deficient 7 (S. cerevisiae) 0.235
Timeless timeless homolog (Drosophila) 0.189
Cdc6 cell division cycle 6 homolog (S. cerevisiae) 0.184
Orc1 origin recognition complex, subunit 1 0.148
Orc6 origin recognition complex, subunit 6 0.132
Tcf19 transcription factor 19 0.117
Cdc45 cell division cycle 45 homolog (S. cerevisiae) 0.109
Prim2 DNA primase, p58 subunit 0.103
Suds3 suppressor of defective silencing 3 homolog (S. cerevisiae) 0.101
Rrm2 ribonucleotide reductase M2 0.074
Rpgrip1l Rpgrip1-like 0.054
Wdhd1 WD repeat and HMG-box DNA binding protein 1 0.053
Cdca7 cell division cycle associated 7 0.051
Kdm5b lysine (K)-specific demethylase 5B 0.050
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.046
Pold1 polymerase (DNA directed), delta 1, catalytic subunit 0.043
Chaf1b chromatin assembly factor 1, subunit B (p60) 0.032
Hdac1 histone deacetylase 1 0.031
Mcm6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae) 0.028
Lig1 ligase I, DNA, ATP-dependent 0.028
Lrrk2 leucine-rich repeat kinase 2 0.023
Iqcb1 IQ calmodulin-binding motif containing 1 0.022
Ccna2 cyclin A2 0.020
Crk v-crk sarcoma virus CT10 oncogene homolog (avian) 0.019
Pole2 polymerase (DNA directed), epsilon 2 (p59 subunit) 0.018
Hells helicase, lymphoid specific 0.017
Sept7 septin 7 0.016
Rcc1 regulator of chromosome condensation 1 0.015
Orc2 origin recognition complex, subunit 2 0.014
Gtse1 G two S phase expressed protein 1 0.013
Aurka aurora kinase A 0.013
Rad51ap1 RAD51 associated protein 1 0.013
Rrm1 ribonucleotide reductase M1 0.012
Ung uracil DNA glycosylase 0.012
Pola1 polymerase (DNA directed), alpha 1 0.012
Srebf2 sterol regulatory element binding factor 2 0.012
Rnf220 ring finger protein 220 0.010
Ezh2 enhancer of zeste homolog 2 (Drosophila) 0.010
Asf1b ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism